Development Level

Tbio 272 | 11,178
Tdark 49 | 6,569
Tchem 35 | 1,885
Tclin 16 | 612

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 22 | 979
preweaning lethality, incomple... 14 | 499
decreased bone mineral content 8 | 151
abnormal bone structure 7 | 187
decreased body weight 6 | 161
decreased lean body mass 6 | 135
embryonic lethality prior to t... 6 | 278
enlarged heart 6 | 210
increased startle reflex 6 | 112
abnormal behavior 5 | 298
abnormal lens morphology 5 | 81
cataract 5 | 92
decreased body length 5 | 101
increased heart weight 5 | 62
increased mean corpuscular hem... 5 | 96
short tibia 5 | 97
abnormal gait 4 | 69
abnormal heart morphology 4 | 162
abnormal retina morphology 4 | 71
decreased mean corpuscular hem... 4 | 50
decreased mean corpuscular vol... 4 | 79
decreased vertical activity 4 | 208
embryonic lethality prior to o... 4 | 239
increased circulating HDL chol... 4 | 80
increased circulating alkaline... 4 | 122
increased circulating calcium ... 4 | 34
increased circulating choleste... 4 | 66
prolonged QT interval 4 | 38
abnormal cornea morphology 3 | 31
abnormal cranium morphology 3 | 36
abnormal sleep behavior 3 | 70
corneal opacity 3 | 32
decreased circulating phosphat... 3 | 27
decreased circulating serum al... 3 | 82
decreased circulating triglyce... 3 | 79
decreased lymphocyte cell numb... 3 | 83
decreased total body fat amoun... 3 | 207
hyperactivity 3 | 148
increased blood urea nitrogen ... 3 | 48
increased circulating free fat... 3 | 20
increased circulating potassiu... 3 | 29
increased circulating sodium l... 3 | 71
increased circulating total pr... 3 | 28
increased erythrocyte cell num... 3 | 39
increased lean body mass 3 | 172
increased neutrophil cell numb... 3 | 46
persistence of hyaloid vascula... 3 | 33
prenatal lethality 3 | 28
prolonged ST segment 3 | 36
abnormal behavioral response t... 2 | 66
abnormal embryo size 2 | 220
abnormal joint morphology 2 | 23
abnormal locomotor activation 2 | 16
abnormal rib morphology 2 | 10
abnormal snout morphology 2 | 23
cardiovascular system phenotyp... 2 | 36
decreased blood urea nitrogen ... 2 | 51
decreased bone mineral density 2 | 126
decreased circulating alanine ... 2 | 47
decreased circulating amylase ... 2 | 28
decreased circulating choleste... 2 | 93
decreased circulating iron lev... 2 | 32
decreased circulating total pr... 2 | 49
decreased leukocyte cell numbe... 2 | 73
decreased neutrophil cell numb... 2 | 42
decreased prepulse inhibition 2 | 82
decreased spleen weight 2 | 10
decreased startle reflex 2 | 75
embryonic growth retardation 2 | 106
enlarged kidney 2 | 14
hypoactivity 2 | 132
impaired pupillary reflex 2 | 26
improved glucose tolerance 2 | 79
increased bone mineral content 2 | 108
increased circulating chloride... 2 | 41
increased fasted circulating g... 2 | 76
increased hematocrit 2 | 46
increased hemoglobin content 2 | 45
increased mean corpuscular vol... 2 | 92
increased or absent threshold ... 2 | 101
increased spleen weight 2 | 10
increased total body fat amoun... 2 | 134
limb grasping 2 | 41
male infertility 2 | 123
prenatal lethality prior to he... 2 | 87
thrombocytopenia 2 | 56
abnormal body wall morphology 1 | 9
abnormal craniofacial morpholo... 1 | 33
abnormal spleen morphology 1 | 55
abnormal vertebrae morphology 1 | 18
decreased caudal vertebrae num... 1 | 53
decreased circulating calcium ... 1 | 36
decreased eosinophil cell numb... 1 | 24
decreased red blood cell distr... 1 | 41
increased anti-nuclear antigen... 1 | 19
increased bone mineral density 1 | 72
increased circulating fructosa... 1 | 13
increased circulating iron lev... 1 | 30
increased circulating triglyce... 1 | 42
vertebral fusion 1 | 23

