Development Level

Tchem 9 | 1,890
Tclin 2 | 602
Tbio 1 | 10,625

Collection

Kinase: IDG Consortium (Targets) 1 | 125

IMPC Phenotype

increased erythrocyte cell num... 2 | 26
abnormal gait 1 | 51
decreased body weight 1 | 174
decreased circulating creatini... 1 | 31
decreased total body fat amoun... 1 | 186
increased hematocrit 1 | 36
preweaning lethality, complete... 1 | 633

Disease

atypical teratoid / rhabdoid tumor 8 | 4,369
glioblastoma 7 | 5,572
medulloblastoma, large-cell 7 | 6,234
ovarian cancer 7 | 8,491
psoriasis 7 | 6,685
osteosarcoma 6 | 7,933
Cancer 5 | 2,346
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,988
Intellectual disability 4 | 573
adult high grade glioma 4 | 2,148
lung cancer 4 | 4,473
pilocytic astrocytoma 4 | 3,086
Carcinoma 3 | 2,147
Cardiofaciocutaneous syndrome 3 | 15
Costello Syndrome 3 | 18
Melanoma 3 | 261
Noonan Syndrome 3 | 33
Vascular disease 3 | 281
astrocytic glioma 3 | 2,241
colon cancer 3 | 1,475
ependymoma 3 | 2,514
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,289
invasive ductal carcinoma 3 | 2,950
medulloblastoma 3 | 1,524
oligodendroglioma 3 | 2,849
primitive neuroectodermal tumor 3 | 3,031
subependymal giant cell astrocytoma 3 | 2,287
tuberculosis 3 | 1,563
Alzheimer's disease 2 | 644
Brain Ischemia 2 | 87
Breast cancer 2 | 3,098
Cardio-facio-cutaneous syndrome 2 | 6
Cardiofaciocutaneous syndrome 1 2 | 4
Cardiomyopathy 2 | 110
Costello syndrome (disorder) 2 | 7
Endometriosis 2 | 535
LEOPARD Syndrome 2 | 20
Lung Neoplasms 2 | 171
Malignant Melanoma with BRAF V600E Mutation 2 | 4
Malignant Melanoma with BRAF V600K Mutation 2 | 2
Metastatic malignant melanoma 2 | 9
Multiple myeloma 2 | 1,327
Neurodegenerative disease 2 | 383
Pick disease 2 | 1,893
Renal Cell Carcinoma 2 | 199
Toxic encephalopathy 2 | 131
cystic fibrosis 2 | 1,670
diabetes mellitus 2 | 1,663
glioblastoma multiforme 2 | 347
lung adenocarcinoma 2 | 2,714
lung carcinoma 2 | 2,844
malignant mesothelioma 2 | 3,163
pancreatic cancer 2 | 2,300
pediatric high grade glioma 2 | 2,712
primary pancreatic ductal adenocarcinoma 2 | 1,271
sonic hedgehog group medulloblastoma 2 | 1,482
ulcerative colitis 2 | 2,087
Adenoid Cystic Carcinoma 1 | 99
Arthritis 1 | 248
Atopic dermatitis 1 | 944
Brain disease 1 | 84
COPD 1 | 116
Cardiomyopathies 1 | 90
Cholestasis 1 | 93
Colonic Neoplasms 1 | 126
Common variable immunodeficiency 1 | 98
Congenital heart disease 1 | 63
Dementia 1 | 129
Diarrhea 1 | 155
Epilepsy 1 | 346
Exanthem 1 | 39
Fibrosis 1 | 40
Gaucher disease type 1 1 | 171
Heart failure 1 | 80
Hypersensitivity 1 | 63
Lennox-Gastaut syndrome 1 | 34
Liver neoplasms 1 | 108
Lung disease 1 | 136
Mammary Neoplasms 1 | 410
Mammary Neoplasms, Experimental 1 | 149
Multiple Sclerosis 1 | 498
Multiple system atrophy 1 | 27
Myocardial Ischemia 1 | 169
Nerve Degeneration 1 | 73
PARKINSON DISEASE, LATE-ONSET 1 | 20
Parkinson Disease 1 | 105
Parkinson's disease 1 | 364
Paronychia 1 | 7
Precancerous Conditions 1 | 69
REM sleep behavior disorder 1 | 16
Waldenstrons macroglobulinemia 1 | 764
acute quadriplegic myopathy 1 | 1,157
adrenocortical carcinoma 1 | 1,427
autosomal dominant Emery-Dreifuss muscular dystrophy 1 | 499
axial spondyloarthropathy 1 | 28
inflammatory breast cancer 1 | 404
pancreatic carcinoma 1 | 567
progressive supranuclear palsy 1 | 674
severe Alzheimer's disease 1 | 49

