Development Level

Tbio 10 | 11,445
Tchem 3 | 1,598
Tclin 1 | 613

IMPC Phenotype

preweaning lethality, complete... 2 | 979
abnormal behavior 1 | 298
abnormal embryo size 1 | 220
abnormal skin coloration 1 | 25
abnormal spleen morphology 1 | 55
decreased bone mineral content 1 | 151
decreased circulating iron lev... 1 | 32
decreased fasted circulating g... 1 | 65
decreased respiratory quotient 1 | 16
decreased startle reflex 1 | 75
hyperactivity 1 | 148
impaired righting response 1 | 26
increased body weight 1 | 25
increased circulating creatini... 1 | 38
increased circulating triglyce... 1 | 42
preweaning lethality, incomple... 1 | 499

Disease

Carcinoma 12 | 11,493
ovarian cancer 10 | 8,520
glioblastoma 8 | 5,792
osteosarcoma 8 | 7,950
adult high grade glioma 7 | 3,801
atypical teratoid / rhabdoid tumor 7 | 5,112
ependymoma 7 | 4,679
medulloblastoma, large-cell 7 | 6,241
primitive neuroectodermal tumor 7 | 3,035
Astrocytoma, Pilocytic 6 | 3,081
Breast cancer 6 | 3,578
group 3 medulloblastoma 6 | 4,104
psoriasis 6 | 6,694
oligodendroglioma 5 | 2,850
subependymal giant cell astrocytoma 5 | 2,287
Cancer 4 | 2,499
Kidney cancer 4 | 2,613
astrocytic glioma 4 | 2,597
interstitial cystitis 4 | 2,312
lung cancer 4 | 4,740
lung carcinoma 4 | 2,843
Breast Neoplasms 3 | 445
Carcinoma, Squamous Cell 3 | 110
Cognitive delay 3 | 608
Epilepsy 3 | 792
Fibrous skin tumor of tuberous sclerosis 3 | 18
Global developmental delay 3 | 608
Kidney disease 3 | 430
Mammary Neoplasms 3 | 425
Mental and motor retardation 3 | 608
Sebaceous adenoma 3 | 26
Squamous cell carcinoma 3 | 129
astrocytoma 3 | 1,146
breast carcinoma 3 | 1,638
colon cancer 3 | 1,478
group 4 medulloblastoma 3 | 1,855
malignant mesothelioma 3 | 3,232
Abnormality of metabolism/homeostasis 2 | 134
Adenoma 2 | 167
Adult onset 2 | 82
Amnesia 2 | 17
Big calvaria 2 | 147
Brain disease 2 | 96
Cafe au lait spots, multiple 2 | 17
Colorectal Neoplasms 2 | 243
Duchenne muscular dystrophy 2 | 601
Dull intelligence 2 | 645
Dysgerminoma 2 | 11
Endometrial cancer 2 | 311
Hypothyroidism 2 | 122
Impaired cognition 2 | 96
Increased head circumference 2 | 147
Increased size of cranium 2 | 147
Increased size of skull 2 | 147
Infantile onset 2 | 238
Inflammatory bowel disease 2 | 151
Intellectual disability 2 | 1,016
Isolated cases 2 | 72
Low intelligence 2 | 645
Malignant tumor of prostate 2 | 26
Mental Depression 2 | 333
Mental Retardation 2 | 645
Mental deficiency 2 | 645
Mental impairment 2 | 95
Multiple myeloma 2 | 1,332
Multiple, subcutaneous nodules 2 | 53
Nephrolithiasis 2 | 56
Ovarian Neoplasms 2 | 102
Ovarian papillary adenocarcinoma 2 | 5
Papule 2 | 43
Poor school performance 2 | 645
Precancerous Conditions 2 | 80
Prostate cancer 2 | 175
Prostatic Neoplasms 2 | 495
Renal Cell Carcinoma 2 | 214
Rheumatoid arthritis 2 | 1,191
Round face 2 | 45
Round, full face 2 | 45
Schizophrenia 2 | 1,160
Seizures 2 | 596
Skin disease 2 | 66
Skin tag 2 | 14
Stomach Neoplasms 2 | 300
Subcutaneous nodule 2 | 53
Substance Withdrawal Syndrome 2 | 55
Waldenstrons macroglobulinemia 2 | 765
acute myeloid leukemia 2 | 783
dermatomyositis 2 | 966
diabetes mellitus 2 | 1,728
ductal carcinoma in situ 2 | 1,745
invasive ductal carcinoma 2 | 2,951
lung adenocarcinoma 2 | 2,716
non-small cell lung cancer 2 | 2,890
ovarian neoplasm 2 | 99
pediatric high grade glioma 2 | 1,064
primary pancreatic ductal adenocarcinoma 2 | 1,109
ulcerative colitis 2 | 1,819
Abnormal lung lobation 1 | 10
Malignant neoplasm of breast 1 | 15
Multiple lipomata 1 | 7

Tissue

Blood and immune system 14 | 16,909
Cardiovascular System 14 | 15,192
Digestive Tract 14 | 17,369
Endocrine System 14 | 18,159
Female tissues 14 | 17,400
Liver and Pancreas 14 | 16,750
Male tissues 14 | 17,142
Nervous System 14 | 16,725
Respiratory system 14 | 16,393
Skin and soft tissues 14 | 17,230
Urinary Tract 14 | 16,678

Target Family

Non-IDG 10 | 12,091
Enzyme 3 | 4,145
Kinase 1 | 634

GO Function

GTPase activating protein bind... 14 | 14
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase-activating protein and VPS9 domain-containing protein 1 GAPVD1 Tbio Enzyme -0.69565 4.71 73
Formin-like protein 3 FMNL3 Tbio Non-IDG -1.05785 13.4 42
Regulator of G-protein signaling 14 RGS14 Tbio Non-IDG -1.61170 43.9 233
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 PLCD1 Tchem Enzyme -2.17969 140.9 120
Cadherin-1 CDH1 Tbio Non-IDG -3.85201 6324.3 1880
Guanine nucleotide-binding protein G(o) subunit alpha GNAO1 Tbio Non-IDG -2.24331 158.7 195
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 PIN1 Tchem Enzyme -2.44422 522.8 528
Plexin-B1 PLXNB1 Tbio Non-IDG -1.81774 64.5 140
Guanine nucleotide-binding protein G(i) subunit alpha-1 GNAI1 Tbio Non-IDG -0.63224 3.23 220
Hamartin TSC1 Tbio Non-IDG -2.25451 173.9 1622