Development Level

Tbio 200 | 10,625
Tdark 60 | 7,003
Tchem 11 | 1,890
Tclin 2 | 602

Collection

Eligible Kinase Proteins 1 | 134
Eligible non-olfactory GPCR Proteins 1 | 143

IMPC Term

preweaning lethality, complete... 12 | 633
preweaning lethality, incomple... 8 | 260
decreased circulating glucose ... 5 | 121
increased mean corpuscular hem... 5 | 93
abnormal behavior 4 | 226
decreased bone mineral content 4 | 157
hypoactivity 4 | 89
increased mean corpuscular vol... 4 | 91
short tibia 4 | 82
abnormal retina morphology 3 | 100
abnormal retinal pigmentation 3 | 61
decreased body weight 3 | 174
decreased bone mineral density 3 | 126
decreased circulating insulin ... 3 | 75
decreased circulating serum al... 3 | 79
decreased grip strength 3 | 123
decreased lean body mass 3 | 195
decreased leukocyte cell numbe... 3 | 54
decreased total body fat amoun... 3 | 186
hyperactivity 3 | 108
improved glucose tolerance 3 | 56
increased lean body mass 3 | 107
abnormal bone structure 2 | 131
abnormal embryo size 2 | 112
abnormal gait 2 | 51
abnormal locomotor activation 2 | 26
absent pinna reflex 2 | 21
cardiovascular system phenotyp... 2 | 35
decreased CD4-positive, CD25-p... 2 | 24
decreased body length 2 | 108
decreased circulating HDL chol... 2 | 77
decreased circulating total pr... 2 | 41
decreased mature B cell number 2 | 25
decreased prepulse inhibition 2 | 52
decreased total retina thickne... 2 | 20
impaired glucose tolerance 2 | 52
increased CD4-positive, CD25-p... 2 | 18
increased Ly6C high monocyte n... 2 | 12
increased body length 2 | 20
increased circulating alkaline... 2 | 119
increased hematocrit 2 | 36
increased hemoglobin content 2 | 45
increased total body fat amoun... 2 | 57
microphthalmia 2 | 15
persistence of hyaloid vascula... 2 | 22
thrombocytopenia 2 | 46
tremors 2 | 34
abnormal QRS complex 1 | 25
abnormal behavioral response t... 1 | 52
abnormal coat/ hair morphology 1 | 18
abnormal coping response 1 | 12
abnormal cornea morphology 1 | 24
abnormal cranium morphology 1 | 32
abnormal ear morphology 1 | 5
abnormal femur morphology 1 | 14
abnormal iris morphology 1 | 12
abnormal motor capabilities/co... 1 | 4
abnormal startle reflex 1 | 14
cataract 1 | 26
corneal opacity 1 | 25
decreased KLRG1-positive NK ce... 1 | 9
decreased Ly6C high monocyte n... 1 | 18
decreased Ly6C low monocyte nu... 1 | 23
decreased circulating calcium ... 1 | 33
decreased circulating chloride... 1 | 32
decreased circulating creatini... 1 | 31
decreased circulating iron lev... 1 | 25
decreased circulating triglyce... 1 | 83
decreased eosinophil cell numb... 1 | 41
decreased gamma-delta T cell n... 1 | 18
decreased heart weight 1 | 44
decreased hematocrit 1 | 25
decreased hemoglobin content 1 | 53
decreased lumbar vertebrae num... 1 | 62
decreased mean corpuscular hem... 1 | 19
decreased monocyte cell number 1 | 28
decreased spleen weight 1 | 13
decreased threshold for audito... 1 | 32
enlarged lymph nodes 1 | 27
head bobbing 1 | 3
impaired righting response 1 | 19
increased B cell number 1 | 23
increased NK cell number 1 | 19
increased blood urea nitrogen ... 1 | 44
increased body weight 1 | 42
increased circulating HDL chol... 1 | 63
increased circulating choleste... 1 | 53
increased effector memory CD4-... 1 | 15
increased fasted circulating g... 1 | 68
increased gamma-delta T cell n... 1 | 16
increased leukocyte cell numbe... 1 | 37
increased rib number 1 | 41
increased sacral vertebrae num... 1 | 62
prenatal lethality prior to he... 1 | 64
prolonged PR interval 1 | 4
rough coat 1 | 1
small seminal vesicle 1 | 6
sparse hair 1 | 6
straub tail 1 | 26
trunk curl 1 | 15

