Development Level

Tbio 20 | 11,445
Tchem 1 | 1,598

IMPC Phenotype

decreased circulating choleste... 2 | 93
preweaning lethality, complete... 2 | 979
abnormal behavior 1 | 298
abnormal blood vessel morpholo... 1 | 5
abnormal bone mineralization 1 | 38
cardiovascular system phenotyp... 1 | 36
decreased body weight 1 | 161
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating glucose ... 1 | 126
decreased circulating potassiu... 1 | 20
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased heart rate variabili... 1 | 13
decreased mean corpuscular hem... 1 | 50
embryonic lethality prior to o... 1 | 239
increased body length 1 | 32
increased circulating sodium l... 1 | 71
increased lean body mass 1 | 172
increased monocyte cell number 1 | 63
increased startle reflex 1 | 112
preweaning lethality, incomple... 1 | 499

Disease

Carcinoma 17 | 11,493
ovarian cancer 16 | 8,520
osteosarcoma 13 | 7,950
glioblastoma 7 | 5,792
medulloblastoma, large-cell 7 | 6,241
psoriasis 7 | 6,694
spina bifida 7 | 1,074
subependymal giant cell astrocytoma 6 | 2,287
adult high grade glioma 5 | 3,801
atypical teratoid / rhabdoid tumor 5 | 5,112
ependymoma 5 | 4,679
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,962
Intellectual disability 4 | 1,016
acute myeloid leukemia 4 | 783
astrocytic glioma 4 | 2,597
group 3 medulloblastoma 4 | 4,104
lung cancer 4 | 4,740
malignant mesothelioma 4 | 3,232
oligodendroglioma 4 | 2,850
Amyotrophic lateral sclerosis 3 | 451
Astrocytoma, Pilocytic 3 | 3,081
Cancer 3 | 2,499
Cataract 3 | 297
Kidney cancer 3 | 2,613
Muscle Spasticity 3 | 195
Paget's disease of bone 3 | 36
Rheumatoid arthritis 3 | 1,191
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
non-small cell lung cancer 3 | 2,890
primitive neuroectodermal tumor 3 | 3,035
tuberculosis 3 | 2,010
Anxiety 2 | 136
Anxiety disease 2 | 113
Bipolar Disorder 2 | 666
Breast cancer 2 | 3,578
Deglutition Disorders 2 | 132
Depressive disorder 2 | 409
Dull intelligence 2 | 645
Dysarthria 2 | 192
Dyspnea 2 | 76
Fanconi anemia 2 | 56
Fatigable weakness of respiratory muscles 2 | 28
Fatigable weakness of swallowing muscles 2 | 28
Fatigue 2 | 182
Frontotemporal dementia 2 | 51
Generalized muscle weakness 2 | 57
Glaucoma 2 | 239
Hypohidrotic ectodermal dysplasia 2 | 15
Lens Opacities 2 | 231
Low intelligence 2 | 645
Lytic lesion 2 | 32
Mental Retardation 2 | 645
Mental deficiency 2 | 645
Mood swings 2 | 77
Muscle Cramp 2 | 55
Nerve Degeneration 2 | 121
Neuro-degenerative disease 2 | 43
Neurodegenerative Disorders 2 | 79
Neurodegenerative disease 2 | 414
Neurogenic Muscular Atrophy 2 | 139
Neurogenic muscle atrophy, especially in the lower limbs 2 | 139
Optic Atrophy 2 | 242
Osteitis Deformans 2 | 11
Pain 2 | 103
Paralysed 2 | 42
Poor school performance 2 | 645
Respiratory Failure 2 | 104
Retinal Detachment 2 | 51
Skeletal muscle atrophy 2 | 139
Uveitis 2 | 103
Xerostomia 2 | 42
active ulcerative colitis 2 | 764
astrocytoma 2 | 1,146
diabetes mellitus 2 | 1,728
group 4 medulloblastoma 2 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
muscle degeneration 2 | 139
pituitary cancer 2 | 1,972
Apathy 1 | 16
Aplastic Anemia 1 | 21
Ataxia telangiectasia 1 | 34
Blind loop syndrome 1 | 2
Cell Transformation, Neoplastic 1 | 97
Collapse of vertebra 1 | 14
Coloboma 1 | 51
Compression fracture of vertebral column 1 | 14
Congenital aphakia 1 | 6
Corneal edema 1 | 14
Excessive tearing 1 | 12
Hepatitis A 1 | 11
Hepatoblastoma 1 | 19
Irritation - emotion 1 | 68
Juvenile rheumatoid arthritis 1 | 111
Neoplastic Cell Transformation 1 | 89
Poor speech 1 | 37
Problems speaking 1 | 37
Psoriatic arthritis 1 | 86
Quadriparesis 1 | 8
Restlessness 1 | 14

Tissue

Blood and immune system 21 | 16,909
Cardiovascular System 21 | 15,192
Digestive Tract 21 | 17,369
Endocrine System 21 | 18,159
Female tissues 21 | 17,400
Liver and Pancreas 21 | 16,750
Male tissues 21 | 17,142
Nervous System 21 | 16,725
Respiratory system 21 | 16,393
Skin and soft tissues 21 | 17,230
Urinary Tract 21 | 16,678

Target Family

Non-IDG 13 | 12,091
Enzyme 6 | 4,145
Kinase 1 | 634
Transcription Factor 1 | 1,400

GO Function

K63-linked polyubiquitin modif... 21 | 21
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA annealing helicase and endonuclease ZRANB3 ZRANB3 Tbio Enzyme -2.18014 154.3 36
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.66768 5.75 59
E3 ubiquitin-protein ligase RNF169 RNF169 Tbio Enzyme -0.16291 2.08 60
Pre-mRNA-processing-splicing factor 8 PRPF8 Tbio Non-IDG -1.73166 55.2 78
WD repeat-containing protein 81 WDR81 Tbio Non-IDG -1.27329 20.6 5
Poly [ADP-ribose] polymerase 10 PARP10 Tchem Enzyme -1.07289 14.2 67
OTU domain-containing protein 7A OTUD7A Tbio Non-IDG -0.54041 3.76 78
Sequestosome-1 SQSTM1 Tbio Non-IDG -2.78728 635.1 766
NF-kappa-B essential modulator IKBKG Tbio Kinase -3.07452 1188.4 879
BRCA1-A complex subunit RAP80 UIMC1 Tbio Non-IDG -1.69622 52.7 176