Development Level

Tbio 308 | 11,445
Tchem 22 | 1,598
Tdark 11 | 6,588
Tclin 5 | 613

IMPC Phenotype

preweaning lethality, complete... 17 | 979
preweaning lethality, incomple... 15 | 499
enlarged heart 10 | 210
abnormal behavior 9 | 298
abnormal embryo size 9 | 220
decreased vertical activity 9 | 208
abnormal heart morphology 7 | 162
abnormal seminal vesicle morph... 6 | 114
decreased body weight 6 | 161
decreased total body fat amoun... 6 | 207
embryonic lethality prior to t... 6 | 278
abnormal bone structure 5 | 187
abnormal retina morphology 5 | 71
embryonic growth retardation 5 | 106
increased startle reflex 5 | 112
prenatal lethality prior to he... 5 | 87
decreased bone mineral density 4 | 126
decreased lean body mass 4 | 135
hypoactivity 4 | 132
impaired glucose tolerance 4 | 75
increased bone mineral content 4 | 108
increased lean body mass 4 | 172
increased monocyte cell number 4 | 63
increased total body fat amoun... 4 | 134
male infertility 4 | 123
small superior vagus ganglion 4 | 74
abnormal craniofacial morpholo... 3 | 33
abnormal eye morphology 3 | 68
abnormal forebrain development 3 | 20
abnormal gait 3 | 69
abnormal neural tube closure 3 | 46
abnormal sleep behavior 3 | 70
decreased circulating choleste... 3 | 93
decreased circulating serum al... 3 | 82
decreased circulating triglyce... 3 | 79
decreased lymphocyte cell numb... 3 | 83
embryonic lethality prior to o... 3 | 239
female infertility 3 | 60
hyperactivity 3 | 148
increased bone mineral density 3 | 72
increased circulating alkaline... 3 | 122
increased fasted circulating g... 3 | 76
abnormal bone mineralization 2 | 38
abnormal coat appearance 2 | 31
abnormal cornea morphology 2 | 31
abnormal facial morphology 2 | 17
abnormal hindbrain development 2 | 16
abnormal kidney morphology 2 | 65
anophthalmia 2 | 33
corneal opacity 2 | 32
decreased blood urea nitrogen ... 2 | 51
decreased body length 2 | 101
decreased circulating HDL chol... 2 | 68
decreased circulating alanine ... 2 | 47
decreased circulating aspartat... 2 | 34
decreased circulating bilirubi... 2 | 19
decreased circulating fructosa... 2 | 30
decreased circulating glucose ... 2 | 126
decreased circulating sodium l... 2 | 22
decreased erythrocyte cell num... 2 | 62
decreased grip strength 2 | 116
decreased hematocrit 2 | 46
decreased leukocyte cell numbe... 2 | 73
enlarged lymph nodes 2 | 37
hemorrhage 2 | 23
increased cardiac muscle contr... 2 | 8
increased circulating amylase ... 2 | 25
increased neutrophil cell numb... 2 | 46
increased or absent threshold ... 2 | 101
microphthalmia 2 | 26
pale yolk sac 2 | 25
pallor 2 | 34
thrombocytopenia 2 | 56
abnormal behavioral response t... 1 | 66
abnormal cranium morphology 1 | 36
abnormal ear morphology 1 | 9
abnormal embryo turning 1 | 31
abnormal heart looping 1 | 5
abnormal neural tube morpholog... 1 | 12
abnormal optic disc morphology 1 | 10
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
abnormal tooth morphology 1 | 24
abnormal vertebrae morphology 1 | 18
decreased T cell number 1 | 15
decreased caudal vertebrae num... 1 | 53
decreased circulating amylase ... 1 | 28
decreased circulating chloride... 1 | 30
decreased red blood cell distr... 1 | 41
hydrometra 1 | 53
impaired righting response 1 | 26
increased circulating HDL chol... 1 | 80
increased circulating phosphat... 1 | 26
increased circulating triglyce... 1 | 42
increased exploration in new e... 1 | 8
increased heart weight 1 | 62
increased mean corpuscular vol... 1 | 92
long tibia 1 | 25
prenatal lethality 1 | 28
thin ventricular wall 1 | 24

