Development Level

Tbio 175 | 10,625
Tchem 26 | 1,890
Tdark 21 | 7,003
Tclin 9 | 602

IMPC Term

preweaning lethality, complete... 11 | 633
preweaning lethality, incomple... 6 | 260
abnormal behavior 5 | 226
decreased bone mineral content 5 | 157
increased circulating alkaline... 4 | 119
abnormal bone mineralization 3 | 55
abnormal bone structure 3 | 131
decreased body weight 3 | 174
decreased bone mineral density 3 | 126
decreased lean body mass 3 | 195
decreased mean corpuscular vol... 3 | 50
enlarged heart 3 | 111
increased blood urea nitrogen ... 3 | 44
increased circulating total pr... 3 | 20
increased mean corpuscular hem... 3 | 93
increased mean corpuscular vol... 3 | 91
abnormal retina morphology 2 | 100
decreased body length 2 | 108
decreased circulating total pr... 2 | 41
decreased circulating triglyce... 2 | 83
decreased effector memory CD8-... 2 | 24
decreased grip strength 2 | 123
embryonic lethality prior to t... 2 | 187
improved glucose tolerance 2 | 56
increased circulating calcium ... 2 | 32
increased circulating free fat... 2 | 17
increased circulating potassiu... 2 | 31
increased grip strength 2 | 83
increased heart weight 2 | 37
increased lean body mass 2 | 107
increased or absent threshold ... 2 | 128
increased total body fat amoun... 2 | 57
abnormal QRS complex 1 | 25
abnormal coat/ hair morphology 1 | 18
abnormal cornea morphology 1 | 24
abnormal cranium morphology 1 | 32
abnormal embryo size 1 | 112
abnormal heart morphology 1 | 51
abnormal lens morphology 1 | 73
abnormal neural tube closure 1 | 37
abnormal retinal pigmentation 1 | 61
abnormal rib morphology 1 | 28
abnormal snout morphology 1 | 18
abnormal spleen morphology 1 | 36
cardiovascular system phenotyp... 1 | 35
corneal opacity 1 | 25
decreased Ly6C high monocyte n... 1 | 18
decreased cervical vertebrae n... 1 | 12
decreased circulating iron lev... 1 | 25
decreased circulating phosphat... 1 | 15
decreased eosinophil cell numb... 1 | 41
decreased fasted circulating g... 1 | 49
decreased hematocrit 1 | 25
decreased hemoglobin content 1 | 53
decreased lumbar vertebrae num... 1 | 62
decreased mature B cell number 1 | 25
decreased mean corpuscular hem... 1 | 34
decreased monocyte cell number 1 | 28
decreased neutrophil cell numb... 1 | 37
decreased rib number 1 | 59
decreased spleen weight 1 | 13
decreased thoracic vertebrae n... 1 | 7
decreased vertical activity 1 | 22
enlarged lymph nodes 1 | 27
hydrometra 1 | 13
impaired righting response 1 | 19
increased B cell number 1 | 23
increased CD4-positive, CD25-p... 1 | 18
increased KLRG1+ CD4 alpha bet... 1 | 5
increased NK cell number 1 | 19
increased T cell number 1 | 15
increased circulating HDL chol... 1 | 63
increased circulating choleste... 1 | 53
increased circulating creatini... 1 | 29
increased circulating fructosa... 1 | 11
increased circulating iron lev... 1 | 25
increased circulating serum al... 1 | 25
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 24
increased effector memory CD4-... 1 | 15
increased erythrocyte cell num... 1 | 26
increased fasted circulating g... 1 | 68
increased gamma-delta T cell n... 1 | 16
increased hematocrit 1 | 36
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 37
increased mean platelet volume 1 | 19
increased rib number 1 | 41
increased sacral vertebrae num... 1 | 62
limb grasping 1 | 35
persistence of hyaloid vascula... 1 | 22
polycystic kidney 1 | 9
prenatal lethality 1 | 16
prenatal lethality prior to he... 1 | 64
short tibia 1 | 82
shortened ST segment 1 | 9
small spleen 1 | 11
thrombocytopenia 1 | 46
thrombocytosis 1 | 23
vertebral fusion 1 | 23

