Development Level

Tbio 305 | 10,625
Tdark 106 | 7,003
Tchem 29 | 1,890
Tclin 5 | 602

Collection

Eligible Kinase Proteins 1 | 134

IMPC Term

preweaning lethality, complete... 20 | 633
abnormal behavior 7 | 226
hyperactivity 7 | 108
preweaning lethality, incomple... 6 | 260
decreased circulating glucose ... 5 | 121
decreased lean body mass 5 | 195
embryonic lethality prior to o... 5 | 148
decreased body length 4 | 108
decreased rib number 4 | 59
embryonic lethality prior to t... 4 | 187
abnormal coat/hair pigmentatio... 3 | 54
abnormal retinal outer nuclear... 3 | 5
decreased circulating HDL chol... 3 | 77
decreased circulating choleste... 3 | 85
decreased total body fat amoun... 3 | 186
increased circulating alkaline... 3 | 119
increased grip strength 3 | 83
increased or absent threshold ... 3 | 128
prenatal lethality prior to he... 3 | 64
abnormal bone structure 2 | 131
abnormal cornea morphology 2 | 24
abnormal embryo size 2 | 112
abnormal retina morphology 2 | 100
decreased body weight 2 | 174
decreased bone mineral content 2 | 157
decreased circulating triglyce... 2 | 83
decreased fasted circulating g... 2 | 49
decreased leukocyte cell numbe... 2 | 54
decreased lumbar vertebrae num... 2 | 62
female infertility 2 | 34
impaired righting response 2 | 19
increased body weight 2 | 42
increased bone mineral content 2 | 92
increased exploration in new e... 2 | 56
increased mean corpuscular hem... 2 | 93
abnormal coat appearance 1 | 25
abnormal heart morphology 1 | 51
abnormal iris morphology 1 | 12
abnormal kidney morphology 1 | 30
abnormal lens morphology 1 | 73
abnormal lung morphology 1 | 15
abnormal maxilla morphology 1 | 16
abnormal pancreas morphology 1 | 6
abnormal retinal pigmentation 1 | 61
abnormal rib morphology 1 | 28
abnormal spleen morphology 1 | 36
abnormal tooth morphology 1 | 24
abnormal vocalization 1 | 21
absent startle reflex 1 | 15
cardiovascular system phenotyp... 1 | 35
decreased IgG2b level 1 | 1
decreased KLRG1+ CD4 alpha bet... 1 | 2
decreased KLRG1-positive NK ce... 1 | 9
decreased bone mineral density 1 | 126
decreased circulating LDL chol... 1 | 37
decreased circulating alanine ... 1 | 53
decreased circulating alkaline... 1 | 41
decreased circulating calcium ... 1 | 33
decreased circulating chloride... 1 | 32
decreased circulating fructosa... 1 | 31
decreased circulating insulin ... 1 | 75
decreased coping response 1 | 5
decreased cornea thickness 1 | 2
decreased eosinophil cell numb... 1 | 41
decreased grip strength 1 | 123
decreased heart weight 1 | 44
decreased lymphocyte cell numb... 1 | 9
decreased mean corpuscular hem... 1 | 19
decreased neutrophil cell numb... 1 | 37
decreased thoracic vertebrae n... 1 | 7
decreased threshold for audito... 1 | 32
decreased total retina thickne... 1 | 20
enlarged heart 1 | 111
hydrops fetalis 1 | 22
impaired glucose tolerance 1 | 52
increased KLRG1-positive CD4-p... 1 | 2
increased bone mineral density 1 | 52
increased circulating chloride... 1 | 43
increased circulating glucose ... 1 | 16
increased circulating potassiu... 1 | 31
increased circulating sodium l... 1 | 71
increased fasted circulating g... 1 | 68
increased heart rate 1 | 17
increased heart weight 1 | 37
increased lean body mass 1 | 107
increased mean platelet volume 1 | 19
increased prepulse inhibition 1 | 21
increased startle reflex 1 | 38
increased total body fat amoun... 1 | 57
irregularly shaped pupil 1 | 7
male infertility 1 | 62
persistence of hyaloid vascula... 1 | 22
short tibia 1 | 82
shortened RR interval 1 | 19
thrombocytosis 1 | 23
tremors 1 | 34
vertebral fusion 1 | 23

