Development Level

Tbio 21 | 11,651
Tchem 4 | 1,388
Tclin 4 | 612

IMPC Phenotype

preweaning lethality, complete... 3 | 979
abnormal behavioral response t... 2 | 66
abnormal lens morphology 2 | 81
cataract 2 | 92
abnormal behavior 1 | 298
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
cardiovascular system phenotyp... 1 | 36
decreased circulating chloride... 1 | 30
decreased circulating choleste... 1 | 93
decreased circulating triglyce... 1 | 79
decreased mean corpuscular vol... 1 | 79
female infertility 1 | 60
hypoactivity 1 | 132
impaired righting response 1 | 26
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased circulating sodium l... 1 | 71
increased fasted circulating g... 1 | 76
increased hemoglobin content 1 | 45
preweaning lethality, incomple... 1 | 499
sclerocornea 1 | 2

Disease

Carcinoma 21 | 11,493
ovarian cancer 21 | 8,520
Cancer 16 | 2,499
osteosarcoma 12 | 7,950
psoriasis 11 | 6,694
glioblastoma 10 | 5,792
lung cancer 10 | 4,740
oligodendroglioma 9 | 2,850
medulloblastoma, large-cell 8 | 6,241
Multiple myeloma 7 | 1,332
astrocytoma 7 | 1,146
atypical teratoid / rhabdoid tumor 7 | 5,112
diabetes mellitus 7 | 1,728
ependymoma 7 | 4,679
group 3 medulloblastoma 7 | 4,104
Breast cancer 6 | 3,578
Breast Neoplasms 5 | 445
Schizophrenia 5 | 1,160
adult high grade glioma 5 | 3,801
group 4 medulloblastoma 5 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
primitive neuroectodermal tumor 5 | 3,035
Mammary Neoplasms 4 | 425
Melanoma 4 | 711
Primary cutaneous T-cell lymphoma 4 | 29
Rheumatoid arthritis 4 | 1,191
dermatomyositis 4 | 966
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
lung adenocarcinoma 4 | 2,716
malignant mesothelioma 4 | 3,232
non-small cell lung cancer 4 | 2,890
pancreatic cancer 4 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
subependymal giant cell astrocytoma 4 | 2,287
Asthma 3 | 385
Bipolar Disorder 3 | 666
Carcinoma, Hepatocellular 3 | 228
Cardiomegaly 3 | 116
Heart Diseases 3 | 43
Kidney cancer 3 | 2,613
Liver Cirrhosis, Experimental 3 | 769
Liver carcinoma 3 | 240
Mood Disorders 3 | 184
Myocardial Infarction 3 | 151
Neoplasm Invasiveness 3 | 161
Neoplasm Metastasis 3 | 168
Peripheral T-cell lymphoma 3 | 25
Pick disease 3 | 1,894
Prostatic Neoplasms 3 | 495
Waldenstrons macroglobulinemia 3 | 765
acute myeloid leukemia 3 | 783
acute quadriplegic myopathy 3 | 1,158
colon cancer 3 | 1,478
cystic fibrosis 3 | 1,696
lung carcinoma 3 | 2,843
primary pancreatic ductal adenocarcinoma 3 | 1,109
tuberculosis 3 | 2,010
Adenocarcinoma of lung 2 | 142
Arthritis 2 | 290
Astrocytoma, Pilocytic 2 | 3,081
Atherosclerosis 2 | 291
Autosomal recessive predisposition 2 | 1,442
Barrett's esophagus 2 | 182
Brain Injuries 2 | 65
Brain Ischemia 2 | 110
Carcinoma, Renal Cell 2 | 124
Carcinoma, Squamous Cell 2 | 110
Diarrhea 2 | 253
Disease Models, Animal 2 | 155
Down syndrome 2 | 499
Endometriosis 2 | 540
Fever 2 | 138
Hypertension 2 | 396
Hypertensive disease 2 | 292
Infantile onset 2 | 238
Inflammatory bowel disease 2 | 151
Leukemia, Myelocytic, Acute 2 | 120
Leukemia, Myeloid, Acute 2 | 105
Lung disease 2 | 142
Lymphoma 2 | 81
Major Depressive Disorder 2 | 301
Mental Depression 2 | 333
Renal Cell Carcinoma 2 | 214
Seizures 2 | 596
Skin Neoplasms 2 | 69
Squamous cell carcinoma 2 | 129
Stomach Neoplasms 2 | 300
Vascular disease 2 | 319
astrocytic glioma 2 | 2,597
esophageal adenocarcinoma 2 | 737
mucosa-associated lymphoid tissue lymphoma 2 | 484
ulcerative colitis 2 | 1,819
Biliary tract cancer 1 | 19
Carcinoma, Lobular 1 | 6
Chromosome 1q41-q42 deletion syndrome 1 | 4
Diffuse large B-cell lymphoma 1 | 39
Li-Fraumeni syndrome 1 | 13
Stomach cancer 1 | 30
Type 1 diabetes mellitus 1 | 109

Tissue

Blood and immune system 28 | 16,909
Cardiovascular System 28 | 15,192
Digestive Tract 28 | 17,369
Endocrine System 28 | 18,159
Female tissues 28 | 17,400
Liver and Pancreas 28 | 16,750
Male tissues 28 | 17,142
Nervous System 28 | 16,725
Respiratory system 28 | 16,393
Skin and soft tissues 28 | 17,230
Urinary Tract 28 | 16,678

Target Family

Non-IDG 16 | 12,091
Enzyme 5 | 4,145
Epigenetic 4 | 242
Transcription Factor 2 | 1,400
Kinase 1 | 634
Nuclear Receptor 1 | 48

GO Function

NF-kappaB binding 29 | 29
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
B-cell lymphoma/leukemia 10 BCL10 Tbio Non-IDG -0.53932 4.30 895
Hypoxia-inducible factor 1-alpha inhibitor HIF1AN Tbio Non-IDG -1.91636 75.1 429
Breast cancer metastasis-suppressor 1 BRMS1 Tbio Non-IDG -1.68847 54.9 205
Histone deacetylase 1 HDAC1 Tclin Epigenetic -3.03775 954.3 1201
Protein LYRIC MTDH Tbio Non-IDG -2.60328 417.3 249
Cyclin-dependent kinase inhibitor 2A CDKN2A Tbio Enzyme -3.72848 9058.6 1063
DNA-(apurinic or apyrimidinic site) lyase APEX1 Tchem Enzyme -3.47746 2989.0 646
Forkhead box protein P3 FOXP3 Tbio Transcription Factor -3.80046 6233.8 1358
Glycogen synthase kinase-3 beta GSK3B Tclin Kinase -3.00390 610.8 955
Histone deacetylase 3 HDAC3 Tclin Epigenetic -2.28457 142.9 673