Disease

ovarian cancer 129 | 8,484
medulloblastoma, large-cell 110 | 6,234
osteosarcoma 104 | 7,933
psoriasis 91 | 6,685
glioblastoma 89 | 5,572
atypical teratoid / rhabdoid tumor 61 | 4,369
lung cancer 60 | 4,466
pilocytic astrocytoma 54 | 3,086
Pick disease 51 | 1,893
lung carcinoma 49 | 2,844
malignant mesothelioma 48 | 3,162
non-small cell lung cancer 48 | 2,798
Breast cancer 47 | 3,094
pediatric high grade glioma 45 | 2,712
invasive ductal carcinoma 44 | 2,950
pancreatic cancer 44 | 2,300
oligodendroglioma 43 | 2,849
subependymal giant cell astrocytoma 43 | 2,287
Cancer 42 | 2,346
primitive neuroectodermal tumor 41 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 39 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 38 | 3,289
lung adenocarcinoma 38 | 2,713
ulcerative colitis 38 | 2,087
ependymoma 35 | 2,514
Multiple myeloma 34 | 1,327
astrocytoma 33 | 1,493
intraductal papillary-mucinous adenoma (IPMA) 33 | 2,956
astrocytic glioma 32 | 2,241
adult high grade glioma 31 | 2,148
breast carcinoma 31 | 1,614
group 3 medulloblastoma 31 | 2,254
juvenile dermatomyositis 30 | 1,189
dermatomyositis 29 | 933
acute quadriplegic myopathy 28 | 1,157
group 4 medulloblastoma 28 | 1,875
pituitary cancer 28 | 1,972
primary pancreatic ductal adenocarcinoma 27 | 1,271
interstitial cystitis 26 | 2,299
posterior fossa group A ependymoma 26 | 1,511
sonic hedgehog group medulloblastoma 26 | 1,482
colon cancer 25 | 1,475
cystic fibrosis 23 | 1,665
pancreatic ductal adenocarcinoma liver metastasis 23 | 1,795
medulloblastoma 22 | 1,524
posterior fossa group B ependymoma 19 | 1,530
tuberculosis 19 | 1,557
active Crohn's disease 18 | 918
diabetes mellitus 18 | 1,663
atypical teratoid/rhabdoid tumor 17 | 1,095
ductal carcinoma in situ 17 | 1,745
primary Sjogren syndrome 17 | 789
Duchenne muscular dystrophy 16 | 602
nasopharyngeal carcinoma 16 | 1,056
spina bifida 16 | 1,064
cutaneous lupus erythematosus 14 | 1,056
gastric carcinoma 14 | 832
hereditary spastic paraplegia 14 | 313
Rheumatoid Arthritis 13 | 1,160
Waldenstrons macroglobulinemia 13 | 765
non primary Sjogren syndrome sicca 13 | 840
aldosterone-producing adenoma 12 | 664
autosomal dominant Emery-Dreifuss muscular dystrophy 12 | 499
gastric cancer 12 | 430
progressive supranuclear palsy 12 | 674
Amyotrophic Lateral Sclerosis 11 | 431
Carcinoma 11 | 2,147
Neuroblastoma 11 | 78
Neurodegenerative disease 11 | 383
acute myeloid leukemia 11 | 780
adrenocortical carcinoma 11 | 1,427
Alzheimer's disease 10 | 644
hepatocellular carcinoma 10 | 532
tuberculosis and treatment for 6 months 10 | 686
Acute lymphoid leukemia 9 | 25
Burkitt's lymphoma 9 | 15
Carcinoma of breast 9 | 11
Diffuse non-Hodgkin's lymphoma, large cell 9 | 12
Follicular non-Hodgkin's lymphoma 9 | 17
Gestational trophoblastic neoplasia 9 | 14
HER2-positive carcinoma of breast 9 | 10
Hodgkin's disease 9 | 18
Intellectual disability 9 | 573
Kaposi's sarcoma 9 | 20
Langerhans cell histiocytosis, disseminated 9 | 10
Liposarcoma 9 | 20
Malignant tumor of head and/or neck 9 | 15
Malignant tumor of ovary 9 | 25
Malignant tumor of stomach 9 | 12
Malignant tumor of testis 9 | 11
Metastatic Breast Carcinoma 9 | 21
Metastatic Prostate Carcinoma 9 | 18
Nephroblastoma 9 | 45
Ocular hypertension 9 | 27
Open-angle glaucoma 9 | 26
Rhabdomyosarcoma 9 | 29
Secondary malignant neoplasm of pancreas 9 | 10
Transitional cell carcinoma 9 | 18
esophageal adenocarcinoma 9 | 737
pancreatic carcinoma 9 | 567

Tissue

Blood and immune system 225 | 17,995
Digestive Tract 225 | 18,473
Endocrine System 225 | 18,512
Female tissues 225 | 18,647
Liver and Pancreas 225 | 18,136
Male tissues 225 | 17,969
Nervous System 225 | 18,561
Urinary Tract 225 | 18,444
Cardiovascular System 224 | 17,958
Respiratory system 224 | 17,484
Skin and soft tissues 223 | 18,115

