Development Level

Tbio 249 | 10,625
Tdark 54 | 7,003
Tchem 24 | 1,890
Tclin 5 | 602

IMPC Term

preweaning lethality, complete... 9 | 633
preweaning lethality, incomple... 8 | 260
abnormal behavior 7 | 226
abnormal embryo size 6 | 112
embryonic lethality prior to t... 5 | 187
decreased body weight 4 | 174
enlarged heart 4 | 111
abnormal forebrain development 3 | 18
abnormal hindbrain development 3 | 24
abnormal neural tube closure 3 | 37
abnormal retinal pigmentation 3 | 61
decreased lean body mass 3 | 195
decreased total body fat amoun... 3 | 186
hypoactivity 3 | 89
prenatal lethality prior to he... 3 | 64
abnormal bone structure 2 | 131
abnormal eye morphology 2 | 38
abnormal midbrain development 2 | 22
abnormal retina morphology 2 | 100
abnormal seminal vesicle morph... 2 | 47
abnormal sleep behavior 2 | 63
anophthalmia 2 | 20
decreased body length 2 | 108
decreased bone mineral content 2 | 157
decreased caudal vertebrae num... 2 | 49
decreased circulating alanine ... 2 | 53
decreased circulating choleste... 2 | 85
decreased circulating fructosa... 2 | 31
decreased circulating glucose ... 2 | 121
decreased circulating triglyce... 2 | 83
decreased vertical activity 2 | 22
embryonic growth retardation 2 | 28
hyperactivity 2 | 108
impaired glucose tolerance 2 | 52
increased bone mineral content 2 | 92
increased grip strength 2 | 83
increased lean body mass 2 | 107
abnormal allantois morphology 1 | 3
abnormal behavioral response t... 1 | 52
abnormal coat appearance 1 | 25
abnormal coping response 1 | 12
abnormal craniofacial morpholo... 1 | 12
abnormal embryo development 1 | 2
abnormal embryo turning 1 | 15
abnormal forebrain morphology 1 | 4
abnormal gait 1 | 51
abnormal heart looping 1 | 2
abnormal heart morphology 1 | 51
abnormal kidney morphology 1 | 30
abnormal lens morphology 1 | 73
abnormal limb bud morphology 1 | 15
abnormal neural tube morpholog... 1 | 8
abnormal optic disc morphology 1 | 10
abnormal pericardium morpholog... 1 | 11
abnormal skin appearance 1 | 8
abnormal tail bud morphology 1 | 6
abnormal tail morphology 1 | 17
abnormal tooth morphology 1 | 24
abnormal vibrissa morphology 1 | 17
corneal opacity 1 | 25
craniofacial phenotype 1 | 9
decreased anxiety-related resp... 1 | 12
decreased basophil cell number 1 | 11
decreased blood urea nitrogen ... 1 | 31
decreased circulating HDL chol... 1 | 77
decreased circulating bilirubi... 1 | 14
decreased circulating phosphat... 1 | 15
decreased circulating serum al... 1 | 79
decreased exploration in new e... 1 | 9
decreased grip strength 1 | 123
decreased hemoglobin content 1 | 53
decreased lumbar vertebrae num... 1 | 62
decreased macrophage cell numb... 1 | 4
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular vol... 1 | 50
decreased monocyte cell number 1 | 28
decreased prepulse inhibition 1 | 52
embryonic lethality prior to o... 1 | 148
enlarged lymph nodes 1 | 27
hemorrhage 1 | 12
hydrops fetalis 1 | 22
increased body weight 1 | 42
increased circulating alkaline... 1 | 119
increased circulating iron lev... 1 | 25
increased coping response 1 | 3
increased exploration in new e... 1 | 56
increased fasted circulating g... 1 | 68
increased respiratory quotient 1 | 12
increased startle reflex 1 | 38
irregularly shaped pupil 1 | 7
microphthalmia 1 | 15
pale yolk sac 1 | 12
persistence of hyaloid vascula... 1 | 22
prenatal lethality 1 | 16
prolonged PQ interval 1 | 3
shortened ST segment 1 | 9
small testis 1 | 37
thin ventricular wall 1 | 5
thrombocytopenia 1 | 46
trunk curl 1 | 15

