Development Level

Tbio 217 | 11,178
Tdark 33 | 6,569
Tchem 27 | 1,885
Tclin 9 | 612

IMPC Phenotype

preweaning lethality, complete... 21 | 979
preweaning lethality, incomple... 12 | 499
decreased bone mineral content 8 | 151
abnormal bone structure 7 | 187
decreased body length 6 | 101
embryonic lethality prior to t... 6 | 278
abnormal behavior 5 | 298
abnormal lens morphology 5 | 81
cataract 5 | 92
embryonic lethality prior to o... 5 | 239
abnormal cranium morphology 4 | 36
abnormal retina morphology 4 | 71
decreased body weight 4 | 161
increased heart weight 4 | 62
short tibia 4 | 97
abnormal cornea morphology 3 | 31
abnormal sleep behavior 3 | 70
corneal opacity 3 | 32
decreased lean body mass 3 | 135
decreased mean corpuscular hem... 3 | 50
decreased total body fat amoun... 3 | 207
enlarged heart 3 | 210
increased circulating alkaline... 3 | 122
increased circulating free fat... 3 | 20
increased circulating potassiu... 3 | 29
increased circulating total pr... 3 | 28
increased lean body mass 3 | 172
increased mean corpuscular hem... 3 | 96
increased mean corpuscular vol... 3 | 92
increased startle reflex 3 | 112
persistence of hyaloid vascula... 3 | 33
prenatal lethality 3 | 28
abnormal behavioral response t... 2 | 66
abnormal embryo size 2 | 220
abnormal joint morphology 2 | 23
abnormal snout morphology 2 | 23
decreased bone mineral density 2 | 126
decreased circulating alanine ... 2 | 47
decreased circulating choleste... 2 | 93
decreased circulating iron lev... 2 | 32
decreased circulating serum al... 2 | 82
decreased circulating triglyce... 2 | 79
decreased lymphocyte cell numb... 2 | 83
decreased neutrophil cell numb... 2 | 42
decreased spleen weight 2 | 10
decreased vertical activity 2 | 208
embryonic growth retardation 2 | 106
hyperactivity 2 | 148
hypoactivity 2 | 132
impaired pupillary reflex 2 | 26
improved glucose tolerance 2 | 79
increased blood urea nitrogen ... 2 | 48
increased circulating HDL chol... 2 | 80
increased circulating calcium ... 2 | 34
increased circulating choleste... 2 | 66
increased circulating sodium l... 2 | 71
increased erythrocyte cell num... 2 | 39
increased hematocrit 2 | 46
increased hemoglobin content 2 | 45
increased neutrophil cell numb... 2 | 46
limb grasping 2 | 41
prenatal lethality prior to he... 2 | 87
prolonged QT interval 2 | 38
abnormal body wall morphology 1 | 9
abnormal coat- hair morphology 1 | 19
abnormal craniofacial morpholo... 1 | 33
abnormal embryo turning 1 | 31
abnormal gait 1 | 69
abnormal seminal vesicle morph... 1 | 114
abnormal spleen morphology 1 | 55
abnormal tooth morphology 1 | 24
absent pinna reflex 1 | 23
anophthalmia 1 | 33
cardiovascular system phenotyp... 1 | 36
decreased blood urea nitrogen ... 1 | 51
decreased caudal vertebrae num... 1 | 53
decreased circulating amylase ... 1 | 28
decreased circulating insulin ... 1 | 76
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased hematocrit 1 | 46
decreased red blood cell distr... 1 | 41
enlarged lymph nodes 1 | 37
hydrometra 1 | 53
impaired righting response 1 | 26
increased anti-nuclear antigen... 1 | 19
increased circulating creatini... 1 | 38
increased circulating fructosa... 1 | 13
increased circulating iron lev... 1 | 30
increased circulating serum al... 1 | 22
increased circulating triglyce... 1 | 42
increased fasted circulating g... 1 | 76
increased mean platelet volume 1 | 45
increased monocyte cell number 1 | 63
increased total body fat amoun... 1 | 134
shortened RR interval 1 | 17
small spleen 1 | 19
thrombocytosis 1 | 27
vertebral fusion 1 | 23

