Development Level

Tbio 266 | 10,625
Tdark 56 | 7,003
Tchem 36 | 1,890
Tclin 16 | 602

Collection

Eligible Kinase Proteins 1 | 134

IMPC Term

preweaning lethality, complete... 13 | 633
abnormal behavior 9 | 226
preweaning lethality, incomple... 9 | 260
decreased bone mineral content 7 | 157
decreased body weight 6 | 174
decreased lean body mass 6 | 195
enlarged heart 6 | 111
abnormal bone structure 5 | 131
decreased mean corpuscular vol... 5 | 50
increased heart weight 5 | 37
increased mean corpuscular hem... 5 | 93
abnormal heart morphology 4 | 51
abnormal retina morphology 4 | 100
decreased bone mineral density 4 | 126
decreased grip strength 4 | 123
embryonic lethality prior to t... 4 | 187
increased blood urea nitrogen ... 4 | 44
increased circulating alkaline... 4 | 119
abnormal bone mineralization 3 | 55
abnormal gait 3 | 51
abnormal snout morphology 3 | 18
corneal opacity 3 | 25
decreased body length 3 | 108
decreased circulating triglyce... 3 | 83
decreased mean corpuscular hem... 3 | 34
decreased rib number 3 | 59
increased circulating calcium ... 3 | 32
increased circulating potassiu... 3 | 31
increased circulating sodium l... 3 | 71
increased circulating total pr... 3 | 20
increased erythrocyte cell num... 3 | 26
increased grip strength 3 | 83
increased lean body mass 3 | 107
increased mean corpuscular vol... 3 | 91
increased or absent threshold ... 3 | 128
increased total body fat amoun... 3 | 57
male infertility 3 | 62
abnormal QRS complex 2 | 25
abnormal cornea morphology 2 | 24
abnormal cranium morphology 2 | 32
abnormal head morphology 2 | 10
abnormal lens morphology 2 | 73
abnormal locomotor activation 2 | 26
abnormal retinal pigmentation 2 | 61
abnormal rib morphology 2 | 28
cardiovascular system phenotyp... 2 | 35
decreased NK T cell number 2 | 28
decreased blood urea nitrogen ... 2 | 31
decreased circulating amylase ... 2 | 24
decreased circulating choleste... 2 | 85
decreased circulating phosphat... 2 | 15
decreased circulating total pr... 2 | 41
decreased effector memory CD8-... 2 | 24
decreased leukocyte cell numbe... 2 | 54
decreased lumbar vertebrae num... 2 | 62
decreased prepulse inhibition 2 | 52
decreased startle reflex 2 | 48
decreased total body fat amoun... 2 | 186
hyperactivity 2 | 108
improved glucose tolerance 2 | 56
increased bone mineral content 2 | 92
increased circulating HDL chol... 2 | 63
increased circulating chloride... 2 | 43
increased circulating choleste... 2 | 53
increased circulating free fat... 2 | 17
increased fasted circulating g... 2 | 68
increased hemoglobin content 2 | 45
increased rib number 2 | 41
increased sacral vertebrae num... 2 | 62
limb grasping 2 | 35
persistence of hyaloid vascula... 2 | 22
short tibia 2 | 82
thrombocytopenia 2 | 46
abnormal embryo size 1 | 112
abnormal eye size 1 | 11
abnormal neural tube closure 1 | 37
abnormal tail movements 1 | 12
abnormal thoracic vertebrae mo... 1 | 16
absent pinna reflex 1 | 21
decreased alpha-beta T cell nu... 1 | 12
decreased cervical vertebrae n... 1 | 12
decreased eosinophil cell numb... 1 | 41
decreased hematocrit 1 | 25
decreased thoracic vertebrae n... 1 | 7
enlarged lymph nodes 1 | 27
hydrometra 1 | 13
impaired righting response 1 | 19
increased CD4-positive, CD25-p... 1 | 18
increased KLRG1+ CD4 alpha bet... 1 | 5
increased NK cell number 1 | 19
increased bone mineral density 1 | 52
increased circulating creatini... 1 | 29
increased circulating triglyce... 1 | 24
increased effector memory CD4-... 1 | 15
increased mean corpuscular hem... 1 | 25
increased mean platelet volume 1 | 19
polycystic kidney 1 | 9
prenatal lethality 1 | 16
prenatal lethality prior to he... 1 | 64
shortened ST segment 1 | 9

