Development Level

Tbio 1,038 | 11,651
Tdark 264 | 6,593
Tchem 67 | 1,388
Tclin 14 | 612

Collection

Kinase: IDG Consortium (Target... 4 | 125
RFA-RM-18-021 4 | 328
Kinase: IDG Consortium (Comple... 2 | 37

IMPC Phenotype

preweaning lethality, complete... 140 | 979
preweaning lethality, incomple... 38 | 499
embryonic lethality prior to o... 36 | 239
embryonic lethality prior to t... 31 | 278
abnormal embryo size 22 | 220
abnormal behavior 19 | 298
abnormal bone structure 15 | 187
decreased vertical activity 12 | 208
enlarged heart 12 | 210
hyperactivity 12 | 148
increased lean body mass 12 | 172
increased startle reflex 12 | 112
increased total body fat amoun... 11 | 134
decreased bone mineral content 10 | 151
decreased circulating choleste... 9 | 93
decreased circulating glucose ... 9 | 126
hypoactivity 9 | 132
abnormal coat-hair pigmentatio... 8 | 64
cataract 8 | 92
decreased lean body mass 8 | 135
decreased total body fat amoun... 8 | 207
embryonic growth retardation 8 | 106
increased fasted circulating g... 8 | 76
prenatal lethality prior to he... 8 | 87
abnormal heart morphology 7 | 162
decreased body length 7 | 101
decreased body weight 7 | 161
decreased bone mineral density 7 | 126
decreased grip strength 7 | 116
decreased lymphocyte cell numb... 7 | 83
impaired glucose tolerance 7 | 75
increased grip strength 7 | 41
increased mean corpuscular vol... 7 | 92
male infertility 7 | 123
abnormal lens morphology 6 | 81
decreased caudal vertebrae num... 6 | 53
decreased circulating HDL chol... 6 | 68
decreased circulating triglyce... 6 | 79
decreased neutrophil cell numb... 6 | 42
increased or absent threshold ... 6 | 101
pallor 6 | 34
short tibia 6 | 97
abnormal retina morphology 5 | 71
female infertility 5 | 60
increased mean platelet volume 5 | 45
increased monocyte cell number 5 | 63
small superior vagus ganglion 5 | 74
small testis 5 | 58
abnormal seminal vesicle morph... 4 | 114
abnormal sleep behavior 4 | 70
decreased circulating chloride... 4 | 30
decreased erythrocyte cell num... 4 | 62
decreased fasted circulating g... 4 | 65
decreased hemoglobin content 4 | 68
decreased leukocyte cell numbe... 4 | 73
decreased mean corpuscular vol... 4 | 79
edema 4 | 59
hydrometra 4 | 53
increased bone mineral content 4 | 108
increased lymphocyte cell numb... 4 | 32
increased mean corpuscular hem... 4 | 96
abnormal behavioral response t... 3 | 66
abnormal cornea morphology 3 | 31
abnormal embryo turning 3 | 31
abnormal kidney morphology 3 | 65
abnormal neural tube closure 3 | 46
abnormal pericardium morpholog... 3 | 26
abnormal placenta size 3 | 20
abnormal skin coloration 3 | 25
abnormal spleen morphology 3 | 55
decreased circulating LDL chol... 3 | 38
decreased circulating alanine ... 3 | 47
decreased circulating alkaline... 3 | 46
decreased circulating phosphat... 3 | 27
decreased circulating serum al... 3 | 82
decreased circulating sodium l... 3 | 22
decreased mean corpuscular hem... 3 | 31
improved glucose tolerance 3 | 79
increased body length 3 | 32
increased bone mineral density 3 | 72
increased circulating alkaline... 3 | 122
increased circulating chloride... 3 | 41
increased circulating creatini... 3 | 38
increased circulating phosphat... 3 | 26
increased circulating sodium l... 3 | 71
increased heart weight 3 | 62
pale yolk sac 3 | 25
shortened RR interval 3 | 17
thrombocytosis 3 | 27
abnormal epididymis morphology 2 | 42
abnormal eye morphology 2 | 68
abnormal limb bud morphology 2 | 17
abnormal locomotor behavior 2 | 24
absent startle reflex 2 | 24
cardiovascular system phenotyp... 2 | 36
decreased circulating free fat... 2 | 31
decreased circulating insulin ... 2 | 76
increased circulating free fat... 2 | 20
increased hematocrit 2 | 46
increased prepulse inhibition 2 | 32

