Development Level

Tbio 10 | 11,651

IMPC Phenotype

abnormal craniofacial morpholo... 1 | 33
abnormal embryo size 1 | 220
abnormal forebrain morphology 1 | 10
abnormal hindbrain morphology 1 | 10
abnormal lens morphology 1 | 81
abnormal midbrain morphology 1 | 10
abnormal neural tube closure 1 | 46
abnormal placenta size 1 | 20
abnormal retina morphology 1 | 71
cataract 1 | 92
decreased circulating alkaline... 1 | 46
decreased circulating phosphat... 1 | 27
decreased lymphocyte cell numb... 1 | 83
edema 1 | 59
increased mean platelet volume 1 | 45
increased monocyte cell number 1 | 63
preweaning lethality, complete... 1 | 979
preweaning lethality, incomple... 1 | 499

Disease

Carcinoma 7 | 11,493
medulloblastoma, large-cell 5 | 6,241
osteosarcoma 5 | 7,950
astrocytic glioma 4 | 2,597
glioblastoma 4 | 5,792
group 4 medulloblastoma 4 | 1,855
lung carcinoma 4 | 2,843
ovarian cancer 4 | 8,520
Astrocytoma, Pilocytic 3 | 3,081
Breast cancer 3 | 3,578
Pick disease 3 | 1,894
adult high grade glioma 3 | 3,801
atypical teratoid / rhabdoid tumor 3 | 5,112
ependymoma 3 | 4,679
group 3 medulloblastoma 3 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
lung cancer 3 | 4,740
oligodendroglioma 3 | 2,850
primitive neuroectodermal tumor 3 | 3,035
tuberculosis 3 | 2,010
Cancer 2 | 2,499
Choroideremia 2 | 16
Kidney disease 2 | 430
ductal carcinoma in situ 2 | 1,745
esophageal adenocarcinoma 2 | 737
juvenile dermatomyositis 2 | 1,187
pancreatic cancer 2 | 2,398
pediatric high grade glioma 2 | 1,064
pituitary cancer 2 | 1,972
posterior fossa group A ependymoma 2 | 468
primary pancreatic ductal adenocarcinoma 2 | 1,109
spina bifida 2 | 1,074
AMYOTROPHIC LATERAL SCLEROSIS 1 1 | 49
Abnormality of retinal pigmentation 1 | 111
Alzheimer's disease 1 | 658
Atopic dermatitis 1 | 952
Becker muscular dystrophy 1 | 191
Blindness 1 | 88
Bone Diseases, Developmental 1 | 27
Cataract 8 multiple types 1 | 33
Cerebellar dysplasia 1 | 8
Chemical and Drug Induced Liver Injury 1 | 195
Chorioretinal atrophy 1 | 11
Chorioretinal degeneration 1 | 3
Choroidal sclerosis 1 | 8
Cocaine-Related Disorders 1 | 92
Craniofacial Abnormalities 1 | 151
Decreased visual acuity, progressive 1 | 36
DiGeorge syndrome 1 | 47
Difficulties with night vision 1 | 87
Dilated ventricles (finding) 1 | 121
Down syndrome 1 | 499
Duchenne muscular dystrophy 1 | 601
Gaucher disease type 1 1 | 180
HIV Infections 1 | 102
Hemangioma 1 | 69
Hepatomegaly 1 | 285
Hereditary spherocytosis type 5 1 | 12
Hyperplasia of foramen magnum 1 | 6
Hypoplasia of corpus callosum 1 | 90
Increased circumference of foramen magnum 1 | 6
Increased diameter of foramen magnum 1 | 6
Keratitis 1 | 62
Kidney Neoplasms 1 | 37
Large foramen magnum 1 | 6
Low Vision 1 | 174
Mental Retardation, X-Linked 1 | 23
Morphine dependence 1 | 16
Multiple Sclerosis 1 | 540
Myopia 1 | 176
Nephrolithiasis 1 | 56
Night Blindness 1 | 101
Nonsyndromic deafness 1 | 142
Norrie disease 1 | 14
Orofacial cleft 1 | 54
Parkinson's disease 1 | 392
Polymicrogyria 1 | 48
Progressive visual loss 1 | 36
Prostate carcinoma in situ 1 | 11
Retinal pigment epithelial abnormality 1 | 111
Schizophrenia 1 | 1,160
Severe sensorineural hearing impairment 1 | 5
Velocardiofacial syndrome 1 | 46
Visual Impairment 1 | 174
Visual field constriction 1 | 36
X-linked dominant 1 | 57
Zellweger syndrome 1 | 37
active ulcerative colitis 1 | 764
adrenocortical carcinoma 1 | 1,428
cystic fibrosis 1 | 1,696
dermatomyositis 1 | 966
diabetes mellitus 1 | 1,728
fascioscapulohumeral muscular dystrophy 1 | 100
gastric carcinoma 1 | 807
limb girdle muscular dystrophy 2B 1 | 40
non-small cell lung cancer 1 | 2,890
non-syndromic X-linked intellectual disability 1 | 20
progressive supranuclear palsy 1 | 676

Tissue

Blood and immune system 10 | 16,909
Cardiovascular System 10 | 15,192
Digestive Tract 10 | 17,369
Endocrine System 10 | 18,159
Female tissues 10 | 17,400
Liver and Pancreas 10 | 16,750
Male tissues 10 | 17,142
Nervous System 10 | 16,725
Respiratory system 10 | 16,393
Skin and soft tissues 10 | 17,230
Urinary Tract 10 | 16,678

Target Family

Non-IDG 7 | 12,091
Enzyme 3 | 4,145

GO Function

GDP-dissociation inhibitor act... 10 | 10
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ran-specific GTPase-activating protein RANBP1 Tbio Enzyme -1.80548 64.8 193
G-protein-signaling modulator 1 GPSM1 Tbio Non-IDG -1.34464 28.6 132
Sestrin-2 SESN2 Tbio Non-IDG -1.88129 92.6 176
Rab proteins geranylgeranyltransferase component A 1 CHM Tbio Enzyme -2.49909 300.2 109
G-protein-signaling modulator 2 GPSM2 Tbio Non-IDG -2.92381 834.6 138
Integrin beta-1-binding protein 1 ITGB1BP1 Tbio Non-IDG -1.23128 20.8 138
Regulator of G-protein signaling 14 RGS14 Tbio Non-IDG -1.61170 43.9 233
Rab proteins geranylgeranyltransferase component A 2 CHML Tbio Enzyme -1.90137 73.3 126
SH3 domain-binding protein 4 SH3BP4 Tbio Non-IDG -0.65493 4.55 143
Rab GDP dissociation inhibitor alpha GDI1 Tbio Non-IDG -1.57717 38.1 256