Disease

ovarian cancer 197 | 8,484
osteosarcoma 171 | 7,933
medulloblastoma, large-cell 164 | 6,234
glioblastoma 146 | 5,572
psoriasis 136 | 6,685
lung cancer 109 | 4,466
atypical teratoid / rhabdoid tumor 102 | 4,369
pilocytic astrocytoma 89 | 3,086
invasive ductal carcinoma 81 | 2,950
Breast cancer 79 | 3,094
malignant mesothelioma 76 | 3,162
lung carcinoma 75 | 2,844
oligodendroglioma 73 | 2,849
primitive neuroectodermal tumor 73 | 3,031
Pick disease 71 | 1,893
pediatric high grade glioma 71 | 2,712
subependymal giant cell astrocytoma 71 | 2,287
non-small cell lung cancer 70 | 2,798
pancreatic cancer 68 | 2,300
intraductal papillary-mucinous carcinoma (IPMC) 65 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 62 | 3,289
ulcerative colitis 62 | 2,087
astrocytic glioma 61 | 2,241
ependymoma 61 | 2,514
intraductal papillary-mucinous adenoma (IPMA) 60 | 2,956
lung adenocarcinoma 60 | 2,713
Cancer 59 | 2,346
adult high grade glioma 57 | 2,148
group 4 medulloblastoma 53 | 1,875
interstitial cystitis 52 | 2,299
breast carcinoma 51 | 1,614
Multiple myeloma 47 | 1,327
astrocytoma 46 | 1,493
ductal carcinoma in situ 44 | 1,745
medulloblastoma 42 | 1,524
pancreatic ductal adenocarcinoma liver metastasis 42 | 1,795
primary pancreatic ductal adenocarcinoma 41 | 1,271
colon cancer 40 | 1,475
group 3 medulloblastoma 40 | 2,254
juvenile dermatomyositis 40 | 1,189
pituitary cancer 37 | 1,972
sonic hedgehog group medulloblastoma 36 | 1,482
dermatomyositis 35 | 933
primary Sjogren syndrome 35 | 789
cystic fibrosis 33 | 1,665
posterior fossa group A ependymoma 33 | 1,511
tuberculosis 32 | 1,557
acute quadriplegic myopathy 31 | 1,157
posterior fossa group B ependymoma 30 | 1,530
cutaneous lupus erythematosus 29 | 1,056
atypical teratoid/rhabdoid tumor 27 | 1,095
diabetes mellitus 27 | 1,663
spina bifida 26 | 1,064
Carcinoma 23 | 2,147
active Crohn's disease 23 | 918
Rheumatoid Arthritis 21 | 1,160
Waldenstrons macroglobulinemia 21 | 765
gastric cancer 21 | 430
nasopharyngeal carcinoma 21 | 1,056
gastric carcinoma 20 | 832
tuberculosis and treatment for 6 months 20 | 686
acute myeloid leukemia 19 | 780
hepatocellular carcinoma 19 | 532
pancreatic carcinoma 19 | 567
Duchenne muscular dystrophy 18 | 602
progressive supranuclear palsy 18 | 674
non primary Sjogren syndrome sicca 17 | 840
aldosterone-producing adenoma 16 | 664
esophageal adenocarcinoma 16 | 737
adrenocortical carcinoma 15 | 1,427
autosomal dominant Emery-Dreifuss muscular dystrophy 15 | 499
sarcoidosis 15 | 358
Parkinson's disease 14 | 364
hereditary spastic paraplegia 14 | 313
mucosa-associated lymphoid tissue lymphoma 14 | 480
Alzheimer's disease 13 | 644
Hypertensive disorder 13 | 58
Neuroblastoma 13 | 78
Amyotrophic Lateral Sclerosis 12 | 431
Atopic dermatitis 12 | 944
Down syndrome 12 | 548
Intellectual disability 12 | 573
Neurodegenerative disease 12 | 383
Obesity 12 | 616
fibroadenoma 12 | 557
Myocardial Ischemia 11 | 169
Polycystic Ovary Syndrome 11 | 332
facioscapulohumeral dystrophy 11 | 286
glioblastoma multiforme 11 | 347
Endometriosis 10 | 535
Mammary Neoplasms 10 | 410
active ulcerative colitis 10 | 477
inflammatory breast cancer 10 | 404
HER2-positive carcinoma of breast 9 | 10
Liposarcoma 9 | 20
Malignant tumor of ovary 9 | 25
Melanoma 9 | 261
Rhabdomyosarcoma 9 | 29
non-small cell lung carcinoma 9 | 413
tuberculosis and treatment for 3 months 9 | 327

Tissue

Digestive Tract 365 | 18,473
Male tissues 363 | 17,969
Nervous System 363 | 18,561
Urinary Tract 363 | 18,444
Blood and immune system 362 | 17,995
Cardiovascular System 362 | 17,958
Endocrine System 362 | 18,512
Female tissues 362 | 18,647
Liver and Pancreas 362 | 18,136
Respiratory system 361 | 17,484
Skin and soft tissues 359 | 18,115

