Development Level

Tbio 5 | 11,445
Tchem 2 | 1,598

IMPC Phenotype

abnormal behavior 1 | 298
abnormal heart position or ori... 1 | 1
abnormal lung morphology 1 | 26
decreased blood urea nitrogen ... 1 | 51
decreased bone mineral density 1 | 126
decreased circulating creatini... 1 | 39
decreased circulating fructosa... 1 | 30
decreased grip strength 1 | 116
decreased mean corpuscular hem... 1 | 50
embryonic lethality prior to t... 1 | 278
increased body weight 1 | 25
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 36
preweaning lethality, complete... 1 | 979
preweaning lethality, incomple... 1 | 499

Disease

ovarian cancer 5 | 8,520
malignant mesothelioma 3 | 3,232
Carcinoma 2 | 11,493
Multiple myeloma 2 | 1,332
Waldenstrons macroglobulinemia 2 | 765
lung cancer 2 | 4,740
osteosarcoma 2 | 7,950
psoriasis 2 | 6,694
Atopic dermatitis 1 | 952
Cancer 1 | 2,499
Carcinoma, Hepatocellular 1 | 228
Dengue disease 1 | 23
Exanthem 1 | 37
Liver Cirrhosis, Experimental 1 | 769
Liver carcinoma 1 | 240
Neoplasm Metastasis 1 | 168
Pick disease 1 | 1,894
Retinal disease 1 | 25
Retinitis pigmentosa 14 1 | 7
Stevens-Johnson syndrome 1 | 92
Western equine encephalitis 1 | 13
Yellow fever 1 | 16
active ulcerative colitis 1 | 764
colon cancer 1 | 1,478
diabetes mellitus 1 | 1,728
group 4 medulloblastoma 1 | 1,855
interstitial cystitis 1 | 2,312
lung carcinoma 1 | 2,843
posterior fossa group B ependymoma 1 | 416
subependymal giant cell astrocytoma 1 | 2,287
ulcerative colitis 1 | 1,819

Tissue

Blood and immune system 7 | 16,909
Digestive Tract 7 | 17,369
Endocrine System 7 | 18,159
Female tissues 7 | 17,400
Liver and Pancreas 7 | 16,750
Male tissues 7 | 17,142
Nervous System 7 | 16,725
Respiratory system 7 | 16,393
Skin and soft tissues 7 | 17,230
Urinary Tract 7 | 16,678
Cardiovascular System 6 | 15,192

Target Family

Enzyme 5 | 4,145
Non-IDG 2 | 12,091

GO Function

NEDD8-specific protease activi... 7 | 7
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ubiquitin carboxyl-terminal hydrolase 21 USP21 Tbio Enzyme -1.64460 44.9 288
COP9 signalosome complex subunit 4 COPS4 Tbio Non-IDG -0.91181 7.39 88
Ubiquitin thioesterase OTUB2 OTUB2 Tbio Enzyme -1.01946 11.0 252
Ubiquitin thioesterase OTUB1 OTUB1 Tbio Enzyme -1.68151 50.0 281
Ubiquitin carboxyl-terminal hydrolase isozyme L3 UCHL3 Tchem Enzyme -2.08846 121.1 247
COP9 signalosome complex subunit 5 COPS5 Tbio Non-IDG -2.26989 213.6 374
Sentrin-specific protease 8 SENP8 Tchem Enzyme -2.41447 256.8 187