Disease

osteosarcoma 156 | 7,933
ovarian cancer 150 | 8,484
psoriasis 144 | 6,685
medulloblastoma, large-cell 125 | 6,234
glioblastoma 104 | 5,572
Cancer 101 | 2,346
lung cancer 95 | 4,466
atypical teratoid / rhabdoid tumor 84 | 4,369
malignant mesothelioma 72 | 3,162
group 4 medulloblastoma 71 | 1,875
intraductal papillary-mucinous neoplasm (IPMN) 68 | 3,289
primitive neuroectodermal tumor 68 | 3,031
invasive ductal carcinoma 66 | 2,950
Breast cancer 64 | 3,094
pediatric high grade glioma 63 | 2,712
non-small cell lung cancer 57 | 2,798
intraductal papillary-mucinous carcinoma (IPMC) 56 | 2,988
interstitial cystitis 51 | 2,299
intraductal papillary-mucinous adenoma (IPMA) 51 | 2,956
pancreatic cancer 49 | 2,300
lung adenocarcinoma 48 | 2,713
lung carcinoma 48 | 2,844
breast carcinoma 46 | 1,614
pilocytic astrocytoma 46 | 3,086
ependymoma 44 | 2,514
pituitary cancer 44 | 1,972
sonic hedgehog group medulloblastoma 44 | 1,482
ductal carcinoma in situ 42 | 1,745
oligodendroglioma 42 | 2,849
ulcerative colitis 42 | 2,087
astrocytoma 39 | 1,493
Carcinoma 38 | 2,147
subependymal giant cell astrocytoma 38 | 2,287
diabetes mellitus 37 | 1,663
Rheumatoid Arthritis 33 | 1,160
cystic fibrosis 32 | 1,665
tuberculosis 31 | 1,557
colon cancer 30 | 1,475
posterior fossa group A ependymoma 30 | 1,511
primary pancreatic ductal adenocarcinoma 30 | 1,271
Pick disease 29 | 1,893
group 3 medulloblastoma 29 | 2,254
pancreatic ductal adenocarcinoma liver metastasis 29 | 1,795
adult high grade glioma 28 | 2,148
astrocytic glioma 27 | 2,241
Multiple myeloma 26 | 1,327
atypical teratoid/rhabdoid tumor 26 | 1,095
cutaneous lupus erythematosus 26 | 1,056
posterior fossa group B ependymoma 26 | 1,530
acute myeloid leukemia 25 | 780
acute quadriplegic myopathy 25 | 1,157
adrenocortical carcinoma 25 | 1,427
medulloblastoma 25 | 1,524
spina bifida 25 | 1,064
juvenile dermatomyositis 24 | 1,189
primary Sjogren syndrome 24 | 789
Obesity 22 | 616
dermatomyositis 21 | 933
non primary Sjogren syndrome sicca 20 | 840
Mammary Neoplasms 19 | 410
nasopharyngeal carcinoma 19 | 1,056
Craniofacial Abnormalities 17 | 147
active Crohn's disease 17 | 918
aldosterone-producing adenoma 17 | 664
Atopic dermatitis 16 | 944
Crohn's disease 16 | 304
gastric carcinoma 16 | 832
Endometriosis 15 | 535
Liver carcinoma 15 | 217
Parkinson's disease 15 | 364
Prostatic Neoplasms 14 | 471
gastric cancer 14 | 430
sarcoidosis 14 | 358
Acquired metabolic disease 13 | 267
autosomal dominant Emery-Dreifuss muscular dystrophy 13 | 499
hepatocellular carcinoma 13 | 532
inflammatory breast cancer 13 | 404
Intellectual disability 12 | 573
esophageal adenocarcinoma 12 | 737
urothelial carcinoma 12 | 318
Down syndrome 11 | 548
Heart disease 11 | 279
Hyperglycemia 11 | 120
Juvenile arthritis 11 | 124
Prostate cancer 11 | 172
Stomach Neoplasms 11 | 282
Vascular disease 11 | 281
Waldenstrons macroglobulinemia 11 | 765
chronic lymphosyte leukemia 11 | 232
chronic rhinosinusitis 11 | 512
glioblastoma multiforme 11 | 347
mucosa-associated lymphoid tissue lymphoma 11 | 480
nephrosclerosis 11 | 329
pancreatic carcinoma 11 | 567
Alzheimer's disease 10 | 644
Amyotrophic Lateral Sclerosis 10 | 431
Kidney disease 10 | 396
Multiple Sclerosis 10 | 498
head and neck cancer 10 | 270
tuberculosis and treatment for 3 months 10 | 327

Tissue

Endocrine System 330 | 18,512
Nervous System 330 | 18,561
Digestive Tract 329 | 18,473
Female tissues 329 | 18,647
Urinary Tract 325 | 18,444
Cardiovascular System 322 | 17,958
Liver and Pancreas 322 | 18,136
Male tissues 322 | 17,969
Skin and soft tissues 322 | 18,115
Blood and immune system 318 | 17,995
Respiratory system 310 | 17,484

Target Family

Transcription Factor 276 | 1,400
Non-IDG 33 | 11,971
Nuclear Receptor 12 | 48
Epigenetic 4 | 242
TF/Epigenetic 3 | 38
Enzyme 2 | 4,146
Ion Channel 1 | 341
Kinase 1 | 634