Disease

Carcinoma 885 | 11,493
ovarian cancer 843 | 8,520
osteosarcoma 650 | 7,950
medulloblastoma, large-cell 484 | 6,241
lung cancer 474 | 4,740
psoriasis 465 | 6,694
glioblastoma 412 | 5,792
group 3 medulloblastoma 386 | 4,104
atypical teratoid / rhabdoid tumor 348 | 5,112
ependymoma 320 | 4,679
Multiple myeloma 290 | 1,332
Breast cancer 274 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 246 | 3,291
oligodendroglioma 240 | 2,850
malignant mesothelioma 226 | 3,232
Kidney cancer 220 | 2,613
intraductal papillary-mucinous carcinoma (IPMC) 219 | 2,989
primitive neuroectodermal tumor 213 | 3,035
acute quadriplegic myopathy 210 | 1,158
adult high grade glioma 209 | 3,801
astrocytic glioma 202 | 2,597
intraductal papillary-mucinous adenoma (IPMA) 192 | 2,955
invasive ductal carcinoma 188 | 2,951
lung adenocarcinoma 187 | 2,716
Cancer 185 | 2,499
subependymal giant cell astrocytoma 179 | 2,287
Waldenstrons macroglobulinemia 178 | 765
pancreatic ductal adenocarcinoma liver metastasis 175 | 1,962
non-small cell lung cancer 168 | 2,890
Pick disease 167 | 1,894
diabetes mellitus 166 | 1,728
pancreatic cancer 157 | 2,398
Astrocytoma, Pilocytic 148 | 3,081
astrocytoma 148 | 1,146
dermatomyositis 147 | 966
juvenile dermatomyositis 136 | 1,187
colon cancer 125 | 1,478
group 4 medulloblastoma 123 | 1,855
acute myeloid leukemia 110 | 783
lung carcinoma 106 | 2,843
tuberculosis 105 | 2,010
breast carcinoma 102 | 1,638
pediatric high grade glioma 93 | 1,064
Rheumatoid arthritis 92 | 1,191
progressive supranuclear palsy 88 | 676
pituitary cancer 87 | 1,972
Intellectual disability 81 | 1,016
ulcerative colitis 80 | 1,819
primary pancreatic ductal adenocarcinoma 79 | 1,109
non primary Sjogren syndrome sicca 76 | 891
cystic fibrosis 75 | 1,696
ductal carcinoma in situ 73 | 1,745
Amyotrophic lateral sclerosis 71 | 451
adrenocortical carcinoma 68 | 1,428
Schizophrenia 67 | 1,160
Autosomal recessive predisposition 66 | 1,442
nasopharyngeal carcinoma 61 | 1,058
spina bifida 58 | 1,074
tuberculosis and treatment for 6 months 57 | 409
hepatocellular carcinoma 56 | 547
Breast Neoplasms 54 | 445
aldosterone-producing adenoma 51 | 665
Mammary Neoplasms 50 | 425
interstitial cystitis 50 | 2,312
cutaneous lupus erythematosus 49 | 1,057
gastric carcinoma 48 | 807
Cognitive delay 47 | 608
Global developmental delay 47 | 608
Mental and motor retardation 47 | 608
Duchenne muscular dystrophy 46 | 601
Dull intelligence 46 | 645
Low intelligence 46 | 645
Mental Retardation 46 | 645
Mental deficiency 46 | 645
Poor school performance 46 | 645
pancreatic carcinoma 46 | 562
Alzheimer's disease 44 | 658
primary Sjogren syndrome 44 | 735
active Crohn's disease 42 | 922
autosomal dominant Emery-Dreifuss muscular dystrophy 41 | 510
medulloblastoma 41 | 720
Adenocarcinoma of lung 40 | 142
Liver cancer 40 | 604
Neurodegenerative disease 40 | 414
Anemia 39 | 365
Epilepsy 39 | 792
esophageal adenocarcinoma 39 | 737
Disease Models, Animal 38 | 155
sonic hedgehog group medulloblastoma 38 | 467
Multiple Sclerosis 37 | 540
gastric cancer 37 | 459
hereditary spastic paraplegia 37 | 318
Obesity 36 | 678
Prostatic Neoplasms 36 | 495
Short stature 36 | 531
Stomach Neoplasms 36 | 300
Down syndrome 34 | 499
Liver Cirrhosis, Experimental 33 | 769
atypical teratoid/rhabdoid tumor 33 | 357
Muscle hypotonia 32 | 571

Tissue

Endocrine System 1,348 | 18,159
Digestive Tract 1,336 | 17,369
Male tissues 1,332 | 17,142
Skin and soft tissues 1,329 | 17,230
Female tissues 1,328 | 17,400
Liver and Pancreas 1,327 | 16,750
Blood and immune system 1,325 | 16,909
Respiratory system 1,323 | 16,393
Nervous System 1,321 | 16,725
Urinary Tract 1,319 | 16,678
Cardiovascular System 1,299 | 15,192

Target Family

Non-IDG 996 | 12,091
Enzyme 299 | 4,145
Transcription Factor 33 | 1,400
Epigenetic 25 | 242
Kinase 21 | 634
Transporter 5 | 473
Nuclear Receptor 2 | 48
TF/Epigenetic 2 | 38

GO Function

RNA binding 1,383 | 1,383
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Serine/arginine-rich splicing factor 12 SRSF12 Tbio Non-IDG -0.09691 1.17 22
Paraspeckle component 1 PSPC1 Tbio Non-IDG -1.75415 48.3 19
DBIRD complex subunit ZNF326 ZNF326 Tbio Non-IDG -0.42207 3.94 120
tRNA-specific adenosine deaminase 1 ADAT1 Tbio Enzyme -1.08814 11.8 136
Eukaryotic translation initiation factor 1 EIF1 Tbio Non-IDG -2.06392 118.5 92
Zinc finger protein 346 ZNF346 Tbio Non-IDG -2.28393 188.7 213
T-complex protein 1 subunit zeta CCT6A Tbio Non-IDG -1.39880 26.2 90
Zinc finger CCHC domain-containing protein 9 ZCCHC9 Tdark Non-IDG 0.48 0.71 31
28S ribosomal protein S14, mitochondrial MRPS14 Tdark Non-IDG 0.30 0.11 22
Heterogeneous nuclear ribonucleoprotein C-like 2 HNRNPCL2 Tdark Non-IDG 0.33 1.30 0