Disease

ovarian cancer 151 | 8,297
Carcinoma 146 | 11,192
medulloblastoma, large-cell 131 | 6,086
osteosarcoma 123 | 7,766
glioblastoma 121 | 5,635
psoriasis 105 | 6,514
atypical teratoid / rhabdoid tumor 97 | 4,971
ependymoma 91 | 4,559
lung cancer 80 | 4,607
adult high grade glioma 79 | 3,701
group 3 medulloblastoma 69 | 4,002
Breast cancer 64 | 3,469
Astrocytoma, Pilocytic 62 | 3,006
malignant mesothelioma 62 | 3,135
astrocytic glioma 60 | 2,530
lung carcinoma 57 | 2,755
Pick disease 56 | 1,856
invasive ductal carcinoma 56 | 2,867
oligodendroglioma 56 | 2,768
primitive neuroectodermal tumor 56 | 2,957
subependymal giant cell astrocytoma 55 | 2,230
non-small cell lung cancer 53 | 2,799
Cancer 50 | 2,388
pancreatic cancer 49 | 2,322
intraductal papillary-mucinous carcinoma (IPMC) 48 | 2,902
intraductal papillary-mucinous neoplasm (IPMN) 48 | 3,204
group 4 medulloblastoma 46 | 1,806
lung adenocarcinoma 43 | 2,627
intraductal papillary-mucinous adenoma (IPMA) 42 | 2,872
breast carcinoma 38 | 1,589
Multiple myeloma 35 | 1,296
juvenile dermatomyositis 35 | 1,147
interstitial cystitis 34 | 2,237
ulcerative colitis 32 | 1,765
dermatomyositis 31 | 941
pituitary cancer 31 | 1,915
acute quadriplegic myopathy 30 | 1,133
colon cancer 29 | 1,428
pancreatic ductal adenocarcinoma liver metastasis 29 | 1,911
primary pancreatic ductal adenocarcinoma 29 | 1,071
tuberculosis 29 | 1,963
ductal carcinoma in situ 27 | 1,686
astrocytoma 25 | 1,113
cystic fibrosis 25 | 1,629
Kidney cancer 24 | 2,548
Intellectual disability 22 | 998
pediatric high grade glioma 21 | 1,035
primary Sjogren syndrome 21 | 710
cutaneous lupus erythematosus 20 | 1,016
diabetes mellitus 20 | 1,683
nasopharyngeal carcinoma 19 | 1,024
Autosomal recessive predisposition 18 | 1,407
active Crohn's disease 18 | 882
spina bifida 18 | 1,053
Duchenne muscular dystrophy 17 | 587
Rheumatoid arthritis 17 | 1,156
Epilepsy 16 | 775
Liver Cirrhosis, Experimental 16 | 733
active ulcerative colitis 16 | 736
non primary Sjogren syndrome sicca 16 | 861
Muscle hypotonia 15 | 562
gastric carcinoma 15 | 781
Seizures 14 | 584
aldosterone-producing adenoma 14 | 646
gastric cancer 14 | 445
hereditary spastic paraplegia 14 | 313
Amyotrophic lateral sclerosis 13 | 437
Dull intelligence 13 | 634
Low intelligence 13 | 634
Melanoma 13 | 689
Mental Retardation 13 | 634
Mental deficiency 13 | 634
Parkinson's disease 13 | 378
Poor school performance 13 | 634
Waldenstrons macroglobulinemia 13 | 742
adrenocortical carcinoma 13 | 1,385
autosomal dominant Emery-Dreifuss muscular dystrophy 13 | 492
hepatocellular carcinoma 13 | 536
Cognitive delay 12 | 596
Global developmental delay 12 | 596
Griscelli syndrome 12 | 24
Mental and motor retardation 12 | 596
Neuroblastoma 12 | 79
Rhabdomyosarcoma 12 | 39
Schizophrenia 12 | 1,136
acute myeloid leukemia 12 | 760
progressive supranuclear palsy 12 | 656
Myocardial Ischemia 11 | 162
Neurodegenerative disease 11 | 402
Short stature 11 | 514
Small head 11 | 366
esophageal adenocarcinoma 11 | 696
pancreatic carcinoma 11 | 555
Acquired scoliosis 10 | 274
Blepharoptosis 10 | 229
Curvature of spine 10 | 275
facioscapulohumeral dystrophy 10 | 281
medulloblastoma 10 | 702
sarcoidosis 10 | 357
sonic hedgehog group medulloblastoma 9 | 459

Tissue

Endocrine System 275 | 18,159
Digestive Tract 272 | 17,369
Female tissues 272 | 17,400
Skin and soft tissues 271 | 17,230
Male tissues 268 | 17,142
Nervous System 268 | 16,725
Blood and immune system 267 | 16,909
Urinary Tract 267 | 16,678
Liver and Pancreas 265 | 16,750
Respiratory system 264 | 16,393
Cardiovascular System 256 | 15,192

Target Family

Enzyme 162 | 4,145
Non-IDG 123 | 12,091
Kinase 1 | 634

GO Function

GTPase activity 286 | 286
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ras-related protein Rab-3B RAB3B Tbio Enzyme -1.38932 26.8 121
Ras-related protein Rab-4A RAB4A Tbio Enzyme -2.20077 148.7 256
Dynamin-like 120 kDa protein, mitochondrial OPA1 Tbio Non-IDG -2.51554 307.1 210
GTP-binding protein Di-Ras1 DIRAS1 Tbio Enzyme -0.70186 0.00000 175
Ras-related protein Rab-6A RAB6A Tbio Enzyme -2.09488 134.5 207
Rho-related GTP-binding protein RhoU RHOU Tbio Enzyme -1.30084 24.8 95
Eukaryotic translation initiation factor 5 EIF5 Tbio Non-IDG -1.93055 83.2 159
Tubulin beta-4B chain TUBB4B Tclin Non-IDG -0.95954 8.09 107
ADP-ribosylation factor 4 ARF4 Tbio Enzyme -1.67012 46.6 163
ATP-dependent RNA helicase DDX3X DDX3X Tchem Enzyme -2.32036 221.7 479