Development Level

Tbio 22 | 11,445
Tchem 1 | 1,598

IMPC Phenotype

preweaning lethality, complete... 2 | 979
preweaning lethality, incomple... 2 | 499
abnormal body wall morphology 1 | 9
abnormal bone structure 1 | 187
abnormal coat- hair morphology 1 | 19
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal facial morphology 1 | 17
abnormal limb bud morphology 1 | 17
abnormal limb morphology 1 | 13
abnormal retina morphology 1 | 71
abnormal testis morphology 1 | 43
abnormal vitreous body morphol... 1 | 10
anophthalmia 1 | 33
cleft palate 1 | 8
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased circulating serum al... 1 | 82
decreased lean body mass 1 | 135
decreased spleen weight 1 | 10
decreased total body fat amoun... 1 | 207
edema 1 | 59
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
enlarged kidney 1 | 14
facial cleft 1 | 3
hydrometra 1 | 53
increased body length 1 | 32
increased bone mineral content 1 | 108
increased circulating alkaline... 1 | 122
increased lean body mass 1 | 172
increased neutrophil cell numb... 1 | 46
increased spleen weight 1 | 10
increased total body fat amoun... 1 | 134
persistence of hyaloid vascula... 1 | 33
polydactyly 1 | 7
short tibia 1 | 97
small testis 1 | 58

Disease

Carcinoma 16 | 11,493
glioblastoma 11 | 5,792
medulloblastoma, large-cell 11 | 6,241
atypical teratoid / rhabdoid tumor 9 | 5,112
ependymoma 9 | 4,679
lung cancer 9 | 4,740
lung carcinoma 8 | 2,843
Astrocytoma, Pilocytic 7 | 3,081
adult high grade glioma 7 | 3,801
malignant mesothelioma 7 | 3,232
osteosarcoma 7 | 7,950
ovarian cancer 7 | 8,520
psoriasis 7 | 6,694
group 3 medulloblastoma 6 | 4,104
oligodendroglioma 6 | 2,850
astrocytic glioma 5 | 2,597
invasive ductal carcinoma 5 | 2,951
Hermansky-Pudlak syndrome 4 | 42
Schizophrenia 4 | 1,160
ductal carcinoma in situ 4 | 1,745
non-small cell lung cancer 4 | 2,890
primitive neuroectodermal tumor 4 | 3,035
subependymal giant cell astrocytoma 4 | 2,287
Oculocutaneous albinism 3 | 29
Parkinson's disease 3 | 392
Pick disease 3 | 1,894
Platelet storage pool deficiency 3 | 21
acute quadriplegic myopathy 3 | 1,158
interstitial cystitis 3 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
juvenile dermatomyositis 3 | 1,187
spina bifida 3 | 1,074
Alzheimer's disease 2 | 658
Amyotrophic lateral sclerosis 2 | 451
Autosomal recessive predisposition 2 | 1,442
Bipolar Disorder 2 | 666
Breast cancer 2 | 3,578
Griscelli syndrome 2 | 24
HIV Infections 2 | 102
Hemophagocytic lymphohistiocytosis 2 | 30
Hypertension 2 | 396
Kidney cancer 2 | 2,613
Liver Cirrhosis, Experimental 2 | 769
Major Depressive Disorder 2 | 301
Myocardial Ischemia 2 | 169
Nonorganic psychosis 2 | 84
Psychotic Disorders 2 | 151
Pulmonary Fibrosis 2 | 106
Rheumatoid arthritis 2 | 1,191
Small head 2 | 374
Unipolar Depression 2 | 250
adrenocortical carcinoma 2 | 1,428
group 4 medulloblastoma 2 | 1,855
head and neck cancer and chronic obstructive pulmonary disease 2 | 239
hereditary spastic paraplegia 2 | 318
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
lung adenocarcinoma 2 | 2,716
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
pediatric high grade glioma 2 | 1,064
periodontitis 2 | 293
pituitary cancer 2 | 1,972
primary Sjogren syndrome 2 | 735
urothelial carcinoma 2 | 318
Achromasia 1 | 11
Albinism 1 | 11
Cervical cancer 1 | 24
Childhood onset 1 | 38
Deglutition Disorders 1 | 132
Dental caries 1 | 164
Drooling 1 | 27
Enophthalmos 1 | 75
Essential tremor 1 | 28
Gingival Diseases 1 | 19
Hyperactive behavior 1 | 91
Hypomyelinating leukodystrophy 6 1 | 26
Increased susceptibility to bacterial infections 1 | 42
Intermittent fever 1 | 15
Lethargy 1 | 77
Mammary Neoplasms, Animal 1 | 136
Muscle Rigidity 1 | 49
Neutrophil count decreased 1 | 47
Organic writer's cramp 1 | 10
Parkinsonian Disorders 1 | 56
Periodontal Diseases 1 | 21
Phenylketonuria 1 | 20
Photodysphoria 1 | 121
Photophobia 1 | 121
Pointed chin 1 | 33
Progressive mental retardation 1 | 37
Progressive neurologic deterioration 1 | 19
Prone to bacterial infection 1 | 42
Recurrent bacterial infection 1 | 42
Rotting teeth 1 | 73
Sialorrhea 1 | 28
Sunken eyes 1 | 63
Thin upper lip vermilion 1 | 67
Typhoid fever 1 | 22
Varicose veins 1 | 20
Vitiligo 1 | 73
Wilson disease 1 | 16

Tissue

Blood and immune system 22 | 16,909
Digestive Tract 22 | 17,369
Endocrine System 22 | 18,159
Female tissues 22 | 17,400
Liver and Pancreas 22 | 16,750
Male tissues 22 | 17,142
Nervous System 22 | 16,725
Respiratory system 22 | 16,393
Skin and soft tissues 22 | 17,230
Urinary Tract 22 | 16,678
Cardiovascular System 20 | 15,192

Target Family

Enzyme 12 | 4,145
Non-IDG 11 | 12,091

GO Function

GTP-dependent protein binding 23 | 23
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ras-related protein Rab-3D RAB3D Tbio Enzyme -2.56190 342.2 106
GTP cyclohydrolase 1 GCH1 Tbio Enzyme -2.80099 639.3 247
Ras-related protein Rab-34 RAB34 Tbio Enzyme -1.77250 102.9 72
Ras-related protein Rab-5B RAB5B Tbio Enzyme -1.31722 16.6 112
Cell division control protein 42 homolog CDC42 Tchem Enzyme -3.37283 2188.5 380
AP-3 complex subunit beta-1 AP3B1 Tbio Non-IDG -1.27699 21.0 89
Dynamin-1-like protein DNM1L Tbio Non-IDG -2.65717 476.9 426
Ras-related protein Rab-3C RAB3C Tbio Enzyme -1.05905 11.2 90
Early endosome antigen 1 EEA1 Tbio Non-IDG -2.32012 167.6 314
Ras-related protein Rab-3B RAB3B Tbio Enzyme -1.38932 26.8 121