Development Level

Tbio 209 | 11,445
Tdark 58 | 6,588
Tchem 12 | 1,598
Tclin 2 | 613

Collection

RFA-RM-18-021 2 | 328
GPCR: IDG Consortium (Targets) 1 | 126
Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 18 | 979
preweaning lethality, incomple... 10 | 499
increased mean corpuscular hem... 6 | 96
abnormal behavior 5 | 298
abnormal embryo size 5 | 220
decreased circulating glucose ... 5 | 126
decreased circulating insulin ... 5 | 76
decreased total body fat amoun... 5 | 207
increased startle reflex 5 | 112
decreased circulating triglyce... 4 | 79
hyperactivity 4 | 148
hypoactivity 4 | 132
increased circulating alkaline... 4 | 122
increased lean body mass 4 | 172
microphthalmia 4 | 26
short tibia 4 | 97
abnormal bone structure 3 | 187
cataract 3 | 92
decreased body weight 3 | 161
decreased caudal vertebrae num... 3 | 53
decreased circulating serum al... 3 | 82
decreased grip strength 3 | 116
decreased lymphocyte cell numb... 3 | 83
impaired pupillary reflex 3 | 26
improved glucose tolerance 3 | 79
increased hematocrit 3 | 46
increased hemoglobin content 3 | 45
increased red blood cell distr... 3 | 34
increased total body fat amoun... 3 | 134
persistence of hyaloid vascula... 3 | 33
prolonged PR interval 3 | 15
thrombocytopenia 3 | 56
abnormal coat appearance 2 | 31
abnormal forebrain morphology 2 | 10
abnormal gait 2 | 69
abnormal midbrain morphology 2 | 10
abnormal sensory capabilities-... 2 | 8
absent pinna reflex 2 | 23
cardiovascular system phenotyp... 2 | 36
decreased body length 2 | 101
decreased bone mineral content 2 | 151
decreased circulating calcium ... 2 | 36
decreased circulating chloride... 2 | 30
decreased circulating total pr... 2 | 49
decreased hematocrit 2 | 46
decreased leukocyte cell numbe... 2 | 73
decreased prepulse inhibition 2 | 82
decreased total retina thickne... 2 | 17
enlarged heart 2 | 210
increased circulating phosphat... 2 | 26
increased mean corpuscular vol... 2 | 92
increased monocyte cell number 2 | 63
tremors 2 | 39
abnormal behavioral response t... 1 | 66
abnormal body wall morphology 1 | 9
abnormal coat- hair morphology 1 | 19
abnormal cornea morphology 1 | 31
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal ear morphology 1 | 9
abnormal facial morphology 1 | 17
abnormal hair growth 1 | 10
abnormal lens morphology 1 | 81
abnormal locomotor activation 1 | 16
abnormal motor capabilities-co... 1 | 5
abnormal neural tube closure 1 | 46
abnormal retina morphology 1 | 71
abnormal retinal vasculature m... 1 | 27
abnormal startle reflex 1 | 15
abnormal vitreous body morphol... 1 | 10
decreased circulating iron lev... 1 | 32
decreased erythrocyte cell num... 1 | 62
decreased heart rate 1 | 18
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 31
decreased neutrophil cell numb... 1 | 42
edema 1 | 59
enlarged lymph nodes 1 | 37
hemorrhage 1 | 23
impaired righting response 1 | 26
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased circulating HDL chol... 1 | 80
increased circulating alanine ... 1 | 13
increased circulating amylase ... 1 | 25
increased circulating aspartat... 1 | 15
increased circulating calcium ... 1 | 34
increased circulating chloride... 1 | 41
increased circulating choleste... 1 | 66
increased circulating glucose ... 1 | 24
increased circulating potassiu... 1 | 29
increased circulating triglyce... 1 | 42
increased fasted circulating g... 1 | 76
increased heart weight 1 | 62
increased leukocyte cell numbe... 1 | 47
prenatal lethality 1 | 28
prolonged PQ interval 1 | 5
prolonged RR interval 1 | 8
shortened PQ interval 1 | 7
trunk curl 1 | 16

