Development Level

Tbio 66 | 11,445
Tchem 13 | 1,598
Tclin 8 | 613

Collection

GPCR: IDG Consortium (Complete... 1 | 25

IMPC Phenotype

preweaning lethality, complete... 9 | 979
preweaning lethality, incomple... 6 | 499
embryonic lethality prior to o... 5 | 239
embryonic lethality prior to t... 5 | 278
decreased total body fat amoun... 4 | 207
abnormal embryo size 3 | 220
decreased vertical activity 3 | 208
edema 3 | 59
abnormal behavior 2 | 298
abnormal testis morphology 2 | 43
abnormal vibrissa morphology 2 | 25
decreased body weight 2 | 161
decreased grip strength 2 | 116
increased circulating chloride... 2 | 41
increased lean body mass 2 | 172
increased or absent threshold ... 2 | 101
microphthalmia 2 | 26
small testis 2 | 58
thrombocytopenia 2 | 56
abnormal bone structure 1 | 187
abnormal coat-hair pigmentatio... 1 | 64
abnormal craniofacial morpholo... 1 | 33
abnormal embryo turning 1 | 31
abnormal epididymis morphology 1 | 42
abnormal eye morphology 1 | 68
abnormal eye size 1 | 7
abnormal gait 1 | 69
abnormal limb morphology 1 | 13
abnormal seminal vesicle morph... 1 | 114
abnormal tail morphology 1 | 25
abnormal tail movements 1 | 12
absent vibrissae 1 | 12
anophthalmia 1 | 33
cataract 1 | 92
cyanosis 1 | 7
decreased basophil cell number 1 | 16
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating amylase ... 1 | 28
decreased circulating calcium ... 1 | 36
decreased circulating creatini... 1 | 39
decreased circulating glycerol... 1 | 16
decreased circulating phosphat... 1 | 27
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased exploration in new e... 1 | 11
decreased fasted circulating g... 1 | 65
decreased leukocyte cell numbe... 1 | 73
decreased red blood cell distr... 1 | 41
decreased startle reflex 1 | 75
embryonic growth retardation 1 | 106
enlarged epididymis 1 | 31
hemorrhage 1 | 23
hydrops fetalis 1 | 1
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
increased anti-nuclear antigen... 1 | 19
increased bone mineral content 1 | 108
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 42
increased mean corpuscular vol... 1 | 92
increased mean platelet volume 1 | 45
limb grasping 1 | 41
male infertility 1 | 123
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
respiratory system phenotype 1 | 2
tremors 1 | 39
vertebral fusion 1 | 23

