Development Level

Tbio 6 | 11,445
Tchem 1 | 1,598

IMPC Phenotype

decreased prepulse inhibition 1 | 82
preweaning lethality, complete... 1 | 979

Disease

Carcinoma 7 | 11,493
osteosarcoma 6 | 7,950
Autosomal recessive predisposition 5 | 1,442
Kidney cancer 5 | 2,613
Short stature 4 | 531
lung cancer 4 | 4,740
ovarian cancer 4 | 8,520
psoriasis 4 | 6,694
Fanconi anemia 3 | 56
Rothmund-Thomson syndrome 3 | 19
Small head 3 | 374
glioblastoma 3 | 5,792
medulloblastoma, large-cell 3 | 6,241
Baller-Gerold syndrome 2 | 12
Bloom syndrome 2 | 29
Cancer 2 | 2,499
Cataract 2 | 297
Chromosome Breakage 2 | 36
Cockayne syndrome 2 | 60
Cognitive delay 2 | 608
Congenital Epicanthus 2 | 177
Delayed bone age 2 | 136
Diabetes Mellitus, Non-Insulin-Dependent 2 | 145
Dull intelligence 2 | 645
Fetal Growth Retardation 2 | 189
Global developmental delay 2 | 608
Infant, Small for Gestational Age 2 | 176
Intellectual disability 2 | 1,016
Intrauterine retardation 2 | 176
Lens Opacities 2 | 231
Liver cancer 2 | 604
Low intelligence 2 | 645
Mental Retardation 2 | 645
Mental and motor retardation 2 | 608
Mental deficiency 2 | 645
Microcephaly 2 | 166
Muscle hypotonia 2 | 571
Narrow face 2 | 54
Nijmegen breakage syndrome 2 | 24
Photosensitive trichothiodystrophy 2 | 30
Poor school performance 2 | 645
Short nose 2 | 132
Small nose 2 | 132
Thin face 2 | 54
Ventricular Septal Defects 2 | 119
Warsaw breakage syndrome 2 | 11
Werner syndrome 2 | 29
acute quadriplegic myopathy 2 | 1,158
adult high grade glioma 2 | 3,801
atypical teratoid / rhabdoid tumor 2 | 5,112
colon cancer 2 | 1,478
diabetes mellitus 2 | 1,728
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
juvenile dermatomyositis 2 | 1,187
malignant mesothelioma 2 | 3,232
pituitary cancer 2 | 1,972
Aplasia/Hypoplasia of the skin 1 | 16
Ataxia telangiectasia 1 | 34
Birthmark 1 | 35
Bronchiectasis 1 | 64
Cafe-au-Lait Spots 1 | 37
Calcium pyrophosphate deposition disease 1 | 13
Central cleft of nose 1 | 3
Coloboma of optic disc 1 | 9
Decreased IgM 1 | 11
Decreased fertility 1 | 33
Defective enamel matrix 1 | 35
Defective tooth enamel 1 | 31
Dental Enamel Hypoplasia 1 | 43
Dental abnormalities 1 | 60
Depressed cheekbone 1 | 22
Dysplasia of tooth enamel 1 | 35
Dystrophic tooth enamel 1 | 31
Enamel abnormalities 1 | 31
Flattening of the zygomatic bone 1 | 22
Hereditary Breast and Ovarian Cancer Syndrome 1 | 14
Hyperkeratosis 1 | 50
Hypertrichosis 1 | 46
Hypoplasia of the zygomatic bone 1 | 22
Hypotrophic cheekbone 1 | 22
Increased chromosomal breakage 1 | 27
Malignant Squamous Cell Neoplasm 1 | 17
Meningioma 1 | 41
Midline defect of the nose 1 | 3
ODONTOID HYPOPLASIA 1 | 16
Osteosclerosis 1 | 31
Overfolded helix 1 | 24
Paranasal Sinus Diseases 1 | 34
Photosensitivity of skin 1 | 51
Postnatal growth retardation 1 | 57
Premature canities 1 | 24
Rapadilino syndrome 1 | 7
Simple syndactyly of toes, first web space 1 | 23
Sinusitis 1 | 65
Small cheekbone 1 | 22
Small face 1 | 10
Small hand 1 | 36
Sparse scalp hair 1 | 42
Thin dental enamel 1 | 35
Xeroderma pigmentosum 1 | 43

Tissue

Blood and immune system 7 | 16,909
Cardiovascular System 7 | 15,192
Digestive Tract 7 | 17,369
Endocrine System 7 | 18,159
Female tissues 7 | 17,400
Liver and Pancreas 7 | 16,750
Male tissues 7 | 17,142
Nervous System 7 | 16,725
Respiratory system 7 | 16,393
Skin and soft tissues 7 | 17,230
Urinary Tract 7 | 16,678

Target Family

Enzyme 5 | 4,145
Non-IDG 2 | 12,091

GO Function

G-quadruplex DNA binding 7 | 7
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
5'-3' exoribonuclease 1 XRN1 Tbio Enzyme -2.13482 125.3 51
ATP-dependent RNA helicase DHX36 DHX36 Tbio Enzyme -1.55120 37.4 112
Lon protease homolog, mitochondrial LONP1 Tbio Enzyme -2.24805 169.6 174
ATP-dependent DNA helicase DDX11 DDX11 Tbio Enzyme -1.05592 30.0 163
DNA repair protein RAD50 RAD50 Tbio Non-IDG -1.42369 23.8 305
Werner syndrome ATP-dependent helicase WRN Tbio Enzyme -2.73759 569.7 210
Bloom syndrome protein BLM Tchem Non-IDG -2.03028 104.1 314