Development Level

Tbio 11 | 11,445
Tdark 2 | 6,588

IMPC Phenotype

abnormal allantois morphology 1 | 8
abnormal blood vessel morpholo... 1 | 5
abnormal chorioallantoic fusio... 1 | 8
abnormal embryo size 1 | 220
abnormal embryo turning 1 | 31
abnormal forebrain development 1 | 20
abnormal heart looping 1 | 5
abnormal heart morphology 1 | 162
abnormal hindbrain development 1 | 16
abnormal left-right axis patte... 1 | 2
abnormal limb bud morphology 1 | 17
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal neural tube morpholog... 1 | 12
abnormal optic vesicle formati... 1 | 4
abnormal otic vesicle morpholo... 1 | 3
abnormal pericardium morpholog... 1 | 26
abnormal pharyngeal arch morph... 1 | 8
abnormal somite shape 1 | 5
abnormal tail bud morphology 1 | 8
abnormal visceral yolk sac mor... 1 | 6
abnormal vitelline vasculature... 1 | 6
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
pale yolk sac 1 | 25
pallor 1 | 34
small superior vagus ganglion 1 | 74

Disease

Carcinoma 9 | 11,493
osteosarcoma 7 | 7,950
psoriasis 7 | 6,694
ependymoma 6 | 4,679
medulloblastoma, large-cell 6 | 6,241
ovarian cancer 6 | 8,520
atypical teratoid / rhabdoid tumor 5 | 5,112
Astrocytoma, Pilocytic 4 | 3,081
glioblastoma 4 | 5,792
malignant mesothelioma 4 | 3,232
oligodendroglioma 4 | 2,850
Pick disease 3 | 1,894
adult high grade glioma 3 | 3,801
astrocytic glioma 3 | 2,597
cutaneous lupus erythematosus 3 | 1,057
lung cancer 3 | 4,740
subependymal giant cell astrocytoma 3 | 2,287
Abnormality of retinal pigmentation 2 | 111
Abnormality of the musculature 2 | 16
Autosomal recessive predisposition 2 | 1,442
Bleeding time prolonged 2 | 31
Cancer 2 | 2,499
Cone dystrophy 2 | 71
Dermatologic disorders 2 | 93
Ecchymosis 2 | 66
Increased tendency to bruise 2 | 66
Intellectual disability 2 | 1,016
Kidney cancer 2 | 2,613
Photodysphoria 2 | 121
Photophobia 2 | 121
Retinal pigment epithelial abnormality 2 | 111
Retinitis Pigmentosa 2 | 226
Rheumatoid arthritis 2 | 1,191
Skin Abnormalities 2 | 37
Wiskott-Aldrich syndrome 2 | 30
group 3 medulloblastoma 2 | 4,104
group 4 medulloblastoma 2 | 1,855
lung adenocarcinoma 2 | 2,716
lung carcinoma 2 | 2,843
medulloblastoma 2 | 720
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
pediatric high grade glioma 2 | 1,064
pituitary cancer 2 | 1,972
primitive neuroectodermal tumor 2 | 3,035
Abnormal color vision 1 | 31
Acquired flat foot 1 | 72
Anemia, Hemolytic 1 | 55
Aortic Valve Insufficiency 1 | 40
Cavernous Hemangioma of Brain 1 | 3
Cavernous hemangioma 1 | 11
Cerebral calcification 1 | 43
Cerebral cavernous malformation 1 | 3
Chronic Obstructive Airway Disease 1 | 37
Color vision defect 1 | 33
Color vision defect, severe 1 | 31
Cone/cone-rod dystrophy 1 | 20
Dyspnea 1 | 76
Familial cerebral cavernous malformation 1 | 3
Flatfoot 1 | 73
Full lower lip 1 | 64
Fundus dystrophy 1 | 83
Glanzmann's thrombasthenia 1 | 23
Hemangioma 1 | 69
Hemangioma, Cavernous, Central Nervous System 1 | 2
Hematemesis 1 | 4
Hematochezia 1 | 9
Hereditary spherocytosis type 1 1 | 23
Hirsutism 1 | 47
Immunologic Deficiency Syndromes 1 | 113
Increased susceptibility to bacterial infections 1 | 42
Inflammatory Bowel Diseases 1 | 35
Iron-Refractory Iron Deficiency Anemia 1 | 15
Irregular dentition 1 | 3
Klippel-Trenaunay syndrome 1 | 13
Macular Dystrophy, Concentric Annular 1 | 4
Multiple cutaneous and mucosal venous malformations 1 | 10
Nasopharynx carcinoma 1 | 18
Neurodegeneration with brain iron accumulation 6 1 | 8
Neutrophil count decreased 1 | 47
Pallor of optic disc 1 | 39
Paranasal Sinus Diseases 1 | 34
Prominent lower lip 1 | 64
Prone to bacterial infection 1 | 42
Recurrent bacterial infection 1 | 42
Reduced visual acuity 1 | 63
Scoliosis 1 | 44
Sinusitis 1 | 65
Sparse eyebrow 1 | 42
Sparse scalp hair 1 | 42
Spinocerebellar ataxia type 7 1 | 13
Spontaneous haematoma 1 | 8
Sternal anomalies 1 | 19
Type 1 diabetes mellitus 1 | 109
Underweight 1 | 17
Vaccinia 1 | 36
Weight less than 3rd percentile 1 | 17
X- linked recessive 1 | 110
cone-rod dystrophy 1 | 59
inflammatory breast cancer 1 | 286
triple-A syndrome 1 | 17

Tissue

Digestive Tract 13 | 17,369
Endocrine System 13 | 18,159
Female tissues 13 | 17,400
Liver and Pancreas 13 | 16,750
Male tissues 13 | 17,142
Nervous System 13 | 16,725
Respiratory system 13 | 16,393
Skin and soft tissues 13 | 17,230
Urinary Tract 13 | 16,678
Blood and immune system 12 | 16,909
Cardiovascular System 12 | 15,192

Target Family

Non-IDG 13 | 12,091

GO Function

GTPase regulator activity 13 | 13
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ral guanine nucleotide dissociation stimulator RALGDS Tbio Non-IDG -2.85677 683.6 102
Regulator of G-protein signaling 12 RGS12 Tbio Non-IDG -1.39356 26.7 69
Importin-7 IPO7 Tbio Non-IDG -1.69884 46.8 158
DnaJ homolog subfamily A member 3, mitochondrial DNAJA3 Tbio Non-IDG -1.55298 43.3 192
Regulating synaptic membrane exocytosis protein 1 RIMS1 Tbio Non-IDG -1.95711 85.7 11
Wiskott-Aldrich syndrome protein WAS Tbio Non-IDG -3.10496 1242.1 320
G-protein-signaling modulator 3 GPSM3 Tbio Non-IDG -1.97857 92.6 35
ADP-ribosylation factor-like protein 2-binding protein ARL2BP Tbio Non-IDG -0.97103 9.72 188
Ras and Rab interactor 2 RIN2 Tbio Non-IDG -1.45894 28.6 56
Purkinje cell protein 2 homolog PCP2 Tdark Non-IDG -1.20468 15.8 25