Target Family

Enzyme 209 | 4,146
Non-IDG 150 | 11,971
Kinase 14 | 634
GPCR 1 | 406

GO Function

GTP binding 374 | 374
metal ion binding 1,917 | 1,917
ATP binding 1,467 | 1,467
DNA binding 1,432 | 1,432
zinc ion binding 1,155 | 1,155
poly(A) RNA binding 1,107 | 1,107
transcription factor activity,... 853 | 853
calcium ion binding 695 | 695
G-protein coupled receptor act... 661 | 661
protein homodimerization activ... 569 | 569
RNA binding 445 | 445
olfactory receptor activity 424 | 424
sequence-specific DNA binding 398 | 398
chromatin binding 372 | 372
protein serine/threonine kinas... 336 | 336
RNA polymerase II core promote... 332 | 332
identical protein binding 311 | 311
nucleotide binding 311 | 311
receptor binding 303 | 303
protein kinase binding 289 | 289
enzyme binding 286 | 286
cadherin binding involved in c... 277 | 277
GTPase activator activity 273 | 273
ubiquitin protein ligase bindi... 258 | 258
ubiquitin-protein transferase ... 253 | 253
serine-type endopeptidase acti... 246 | 246
transcription coactivator acti... 241 | 241
transcription factor binding 240 | 240
structural molecule activity 232 | 232
GTPase activity 231 | 231
transcriptional activator acti... 230 | 230
ligase activity 227 | 227
protein heterodimerization act... 227 | 227
structural constituent of ribo... 212 | 212
transcription regulatory regio... 202 | 202
transmembrane signaling recept... 201 | 201
RNA polymerase II regulatory r... 200 | 200
receptor activity 200 | 200
transcription corepressor acti... 198 | 198
magnesium ion binding 197 | 197
signal transducer activity 196 | 196
nucleic acid binding 184 | 184
protein kinase activity 183 | 183
carbohydrate binding 180 | 180
ubiquitin protein ligase activ... 173 | 173
RNA polymerase II transcriptio... 162 | 162
heparin binding 160 | 160
iron ion binding 141 | 141
lipid binding 136 | 136
transporter activity 136 | 136
actin binding 133 | 133
ATPase activity 132 | 132
protein C-terminus binding 129 | 129
heme binding 127 | 127
microtubule binding 123 | 123
protein tyrosine kinase activi... 119 | 119
cytokine activity 118 | 118
Ras guanyl-nucleotide exchange... 113 | 113
mRNA binding 112 | 112
metalloendopeptidase activity 112 | 112
transcriptional repressor acti... 110 | 110
structural constituent of cyto... 108 | 108
Rab GTPase binding 105 | 105
antigen binding 104 | 104
protein domain specific bindin... 102 | 102
peptide antigen binding 101 | 101
guanyl-nucleotide exchange fac... 98 | 98
protein complex binding 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 92 | 92
oxidoreductase activity 91 | 91
transcriptional activator acti... 91 | 91
actin filament binding 89 | 89
hydrolase activity 89 | 89
ion channel binding 89 | 89
protein tyrosine phosphatase a... 88 | 88
electron carrier activity 87 | 87
protease binding 87 | 87
histone binding 86 | 86
integrin binding 83 | 83
growth factor activity 82 | 82
phospholipid binding 82 | 82
single-stranded DNA binding 81 | 81
unfolded protein binding 77 | 77
kinase activity 75 | 75
thiol-dependent ubiquitin-spec... 75 | 75
phosphatidylinositol binding 74 | 74
calmodulin binding 73 | 73
histone deacetylase binding 73 | 73
Rho guanyl-nucleotide exchange... 72 | 72
drug binding 71 | 71
double-stranded DNA binding 70 | 70
peptidase activity 70 | 70
protein N-terminus binding 70 | 70
virus receptor activity 68 | 68
beta-catenin binding 67 | 67
microtubule motor activity 67 | 67
protein transporter activity 67 | 67
calcium channel activity 66 | 66
ubiquitin binding 66 | 66

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
ADP-ribosylation factor-like protein 16 ARL16 Tdark Enzyme -0.13389 1.44 17
Nucleolar GTP-binding protein 1 GTPBP4 Tbio Non-IDG -3.21425 1443.3 95
Putative GTP-binding protein 6 GTPBP6 Tdark Non-IDG -1.08636 13.1 0
Ras-related protein Rab-11A RAB11A Tbio Enzyme -2.60207 398.9 288
Ras-related protein Rab-14 RAB14 Tbio Enzyme -1.40555 28.2 91
Glutamate dehydrogenase 2, mitochondrial GLUD2 Tbio Enzyme -1.13407 13.6 143
Ras-related protein Rab-43 RAB43 Tbio Enzyme -1.56506 35.9 63
Ras-related protein Rab-5C RAB5C Tbio Enzyme -1.13458 11.1 135
Ras-related protein Rab-27A RAB27A Tbio Enzyme -2.22946 184.9 247