Disease

Carcinoma 205 | 11,192
ovarian cancer 196 | 8,297
osteosarcoma 167 | 7,766
medulloblastoma, large-cell 165 | 6,086
glioblastoma 155 | 5,635
psoriasis 134 | 6,514
atypical teratoid / rhabdoid tumor 124 | 4,971
ependymoma 113 | 4,559
lung cancer 111 | 4,607
adult high grade glioma 102 | 3,701
group 3 medulloblastoma 87 | 4,002
Astrocytoma, Pilocytic 85 | 3,006
Breast cancer 84 | 3,469
invasive ductal carcinoma 82 | 2,867
astrocytic glioma 77 | 2,530
malignant mesothelioma 76 | 3,135
lung carcinoma 75 | 2,755
oligodendroglioma 73 | 2,768
primitive neuroectodermal tumor 73 | 2,957
subependymal giant cell astrocytoma 73 | 2,230
non-small cell lung cancer 70 | 2,799
Pick disease 69 | 1,856
pancreatic cancer 67 | 2,322
intraductal papillary-mucinous carcinoma (IPMC) 65 | 2,902
intraductal papillary-mucinous neoplasm (IPMN) 62 | 3,204
lung adenocarcinoma 60 | 2,627
group 4 medulloblastoma 59 | 1,806
intraductal papillary-mucinous adenoma (IPMA) 59 | 2,872
Cancer 56 | 2,388
breast carcinoma 53 | 1,589
ulcerative colitis 53 | 1,765
interstitial cystitis 52 | 2,237
Multiple myeloma 46 | 1,296
tuberculosis 46 | 1,963
ductal carcinoma in situ 45 | 1,686
pancreatic ductal adenocarcinoma liver metastasis 44 | 1,911
colon cancer 40 | 1,428
juvenile dermatomyositis 39 | 1,147
primary pancreatic ductal adenocarcinoma 38 | 1,071
Kidney cancer 37 | 2,548
pituitary cancer 37 | 1,915
dermatomyositis 35 | 941
primary Sjogren syndrome 34 | 710
cystic fibrosis 33 | 1,629
acute quadriplegic myopathy 31 | 1,133
Autosomal recessive predisposition 30 | 1,407
astrocytoma 29 | 1,113
cutaneous lupus erythematosus 29 | 1,016
diabetes mellitus 29 | 1,683
Intellectual disability 26 | 998
pediatric high grade glioma 26 | 1,035
spina bifida 26 | 1,053
active Crohn's disease 23 | 882
Epilepsy 22 | 775
gastric cancer 22 | 445
nasopharyngeal carcinoma 21 | 1,024
Rheumatoid arthritis 20 | 1,156
Schizophrenia 20 | 1,136
Waldenstrons macroglobulinemia 20 | 742
Seizures 19 | 584
acute myeloid leukemia 19 | 760
gastric carcinoma 19 | 781
hepatocellular carcinoma 19 | 536
Duchenne muscular dystrophy 18 | 587
Liver Cirrhosis, Experimental 18 | 733
active ulcerative colitis 18 | 736
pancreatic carcinoma 18 | 555
progressive supranuclear palsy 18 | 656
non primary Sjogren syndrome sicca 17 | 861
Dull intelligence 16 | 634
Low intelligence 16 | 634
Mental Retardation 16 | 634
Mental deficiency 16 | 634
Muscle hypotonia 16 | 562
Parkinson's disease 16 | 378
Poor school performance 16 | 634
aldosterone-producing adenoma 16 | 646
Melanoma 15 | 689
adrenocortical carcinoma 15 | 1,385
autosomal dominant Emery-Dreifuss muscular dystrophy 15 | 492
esophageal adenocarcinoma 15 | 696
medulloblastoma 15 | 702
sarcoidosis 15 | 357
Cognitive delay 14 | 596
Global developmental delay 14 | 596
Mental and motor retardation 14 | 596
Obesity 14 | 655
Small head 14 | 366
hereditary spastic paraplegia 14 | 313
mucosa-associated lymphoid tissue lymphoma 14 | 473
Amyotrophic lateral sclerosis 13 | 437
Hypertensive disorder 13 | 56
Neuroblastoma 13 | 79
Polycystic ovary syndrome 13 | 348
Alzheimer's disease 12 | 640
Griscelli syndrome 12 | 24
Neurodegenerative disease 12 | 402
Rhabdomyosarcoma 12 | 39
Short stature 12 | 514
fibroadenoma 12 | 538

Tissue

Endocrine System 359 | 18,159
Digestive Tract 354 | 17,369
Female tissues 353 | 17,400
Skin and soft tissues 350 | 17,230
Male tissues 349 | 17,142
Blood and immune system 348 | 16,909
Liver and Pancreas 348 | 16,750
Urinary Tract 347 | 16,678
Nervous System 346 | 16,725
Respiratory system 343 | 16,393
Cardiovascular System 331 | 15,192

Target Family

Enzyme 207 | 4,145
Non-IDG 150 | 12,091
Kinase 14 | 634
GPCR 1 | 408

GO Function

GTP binding 372 | 372
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Insulin receptor INSR Tclin Kinase -2.50045 306.8 1417
Ras-related protein Rab-3B RAB3B Tbio Enzyme -1.38932 26.8 121
Ras-related protein Rab-4A RAB4A Tbio Enzyme -2.20077 148.7 256
Dynamin-like 120 kDa protein, mitochondrial OPA1 Tbio Non-IDG -2.51554 307.1 210
GTP-binding protein Di-Ras1 DIRAS1 Tbio Enzyme -0.70186 0.00000 175
Ras-related protein Rab-6A RAB6A Tbio Enzyme -2.09488 134.5 207
Rho-related GTP-binding protein RhoU RHOU Tbio Enzyme -1.30084 24.8 95
Eukaryotic translation initiation factor 5 EIF5 Tbio Non-IDG -1.93055 83.2 159
Tubulin beta-4B chain TUBB4B Tclin Non-IDG -0.95954 8.09 107
ADP-ribosylation factor 4 ARF4 Tbio Enzyme -1.67012 46.6 163