Development Level

Tbio 19 | 11,445
Tchem 10 | 1,598
Tclin 2 | 613
Tdark 2 | 6,588

IMPC Phenotype

abnormal behavior 1 | 298
abnormal epididymis morphology 1 | 42
abnormal stomach morphology 1 | 10
decreased body weight 1 | 161
decreased circulating choleste... 1 | 93
increased startle reflex 1 | 112
increased vertical activity 1 | 24
preweaning lethality, incomple... 1 | 499

Disease

Carcinoma 25 | 11,493
ovarian cancer 16 | 8,520
osteosarcoma 14 | 7,950
psoriasis 13 | 6,694
glioblastoma 12 | 5,792
lung cancer 12 | 4,740
non-small cell lung cancer 12 | 2,890
Cancer 11 | 2,499
Autosomal recessive predisposition 10 | 1,442
ependymoma 10 | 4,679
intraductal papillary-mucinous adenoma (IPMA) 10 | 2,955
lung carcinoma 10 | 2,843
adult high grade glioma 9 | 3,801
interstitial cystitis 9 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,989
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,962
Hypertension 8 | 396
Seizures 8 | 596
adrenocortical carcinoma 8 | 1,428
diabetes mellitus 8 | 1,728
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,291
lung adenocarcinoma 8 | 2,716
Breast cancer 7 | 3,578
Kidney disease 7 | 430
malignant mesothelioma 7 | 3,232
pituitary cancer 7 | 1,972
tuberculosis 7 | 2,010
Astrocytoma, Pilocytic 6 | 3,081
Atherosclerosis 6 | 291
Epilepsy 6 | 792
Kidney cancer 6 | 2,613
cystic fibrosis 6 | 1,696
invasive ductal carcinoma 6 | 2,951
medulloblastoma, large-cell 6 | 6,241
Alzheimer's disease 5 | 658
Autistic Disorder 5 | 364
Bipolar Disorder 5 | 666
Brain Ischemia 5 | 110
Breast Neoplasms 5 | 445
Cognitive delay 5 | 608
Depressive disorder 5 | 409
Global developmental delay 5 | 608
Intellectual disability 5 | 1,016
Mammary Neoplasms 5 | 425
Mental and motor retardation 5 | 608
Obesity 5 | 678
Small head 5 | 374
atypical teratoid / rhabdoid tumor 5 | 5,112
colon cancer 5 | 1,478
ductal carcinoma in situ 5 | 1,745
group 3 medulloblastoma 5 | 4,104
Acute kidney injury 4 | 70
Anemia 4 | 365
Atopic dermatitis 4 | 952
Carcinoma, Hepatocellular 4 | 228
Cerebrovascular disease 4 | 238
Chemical and Drug Induced Liver Injury 4 | 195
Colonic Neoplasms 4 | 142
Colorectal Neoplasms 4 | 243
Diabetes Mellitus, Experimental 4 | 108
Down syndrome 4 | 499
Dull intelligence 4 | 645
Failure to gain weight 4 | 365
Heart failure 4 | 162
Hypertensive disease 4 | 292
Liver carcinoma 4 | 240
Low intelligence 4 | 645
Male infertility 4 | 206
Mental Retardation 4 | 645
Mental deficiency 4 | 645
Necrosis 4 | 53
Nervous System Diseases 4 | 53
Pediatric failure to thrive 4 | 365
Poor school performance 4 | 645
Rheumatoid arthritis 4 | 1,191
Toxic encephalopathy 4 | 141
active Crohn's disease 4 | 922
acute quadriplegic myopathy 4 | 1,158
astrocytic glioma 4 | 2,597
breast carcinoma 4 | 1,638
cutaneous lupus erythematosus 4 | 1,057
esophageal adenocarcinoma 4 | 737
nasopharyngeal carcinoma 4 | 1,058
nervous system disorder 4 | 53
non diabetic and post-ischemic heart failure 4 | 200
oligodendroglioma 4 | 2,850
primitive neuroectodermal tumor 4 | 3,035
ulcerative colitis 4 | 1,819
Infertility, Male 3 | 46
Mental Depression 3 | 333
Pick disease 3 | 1,894
Schizophrenia 3 | 1,160
Vascular disease 3 | 319
Waldenstrons macroglobulinemia 3 | 765
aldosterone-producing adenoma 3 | 665
astrocytoma 3 | 1,146
mucosa-associated lymphoid tissue lymphoma 3 | 484
nephrosclerosis 3 | 333
pancreatic cancer 3 | 2,398
subependymal giant cell astrocytoma 3 | 2,287

Tissue

Blood and immune system 32 | 16,909
Digestive Tract 32 | 17,369
Endocrine System 32 | 18,159
Female tissues 32 | 17,400
Liver and Pancreas 32 | 16,750
Male tissues 32 | 17,142
Nervous System 32 | 16,725
Skin and soft tissues 32 | 17,230
Urinary Tract 32 | 16,678
Respiratory system 31 | 16,393
Cardiovascular System 29 | 15,192

Target Family

Enzyme 31 | 4,145
Non-IDG 2 | 12,091

GO Function

NADP binding 33 | 33
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Methylenetetrahydrofolate reductase MTHFR Tbio Enzyme -3.68447 5032.2 275
NAD(P) transhydrogenase, mitochondrial NNT Tbio Enzyme -2.49624 309.2 112
Quinone oxidoreductase-like protein 1 CRYZL1 Tbio Enzyme -1.37951 20.5 157
Ketimine reductase mu-crystallin CRYM Tbio Enzyme -1.70644 52.5 199
NADPH--cytochrome P450 reductase POR Tbio Enzyme -2.43541 216.2 257
Dihydropyrimidine dehydrogenase [NADP(+)] DPYD Tclin Enzyme -2.62432 395.0 159
Delta(14)-sterol reductase TM7SF2 Tbio Enzyme -1.10571 12.4 88
NADP-dependent malic enzyme ME1 Tchem Non-IDG -1.98857 92.8 234
Sepiapterin reductase SPR Tbio Enzyme -1.58814 36.9 174
Nitric oxide synthase, inducible NOS2 Tchem Enzyme -3.35134 2277.5 752