Disease

ovarian cancer 225 | 8,492
osteosarcoma 181 | 7,933
medulloblastoma, large-cell 155 | 6,234
psoriasis 133 | 6,685
lung cancer 127 | 4,473
glioblastoma 116 | 5,572
atypical teratoid / rhabdoid tumor 103 | 4,369
Multiple myeloma 82 | 1,328
group 3 medulloblastoma 81 | 2,254
primitive neuroectodermal tumor 78 | 3,031
intraductal papillary-mucinous neoplasm (IPMN) 77 | 3,289
acute quadriplegic myopathy 76 | 1,157
Breast cancer 75 | 3,099
oligodendroglioma 74 | 2,849
malignant mesothelioma 69 | 3,163
ependymoma 62 | 2,514
intraductal papillary-mucinous carcinoma (IPMC) 62 | 2,988
subependymal giant cell astrocytoma 58 | 2,287
astrocytic glioma 56 | 2,241
Waldenstrons macroglobulinemia 54 | 765
lung adenocarcinoma 54 | 2,714
pilocytic astrocytoma 53 | 3,086
intraductal papillary-mucinous adenoma (IPMA) 52 | 2,956
pediatric high grade glioma 52 | 2,712
invasive ductal carcinoma 50 | 2,950
Cancer 47 | 2,346
Pick disease 47 | 1,893
sonic hedgehog group medulloblastoma 45 | 1,482
juvenile dermatomyositis 43 | 1,189
non-small cell lung cancer 42 | 2,798
dermatomyositis 41 | 967
lung carcinoma 41 | 2,844
astrocytoma 40 | 1,493
adult high grade glioma 39 | 2,148
diabetes mellitus 38 | 1,663
group 4 medulloblastoma 36 | 1,875
pancreatic cancer 35 | 2,300
pituitary cancer 34 | 1,972
acute myeloid leukemia 33 | 785
cystic fibrosis 33 | 1,670
Carcinoma 32 | 2,147
colon cancer 32 | 1,475
pancreatic ductal adenocarcinoma liver metastasis 31 | 1,795
breast carcinoma 29 | 1,614
progressive supranuclear palsy 29 | 674
tuberculosis and treatment for 6 months 29 | 686
Amyotrophic Lateral Sclerosis 26 | 432
posterior fossa group A ependymoma 25 | 1,511
adrenocortical carcinoma 24 | 1,427
posterior fossa group B ependymoma 24 | 1,530
ulcerative colitis 24 | 2,087
atypical teratoid/rhabdoid tumor 23 | 1,095
primary pancreatic ductal adenocarcinoma 22 | 1,271
medulloblastoma 21 | 1,524
primary Sjogren syndrome 21 | 789
cutaneous lupus erythematosus 20 | 1,056
nasopharyngeal carcinoma 20 | 1,056
Rheumatoid Arthritis 19 | 1,171
non primary Sjogren syndrome sicca 19 | 840
spina bifida 19 | 1,064
Intellectual disability 18 | 573
Mammary Neoplasms 17 | 410
aldosterone-producing adenoma 17 | 664
ductal carcinoma in situ 17 | 1,745
tuberculosis 17 | 1,563
interstitial cystitis 15 | 2,299
hepatocellular carcinoma 14 | 550
Duchenne muscular dystrophy 13 | 602
Infertility 13 | 163
autosomal dominant Emery-Dreifuss muscular dystrophy 13 | 499
Neurodegenerative disease 12 | 383
active Crohn's disease 12 | 918
pancreatic carcinoma 12 | 567
Alzheimer's disease 11 | 644
gastric carcinoma 11 | 832
Azoospermia 10 | 89
Diamond-Blackfan anemia 10 | 30
Male infertility 10 | 170
Multiple Sclerosis 10 | 498
Prostatic Neoplasms 10 | 471
Schizophrenia 10 | 503
gastric cancer 10 | 436
inflammatory breast cancer 10 | 404
interstitial lung disease 10 | 292
mucosa-associated lymphoid tissue lymphoma 10 | 480
relapsing-remitting multiple sclerosis 10 | 18
Anemia 9 | 252
Disease Progression 9 | 125
Down syndrome 9 | 548
Stomach Neoplasms 9 | 282
Gaucher disease type 1 8 | 171
Influenza 8 | 142
Lupus erythematosus 8 | 80
Mammary Neoplasms, Experimental 8 | 150
Parkinson's disease 8 | 364
Peripheral Neuropathy 8 | 303
Type 2 diabetes mellitus 8 | 192
esophageal adenocarcinoma 8 | 737
glioblastoma multiforme 8 | 347
IGA Glomerulonephritis 7 | 454

Tissue

Female tissues 425 | 18,647
Male tissues 422 | 17,969
Digestive Tract 420 | 18,473
Endocrine System 420 | 18,512
Blood and immune system 419 | 17,995
Urinary Tract 417 | 18,444
Nervous System 416 | 18,561
Liver and Pancreas 415 | 18,136
Cardiovascular System 413 | 17,958
Skin and soft tissues 411 | 18,115
Respiratory system 410 | 17,484

Target Family

Non-IDG 320 | 11,969
Enzyme 98 | 4,146
Transcription Factor 13 | 1,400
Epigenetic 8 | 242
Kinase 2 | 634
Nuclear Receptor 2 | 48
TF/Epigenetic 2 | 38