Disease

osteosarcoma 147 | 7,933
ovarian cancer 136 | 8,484
medulloblastoma, large-cell 110 | 6,234
glioblastoma 107 | 5,572
psoriasis 87 | 6,685
atypical teratoid / rhabdoid tumor 83 | 4,369
lung cancer 79 | 4,466
invasive ductal carcinoma 69 | 2,950
pilocytic astrocytoma 66 | 3,086
primitive neuroectodermal tumor 63 | 3,031
Breast cancer 62 | 3,094
lung carcinoma 62 | 2,844
oligodendroglioma 61 | 2,849
intraductal papillary-mucinous carcinoma (IPMC) 59 | 2,988
Carcinoma 58 | 2,147
pediatric high grade glioma 58 | 2,712
non-small cell lung cancer 57 | 2,798
malignant mesothelioma 56 | 3,162
intraductal papillary-mucinous neoplasm (IPMN) 55 | 3,289
subependymal giant cell astrocytoma 53 | 2,287
lung adenocarcinoma 51 | 2,713
ependymoma 48 | 2,514
astrocytic glioma 47 | 2,241
intraductal papillary-mucinous adenoma (IPMA) 47 | 2,956
ulcerative colitis 47 | 2,087
group 4 medulloblastoma 43 | 1,875
Pick disease 40 | 1,893
adult high grade glioma 40 | 2,148
interstitial cystitis 40 | 2,299
pancreatic cancer 37 | 2,300
Cancer 34 | 2,346
tuberculosis 34 | 1,557
medulloblastoma 32 | 1,524
ductal carcinoma in situ 31 | 1,745
pituitary cancer 31 | 1,972
sonic hedgehog group medulloblastoma 30 | 1,482
astrocytoma 29 | 1,493
posterior fossa group B ependymoma 28 | 1,530
breast carcinoma 25 | 1,614
colon cancer 24 | 1,475
cystic fibrosis 24 | 1,665
acute quadriplegic myopathy 23 | 1,157
group 3 medulloblastoma 22 | 2,254
juvenile dermatomyositis 22 | 1,189
pancreatic ductal adenocarcinoma liver metastasis 22 | 1,795
primary Sjogren syndrome 22 | 789
spina bifida 22 | 1,064
Rheumatoid Arthritis 21 | 1,160
adrenocortical carcinoma 20 | 1,427
diabetes mellitus 18 | 1,663
posterior fossa group A ependymoma 18 | 1,511
primary pancreatic ductal adenocarcinoma 18 | 1,271
Intellectual disability 17 | 573
atypical teratoid/rhabdoid tumor 17 | 1,095
tuberculosis and treatment for 6 months 16 | 686
Duchenne muscular dystrophy 15 | 602
cutaneous lupus erythematosus 15 | 1,056
dermatomyositis 15 | 933
gastric carcinoma 15 | 832
Atopic dermatitis 14 | 944
active Crohn's disease 14 | 918
autosomal dominant Emery-Dreifuss muscular dystrophy 14 | 499
Waldenstrons macroglobulinemia 12 | 765
esophageal adenocarcinoma 12 | 737
Amyotrophic Lateral Sclerosis 11 | 431
Schizophrenia 11 | 501
nasopharyngeal carcinoma 11 | 1,056
non primary Sjogren syndrome sicca 11 | 840
tuberculosis and treatment for 3 months 11 | 327
Alzheimer's disease 10 | 644
IGA Glomerulonephritis 10 | 454
aldosterone-producing adenoma 10 | 664
mucosa-associated lymphoid tissue lymphoma 10 | 480
pancreatic carcinoma 10 | 567
Down syndrome 9 | 548
Endometriosis 9 | 535
Parkinson's disease 9 | 364
Melanoma 8 | 261
acute myeloid leukemia 8 | 780
fibroadenoma 8 | 557
progressive supranuclear palsy 8 | 674
urothelial carcinoma 8 | 318
Crohn's disease 7 | 304
Epilepsy 7 | 346
Multiple Sclerosis 7 | 498
Multiple myeloma 7 | 1,327
Obesity 7 | 616
Polycystic Ovary Syndrome 7 | 332
gastric cancer 7 | 430
hepatocellular carcinoma 7 | 532
Hypertensive disease 6 | 193
Vascular disease 6 | 281
glioblastoma multiforme 6 | 347
hereditary spastic paraplegia 6 | 313
inflammatory breast cancer 6 | 404
interstitial lung disease 6 | 291
non-small cell lung carcinoma 6 | 413
periodontitis 6 | 269
Type 2 diabetes mellitus 5 | 189
head and neck cancer 5 | 270

Tissue

Male tissues 263 | 17,969
Female tissues 260 | 18,647
Nervous System 260 | 18,561
Digestive Tract 259 | 18,473
Liver and Pancreas 259 | 18,136
Blood and immune system 258 | 17,995
Endocrine System 258 | 18,512
Cardiovascular System 257 | 17,958
Urinary Tract 257 | 18,444
Respiratory system 255 | 17,484
Skin and soft tissues 255 | 18,115

Target Family

Non-IDG 174 | 11,971
Enzyme 93 | 4,146
Kinase 3 | 634
GPCR 2 | 406
Transcription Factor 1 | 1,400

