Development Level

Tclin 11 | 612

IMPC Phenotype

preweaning lethality, complete... 2 | 979
abnormal lens morphology 1 | 81
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased hemoglobin content 1 | 45

Disease

Multiple myeloma 11 | 1,296
Peripheral T-cell lymphoma 11 | 25
Primary cutaneous T-cell lymphoma 11 | 29
Cancer 9 | 2,388
Carcinoma 8 | 11,192
osteosarcoma 7 | 7,766
Mental Depression 5 | 325
Schizophrenia 5 | 1,136
glioblastoma 5 | 5,635
lung cancer 5 | 4,607
malignant mesothelioma 5 | 3,135
adult high grade glioma 4 | 3,701
atypical teratoid / rhabdoid tumor 4 | 4,971
ependymoma 4 | 4,559
medulloblastoma, large-cell 4 | 6,086
primitive neuroectodermal tumor 4 | 2,957
Depressive disorder 3 | 401
Familial primary pulmonary hypertension 3 | 11
Mood Disorders 3 | 181
group 3 medulloblastoma 3 | 4,002
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,204
ovarian cancer 3 | 8,297
subependymal giant cell astrocytoma 3 | 2,230
Astrocytoma, Pilocytic 2 | 3,006
Carcinoma, Squamous Cell 2 | 107
Cocaine-Related Disorders 2 | 90
Endometriosis 2 | 521
Frontal bossing 2 | 154
Heart Diseases 2 | 41
Hypoplastic feet 2 | 66
Intellectual disability 2 | 998
Melanoma 2 | 689
Neuronal ceroid lipofuscinosis 2 2 | 16
Obesity 2 | 655
Polycystic kidney disease 1 2 | 21
Short hands 2 | 50
Short stature 2 | 514
Squamous cell carcinoma 2 | 125
Unipolar Depression 2 | 244
astrocytoma 2 | 1,113
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,872
medulloblastoma 2 | 702
oligodendroglioma 2 | 2,768
tuberculosis 2 | 1,963
Accessory nipple 1 | 11
Alcoholic Intoxication, Chronic 1 | 283
Alopecia universalis 1 | 15
Amyotrophic lateral sclerosis 1 | 437
Balkan Nephropathy 1 | 6
Big calvaria 1 | 147
Bladder Diverticulum 1 | 15
Bladder Neoplasm 1 | 106
Brachydactyly 1 | 154
Brain infarction 1 | 22
Cardiomegaly 1 | 114
Cerebrovascular accident 1 | 60
Chromosome 2q37 deletion syndrome 1 | 4
Chronic Obstructive Airway Disease 1 | 33
Death in early childhood 1 | 82
Death in infancy 1 | 82
Decreased projection of midface 1 | 104
Enophthalmos 1 | 74
Hypotrophic midface 1 | 104
Increased head circumference 1 | 147
Increased size of cranium 1 | 147
Increased size of skull 1 | 147
Joint hyperflexibility 1 | 76
Leukemia, Myeloid 1 | 18
Liver Cirrhosis 1 | 173
Major Depressive Disorder 1 | 293
Mesothelioma, Malignant 1 | 103
Microsatellite Instability 1 | 12
Midface retrusion 1 | 104
Myeloid Leukemia 1 | 19
Neurodegenerative disease 1 | 402
Nonorganic psychosis 1 | 83
Osteoporosis 1 | 348
Ovarian Neoplasms 1 | 96
Polycystic kidney disease 2 1 | 11
Pseudohypoparathyroidism 1 | 18
Rhizomelia 1 | 24
Round face 1 | 43
Round, full face 1 | 43
Salmonellosis 1 | 42
Small hand 1 | 36
Small midface 1 | 104
Sparse eyebrow 1 | 40
Sparse scalp hair 1 | 41
Stroke 1 | 32
Sunken eyes 1 | 62
Syndactyly of fingers 1 | 48
Thin rib 1 | 21
Typhoid fever 1 | 22
Urinary Bladder Neoplasms 1 | 108
X-linked dominant 1 | 56
atypical teratoid/rhabdoid tumor 1 | 349
fascioscapulohumeral muscular dystrophy 1 | 98
non-inflammatory breast cancer 1 | 63
ovarian neoplasm 1 | 93
posterior fossa group A ependymoma 1 | 456

Tissue

Blood and immune system 11 | 16,909
Cardiovascular System 11 | 15,192
Digestive Tract 11 | 17,369
Endocrine System 11 | 18,159
Female tissues 11 | 17,400
Liver and Pancreas 11 | 16,750
Male tissues 11 | 17,142
Nervous System 11 | 16,725
Respiratory system 11 | 16,393
Skin and soft tissues 11 | 17,230
Urinary Tract 11 | 16,678

Target Family

Epigenetic 11 | 242

GO Function

NAD-dependent histone deacetyl... 11 | 11
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone deacetylase 9 HDAC9 Tclin Epigenetic -2.27309 185.2 431
Histone deacetylase 8 HDAC8 Tclin Epigenetic -2.41838 263.5 487
Histone deacetylase 5 HDAC5 Tclin Epigenetic -2.19942 147.5 520
Histone deacetylase 7 HDAC7 Tclin Epigenetic -2.02475 107.6 477
Histone deacetylase 1 HDAC1 Tclin Epigenetic -3.03775 954.3 1201
Histone deacetylase 10 HDAC10 Tclin Epigenetic -1.63837 44.1 314
Histone deacetylase 3 HDAC3 Tclin Epigenetic -2.28457 142.9 673
Histone deacetylase 11 HDAC11 Tclin Epigenetic -2.27888 181.5 353
Histone deacetylase 2 HDAC2 Tclin Epigenetic -2.79651 587.9 712
Histone deacetylase 4 HDAC4 Tclin Epigenetic -2.42231 255.5 825