Development Level

Tbio 8 | 11,445
Tdark 1 | 6,588

IMPC Phenotype

abnormal behavior 1 | 298
corneal opacity 1 | 32
decreased circulating HDL chol... 1 | 68
decreased circulating choleste... 1 | 93
decreased red blood cell distr... 1 | 41
hypoactivity 1 | 132
increased circulating aspartat... 1 | 15
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased mean platelet volume 1 | 45
preweaning lethality, complete... 1 | 979
thrombocytosis 1 | 27

Disease

Carcinoma 7 | 11,493
lung cancer 5 | 4,740
atypical teratoid / rhabdoid tumor 4 | 5,112
glioblastoma 4 | 5,792
medulloblastoma, large-cell 4 | 6,241
osteosarcoma 4 | 7,950
ovarian cancer 4 | 8,520
psoriasis 4 | 6,694
Cancer 3 | 2,499
adult high grade glioma 3 | 3,801
ependymoma 3 | 4,679
group 3 medulloblastoma 3 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
primitive neuroectodermal tumor 3 | 3,035
Breast cancer 2 | 3,578
Crohn's disease 2 | 321
Kidney cancer 2 | 2,613
Pick disease 2 | 1,894
Rheumatoid arthritis 2 | 1,191
acute myeloid leukemia 2 | 783
astrocytic glioma 2 | 2,597
cutaneous lupus erythematosus 2 | 1,057
cystic fibrosis 2 | 1,696
diabetes mellitus 2 | 1,728
lung carcinoma 2 | 2,843
malignant mesothelioma 2 | 3,232
non-small cell lung cancer 2 | 2,890
oligodendroglioma 2 | 2,850
pancreatic cancer 2 | 2,398
pituitary cancer 2 | 1,972
primary Sjogren syndrome 2 | 735
spina bifida 2 | 1,074
Adult onset 1 | 82
Amyotrophic lateral sclerosis 1 | 451
Ataxia, Appendicular 1 | 25
Ataxia, Truncal 1 | 21
Atrophy of cerebellum 1 | 103
Autoimmune Diseases 1 | 67
Autosomal dominant cerebellar ataxia 1 | 33
Babinski Reflex 1 | 100
Blepharoptosis 1 | 231
Blind loop syndrome 1 | 2
Bradykinesia 1 | 34
Carcinoma, Non-Small-Cell Lung 1 | 107
Cell Transformation, Neoplastic 1 | 97
Cerebellar degeneration 1 | 103
Choreatic disease 1 | 52
Decreased vibratory sense 1 | 7
Deglutition Disorders 1 | 132
Dementia 1 | 175
Distal amyotrophy 1 | 51
Dysmetric saccades 1 | 9
Dystonia 1 | 164
Edwards syndrome 1 | 17
Exophthalmos 1 | 112
Friedreich ataxia 1 | 24
Gliosis 1 | 56
Inflammation 1 | 120
Infratentorial atrophy 1 | 103
Juvenile rheumatoid arthritis 1 | 111
Kennedy's disease 1 | 11
Lupus Erythematosus, Systemic 1 | 67
Lymphoid leukemia 1 | 160
Lymphoma, Follicular 1 | 18
Lymphoma, T-Cell, Cutaneous 1 | 22
Machado-Joseph disease 1 | 18
Malignant neoplasm of skin 1 | 15
Milium Cyst 1 | 16
Multiple system atrophy 1 | 29
Muscle Cramp 1 | 55
Muscle Rigidity 1 | 49
Narcolepsy 1 | 72
Neoplastic Cell Transformation 1 | 89
Nerve Degeneration 1 | 121
Neurodegenerative disease 1 | 414
Neuropathy 1 | 261
PARKINSON DISEASE, LATE-ONSET 1 | 20
Paralytic ileus 1 | 5
Pneumonia 1 | 174
Postural instability 1 | 19
Progressive cerebellar ataxia 1 | 13
Progressive disorder 1 | 142
Prominent eyes 1 | 96
Prominent globes 1 | 96
Proteinuria 1 | 144
Protruding eyes 1 | 96
Restless legs syndrome 1 | 27
Sjogren's syndrome 1 | 26
Skin Neoplasms 1 | 69
Sphincter disturbances 1 | 16
Spinocerebellar ataxia type 1 1 | 16
Spinocerebellar ataxia type 2 1 | 23
Systemic lupus erythematosus 1 | 194
Telangiectasia of the skin 1 | 39
Uterine adnexa cancer 1 | 4
dentatorubral-pallidoluysian atrophy 1 | 21
non-small cell lung carcinoma 1 | 317
non-syndromic X-linked intellectual disability 1 | 20
tuberculosis and treatment for 6 months 1 | 409

Tissue

Blood and immune system 9 | 16,909
Cardiovascular System 9 | 15,192
Digestive Tract 9 | 17,369
Endocrine System 9 | 18,159
Female tissues 9 | 17,400
Liver and Pancreas 9 | 16,750
Male tissues 9 | 17,142
Nervous System 9 | 16,725
Respiratory system 9 | 16,393
Skin and soft tissues 9 | 17,230
Urinary Tract 9 | 16,678

Target Family

Enzyme 6 | 4,145
Non-IDG 3 | 12,091

GO Function

Lys63-specific deubiquitinase ... 9 | 9
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ubiquitin thioesterase OTU1 YOD1 Tbio Enzyme -1.63573 39.8 111
Ubiquitin carboxyl-terminal hydrolase 27 USP27X Tdark Enzyme 0.00000 61
26S proteasome non-ATPase regulatory subunit 14 PSMD14 Tbio Enzyme -1.80255 64.2 195
OTU domain-containing protein 5 OTUD5 Tbio Non-IDG -0.89861 6.92 100
Ubiquitin carboxyl-terminal hydrolase CYLD CYLD Tbio Enzyme -2.94112 884.9 183
Lys-63-specific deubiquitinase BRCC36 BRCC3 Tbio Enzyme -1.15215 13.4 225
Tumor necrosis factor alpha-induced protein 3 TNFAIP3 Tbio Non-IDG -2.45615 259.2 309
AMSH-like protease STAMBPL1 Tbio Enzyme -0.57888 3.77 84
Ataxin-3 ATXN3 Tbio Non-IDG -2.89207 773.7 230