Target Family

Non-IDG 116 | 11,971
Enzyme 114 | 4,146
Kinase 1 | 634

GO Function

GTPase activity 231 | 231
metal ion binding 1,917 | 1,917
ATP binding 1,467 | 1,467
DNA binding 1,432 | 1,432
zinc ion binding 1,155 | 1,155
poly(A) RNA binding 1,107 | 1,107
transcription factor activity,... 853 | 853
calcium ion binding 695 | 695
G-protein coupled receptor act... 661 | 661
protein homodimerization activ... 569 | 569
RNA binding 445 | 445
olfactory receptor activity 424 | 424
sequence-specific DNA binding 398 | 398
GTP binding 374 | 374
chromatin binding 372 | 372
protein serine/threonine kinas... 336 | 336
RNA polymerase II core promote... 332 | 332
identical protein binding 311 | 311
nucleotide binding 311 | 311
receptor binding 303 | 303
protein kinase binding 289 | 289
enzyme binding 286 | 286
cadherin binding involved in c... 277 | 277
GTPase activator activity 273 | 273
ubiquitin protein ligase bindi... 258 | 258
ubiquitin-protein transferase ... 253 | 253
serine-type endopeptidase acti... 246 | 246
transcription coactivator acti... 241 | 241
transcription factor binding 240 | 240
structural molecule activity 232 | 232
transcriptional activator acti... 230 | 230
ligase activity 227 | 227
protein heterodimerization act... 227 | 227
structural constituent of ribo... 212 | 212
transcription regulatory regio... 202 | 202
transmembrane signaling recept... 201 | 201
RNA polymerase II regulatory r... 200 | 200
receptor activity 200 | 200
transcription corepressor acti... 198 | 198
magnesium ion binding 197 | 197
signal transducer activity 196 | 196
nucleic acid binding 184 | 184
protein kinase activity 183 | 183
carbohydrate binding 180 | 180
ubiquitin protein ligase activ... 173 | 173
RNA polymerase II transcriptio... 162 | 162
heparin binding 160 | 160
iron ion binding 141 | 141
lipid binding 136 | 136
transporter activity 136 | 136
actin binding 133 | 133
ATPase activity 132 | 132
protein C-terminus binding 129 | 129
heme binding 127 | 127
microtubule binding 123 | 123
protein tyrosine kinase activi... 119 | 119
cytokine activity 118 | 118
Ras guanyl-nucleotide exchange... 113 | 113
mRNA binding 112 | 112
metalloendopeptidase activity 112 | 112
transcriptional repressor acti... 110 | 110
structural constituent of cyto... 108 | 108
Rab GTPase binding 105 | 105
antigen binding 104 | 104
protein domain specific bindin... 102 | 102
peptide antigen binding 101 | 101
guanyl-nucleotide exchange fac... 98 | 98
protein complex binding 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 92 | 92
oxidoreductase activity 91 | 91
transcriptional activator acti... 91 | 91
actin filament binding 89 | 89
hydrolase activity 89 | 89
ion channel binding 89 | 89
protein tyrosine phosphatase a... 88 | 88
electron carrier activity 87 | 87
protease binding 87 | 87
histone binding 86 | 86
integrin binding 83 | 83
growth factor activity 82 | 82
phospholipid binding 82 | 82
single-stranded DNA binding 81 | 81
unfolded protein binding 77 | 77
kinase activity 75 | 75
thiol-dependent ubiquitin-spec... 75 | 75
phosphatidylinositol binding 74 | 74
calmodulin binding 73 | 73
histone deacetylase binding 73 | 73
Rho guanyl-nucleotide exchange... 72 | 72
drug binding 71 | 71
double-stranded DNA binding 70 | 70
peptidase activity 70 | 70
protein N-terminus binding 70 | 70
virus receptor activity 68 | 68
beta-catenin binding 67 | 67
microtubule motor activity 67 | 67
protein transporter activity 67 | 67
calcium channel activity 66 | 66
ubiquitin binding 66 | 66

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Nucleolar GTP-binding protein 1 GTPBP4 Tbio Non-IDG -3.21425 1443.3 95
Ras-related protein Rab-11A RAB11A Tbio Enzyme -2.60207 398.9 288
Ras-related protein Rab-14 RAB14 Tbio Enzyme -1.40555 28.2 91
Ras-related protein Rab-43 RAB43 Tbio Enzyme -1.56506 35.9 63
Ras-related protein Rab-5C RAB5C Tbio Enzyme -1.13458 11.1 135
Ras-related protein Rab-27A RAB27A Tbio Enzyme -2.22946 184.9 247
Tubulin beta-2A chain TUBB2A Tclin Non-IDG -1.58651 36.1 215
Ras-related protein Rab-13 RAB13 Tbio Enzyme -1.35800 26.2 55
Ras-related protein Rab-28 RAB28 Tbio Enzyme -1.12829 14.9 57