Development Level

Tbio 305 | 10,625
Tdark 106 | 7,003
Tchem 29 | 1,890
Tclin 5 | 602

Collection

Eligible Kinase Proteins 1 | 134

IMPC Term

preweaning lethality, complete... 20 | 633
abnormal behavior 7 | 226
hyperactivity 7 | 108
preweaning lethality, incomple... 6 | 260
decreased circulating glucose ... 5 | 121
decreased lean body mass 5 | 195
embryonic lethality prior to o... 5 | 148
decreased body length 4 | 108
decreased rib number 4 | 59
embryonic lethality prior to t... 4 | 187
abnormal coat/hair pigmentatio... 3 | 54
abnormal retinal outer nuclear... 3 | 5
decreased circulating HDL chol... 3 | 77
decreased circulating choleste... 3 | 85
decreased total body fat amoun... 3 | 186
increased circulating alkaline... 3 | 119
increased grip strength 3 | 83
increased or absent threshold ... 3 | 128
prenatal lethality prior to he... 3 | 64
abnormal bone structure 2 | 131
abnormal cornea morphology 2 | 24
abnormal embryo size 2 | 112
abnormal retina morphology 2 | 100
decreased body weight 2 | 174
decreased bone mineral content 2 | 157
decreased circulating triglyce... 2 | 83
decreased fasted circulating g... 2 | 49
decreased leukocyte cell numbe... 2 | 54
decreased lumbar vertebrae num... 2 | 62
female infertility 2 | 34
impaired righting response 2 | 19
increased body weight 2 | 42
increased bone mineral content 2 | 92
increased exploration in new e... 2 | 56
increased mean corpuscular hem... 2 | 93
abnormal coat appearance 1 | 25
abnormal heart morphology 1 | 51
abnormal iris morphology 1 | 12
abnormal kidney morphology 1 | 30
abnormal lens morphology 1 | 73
abnormal lung morphology 1 | 15
abnormal maxilla morphology 1 | 16
abnormal pancreas morphology 1 | 6
abnormal retinal pigmentation 1 | 61
abnormal rib morphology 1 | 28
abnormal spleen morphology 1 | 36
abnormal tooth morphology 1 | 24
abnormal vocalization 1 | 21
absent startle reflex 1 | 15
cardiovascular system phenotyp... 1 | 35
decreased IgG2b level 1 | 1
decreased KLRG1+ CD4 alpha bet... 1 | 2
decreased KLRG1-positive NK ce... 1 | 9
decreased bone mineral density 1 | 126
decreased circulating LDL chol... 1 | 37
decreased circulating alanine ... 1 | 53
decreased circulating alkaline... 1 | 41
decreased circulating calcium ... 1 | 33
decreased circulating chloride... 1 | 32
decreased circulating fructosa... 1 | 31
decreased circulating insulin ... 1 | 75
decreased coping response 1 | 5
decreased cornea thickness 1 | 2
decreased eosinophil cell numb... 1 | 41
decreased grip strength 1 | 123
decreased heart weight 1 | 44
decreased lymphocyte cell numb... 1 | 9
decreased mean corpuscular hem... 1 | 19
decreased neutrophil cell numb... 1 | 37
decreased thoracic vertebrae n... 1 | 7
decreased threshold for audito... 1 | 32
decreased total retina thickne... 1 | 20
enlarged heart 1 | 111
hydrops fetalis 1 | 22
impaired glucose tolerance 1 | 52
increased KLRG1-positive CD4-p... 1 | 2
increased bone mineral density 1 | 52
increased circulating chloride... 1 | 43
increased circulating glucose ... 1 | 16
increased circulating potassiu... 1 | 31
increased circulating sodium l... 1 | 71
increased fasted circulating g... 1 | 68
increased heart rate 1 | 17
increased heart weight 1 | 37
increased lean body mass 1 | 107
increased mean platelet volume 1 | 19
increased prepulse inhibition 1 | 21
increased startle reflex 1 | 38
increased total body fat amoun... 1 | 57
irregularly shaped pupil 1 | 7
male infertility 1 | 62
persistence of hyaloid vascula... 1 | 22
short tibia 1 | 82
shortened RR interval 1 | 19
thrombocytosis 1 | 23
tremors 1 | 34
vertebral fusion 1 | 23

