Development Level

Tbio 29 | 11,445
Tchem 5 | 1,598

IMPC Phenotype

preweaning lethality, complete... 6 | 979
embryonic lethality prior to o... 3 | 239
decreased body weight 2 | 161
embryonic lethality prior to t... 2 | 278
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal embryo size 1 | 220
abnormal lung morphology 1 | 26
abnormal sleep behavior 1 | 70
abnormal snout morphology 1 | 23
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating choleste... 1 | 93
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased lactate dehydrogenas... 1 | 16
decreased red blood cell distr... 1 | 41
embryonic growth retardation 1 | 106
increased circulating serum al... 1 | 22
increased fasted circulating g... 1 | 76
increased grip strength 1 | 41
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 96
increased red blood cell distr... 1 | 34
increased startle reflex 1 | 112
male infertility 1 | 123

Disease

Carcinoma 26 | 11,493
osteosarcoma 21 | 7,950
ovarian cancer 21 | 8,520
lung cancer 15 | 4,740
Cancer 13 | 2,499
Multiple myeloma 12 | 1,332
psoriasis 12 | 6,694
medulloblastoma, large-cell 11 | 6,241
glioblastoma 10 | 5,792
Breast cancer 9 | 3,578
pancreatic cancer 9 | 2,398
Kidney cancer 8 | 2,613
diabetes mellitus 8 | 1,728
ependymoma 8 | 4,679
Waldenstrons macroglobulinemia 6 | 765
adult high grade glioma 6 | 3,801
atypical teratoid / rhabdoid tumor 6 | 5,112
esophageal adenocarcinoma 6 | 737
group 4 medulloblastoma 6 | 1,855
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
lung adenocarcinoma 6 | 2,716
non-small cell lung cancer 6 | 2,890
oligodendroglioma 6 | 2,850
Astrocytoma, Pilocytic 5 | 3,081
Pick disease 5 | 1,894
acute myeloid leukemia 5 | 783
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
malignant mesothelioma 5 | 3,232
non primary Sjogren syndrome sicca 5 | 891
primary pancreatic ductal adenocarcinoma 5 | 1,109
tuberculosis and treatment for 6 months 5 | 409
Breast Neoplasms 4 | 445
Mammary Neoplasms 4 | 425
Schizophrenia 4 | 1,160
adrenocortical carcinoma 4 | 1,428
astrocytoma 4 | 1,146
colon cancer 4 | 1,478
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
lung carcinoma 4 | 2,843
primitive neuroectodermal tumor 4 | 3,035
subependymal giant cell astrocytoma 4 | 2,287
Duchenne muscular dystrophy 3 | 601
Intellectual disability 3 | 1,016
Liver Cirrhosis, Experimental 3 | 769
Rheumatoid arthritis 3 | 1,191
Seizures 3 | 596
Vascular disease 3 | 319
acute quadriplegic myopathy 3 | 1,158
astrocytic glioma 3 | 2,597
group 3 medulloblastoma 3 | 4,104
interstitial cystitis 3 | 2,312
invasive ductal carcinoma 3 | 2,951
medulloblastoma 3 | 720
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
pituitary cancer 3 | 1,972
spina bifida 3 | 1,074
ulcerative colitis 3 | 1,819
Adenocarcinoma of lung 2 | 142
Animal Mammary Neoplasms 2 | 136
Becker muscular dystrophy 2 | 191
Bleeding tendency 2 | 37
Candidiasis 2 | 55
Carcinoma, Squamous Cell 2 | 110
Coarse facial features 2 | 108
Cognitive delay 2 | 608
Colonic Neoplasms 2 | 142
Contact Dermatitis 2 | 81
Depressive disorder 2 | 409
Dermatitis, Contact 2 | 71
Endometrial cancer 2 | 311
Epilepsy 2 | 792
Failure to gain weight 2 | 365
Global developmental delay 2 | 608
Heart disease 2 | 306
Hypersensitivity reaction type II disease 2 | 253
Hypertension 2 | 396
Leukemia, Myelocytic, Acute 2 | 120
Major Depressive Disorder 2 | 301
Mammary Neoplasms, Animal 2 | 136
Mammary Neoplasms, Experimental 2 | 154
Mental and motor retardation 2 | 608
Mood Disorders 2 | 184
Neurodegenerative disease 2 | 414
Osteoporosis 2 | 363
Pediatric failure to thrive 2 | 365
Prostatic Neoplasms 2 | 495
Squamous cell carcinoma 2 | 129
Stomach Neoplasms 2 | 300
Thickened facial skin with coarse facial features 2 | 108
Unipolar Depression 2 | 250
Weight Gain 2 | 100
breast carcinoma 2 | 1,638
cutaneous lupus erythematosus 2 | 1,057
dermatomyositis 2 | 966
ductal carcinoma in situ 2 | 1,745
hepatocellular carcinoma 2 | 547
hereditary spastic paraplegia 2 | 318
juvenile dermatomyositis 2 | 1,187
pancreatic carcinoma 2 | 562
progressive supranuclear palsy 2 | 676

Tissue

Blood and immune system 34 | 16,909
Digestive Tract 34 | 17,369
Endocrine System 34 | 18,159
Female tissues 34 | 17,400
Nervous System 34 | 16,725
Skin and soft tissues 34 | 17,230
Cardiovascular System 33 | 15,192
Liver and Pancreas 33 | 16,750
Male tissues 33 | 17,142
Respiratory system 33 | 16,393
Urinary Tract 33 | 16,678

Target Family

Non-IDG 23 | 12,091
Enzyme 6 | 4,145
Transcription Factor 3 | 1,400
Epigenetic 1 | 242
Kinase 1 | 634

GO Function

GTPase binding 34 | 34
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endophilin-A2 SH3GL1 Tbio Non-IDG -2.15479 134.2 257
Isoleucine--tRNA ligase, cytoplasmic IARS Tchem Enzyme -3.11190 1198.0 95
Neurabin-1 PPP1R9A Tbio Non-IDG -1.00329 12.4 117
POU domain, class 4, transcription factor 1 POU4F1 Tbio Transcription Factor -2.19846 154.8 107
Clathrin light chain A CLTA Tbio Non-IDG -1.32676 16.0 244
Ras-related GTP-binding protein B RRAGB Tbio Non-IDG -1.40729 26.2 113
Autophagy-related protein 16-1 ATG16L1 Tbio Non-IDG -2.26343 183.4 600
Formin-binding protein 1-like FNBP1L Tbio Non-IDG -1.58385 34.7 142
Ras-related GTP-binding protein C RRAGC Tbio Non-IDG -1.45388 30.6 200
Alpha-enolase ENO1 Tchem Enzyme -2.83087 656.7 508