GO Function

RNA binding 445 | 445
metal ion binding 1,917 | 1,917
ATP binding 1,467 | 1,467
DNA binding 1,432 | 1,432
zinc ion binding 1,155 | 1,155
poly(A) RNA binding 1,107 | 1,107
transcription factor activity,... 853 | 853
calcium ion binding 695 | 695
G-protein coupled receptor act... 661 | 661
protein homodimerization activ... 569 | 569
olfactory receptor activity 424 | 424
sequence-specific DNA binding 398 | 398
GTP binding 374 | 374
chromatin binding 372 | 372
protein serine/threonine kinas... 336 | 336
RNA polymerase II core promote... 332 | 332
identical protein binding 311 | 311
nucleotide binding 311 | 311
receptor binding 303 | 303
protein kinase binding 289 | 289
enzyme binding 286 | 286
cadherin binding involved in c... 277 | 277
GTPase activator activity 273 | 273
ubiquitin protein ligase bindi... 258 | 258
ubiquitin-protein transferase ... 253 | 253
serine-type endopeptidase acti... 246 | 246
transcription coactivator acti... 241 | 241
transcription factor binding 240 | 240
structural molecule activity 232 | 232
GTPase activity 231 | 231
transcriptional activator acti... 230 | 230
ligase activity 227 | 227
protein heterodimerization act... 227 | 227
structural constituent of ribo... 212 | 212
transcription regulatory regio... 202 | 202
transmembrane signaling recept... 201 | 201
RNA polymerase II regulatory r... 200 | 200
receptor activity 200 | 200
transcription corepressor acti... 198 | 198
magnesium ion binding 197 | 197
signal transducer activity 196 | 196
nucleic acid binding 184 | 184
protein kinase activity 183 | 183
carbohydrate binding 180 | 180
ubiquitin protein ligase activ... 173 | 173
RNA polymerase II transcriptio... 162 | 162
heparin binding 160 | 160
iron ion binding 141 | 141
lipid binding 136 | 136
transporter activity 136 | 136
actin binding 133 | 133
ATPase activity 132 | 132
protein C-terminus binding 129 | 129
heme binding 127 | 127
microtubule binding 123 | 123
protein tyrosine kinase activi... 119 | 119
cytokine activity 118 | 118
Ras guanyl-nucleotide exchange... 113 | 113
mRNA binding 112 | 112
metalloendopeptidase activity 112 | 112
transcriptional repressor acti... 110 | 110
structural constituent of cyto... 108 | 108
Rab GTPase binding 105 | 105
antigen binding 104 | 104
protein domain specific bindin... 102 | 102
peptide antigen binding 101 | 101
guanyl-nucleotide exchange fac... 98 | 98
protein complex binding 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 92 | 92
oxidoreductase activity 91 | 91
transcriptional activator acti... 91 | 91
actin filament binding 89 | 89
hydrolase activity 89 | 89
ion channel binding 89 | 89
protein tyrosine phosphatase a... 88 | 88
electron carrier activity 87 | 87
protease binding 87 | 87
histone binding 86 | 86
integrin binding 83 | 83
growth factor activity 82 | 82
phospholipid binding 82 | 82
single-stranded DNA binding 81 | 81
unfolded protein binding 77 | 77
kinase activity 75 | 75
thiol-dependent ubiquitin-spec... 75 | 75
phosphatidylinositol binding 74 | 74
calmodulin binding 73 | 73
histone deacetylase binding 73 | 73
Rho guanyl-nucleotide exchange... 72 | 72
drug binding 71 | 71
double-stranded DNA binding 70 | 70
peptidase activity 70 | 70
protein N-terminus binding 70 | 70
virus receptor activity 68 | 68
beta-catenin binding 67 | 67
microtubule motor activity 67 | 67
protein transporter activity 67 | 67
calcium channel activity 66 | 66
ubiquitin binding 66 | 66

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Bromodomain adjacent to zinc finger domain protein 2A BAZ2A Tchem TF/Epigenetic -2.05410 110.9 33
La-related protein 6 LARP6 Tbio Non-IDG -1.40785 25.6 72
60S ribosomal protein L6 RPL6 Tbio Non-IDG -1.54952 37.8 65
THO complex subunit 6 homolog THOC6 Tbio Non-IDG -1.72319 50.1 112
Ribonuclease P protein subunit p29 POP4 Tbio Enzyme -1.55080 40.6 57
RNA-binding protein 14 RBM14 Tbio Non-IDG -2.03819 113.7 159
DnaJ homolog subfamily C member 17 DNAJC17 Tdark Non-IDG -0.04079 1.12 105
60S ribosomal protein L3 RPL3 Tbio Non-IDG -2.00824 98.4 170
ATP-dependent RNA helicase DDX19A DDX19A Tdark Enzyme 0.02 0.99 53
MIF4G domain-containing protein MIF4GD Tbio Non-IDG -1.20548 14.8 62