GO Function

RNA polymerase II core promote... 332 | 332
metal ion binding 1,917 | 1,917
ATP binding 1,467 | 1,467
DNA binding 1,432 | 1,432
zinc ion binding 1,155 | 1,155
poly(A) RNA binding 1,107 | 1,107
transcription factor activity,... 853 | 853
calcium ion binding 695 | 695
G-protein coupled receptor act... 661 | 661
protein homodimerization activ... 569 | 569
RNA binding 445 | 445
olfactory receptor activity 424 | 424
sequence-specific DNA binding 398 | 398
GTP binding 374 | 374
chromatin binding 372 | 372
protein serine/threonine kinas... 336 | 336
identical protein binding 311 | 311
nucleotide binding 311 | 311
receptor binding 303 | 303
protein kinase binding 289 | 289
enzyme binding 286 | 286
cadherin binding involved in c... 277 | 277
GTPase activator activity 273 | 273
ubiquitin protein ligase bindi... 258 | 258
ubiquitin-protein transferase ... 253 | 253
serine-type endopeptidase acti... 246 | 246
transcription coactivator acti... 241 | 241
transcription factor binding 240 | 240
structural molecule activity 232 | 232
GTPase activity 231 | 231
transcriptional activator acti... 230 | 230
ligase activity 227 | 227
protein heterodimerization act... 227 | 227
structural constituent of ribo... 212 | 212
transcription regulatory regio... 202 | 202
transmembrane signaling recept... 201 | 201
RNA polymerase II regulatory r... 200 | 200
receptor activity 200 | 200
transcription corepressor acti... 198 | 198
magnesium ion binding 197 | 197
signal transducer activity 196 | 196
nucleic acid binding 184 | 184
protein kinase activity 183 | 183
carbohydrate binding 180 | 180
ubiquitin protein ligase activ... 173 | 173
RNA polymerase II transcriptio... 162 | 162
heparin binding 160 | 160
iron ion binding 141 | 141
lipid binding 136 | 136
transporter activity 136 | 136
actin binding 133 | 133
ATPase activity 132 | 132
protein C-terminus binding 129 | 129
heme binding 127 | 127
microtubule binding 123 | 123
protein tyrosine kinase activi... 119 | 119
cytokine activity 118 | 118
Ras guanyl-nucleotide exchange... 113 | 113
mRNA binding 112 | 112
metalloendopeptidase activity 112 | 112
transcriptional repressor acti... 110 | 110
structural constituent of cyto... 108 | 108
Rab GTPase binding 105 | 105
antigen binding 104 | 104
protein domain specific bindin... 102 | 102
peptide antigen binding 101 | 101
guanyl-nucleotide exchange fac... 98 | 98
protein complex binding 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 92 | 92
oxidoreductase activity 91 | 91
transcriptional activator acti... 91 | 91
actin filament binding 89 | 89
hydrolase activity 89 | 89
ion channel binding 89 | 89
protein tyrosine phosphatase a... 88 | 88
electron carrier activity 87 | 87
protease binding 87 | 87
histone binding 86 | 86
integrin binding 83 | 83
growth factor activity 82 | 82
phospholipid binding 82 | 82
single-stranded DNA binding 81 | 81
unfolded protein binding 77 | 77
kinase activity 75 | 75
thiol-dependent ubiquitin-spec... 75 | 75
phosphatidylinositol binding 74 | 74
calmodulin binding 73 | 73
histone deacetylase binding 73 | 73
Rho guanyl-nucleotide exchange... 72 | 72
drug binding 71 | 71
double-stranded DNA binding 70 | 70
peptidase activity 70 | 70
protein N-terminus binding 70 | 70
virus receptor activity 68 | 68
beta-catenin binding 67 | 67
microtubule motor activity 67 | 67
protein transporter activity 67 | 67
calcium channel activity 66 | 66
ubiquitin binding 66 | 66

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Achaete-scute homolog 1 ASCL1 Tbio Transcription Factor -2.39907 258.0 359
Mucin-1 MUC1 Tbio Non-IDG -3.49560 3532.0 1851
Zinc finger protein 148 ZNF148 Tbio Transcription Factor -1.71996 60.7 178
Transcription factor E2-alpha TCF3 Tbio Transcription Factor -2.76637 577.9 373
Pancreas/duodenum homeobox protein 1 PDX1 Tbio Transcription Factor -2.33707 243.8 508
Cyclic AMP-responsive element-binding protein 3 CREB3 Tbio Transcription Factor -1.61736 42.0 159
Erythroid transcription factor GATA1 Tbio Transcription Factor -2.97791 941.1 675
Zinc finger protein 732 ZNF732 Tdark Transcription Factor 0.00000 3
Zinc finger protein 536 ZNF536 Tdark Transcription Factor -0.17194 1.30 69