Development Level

Tbio 22 | 10,625
Tchem 11 | 1,890
Tclin 3 | 602

IMPC Term

decreased circulating HDL chol... 2 | 77
abnormal lens morphology 1 | 73
abnormal retina morphology 1 | 100
abnormal retinal inner nuclear... 1 | 5
decreased circulating alanine ... 1 | 53
decreased circulating alkaline... 1 | 41
decreased fasted circulating g... 1 | 49
decreased grip strength 1 | 123
decreased lactate dehydrogenas... 1 | 14
decreased lean body mass 1 | 195
decreased lumbar vertebrae num... 1 | 62
decreased total body fat amoun... 1 | 186
decreased total retina thickne... 1 | 20
embryonic lethality prior to o... 1 | 148
embryonic lethality prior to t... 1 | 187
increased bone mineral density 1 | 52
increased effector memory CD4-... 1 | 15
increased effector memory CD8-... 1 | 14
increased mean corpuscular hem... 1 | 93
preweaning lethality, complete... 1 | 633
preweaning lethality, incomple... 1 | 260

Disease

ovarian cancer 23 | 8,484
osteosarcoma 18 | 7,933
psoriasis 16 | 6,685
pancreatic ductal adenocarcinoma liver metastasis 15 | 1,795
Multiple myeloma 13 | 1,327
glioblastoma 12 | 5,572
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,289
lung cancer 11 | 4,466
non-small cell lung cancer 10 | 2,798
primitive neuroectodermal tumor 10 | 3,031
Cancer 9 | 2,346
atypical teratoid / rhabdoid tumor 9 | 4,369
colon cancer 9 | 1,475
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,988
invasive ductal carcinoma 9 | 2,950
lung adenocarcinoma 9 | 2,713
medulloblastoma, large-cell 9 | 6,234
oligodendroglioma 9 | 2,849
Breast cancer 8 | 3,094
Prostatic Neoplasms 7 | 471
Waldenstrons macroglobulinemia 7 | 765
ependymoma 7 | 2,514
malignant mesothelioma 7 | 3,162
ulcerative colitis 7 | 2,087
Atopic dermatitis 6 | 944
astrocytic glioma 6 | 2,241
breast carcinoma 6 | 1,614
interstitial cystitis 6 | 2,299
pancreatic cancer 6 | 2,300
Degenerative polyarthritis 5 | 93
Pick disease 5 | 1,893
adult high grade glioma 5 | 2,148
diabetes mellitus 5 | 1,663
ductal carcinoma in situ 5 | 1,745
pilocytic astrocytoma 5 | 3,086
Carcinoma 4 | 2,147
Cardiomyopathies 4 | 90
Rheumatoid Arthritis 4 | 1,160
aldosterone-producing adenoma 4 | 664
astrocytoma 4 | 1,493
lung carcinoma 4 | 2,844
nasopharyngeal carcinoma 4 | 1,056
pediatric high grade glioma 4 | 2,712
sonic hedgehog group medulloblastoma 4 | 1,482
Alzheimer's disease 3 | 644
Kidney disease 3 | 396
Leigh disease 3 | 81
Liver carcinoma 3 | 217
Mammary Neoplasms 3 | 410
Myocardial Infarction 3 | 126
adrenocortical carcinoma 3 | 1,427
atypical teratoid/rhabdoid tumor 3 | 1,095
cystic fibrosis 3 | 1,665
dermatomyositis 3 | 933
fibroadenoma 3 | 557
group 3 medulloblastoma 3 | 2,254
group 4 medulloblastoma 3 | 1,875
medulloblastoma 3 | 1,524
pituitary cancer 3 | 1,972
posterior fossa group A ependymoma 3 | 1,511
posterior fossa group B ependymoma 3 | 1,530
primary pancreatic ductal adenocarcinoma 3 | 1,271
Anoxia 2 | 33
Asthma 2 | 349
COPD 2 | 113
Cholangiocarcinoma 2 | 32
Chondroma 2 | 12
Congenital adrenal hyperplasia 2 | 74
DOID:2627 2 | 14
Diabetes mellitus type 2 2 | 69
Disease Progression 2 | 125
Hemangioma 2 | 35
Hypertensive disease 2 | 193
Hypoglycemia 2 | 81
IGA Glomerulonephritis 2 | 454
Immune system cancer 2 | 38
Liver disease 2 | 219
MITOCHONDRIAL COMPLEX I DEFICIENCY 2 | 37
Melanoma 2 | 261
Myelofibrosis 2 | 11
NADH:Q(1) Oxidoreductase deficiency 2 | 20
Neurodegenerative disease 2 | 383
Obesity 2 | 616
Osteoporosis 2 | 257
Papilloma 2 | 27
Polycystic Ovary Syndrome 2 | 332
Stomach Neoplasms 2 | 282
Treatment Refractory Type 2 Diabetes Mellitus 2 | 53
Vaccinia 2 | 37
active Crohn's disease 2 | 918
acute quadriplegic myopathy 2 | 1,157
chronic rhinosinusitis 2 | 512
cutaneous lupus erythematosus 2 | 1,056
gastric carcinoma 2 | 832
inflammatory breast cancer 2 | 404
nephrosclerosis 2 | 329
primary Sjogren syndrome 2 | 789
tuberculosis 2 | 1,557
tuberculosis and treatment for 3 months 2 | 327