Disease

Carcinoma 210 | 11,493
osteosarcoma 150 | 7,950
ovarian cancer 140 | 8,520
glioblastoma 112 | 5,792
medulloblastoma, large-cell 112 | 6,241
atypical teratoid / rhabdoid tumor 97 | 5,112
ependymoma 88 | 4,679
psoriasis 88 | 6,694
lung cancer 85 | 4,740
adult high grade glioma 84 | 3,801
Kidney cancer 77 | 2,613
Breast cancer 72 | 3,578
invasive ductal carcinoma 71 | 2,951
Astrocytoma, Pilocytic 67 | 3,081
group 3 medulloblastoma 65 | 4,104
primitive neuroectodermal tumor 65 | 3,035
lung carcinoma 64 | 2,843
oligodendroglioma 63 | 2,850
intraductal papillary-mucinous carcinoma (IPMC) 60 | 2,989
non-small cell lung cancer 58 | 2,890
astrocytic glioma 57 | 2,597
malignant mesothelioma 57 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 56 | 3,291
lung adenocarcinoma 53 | 2,716
subependymal giant cell astrocytoma 53 | 2,287
tuberculosis 50 | 2,010
group 4 medulloblastoma 48 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 48 | 2,955
ulcerative colitis 43 | 1,819
interstitial cystitis 41 | 2,312
Pick disease 40 | 1,894
Cancer 39 | 2,499
pancreatic cancer 38 | 2,398
ductal carcinoma in situ 31 | 1,745
pituitary cancer 31 | 1,972
Schizophrenia 27 | 1,160
cystic fibrosis 27 | 1,696
pancreatic ductal adenocarcinoma liver metastasis 27 | 1,962
breast carcinoma 25 | 1,638
colon cancer 25 | 1,478
acute quadriplegic myopathy 24 | 1,158
Intellectual disability 23 | 1,016
spina bifida 23 | 1,074
juvenile dermatomyositis 22 | 1,187
Rheumatoid arthritis 21 | 1,191
astrocytoma 21 | 1,146
adrenocortical carcinoma 20 | 1,428
Melanoma 19 | 711
primary Sjogren syndrome 19 | 735
diabetes mellitus 18 | 1,728
Liver Cirrhosis, Experimental 17 | 769
Liver cancer 17 | 604
pediatric high grade glioma 16 | 1,064
Atopic dermatitis 15 | 952
cutaneous lupus erythematosus 15 | 1,057
dermatomyositis 15 | 966
gastric carcinoma 15 | 807
non primary Sjogren syndrome sicca 15 | 891
Duchenne muscular dystrophy 14 | 601
active Crohn's disease 14 | 922
autosomal dominant Emery-Dreifuss muscular dystrophy 14 | 510
Dull intelligence 13 | 645
Low intelligence 13 | 645
Mental Retardation 13 | 645
Mental deficiency 13 | 645
Poor school performance 13 | 645
Skin cancer 13 | 469
sonic hedgehog group medulloblastoma 13 | 467
Amyotrophic lateral sclerosis 12 | 451
Epilepsy 12 | 792
Waldenstrons macroglobulinemia 12 | 765
esophageal adenocarcinoma 12 | 737
nasopharyngeal carcinoma 12 | 1,058
primary pancreatic ductal adenocarcinoma 12 | 1,109
Endometriosis 11 | 540
active ulcerative colitis 11 | 764
Alzheimer's disease 10 | 658
Cognitive delay 10 | 608
Down syndrome 10 | 499
Global developmental delay 10 | 608
Mental and motor retardation 10 | 608
aldosterone-producing adenoma 10 | 665
mucosa-associated lymphoid tissue lymphoma 10 | 484
pancreatic carcinoma 10 | 562
Attention deficit hyperactivity disorder 9 | 278
Muscle hypotonia 9 | 571
Parkinson's disease 9 | 392
Crohn's disease 8 | 321
Cryptorchidism 8 | 296
Short stature 8 | 531
acute myeloid leukemia 8 | 783
fibroadenoma 8 | 559
hepatocellular carcinoma 8 | 547
progressive supranuclear palsy 8 | 676
tuberculosis and treatment for 6 months 8 | 409
urothelial carcinoma 8 | 318
Autosomal recessive predisposition 7 | 1,442
Multiple myeloma 7 | 1,332
Small head 7 | 374
gastric cancer 7 | 459

Tissue

Endocrine System 275 | 18,159
Blood and immune system 270 | 16,909
Skin and soft tissues 269 | 17,230
Digestive Tract 268 | 17,369
Female tissues 268 | 17,400
Male tissues 267 | 17,142
Liver and Pancreas 265 | 16,750
Urinary Tract 265 | 16,678
Nervous System 262 | 16,725
Respiratory system 262 | 16,393
Cardiovascular System 256 | 15,192

Target Family

Non-IDG 178 | 12,091
Enzyme 96 | 4,145
Kinase 3 | 634
GPCR 2 | 408
Transcription Factor 2 | 1,400

GO Function

GTPase activator activity 281 | 281
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4 AGAP4 Tdark Enzyme 0.23 0.50 66
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 ARAP3 Tbio Non-IDG -0.96067 13.8 85
TBC1 domain family member 3B TBC1D3B Tbio Non-IDG 0.00000 3
5-hydroxytryptamine receptor 2B HTR2B Tclin GPCR -2.66641 486.3 265
TBC1 domain family member 3L TBC1D3L Tdark Non-IDG 0.00000 2
Rho GTPase-activating protein 9 ARHGAP9 Tbio Enzyme -1.74771 54.3 35
DEP domain-containing protein 7 DEPDC7 Tdark Non-IDG -0.44370 3.01 132
Tubulin-specific chaperone D TBCD Tbio Non-IDG -1.71996 50.5 50
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 ASAP1 Tbio Non-IDG -1.76454 62.6 183
Rho GTPase-activating protein 6 ARHGAP6 Tbio Enzyme -0.85601 8.06 45