Development Level

Tbio 9 | 11,445
Tdark 1 | 6,588

IMPC Phenotype

decreased circulating choleste... 2 | 93
abnormal behavior 1 | 298
abnormal gait 1 | 69
abnormal hindlimb morphology 1 | 2
abnormal locomotor activation 1 | 16
abnormal spine curvature 1 | 9
corneal opacity 1 | 32
decreased body weight 1 | 161
decreased circulating HDL chol... 1 | 68
decreased circulating free fat... 1 | 31
decreased circulating glycerol... 1 | 16
decreased total body fat amoun... 1 | 207
hyperactivity 1 | 148
hypoactivity 1 | 132
increased bone mineral content 1 | 108
increased circulating alkaline... 1 | 122
increased circulating aspartat... 1 | 15
increased hemoglobin content 1 | 45
increased startle reflex 1 | 112

Disease

Carcinoma 9 | 11,493
osteosarcoma 7 | 7,950
psoriasis 5 | 6,694
medulloblastoma, large-cell 4 | 6,241
ovarian cancer 4 | 8,520
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
malignant mesothelioma 3 | 3,232
spina bifida 3 | 1,074
Breast cancer 2 | 3,578
Kidney cancer 2 | 2,613
Pick disease 2 | 1,894
adult high grade glioma 2 | 3,801
atypical teratoid / rhabdoid tumor 2 | 5,112
ependymoma 2 | 4,679
glioblastoma 2 | 5,792
group 4 medulloblastoma 2 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
lung cancer 2 | 4,740
pancreatic cancer 2 | 2,398
Adult onset 1 | 82
Allergic hypersensitivity disease 1 | 126
Alzheimer's disease 1 | 658
Amyotrophic lateral sclerosis 1 | 451
Ataxia, Appendicular 1 | 25
Ataxia, Truncal 1 | 21
Atopic dermatitis 1 | 952
Atrophy of cerebellum 1 | 103
Autosomal dominant cerebellar ataxia 1 | 33
Babinski Reflex 1 | 100
Blepharoptosis 1 | 231
Bradykinesia 1 | 34
Brown-Sequard syndrome 1 | 3
Carcinoma, Hepatocellular 1 | 228
Carcinoma, Non-Small-Cell Lung 1 | 107
Cerebellar degeneration 1 | 103
Choreatic disease 1 | 52
Decreased vibratory sense 1 | 7
Deglutition Disorders 1 | 132
Dementia 1 | 175
Diplopia 1 | 8
Distal amyotrophy 1 | 51
Dysmetric saccades 1 | 9
Dystonia 1 | 164
Edwards syndrome 1 | 17
Exophthalmos 1 | 112
Familial cold autoinflammatory syndrome 1 | 10
Friedreich ataxia 1 | 24
Gaucher disease type 1 1 | 180
Gliosis 1 | 56
Huntington's disease 1 | 76
Impaired horizontal smooth pursuit 1 | 6
Infratentorial atrophy 1 | 103
Kennedy's disease 1 | 11
Leprosy 1 | 73
Listeriosis 1 | 18
Liver Cirrhosis, Experimental 1 | 769
Liver carcinoma 1 | 240
Machado-Joseph disease 1 | 18
Malignant neoplasm of skin 1 | 15
Milium Cyst 1 | 16
Multiple system atrophy 1 | 29
Muscle Cramp 1 | 55
Muscle Rigidity 1 | 49
Muscular atrophy 1 | 71
Narcolepsy 1 | 72
Nerve Degeneration 1 | 121
Neurodegenerative disease 1 | 414
Neuropathy 1 | 261
Olivopontocerebellar atrophy 1 | 9
Orofacial cleft 1 | 54
PARKINSON DISEASE, LATE-ONSET 1 | 20
Papule 1 | 43
Paralytic ileus 1 | 5
Parkinson's disease 1 | 392
Pneumonia 1 | 174
Postural instability 1 | 19
Progressive cerebellar ataxia 1 | 13
Progressive disorder 1 | 142
Prominent eyes 1 | 96
Prominent globes 1 | 96
Proteinuria 1 | 144
Protruding eyes 1 | 96
Reflex, Ankle, Absent 1 | 8
Restless legs syndrome 1 | 27
Rhinitis 1 | 54
Skin Neoplasms 1 | 69
Skin cancer 1 | 469
Sphincter disturbances 1 | 16
Spinocerebellar ataxia type 1 1 | 16
Spinocerebellar ataxia type 2 1 | 23
Subcutaneous nodule 1 | 53
Telangiectasia of the skin 1 | 39
Thymoma 1 | 16
Uterine adnexa cancer 1 | 4
dentatorubral-pallidoluysian atrophy 1 | 21
non-small cell lung carcinoma 1 | 317
non-syndromic X-linked intellectual disability 1 | 20
tuberculosis and treatment for 3 months 1 | 179
tuberculosis and treatment for 6 months 1 | 409

Tissue

Blood and immune system 10 | 16,909
Cardiovascular System 10 | 15,192
Digestive Tract 10 | 17,369
Endocrine System 10 | 18,159
Female tissues 10 | 17,400
Liver and Pancreas 10 | 16,750
Male tissues 10 | 17,142
Nervous System 10 | 16,725
Respiratory system 10 | 16,393
Skin and soft tissues 10 | 17,230
Urinary Tract 10 | 16,678

Target Family

Non-IDG 6 | 12,091
Enzyme 4 | 4,145

GO Function

Lys48-specific deubiquitinase ... 10 | 10
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ubiquitin thioesterase OTU1 YOD1 Tbio Enzyme -1.63573 39.8 111
Ubiquitin carboxyl-terminal hydrolase 27 USP27X Tdark Enzyme 0.00000 61
OTU domain-containing protein 5 OTUD5 Tbio Non-IDG -0.89861 6.92 100
Ubiquitin carboxyl-terminal hydrolase 19 USP19 Tbio Enzyme -1.25950 22.1 126
Ubiquitin carboxyl-terminal hydrolase MINDY-2 MINDY2 Tbio Non-IDG -0.30103 1.50 54
Ubiquitin carboxyl-terminal hydrolase MINDY-1 MINDY1 Tbio Non-IDG 0.00000 0.42 62
Ubiquitin carboxyl-terminal hydrolase CYLD CYLD Tbio Enzyme -2.94112 884.9 183
OTU domain-containing protein 7B OTUD7B Tbio Non-IDG -1.59780 41.4 125
Ubiquitin carboxyl-terminal hydrolase MINDY-3 MINDY3 Tbio Non-IDG -1.49663 27.7 36
Ataxin-3 ATXN3 Tbio Non-IDG -2.89207 773.7 230