Disease

Carcinoma 63 | 11,493
osteosarcoma 54 | 7,950
ovarian cancer 52 | 8,520
medulloblastoma, large-cell 49 | 6,241
psoriasis 46 | 6,694
glioblastoma 40 | 5,792
ependymoma 38 | 4,679
atypical teratoid / rhabdoid tumor 37 | 5,112
adult high grade glioma 34 | 3,801
lung cancer 32 | 4,740
group 3 medulloblastoma 31 | 4,104
lung carcinoma 28 | 2,843
malignant mesothelioma 28 | 3,232
Breast cancer 27 | 3,578
astrocytic glioma 26 | 2,597
Kidney cancer 25 | 2,613
oligodendroglioma 25 | 2,850
primitive neuroectodermal tumor 25 | 3,035
invasive ductal carcinoma 23 | 2,951
Astrocytoma, Pilocytic 22 | 3,081
intraductal papillary-mucinous adenoma (IPMA) 21 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 21 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 19 | 3,291
lung adenocarcinoma 18 | 2,716
pituitary cancer 18 | 1,972
subependymal giant cell astrocytoma 18 | 2,287
Cancer 17 | 2,499
interstitial cystitis 17 | 2,312
non-small cell lung cancer 17 | 2,890
group 4 medulloblastoma 16 | 1,855
Pick disease 15 | 1,894
Schizophrenia 15 | 1,160
ulcerative colitis 15 | 1,819
cystic fibrosis 14 | 1,696
ductal carcinoma in situ 14 | 1,745
pancreatic cancer 14 | 2,398
tuberculosis 14 | 2,010
breast carcinoma 13 | 1,638
Autistic Disorder 12 | 364
Autosomal recessive predisposition 12 | 1,442
juvenile dermatomyositis 11 | 1,187
Rheumatoid arthritis 10 | 1,191
acute quadriplegic myopathy 10 | 1,158
aldosterone-producing adenoma 10 | 665
Atopic dermatitis 9 | 952
Melanoma 9 | 711
autosomal dominant Emery-Dreifuss muscular dystrophy 9 | 510
nasopharyngeal carcinoma 9 | 1,058
Bipolar Disorder 8 | 666
Cognitive delay 8 | 608
Epilepsy 8 | 792
Global developmental delay 8 | 608
Intellectual disability 8 | 1,016
Mental and motor retardation 8 | 608
Skin cancer 8 | 469
colon cancer 8 | 1,478
cutaneous lupus erythematosus 8 | 1,057
diabetes mellitus 8 | 1,728
non primary Sjogren syndrome sicca 8 | 891
spina bifida 8 | 1,074
Hypertension 7 | 396
Liver cancer 7 | 604
Obesity 7 | 678
Parkinson's disease 7 | 392
Vascular disease 7 | 319
adrenocortical carcinoma 7 | 1,428
gastric carcinoma 7 | 807
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
pediatric high grade glioma 7 | 1,064
Concave bridge of nose 6 | 195
Depressed nasal bridge 6 | 195
Depressed nasal root/bridge 6 | 195
Depressive disorder 6 | 409
Duchenne muscular dystrophy 6 | 601
Frontal bossing 6 | 157
Hypertensive disease 6 | 292
Mental Depression 6 | 333
Muscle hypotonia 6 | 571
Neurodegenerative disease 6 | 414
Osteoporosis 6 | 363
active Crohn's disease 6 | 922
active ulcerative colitis 6 | 764
acute myeloid leukemia 6 | 783
atypical teratoid/rhabdoid tumor 6 | 357
dermatomyositis 6 | 966
pancreatic carcinoma 6 | 562
Alzheimer's disease 5 | 658
Asthma 5 | 385
Down syndrome 5 | 499
Dull intelligence 5 | 645
Low intelligence 5 | 645
Mental Retardation 5 | 645
Mental deficiency 5 | 645
Multiple myeloma 5 | 1,332
Orbital separation excessive 5 | 244
Poor school performance 5 | 645
Prostatic Neoplasms 5 | 495
Short stature 5 | 531
primary Sjogren syndrome 5 | 735
progressive supranuclear palsy 5 | 676

Tissue

Digestive Tract 87 | 17,369
Endocrine System 85 | 18,159
Nervous System 85 | 16,725
Skin and soft tissues 85 | 17,230
Female tissues 84 | 17,400
Male tissues 84 | 17,142
Urinary Tract 84 | 16,678
Liver and Pancreas 82 | 16,750
Respiratory system 81 | 16,393
Blood and immune system 79 | 16,909
Cardiovascular System 77 | 15,192

Target Family

Non-IDG 42 | 12,091
Enzyme 11 | 4,145
GPCR 11 | 408
Transporter 10 | 473
Ion Channel 9 | 344
Kinase 4 | 634

GO Function

PDZ domain binding 87 | 87
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Junctional adhesion molecule A F11R Tbio Non-IDG -2.56739 380.0 394
Somatostatin receptor type 2 SSTR2 Tclin GPCR -2.53936 363.5 246
Metabotropic glutamate receptor 7 GRM7 Tchem GPCR -2.25415 190.8 304
Rap guanine nucleotide exchange factor 2 RAPGEF2 Tbio Non-IDG -1.41107 29.0 79
Activin receptor type-2A ACVR2A Tchem Kinase -2.08745 108.0 315
Alpha-1-syntrophin SNTA1 Tbio Non-IDG -1.49227 31.4 254
Acid-sensing ion channel 3 ASIC3 Tchem Ion Channel -2.28745 195.8 130
TBC1 domain family member 10A TBC1D10A Tbio Non-IDG -0.65759 0.00000 99
H(+)/Cl(-) exchange transporter 3 CLCN3 Tchem Ion Channel -2.27689 203.4 183
Beta-1-syntrophin SNTB1 Tbio Non-IDG -1.06492 9.50 111