Disease

ovarian cancer 224 | 8,484
osteosarcoma 181 | 7,933
medulloblastoma, large-cell 155 | 6,234
psoriasis 133 | 6,685
lung cancer 127 | 4,466
glioblastoma 116 | 5,572
atypical teratoid / rhabdoid tumor 103 | 4,369
Multiple myeloma 82 | 1,327
group 3 medulloblastoma 81 | 2,254
primitive neuroectodermal tumor 78 | 3,031
intraductal papillary-mucinous neoplasm (IPMN) 77 | 3,289
acute quadriplegic myopathy 76 | 1,157
Breast cancer 74 | 3,094
oligodendroglioma 74 | 2,849
malignant mesothelioma 69 | 3,162
ependymoma 62 | 2,514
intraductal papillary-mucinous carcinoma (IPMC) 62 | 2,988
subependymal giant cell astrocytoma 58 | 2,287
astrocytic glioma 56 | 2,241
Waldenstrons macroglobulinemia 54 | 765
lung adenocarcinoma 54 | 2,713
pilocytic astrocytoma 53 | 3,086
intraductal papillary-mucinous adenoma (IPMA) 52 | 2,956
pediatric high grade glioma 52 | 2,712
invasive ductal carcinoma 50 | 2,950
Cancer 47 | 2,346
Pick disease 47 | 1,893
sonic hedgehog group medulloblastoma 45 | 1,482
juvenile dermatomyositis 43 | 1,189
non-small cell lung cancer 42 | 2,798
dermatomyositis 41 | 933
lung carcinoma 41 | 2,844
astrocytoma 40 | 1,493
adult high grade glioma 39 | 2,148
diabetes mellitus 38 | 1,663
group 4 medulloblastoma 36 | 1,875
pancreatic cancer 35 | 2,300
pituitary cancer 34 | 1,972
acute myeloid leukemia 33 | 780
cystic fibrosis 33 | 1,665
Carcinoma 32 | 2,147
colon cancer 32 | 1,475
pancreatic ductal adenocarcinoma liver metastasis 31 | 1,795
breast carcinoma 29 | 1,614
progressive supranuclear palsy 29 | 674
tuberculosis and treatment for 6 months 29 | 686
Amyotrophic Lateral Sclerosis 26 | 431
posterior fossa group A ependymoma 25 | 1,511
adrenocortical carcinoma 24 | 1,427
posterior fossa group B ependymoma 24 | 1,530
ulcerative colitis 24 | 2,087
atypical teratoid/rhabdoid tumor 23 | 1,095
primary pancreatic ductal adenocarcinoma 22 | 1,271
medulloblastoma 21 | 1,524
primary Sjogren syndrome 21 | 789
cutaneous lupus erythematosus 20 | 1,056
nasopharyngeal carcinoma 20 | 1,056
Rheumatoid Arthritis 19 | 1,160
non primary Sjogren syndrome sicca 19 | 840
spina bifida 19 | 1,064
Intellectual disability 18 | 573
Mammary Neoplasms 17 | 410
aldosterone-producing adenoma 17 | 664
ductal carcinoma in situ 17 | 1,745
tuberculosis 17 | 1,557
interstitial cystitis 15 | 2,299
hepatocellular carcinoma 14 | 532
Duchenne muscular dystrophy 13 | 602
Infertility 13 | 163
autosomal dominant Emery-Dreifuss muscular dystrophy 13 | 499
Neurodegenerative disease 12 | 383
active Crohn's disease 12 | 918
pancreatic carcinoma 12 | 567
Alzheimer's disease 11 | 644
gastric carcinoma 11 | 832
Azoospermia 10 | 89
Diamond-Blackfan anemia 10 | 28
Male infertility 10 | 170
Multiple Sclerosis 10 | 498
Prostatic Neoplasms 10 | 471
gastric cancer 10 | 430
inflammatory breast cancer 10 | 404
interstitial lung disease 10 | 291
mucosa-associated lymphoid tissue lymphoma 10 | 480
relapsing-remitting multiple sclerosis 10 | 18
Anemia 9 | 252
Disease Progression 9 | 125
Down syndrome 9 | 548
Schizophrenia 9 | 501
Stomach Neoplasms 9 | 282
Gaucher disease type 1 8 | 171
Influenza 8 | 142
Lupus erythematosus 8 | 80
Mammary Neoplasms, Experimental 8 | 150
Parkinson's disease 8 | 364
Peripheral Neuropathy 8 | 303
Type 2 diabetes mellitus 8 | 189
esophageal adenocarcinoma 8 | 737
glioblastoma multiforme 8 | 347
IGA Glomerulonephritis 7 | 454

Tissue

Female tissues 425 | 18,647
Male tissues 422 | 17,969
Digestive Tract 420 | 18,473
Endocrine System 420 | 18,512
Blood and immune system 419 | 17,995
Urinary Tract 417 | 18,444
Nervous System 416 | 18,561
Liver and Pancreas 415 | 18,136
Cardiovascular System 413 | 17,958
Skin and soft tissues 411 | 18,115
Respiratory system 410 | 17,484

Target Family

Non-IDG 320 | 11,971
Enzyme 98 | 4,146
Transcription Factor 13 | 1,400
Epigenetic 8 | 242
Kinase 2 | 634
Nuclear Receptor 2 | 48
TF/Epigenetic 2 | 38