Disease

Carcinoma 234 | 11,493
ovarian cancer 183 | 8,520
osteosarcoma 179 | 7,950
psoriasis 155 | 6,694
medulloblastoma, large-cell 139 | 6,241
glioblastoma 127 | 5,792
Cancer 118 | 2,499
lung cancer 116 | 4,740
atypical teratoid / rhabdoid tumor 110 | 5,112
Breast cancer 94 | 3,578
ependymoma 93 | 4,679
group 3 medulloblastoma 90 | 4,104
malignant mesothelioma 84 | 3,232
invasive ductal carcinoma 78 | 2,951
intraductal papillary-mucinous neoplasm (IPMN) 74 | 3,291
adult high grade glioma 72 | 3,801
non-small cell lung cancer 69 | 2,890
primitive neuroectodermal tumor 67 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 62 | 2,989
lung carcinoma 62 | 2,843
pancreatic cancer 61 | 2,398
interstitial cystitis 59 | 2,312
lung adenocarcinoma 58 | 2,716
intraductal papillary-mucinous adenoma (IPMA) 57 | 2,955
Astrocytoma, Pilocytic 52 | 3,081
breast carcinoma 52 | 1,638
pituitary cancer 51 | 1,972
subependymal giant cell astrocytoma 47 | 2,287
diabetes mellitus 45 | 1,728
ductal carcinoma in situ 45 | 1,745
group 4 medulloblastoma 45 | 1,855
oligodendroglioma 45 | 2,850
ulcerative colitis 45 | 1,819
pancreatic ductal adenocarcinoma liver metastasis 44 | 1,962
tuberculosis 42 | 2,010
Kidney cancer 40 | 2,613
astrocytic glioma 40 | 2,597
Rheumatoid arthritis 39 | 1,191
Intellectual disability 37 | 1,016
astrocytoma 37 | 1,146
cystic fibrosis 37 | 1,696
Obesity 35 | 678
Autosomal recessive predisposition 34 | 1,442
Pick disease 33 | 1,894
Schizophrenia 33 | 1,160
colon cancer 33 | 1,478
cutaneous lupus erythematosus 31 | 1,057
pediatric high grade glioma 31 | 1,064
acute quadriplegic myopathy 29 | 1,158
primary pancreatic ductal adenocarcinoma 29 | 1,109
Multiple myeloma 28 | 1,332
juvenile dermatomyositis 28 | 1,187
Dull intelligence 27 | 645
Low intelligence 27 | 645
Mental Retardation 27 | 645
Mental deficiency 27 | 645
Poor school performance 27 | 645
Short stature 27 | 531
acute myeloid leukemia 26 | 783
primary Sjogren syndrome 26 | 735
adrenocortical carcinoma 25 | 1,428
Breast Neoplasms 24 | 445
Muscle hypotonia 24 | 571
Strabismus 24 | 270
nasopharyngeal carcinoma 24 | 1,058
medulloblastoma 23 | 720
non primary Sjogren syndrome sicca 23 | 891
Bipolar Disorder 22 | 666
Cognitive delay 22 | 608
Global developmental delay 22 | 608
Mammary Neoplasms 22 | 425
Mental and motor retardation 22 | 608
Prostatic Neoplasms 22 | 495
dermatomyositis 22 | 966
spina bifida 22 | 1,074
Epilepsy 21 | 792
Cleft Palate 20 | 271
Craniofacial Abnormalities 20 | 151
Cryptorchidism 20 | 296
aldosterone-producing adenoma 20 | 665
Atopic dermatitis 18 | 952
Crohn's disease 18 | 321
Liver Cirrhosis, Experimental 18 | 769
Parkinson's disease 18 | 392
Seizures 18 | 596
Carcinoma, Hepatocellular 17 | 228
Congenital hypoplasia of penis 17 | 176
Depressive disorder 17 | 409
Endometriosis 17 | 540
Liver carcinoma 17 | 240
Small head 17 | 374
active ulcerative colitis 17 | 764
gastric carcinoma 17 | 807
Acquired metabolic disease 16 | 336
Alzheimer's disease 16 | 658
Deafness 16 | 198
Uranostaphyloschisis 16 | 167
Vascular disease 16 | 319
gastric cancer 16 | 459
hearing impairment 16 | 199

Tissue

Endocrine System 335 | 18,159
Skin and soft tissues 323 | 17,230
Digestive Tract 322 | 17,369
Female tissues 310 | 17,400
Male tissues 308 | 17,142
Blood and immune system 305 | 16,909
Nervous System 305 | 16,725
Liver and Pancreas 300 | 16,750
Urinary Tract 299 | 16,678
Respiratory system 290 | 16,393
Cardiovascular System 266 | 15,192

Target Family

Transcription Factor 282 | 1,400
Non-IDG 34 | 12,091
Nuclear Receptor 18 | 48
Epigenetic 4 | 242
TF/Epigenetic 4 | 38
Enzyme 2 | 4,145
Ion Channel 1 | 344
Kinase 1 | 634

GO Function

RNA polymerase II core promote... 346 | 346
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
CCAAT/enhancer-binding protein beta CEBPB Tbio Transcription Factor -2.96589 857.9 436
Glucocorticoid modulatory element-binding protein 2 GMEB2 Tdark Transcription Factor -0.50644 3.05 75
Achaete-scute homolog 2 ASCL2 Tbio Transcription Factor -1.84293 66.0 190
ETS domain-containing protein Elk-4 ELK4 Tbio Transcription Factor -1.07328 11.4 100
PAX3- and PAX7-binding protein 1 PAXBP1 Tbio Non-IDG -0.89267 7.14 100
Transcription factor-like 5 protein TCFL5 Tbio Transcription Factor -2.62447 404.7 161
Neural retina-specific leucine zipper protein NRL Tbio Transcription Factor -2.46080 279.4 74
PR domain zinc finger protein 4 PRDM4 Tbio TF/Epigenetic -0.87918 7.84 221
POU domain, class 2, transcription factor 3 POU2F3 Tbio Transcription Factor -2.50813 322.4 96
Transcription factor SOX-21 SOX21 Tbio Transcription Factor -1.47198 29.1 106