Tissue

Blood and immune system 36 | 17,995
Cardiovascular System 36 | 17,958
Digestive Tract 36 | 18,473
Endocrine System 36 | 18,512
Female tissues 36 | 18,647
Liver and Pancreas 36 | 18,136
Male tissues 36 | 17,969
Nervous System 36 | 18,561
Respiratory system 36 | 17,484
Skin and soft tissues 36 | 18,115
Urinary Tract 36 | 18,444

Target Family

Enzyme 29 | 4,146
Non-IDG 6 | 11,971
Epigenetic 1 | 242

GO Function

NAD binding 36 | 36
metal ion binding 1,917 | 1,917
ATP binding 1,467 | 1,467
DNA binding 1,432 | 1,432
zinc ion binding 1,155 | 1,155
poly(A) RNA binding 1,107 | 1,107
transcription factor activity,... 853 | 853
calcium ion binding 695 | 695
G-protein coupled receptor act... 661 | 661
protein homodimerization activ... 569 | 569
RNA binding 445 | 445
olfactory receptor activity 424 | 424
sequence-specific DNA binding 398 | 398
GTP binding 374 | 374
chromatin binding 372 | 372
protein serine/threonine kinas... 336 | 336
RNA polymerase II core promote... 332 | 332
identical protein binding 311 | 311
nucleotide binding 311 | 311
receptor binding 303 | 303
protein kinase binding 289 | 289
enzyme binding 286 | 286
cadherin binding involved in c... 277 | 277
GTPase activator activity 273 | 273
ubiquitin protein ligase bindi... 258 | 258
ubiquitin-protein transferase ... 253 | 253
serine-type endopeptidase acti... 246 | 246
transcription coactivator acti... 241 | 241
transcription factor binding 240 | 240
structural molecule activity 232 | 232
GTPase activity 231 | 231
transcriptional activator acti... 230 | 230
ligase activity 227 | 227
protein heterodimerization act... 227 | 227
structural constituent of ribo... 212 | 212
transcription regulatory regio... 202 | 202
transmembrane signaling recept... 201 | 201
RNA polymerase II regulatory r... 200 | 200
receptor activity 200 | 200
transcription corepressor acti... 198 | 198
magnesium ion binding 197 | 197
signal transducer activity 196 | 196
nucleic acid binding 184 | 184
protein kinase activity 183 | 183
carbohydrate binding 180 | 180
ubiquitin protein ligase activ... 173 | 173
RNA polymerase II transcriptio... 162 | 162
heparin binding 160 | 160
iron ion binding 141 | 141
lipid binding 136 | 136
transporter activity 136 | 136
actin binding 133 | 133
ATPase activity 132 | 132
protein C-terminus binding 129 | 129
heme binding 127 | 127
microtubule binding 123 | 123
protein tyrosine kinase activi... 119 | 119
cytokine activity 118 | 118
Ras guanyl-nucleotide exchange... 113 | 113
mRNA binding 112 | 112
metalloendopeptidase activity 112 | 112
transcriptional repressor acti... 110 | 110
structural constituent of cyto... 108 | 108
Rab GTPase binding 105 | 105
antigen binding 104 | 104
protein domain specific bindin... 102 | 102
peptide antigen binding 101 | 101
guanyl-nucleotide exchange fac... 98 | 98
protein complex binding 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 92 | 92
oxidoreductase activity 91 | 91
transcriptional activator acti... 91 | 91
actin filament binding 89 | 89
hydrolase activity 89 | 89
ion channel binding 89 | 89
protein tyrosine phosphatase a... 88 | 88
electron carrier activity 87 | 87
protease binding 87 | 87
histone binding 86 | 86
integrin binding 83 | 83
growth factor activity 82 | 82
phospholipid binding 82 | 82
single-stranded DNA binding 81 | 81
unfolded protein binding 77 | 77
kinase activity 75 | 75
thiol-dependent ubiquitin-spec... 75 | 75
phosphatidylinositol binding 74 | 74
calmodulin binding 73 | 73
histone deacetylase binding 73 | 73
Rho guanyl-nucleotide exchange... 72 | 72
drug binding 71 | 71
double-stranded DNA binding 70 | 70
peptidase activity 70 | 70
protein N-terminus binding 70 | 70
virus receptor activity 68 | 68
beta-catenin binding 67 | 67
microtubule motor activity 67 | 67
protein transporter activity 67 | 67
calcium channel activity 66 | 66
ubiquitin binding 66 | 66

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Malate dehydrogenase, cytoplasmic MDH1 Tbio Enzyme -2.61325 409.6 244
Trifunctional enzyme subunit alpha, mitochondrial HADHA Tbio Non-IDG -2.96515 948.2 132
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B Tbio Enzyme -1.13428 13.6 146
NADP-dependent malic enzyme ME1 Tchem Non-IDG -1.96870 90.3 172
NAD-dependent malic enzyme, mitochondrial ME2 Tbio Non-IDG -1.91597 82.7 90
L-lactate dehydrogenase A chain LDHA Tchem Enzyme -2.99664 983.0 487
NADH-cytochrome b5 reductase 3 CYB5R3 Tchem Enzyme -1.93440 89.2 241
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial NDUFV1 Tclin Enzyme -1.36250 23.7 158
3-hydroxybutyrate dehydrogenase type 2 BDH2 Tbio Enzyme -1.12843 14.8 92
Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial IDH3G Tbio Enzyme -0.19018 0.67 161