GO Function

RNA binding 445 | 445
metal ion binding 1,917 | 1,917
ATP binding 1,467 | 1,467
DNA binding 1,432 | 1,432
zinc ion binding 1,155 | 1,155
poly(A) RNA binding 1,107 | 1,107
transcription factor activity,... 853 | 853
calcium ion binding 695 | 695
G-protein coupled receptor act... 661 | 661
protein homodimerization activ... 569 | 569
olfactory receptor activity 424 | 424
sequence-specific DNA binding 398 | 398
GTP binding 374 | 374
chromatin binding 372 | 372
protein serine/threonine kinas... 336 | 336
RNA polymerase II core promote... 332 | 332
identical protein binding 311 | 311
nucleotide binding 311 | 311
receptor binding 303 | 303
protein kinase binding 289 | 289
enzyme binding 286 | 286
cadherin binding involved in c... 277 | 277
GTPase activator activity 273 | 273
ubiquitin protein ligase bindi... 258 | 258
ubiquitin-protein transferase ... 253 | 253
serine-type endopeptidase acti... 246 | 246
transcription coactivator acti... 241 | 241
transcription factor binding 240 | 240
structural molecule activity 232 | 232
GTPase activity 231 | 231
transcriptional activator acti... 230 | 230
ligase activity 227 | 227
protein heterodimerization act... 227 | 227
structural constituent of ribo... 212 | 212
transcription regulatory regio... 202 | 202
transmembrane signaling recept... 201 | 201
RNA polymerase II regulatory r... 200 | 200
receptor activity 200 | 200
transcription corepressor acti... 198 | 198
magnesium ion binding 197 | 197
signal transducer activity 196 | 196
nucleic acid binding 184 | 184
protein kinase activity 183 | 183
carbohydrate binding 180 | 180
ubiquitin protein ligase activ... 173 | 173
RNA polymerase II transcriptio... 162 | 162
heparin binding 160 | 160
iron ion binding 141 | 141
lipid binding 136 | 136
transporter activity 136 | 136
actin binding 133 | 133
ATPase activity 132 | 132
protein C-terminus binding 129 | 129
heme binding 127 | 127
microtubule binding 123 | 123
protein tyrosine kinase activi... 119 | 119
cytokine activity 118 | 118
Ras guanyl-nucleotide exchange... 113 | 113
mRNA binding 112 | 112
metalloendopeptidase activity 112 | 112
transcriptional repressor acti... 110 | 110
structural constituent of cyto... 108 | 108
Rab GTPase binding 105 | 105
antigen binding 104 | 104
protein domain specific bindin... 102 | 102
peptide antigen binding 101 | 101
guanyl-nucleotide exchange fac... 98 | 98
protein complex binding 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 92 | 92
oxidoreductase activity 91 | 91
transcriptional activator acti... 91 | 91
actin filament binding 89 | 89
hydrolase activity 89 | 89
ion channel binding 89 | 89
protein tyrosine phosphatase a... 88 | 88
electron carrier activity 87 | 87
protease binding 87 | 87
histone binding 86 | 86
integrin binding 83 | 83
growth factor activity 82 | 82
phospholipid binding 82 | 82
single-stranded DNA binding 81 | 81
unfolded protein binding 77 | 77
kinase activity 75 | 75
thiol-dependent ubiquitin-spec... 75 | 75
phosphatidylinositol binding 74 | 74
calmodulin binding 73 | 73
histone deacetylase binding 73 | 73
Rho guanyl-nucleotide exchange... 72 | 72
drug binding 71 | 71
double-stranded DNA binding 70 | 70
peptidase activity 70 | 70
protein N-terminus binding 70 | 70
virus receptor activity 68 | 68
beta-catenin binding 67 | 67
microtubule motor activity 67 | 67
protein transporter activity 67 | 67
calcium channel activity 66 | 66
ubiquitin binding 66 | 66

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endoplasmin HSP90B1 Tchem Non-IDG -2.72785 604.5 748
Programmed cell death protein 4 PDCD4 Tchem Non-IDG -2.40380 284.9 546
Histone-lysine N-methyltransferase SETD1B SETD1B Tbio Epigenetic -1.20916 14.6 78
Small nuclear ribonucleoprotein F SNRPF Tdark Non-IDG -0.25254 1.81 65
Interleukin enhancer-binding factor 3 ILF3 Tbio Non-IDG -2.09543 135.8 239
tRNA pseudouridine(38/39) synthase PUS3 Tbio Enzyme -1.19198 15.4 62
Small nuclear ribonucleoprotein E SNRPE Tbio Non-IDG -2.70963 540.8 230
m7GpppN-mRNA hydrolase DCP2 Tbio Enzyme -1.89749 80.7 139
Nuclear pore complex protein Nup98-Nup96 NUP98 Tbio Enzyme -2.21148 186.3 172
Adenosylhomocysteinase 2 AHCYL1 Tchem Enzyme -1.57893 43.2 102