Development Level

Tbio 29 | 11,445
Tchem 9 | 1,598
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, complete... 4 | 979
abnormal bone structure 3 | 187
decreased lean body mass 3 | 135
increased total body fat amoun... 3 | 134
abnormal behavior 2 | 298
abnormal seminal vesicle morph... 2 | 114
decreased bone mineral content 2 | 151
decreased prepulse inhibition 2 | 82
embryonic lethality prior to o... 2 | 239
increased bone mineral content 2 | 108
increased bone mineral density 2 | 72
increased lean body mass 2 | 172
small testis 2 | 58
abnormal bone mineralization 1 | 38
abnormal epididymis morphology 1 | 42
abnormal head morphology 1 | 10
abnormal optic disc morphology 1 | 10
abnormal ovary morphology 1 | 7
abnormal pancreas morphology 1 | 13
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal startle reflex 1 | 15
abnormal testis morphology 1 | 43
abnormal tooth morphology 1 | 24
absent epididymis 1 | 3
absent ovary 1 | 3
absent seminal vesicle 1 | 4
absent testes 1 | 6
cardiovascular system phenotyp... 1 | 36
corneal opacity 1 | 32
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating LDL chol... 1 | 38
decreased circulating glucose ... 1 | 126
decreased circulating magnesiu... 1 | 13
decreased circulating total pr... 1 | 49
decreased fasted circulating g... 1 | 65
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
female infertility 1 | 60
hydrometra 1 | 53
impaired glucose tolerance 1 | 75
increased circulating alkaline... 1 | 122
increased fasted circulating g... 1 | 76
increased kidney weight 1 | 6
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased startle reflex 1 | 112
increased total retina thickne... 1 | 4
irregularly shaped pupil 1 | 7
male infertility 1 | 123
mammalian phenotype 1 | 17
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
preweaning lethality, incomple... 1 | 499
short tibia 1 | 97
small superior vagus ganglion 1 | 74
small uterus 1 | 3

Disease

Carcinoma 25 | 11,493
ovarian cancer 24 | 8,520
osteosarcoma 22 | 7,950
Cancer 19 | 2,499
psoriasis 18 | 6,694
glioblastoma 17 | 5,792
Breast cancer 13 | 3,578
lung cancer 13 | 4,740
medulloblastoma, large-cell 13 | 6,241
atypical teratoid / rhabdoid tumor 12 | 5,112
group 3 medulloblastoma 12 | 4,104
malignant mesothelioma 12 | 3,232
pituitary cancer 12 | 1,972
ependymoma 11 | 4,679
diabetes mellitus 10 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 10 | 2,955
lung carcinoma 10 | 2,843
Dull intelligence 9 | 645
Intellectual disability 9 | 1,016
Kidney cancer 9 | 2,613
Low intelligence 9 | 645
Mental Retardation 9 | 645
Mental deficiency 9 | 645
Poor school performance 9 | 645
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,291
Breast Neoplasms 8 | 445
Mammary Neoplasms 8 | 425
Obesity 8 | 678
Schizophrenia 8 | 1,160
interstitial cystitis 8 | 2,312
subependymal giant cell astrocytoma 8 | 2,287
Bipolar Disorder 7 | 666
Muscle hypotonia 7 | 571
Parkinson's disease 7 | 392
Short stature 7 | 531
astrocytic glioma 7 | 2,597
pancreatic cancer 7 | 2,398
tuberculosis 7 | 2,010
Acquired scoliosis 6 | 281
Alzheimer's disease 6 | 658
Bladder Neoplasm 6 | 112
Broad flat nasal bridge 6 | 236
Curvature of spine 6 | 282
Nasal bridge wide 6 | 236
Rheumatoid arthritis 6 | 1,191
Small head 6 | 374
Urinary Bladder Neoplasms 6 | 114
adult high grade glioma 6 | 3,801
astrocytoma 6 | 1,146
breast carcinoma 6 | 1,638
group 4 medulloblastoma 6 | 1,855
lung adenocarcinoma 6 | 2,716
non-small cell lung cancer 6 | 2,890
primitive neuroectodermal tumor 6 | 3,035
ulcerative colitis 6 | 1,819
Carcinoma, Hepatocellular 5 | 228
Cognitive delay 5 | 608
Craniofacial Abnormalities 5 | 151
Epilepsy 5 | 792
Global developmental delay 5 | 608
Heart disease 5 | 306
Kidney disease 5 | 430
Liver carcinoma 5 | 240
Lung Neoplasms 5 | 232
Mental and motor retardation 5 | 608
Pick disease 5 | 1,894
Strabismus 5 | 270
Toxic encephalopathy 5 | 141
Waldenstrons macroglobulinemia 5 | 765
acute myeloid leukemia 5 | 783
cystic fibrosis 5 | 1,696
gastric carcinoma 5 | 807
invasive ductal carcinoma 5 | 2,951
oligodendroglioma 5 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,962
primary Sjogren syndrome 5 | 735
Astrocytoma, Pilocytic 4 | 3,081
Attention deficit hyperactivity disorder 4 | 278
Autistic Disorder 4 | 364
Autosomal recessive predisposition 4 | 1,442
Byzanthine arch palate 4 | 194
Cerebrovascular disease 4 | 238
Congenital Epicanthus 4 | 177
Endometrial cancer 4 | 311
Glaucoma 4 | 239
Hernia, Inguinal 4 | 89
Highly variable severity 4 | 157
Liver neoplasms 4 | 130
Seizures 4 | 596
Stomach Neoplasms 4 | 300
Variable expressivity 4 | 157
acute quadriplegic myopathy 4 | 1,158
adrenocortical carcinoma 4 | 1,428
colon cancer 4 | 1,478
dermatomyositis 4 | 966
juvenile dermatomyositis 4 | 1,187
nephrosclerosis 4 | 333
pediatric high grade glioma 4 | 1,064
posterior fossa group A ependymoma 4 | 468

Tissue

Endocrine System 38 | 18,159
Skin and soft tissues 37 | 17,230
Digestive Tract 36 | 17,369
Female tissues 36 | 17,400
Liver and Pancreas 36 | 16,750
Blood and immune system 35 | 16,909
Nervous System 35 | 16,725
Urinary Tract 35 | 16,678
Cardiovascular System 34 | 15,192
Male tissues 34 | 17,142
Respiratory system 33 | 16,393

Target Family

Transcription Factor 22 | 1,400
Non-IDG 9 | 12,091
Epigenetic 4 | 242
Enzyme 2 | 4,145
Kinase 1 | 634
Nuclear Receptor 1 | 48

GO Function

RNA polymerase II activating t... 39 | 39
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 26 DUSP26 Tbio Enzyme -2.81752 661.7 128
Eomesodermin homolog EOMES Tbio Transcription Factor -2.37902 230.4 333
T-box transcription factor TBX6 TBX6 Tbio Transcription Factor -1.78720 63.0 315
Interferon alpha-inducible protein 27, mitochondrial IFI27 Tbio Non-IDG -1.51419 33.3 0
Protein BEX1 BEX1 Tbio Non-IDG -1.32314 23.8 124
LIM domain-binding protein 1 LDB1 Tbio Non-IDG -2.22623 164.4 206
TP53-binding protein 1 TP53BP1 Tbio Epigenetic -2.69485 464.8 577
T-box transcription factor TBX3 TBX3 Tbio Transcription Factor -2.42253 255.6 328
Brachyury protein TBXT Tbio Transcription Factor -2.24737 158.4 337
Insulin gene enhancer protein ISL-1 ISL1 Tbio Transcription Factor -2.63352 410.3 382