Development Level

Tchem 16 | 1,598
Tclin 3 | 613
Tbio 2 | 11,445
Tdark 1 | 6,588

Collection

Kinase: IDG Consortium (Comple... 3 | 37
Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 3 | 979
abnormal lens morphology 2 | 81
abnormal bone structure 1 | 187
abnormal retina morphology 1 | 71
abnormal startle reflex 1 | 15
cataract 1 | 92
decreased body length 1 | 101
decreased circulating fructosa... 1 | 30
decreased circulating sodium l... 1 | 22
decreased fasted circulating g... 1 | 65
decreased leukocyte cell numbe... 1 | 73
decreased mean corpuscular vol... 1 | 79
decreased vertical activity 1 | 208
embryonic lethality prior to t... 1 | 278
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased startle reflex 1 | 112
preweaning lethality, incomple... 1 | 499

Disease

Carcinoma 19 | 11,493
ovarian cancer 16 | 8,520
glioblastoma 11 | 5,792
Kidney cancer 10 | 2,613
malignant mesothelioma 10 | 3,232
medulloblastoma, large-cell 10 | 6,241
osteosarcoma 10 | 7,950
atypical teratoid / rhabdoid tumor 9 | 5,112
lung cancer 9 | 4,740
Cancer 8 | 2,499
lung carcinoma 7 | 2,843
non-small cell lung cancer 7 | 2,890
psoriasis 7 | 6,694
tuberculosis 7 | 2,010
Astrocytoma, Pilocytic 6 | 3,081
Pick disease 6 | 1,894
adult high grade glioma 6 | 3,801
ependymoma 6 | 4,679
group 3 medulloblastoma 6 | 4,104
Breast cancer 5 | 3,578
Rheumatoid arthritis 5 | 1,191
pancreatic cancer 5 | 2,398
Breast Neoplasms 4 | 445
Carcinoma of thyroid 4 | 17
Lung Neoplasms 4 | 232
Mammary Neoplasms 4 | 425
acute myeloid leukemia 4 | 783
acute quadriplegic myopathy 4 | 1,158
adrenocortical carcinoma 4 | 1,428
astrocytic glioma 4 | 2,597
group 4 medulloblastoma 4 | 1,855
interstitial cystitis 4 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
oligodendroglioma 4 | 2,850
pituitary cancer 4 | 1,972
primitive neuroectodermal tumor 4 | 3,035
subependymal giant cell astrocytoma 4 | 2,287
Acquired scoliosis 3 | 281
Autosomal recessive predisposition 3 | 1,442
Bronchioloalveolar Adenocarcinoma 3 | 14
Byzanthine arch palate 3 | 194
Cryptorchidism 3 | 296
Curvature of spine 3 | 282
Downward slant of palpebral fissure 3 | 158
Freckles 3 | 33
Hypogonadism, Isolated Hypogonadotropic 3 | 71
Hypogonadotropic hypogonadism 3 | 89
Hypoplastic mandible condyle 3 | 275
Langerhans-cell histiocytosis 3 | 12
Liver cell carcinoma 3 | 15
Mandibular hypoplasia 3 | 275
Melanoma 3 | 711
Micrognathism 3 | 275
Orbital separation excessive 3 | 244
Prostatic Neoplasms 3 | 495
Renal Cell Carcinoma 3 | 214
Short stature 3 | 531
active Crohn's disease 3 | 922
astrocytoma 3 | 1,146
cystic fibrosis 3 | 1,696
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
juvenile dermatomyositis 3 | 1,187
pediatric high grade glioma 3 | 1,064
primary pancreatic ductal adenocarcinoma 3 | 1,109
spina bifida 3 | 1,074
ulcerative colitis 3 | 1,819
ATRIOVENTRICULAR CANAL DEFECT 2 | 17
Abnormality of pulmonary valve 2 | 23
Bleeding tendency 2 | 37
Blood Coagulation Disorders 2 | 42
Cardiac Arrhythmia 2 | 103
Cardiac conduction abnormalities 2 | 78
Cardiomyopathy 2 | 116
Cholangiocarcinoma 2 | 35
Coagulation abnormalities 2 | 27
Colorectal Neoplasms 2 | 243
Conduction disorder of the heart 2 | 79
DOID:2627 2 | 94
EKG abnormalities 2 | 78
Electrocardiogram abnormal 2 | 81
Electrocardiogram change 2 | 78
Endocardial Cushion Defects 2 | 17
Hemorrhagic Disorders 2 | 30
High forehead 2 | 102
Hypertrophic Cardiomyopathy 2 | 117
Long narrow head 2 | 75
Melanocytic nevus 2 | 43
Muscle Weakness 2 | 170
Narrow cranium shape 2 | 75
Narrow head shape 2 | 75
Narrow skull shape 2 | 75
Noncancerous mole 2 | 28
Prominent eyes 2 | 96
Prominent globes 2 | 96
Protruding eyes 2 | 96
Sensorineural Hearing Loss (disorder) 2 | 284
Tall forehead 2 | 102
Turridolichocephaly 2 | 75
sarcoidosis 2 | 370

Tissue

Endocrine System 22 | 18,159
Blood and immune system 21 | 16,909
Female tissues 21 | 17,400
Liver and Pancreas 21 | 16,750
Respiratory system 21 | 16,393
Urinary Tract 21 | 16,678
Cardiovascular System 20 | 15,192
Digestive Tract 20 | 17,369
Male tissues 20 | 17,142
Nervous System 20 | 16,725
Skin and soft tissues 20 | 17,230

Target Family

Kinase 21 | 634
Non-IDG 1 | 12,091

GO Function

MAP kinase kinase kinase activ... 22 | 22
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitogen-activated protein kinase kinase kinase 4 MAP3K4 Tbio Kinase -1.49704 31.8 244
Serine/threonine-protein kinase TAO2 TAOK2 Tchem Kinase -1.52454 36.1 154
Mitogen-activated protein kinase kinase kinase 2 MAP3K2 Tchem Kinase -1.47034 26.6 199
Mitogen-activated protein kinase kinase kinase 12 MAP3K12 Tchem Kinase -2.06440 121.0 134
Mitogen-activated protein kinase kinase kinase 20 MAP3K20 Tchem Kinase -1.18567 14.9 215
Mitogen-activated protein kinase kinase kinase 15 MAP3K15 Tchem Kinase -0.94156 6.81 97
MAP3K7 C-terminal-like protein MAP3K7CL Tdark Non-IDG -0.51188 3.20 110
Serine/threonine-protein kinase TAO3 TAOK3 Tchem Kinase -2.62072 379.0 325
Mitogen-activated protein kinase kinase kinase 1 MAP3K1 Tchem Kinase -2.12399 119.4 334
Serine/threonine-protein kinase TAO1 TAOK1 Tchem Kinase -1.59388 36.9 221