Development Level

Tbio 10 | 11,445
Tclin 3 | 613
Tchem 1 | 1,598

Collection

Ion Channel: IDG Consortium (T... 2 | 99

IMPC Phenotype

decreased circulating serum al... 1 | 82
preweaning lethality, complete... 1 | 979

Disease

Carcinoma 10 | 11,493
medulloblastoma, large-cell 10 | 6,241
ovarian cancer 10 | 8,520
atypical teratoid / rhabdoid tumor 9 | 5,112
glioblastoma 9 | 5,792
adult high grade glioma 8 | 3,801
astrocytic glioma 8 | 2,597
oligodendroglioma 7 | 2,850
osteosarcoma 7 | 7,950
Astrocytoma, Pilocytic 6 | 3,081
ependymoma 6 | 4,679
primitive neuroectodermal tumor 6 | 3,035
psoriasis 6 | 6,694
subependymal giant cell astrocytoma 6 | 2,287
Kidney cancer 5 | 2,613
Schizophrenia 5 | 1,160
group 3 medulloblastoma 5 | 4,104
Autistic Disorder 4 | 364
Breast cancer 4 | 3,578
Epilepsy 4 | 792
lung adenocarcinoma 4 | 2,716
Alcoholic Intoxication, Chronic 3 | 289
Anxiety 3 | 136
Bipolar Disorder 3 | 666
General anesthesia 3 | 53
Insomnia 3 | 20
Sedation as Adjunct to Anesthesia 3 | 15
Tonic-clonic epilepsy 3 | 47
Waldenstrons macroglobulinemia 3 | 765
aldosterone-producing adenoma 3 | 665
colon cancer 3 | 1,478
dermatomyositis 3 | 966
lung cancer 3 | 4,740
pituitary cancer 3 | 1,972
tuberculosis 3 | 2,010
Alcohol dependence 2 | 107
Autism spectrum disorder 2 | 101
Endometriosis 2 | 540
Granulomatous amebic encephalitis 2 | 8
Malaria 2 | 160
Pick disease 2 | 1,894
Schizoaffective Disorder 2 | 55
Seizures 2 | 596
acute myeloid leukemia 2 | 783
astrocytoma 2 | 1,146
group 4 medulloblastoma 2 | 1,855
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
invasive ductal carcinoma 2 | 2,951
lung carcinoma 2 | 2,843
mucosa-associated lymphoid tissue lymphoma 2 | 484
pancreatic cancer 2 | 2,398
pancreatic carcinoma 2 | 562
progressive supranuclear palsy 2 | 676
tuberculosis and treatment for 6 months 2 | 409
ulcerative colitis 2 | 1,819
Acquired immunodeficiency syndrome 1 | 197
Acquired metabolic disease 1 | 336
Angelman syndrome 1 | 34
Cataract 7 1 | 32
Cerebral palsy 1 | 40
Essential Hypertension 1 | 94
Gaucher disease type 3 1 | 67
Generalized anxiety disorder 1 | 29
Hepatic encephalopathy 1 | 27
Heterotopia, Periventricular, Autosomal Recessive 1 | 3
Hypoplasia of corpus callosum 1 | 90
Hypsarrhythmia 1 | 25
Infantile onset 1 | 238
Intracranial aneurysm 1 | 24
Irritable bowel syndrome 1 | 60
Liver Cirrhosis, Experimental 1 | 769
Liver cancer 1 | 604
Local anesthesia 1 | 40
Meckel's diverticulum 1 | 5
Melanoma 1 | 711
Microcephaly 1 | 166
Mood Disorders 1 | 184
Neuronal ceroid lipofuscinosis 8 northern epilepsy variant 1 | 6
Osteoporosis 1 | 363
Panic disorder 1 | 61
Partial Epilepsy Treatment Adjunct 1 | 16
Periventricular nodular heterotopia 1 | 30
Poor eye contact 1 | 12
Prader-Willi syndrome 1 | 48
Prostate cancer 1 | 175
Pseudobulbar palsy 1 | 11
Quadriparesis 1 | 8
Severe mental retardation (I.Q. 20-34) 1 | 99
Skin cancer 1 | 469
Spasticity 1 | 26
Status Epilepticus 1 | 98
Stiff-Person syndrome 1 | 12
Usher syndrome type 1C 1 | 3
Vici syndrome 1 | 14
Visual epilepsy 1 | 4
breast carcinoma 1 | 1,638
head and neck cancer 1 | 271
hereditary spastic paraplegia 1 | 318
posterior fossa group B ependymoma 1 | 416
substance-related disorder 1 | 162

Tissue

Endocrine System 14 | 18,159
Nervous System 14 | 16,725
Blood and immune system 13 | 16,909
Digestive Tract 13 | 17,369
Female tissues 13 | 17,400
Liver and Pancreas 13 | 16,750
Skin and soft tissues 13 | 17,230
Urinary Tract 13 | 16,678
Cardiovascular System 12 | 15,192
Male tissues 12 | 17,142
Respiratory system 12 | 16,393

Target Family

Non-IDG 6 | 12,091
Enzyme 5 | 4,145
Ion Channel 3 | 344

GO Function

GABA receptor binding 14 | 14
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

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