GO Function

GTPase activator activity 273 | 273
metal ion binding 1,917 | 1,917
ATP binding 1,467 | 1,467
DNA binding 1,432 | 1,432
zinc ion binding 1,155 | 1,155
poly(A) RNA binding 1,107 | 1,107
transcription factor activity,... 853 | 853
calcium ion binding 695 | 695
G-protein coupled receptor act... 661 | 661
protein homodimerization activ... 569 | 569
RNA binding 445 | 445
olfactory receptor activity 424 | 424
sequence-specific DNA binding 398 | 398
GTP binding 374 | 374
chromatin binding 372 | 372
protein serine/threonine kinas... 336 | 336
RNA polymerase II core promote... 332 | 332
identical protein binding 311 | 311
nucleotide binding 311 | 311
receptor binding 303 | 303
protein kinase binding 289 | 289
enzyme binding 286 | 286
cadherin binding involved in c... 277 | 277
ubiquitin protein ligase bindi... 258 | 258
ubiquitin-protein transferase ... 253 | 253
serine-type endopeptidase acti... 246 | 246
transcription coactivator acti... 241 | 241
transcription factor binding 240 | 240
structural molecule activity 232 | 232
GTPase activity 231 | 231
transcriptional activator acti... 230 | 230
ligase activity 227 | 227
protein heterodimerization act... 227 | 227
structural constituent of ribo... 212 | 212
transcription regulatory regio... 202 | 202
transmembrane signaling recept... 201 | 201
RNA polymerase II regulatory r... 200 | 200
receptor activity 200 | 200
transcription corepressor acti... 198 | 198
magnesium ion binding 197 | 197
signal transducer activity 196 | 196
nucleic acid binding 184 | 184
protein kinase activity 183 | 183
carbohydrate binding 180 | 180
ubiquitin protein ligase activ... 173 | 173
RNA polymerase II transcriptio... 162 | 162
heparin binding 160 | 160
iron ion binding 141 | 141
lipid binding 136 | 136
transporter activity 136 | 136
actin binding 133 | 133
ATPase activity 132 | 132
protein C-terminus binding 129 | 129
heme binding 127 | 127
microtubule binding 123 | 123
protein tyrosine kinase activi... 119 | 119
cytokine activity 118 | 118
Ras guanyl-nucleotide exchange... 113 | 113
mRNA binding 112 | 112
metalloendopeptidase activity 112 | 112
transcriptional repressor acti... 110 | 110
structural constituent of cyto... 108 | 108
Rab GTPase binding 105 | 105
antigen binding 104 | 104
protein domain specific bindin... 102 | 102
peptide antigen binding 101 | 101
guanyl-nucleotide exchange fac... 98 | 98
protein complex binding 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 92 | 92
oxidoreductase activity 91 | 91
transcriptional activator acti... 91 | 91
actin filament binding 89 | 89
hydrolase activity 89 | 89
ion channel binding 89 | 89
protein tyrosine phosphatase a... 88 | 88
electron carrier activity 87 | 87
protease binding 87 | 87
histone binding 86 | 86
integrin binding 83 | 83
growth factor activity 82 | 82
phospholipid binding 82 | 82
single-stranded DNA binding 81 | 81
unfolded protein binding 77 | 77
kinase activity 75 | 75
thiol-dependent ubiquitin-spec... 75 | 75
phosphatidylinositol binding 74 | 74
calmodulin binding 73 | 73
histone deacetylase binding 73 | 73
Rho guanyl-nucleotide exchange... 72 | 72
drug binding 71 | 71
double-stranded DNA binding 70 | 70
peptidase activity 70 | 70
protein N-terminus binding 70 | 70
virus receptor activity 68 | 68
beta-catenin binding 67 | 67
microtubule motor activity 67 | 67
protein transporter activity 67 | 67
calcium channel activity 66 | 66
ubiquitin binding 66 | 66

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
TBC1 domain family member 2B TBC1D2B Tdark Non-IDG 0.64 0.18 19
Regulator of G-protein signaling 22 RGS22 Tbio Non-IDG -0.31702 2.73 99
Rho guanine nucleotide exchange factor 11 ARHGEF11 Tbio Non-IDG -1.54485 39.7 163
Beta-arrestin-1 ARRB1 Tchem Non-IDG -2.54226 366.3 416
Ras and Rab interactor 2 RIN2 Tbio Non-IDG -1.36829 24.1 51
GTPase-activating protein and VPS9 domain-containing protein 1 GAPVD1 Tbio Enzyme -0.50735 3.46 71
Rho guanine nucleotide exchange factor 15 ARHGEF15 Tdark Non-IDG -0.67221 6.56 21
Protein FAM13A FAM13A Tbio Non-IDG -1.18459 18.4 16
[Protein ADP-ribosylarginine] hydrolase-like protein 1 ADPRHL1 Tdark Enzyme 0.37 0.83 31
Regulator of G-protein signaling 16 RGS16 Tbio Non-IDG -1.59717 42.2 162