Tissue

Blood and immune system 12 | 17,994
Cardiovascular System 12 | 17,957
Digestive Tract 12 | 18,472
Endocrine System 12 | 18,511
Female tissues 12 | 18,646
Liver and Pancreas 12 | 18,135
Male tissues 12 | 17,968
Nervous System 12 | 18,560
Respiratory system 12 | 17,483
Skin and soft tissues 12 | 18,114
Urinary Tract 12 | 18,443

Target Family

Kinase 12 | 634

GO Function

MAP kinase kinase activity 12 | 12
metal ion binding 1,917 | 1,917
ATP binding 1,467 | 1,467
DNA binding 1,432 | 1,432
zinc ion binding 1,155 | 1,155
poly(A) RNA binding 1,107 | 1,107
transcription factor activity,... 853 | 853
calcium ion binding 695 | 695
G-protein coupled receptor act... 661 | 661
protein homodimerization activ... 569 | 569
RNA binding 445 | 445
olfactory receptor activity 424 | 424
sequence-specific DNA binding 398 | 398
GTP binding 374 | 374
chromatin binding 372 | 372
protein serine-threonine kinas... 336 | 336
RNA polymerase II core promote... 332 | 332
identical protein binding 311 | 311
nucleotide binding 311 | 311
receptor binding 303 | 303
protein kinase binding 289 | 289
enzyme binding 286 | 286
cadherin binding involved in c... 277 | 277
GTPase activator activity 273 | 273
ubiquitin protein ligase bindi... 258 | 258
ubiquitin-protein transferase ... 253 | 253
serine-type endopeptidase acti... 246 | 246
transcription coactivator acti... 241 | 241
transcription factor binding 240 | 240
structural molecule activity 232 | 232
GTPase activity 231 | 231
transcriptional activator acti... 230 | 230
ligase activity 227 | 227
protein heterodimerization act... 227 | 227
structural constituent of ribo... 212 | 212
transcription regulatory regio... 202 | 202
transmembrane signaling recept... 201 | 201
RNA polymerase II regulatory r... 200 | 200
receptor activity 200 | 200
transcription corepressor acti... 198 | 198
magnesium ion binding 197 | 197
signal transducer activity 196 | 196
nucleic acid binding 184 | 184
protein kinase activity 183 | 183
carbohydrate binding 180 | 180
ubiquitin protein ligase activ... 173 | 173
RNA polymerase II transcriptio... 162 | 162
heparin binding 160 | 160
iron ion binding 141 | 141
lipid binding 136 | 136
transporter activity 136 | 136
actin binding 133 | 133
ATPase activity 132 | 132
protein C-terminus binding 129 | 129
heme binding 127 | 127
microtubule binding 123 | 123
protein tyrosine kinase activi... 119 | 119
cytokine activity 118 | 118
Ras guanyl-nucleotide exchange... 113 | 113
mRNA binding 112 | 112
metalloendopeptidase activity 112 | 112
transcriptional repressor acti... 110 | 110
structural constituent of cyto... 108 | 108
Rab GTPase binding 105 | 105
antigen binding 104 | 104
protein domain specific bindin... 102 | 102
peptide antigen binding 101 | 101
guanyl-nucleotide exchange fac... 98 | 98
protein complex binding 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 92 | 92
oxidoreductase activity 91 | 91
transcriptional activator acti... 91 | 91
actin filament binding 89 | 89
hydrolase activity 89 | 89
ion channel binding 89 | 89
protein tyrosine phosphatase a... 88 | 88
electron carrier activity 87 | 87
protease binding 87 | 87
histone binding 86 | 86
integrin binding 83 | 83
growth factor activity 82 | 82
phospholipid binding 82 | 82
single-stranded DNA binding 81 | 81
unfolded protein binding 77 | 77
kinase activity 75 | 75
thiol-dependent ubiquitin-spec... 75 | 75
phosphatidylinositol binding 74 | 74
calmodulin binding 73 | 73
histone deacetylase binding 73 | 73
Rho guanyl-nucleotide exchange... 72 | 72
drug binding 71 | 71
double-stranded DNA binding 70 | 70
peptidase activity 70 | 70
protein N-terminus binding 70 | 70
virus receptor activity 68 | 68
beta-catenin binding 67 | 67
microtubule motor activity 67 | 67
protein transporter activity 67 | 67
calcium channel activity 66 | 66
ubiquitin binding 66 | 66

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