Development Level

Tdark 12 | 6,593
Tclin 8 | 612
Tchem 4 | 1,388

Collection

GPCR: IDG Consortium (Targets) 2 | 126

IMPC Phenotype

abnormal behavioral response t... 2 | 66
decreased total body fat amoun... 2 | 207
increased circulating sodium l... 2 | 71
abnormal tail length 1 | 3
cardiovascular system phenotyp... 1 | 36
decreased anxiety-related resp... 1 | 12
decreased lean body mass 1 | 135
impaired pupillary reflex 1 | 26
increased circulating chloride... 1 | 41
increased lean body mass 1 | 172
increased mean corpuscular vol... 1 | 92
increased total body fat amoun... 1 | 134
preweaning lethality, complete... 1 | 979
preweaning lethality, incomple... 1 | 499

Disease

Carcinoma 21 | 11,493
Migraine 12 | 83
Schizophrenia 12 | 1,160
Major Depressive Disorder 9 | 301
Bipolar Disorder 8 | 666
Depressive disorder 8 | 409
Mood Disorders 8 | 184
Alzheimer's disease 6 | 658
Autistic Disorder 6 | 364
Mental Depression 6 | 333
Alcohol dependence 5 | 107
Alcoholic Intoxication, Chronic 5 | 289
Amnestic disorder 5 | 35
Cluster headache syndrome 5 | 8
Parkinson's disease 5 | 392
Substance abuse 5 | 59
malignant mesothelioma 5 | 3,232
obsessive-compulsive disorder 5 | 61
psoriasis 5 | 6,694
Attention deficit hyperactivity disorder 4 | 278
Dementia 4 | 175
Generalized anxiety disorder 4 | 29
Migraine Prevention 4 | 23
Obesity 4 | 678
Personality disorder 4 | 25
Unipolar Depression 4 | 250
Vascular headache 4 | 7
diabetes mellitus 4 | 1,728
medulloblastoma, large-cell 4 | 6,241
Bipolar affective disorder, current episode manic 3 | 13
Cluster Headache Prevention 3 | 6
Cocaine-Related Disorders 3 | 92
Hyperprolactinemia 3 | 27
Hypoactive sexual desire disorder 3 | 8
Irritable bowel syndrome 3 | 60
Kidney cancer 3 | 2,613
Memory Disorders 3 | 40
Mixed bipolar I disorder 3 | 9
Panic disorder 3 | 61
Premature ejaculation 3 | 16
Psychotic Disorders 3 | 151
Treatment-resistant schizophrenia 3 | 6
astrocytic glioma 3 | 2,597
ependymoma 3 | 4,679
glioblastoma 3 | 5,792
oligodendroglioma 3 | 2,850
osteosarcoma 3 | 7,950
primitive neuroectodermal tumor 3 | 3,035
Acromegaly 2 | 51
Agitation associated with Bipolar Mania 2 | 5
Agitation associated with Schizophrenia 2 | 5
Alcohol abuse 2 | 50
Amphetamine-Related Disorders 2 | 74
Astrocytoma, Pilocytic 2 | 3,081
Bipolar disorder in remission 2 | 19
Chronic thromboembolic pulmonary hypertension 2 | 4
Cocaine abuse 2 | 19
Constipation 2 | 181
Depression Treatment Adjunct 2 | 5
Diarrhea 2 | 253
Drug psychosis 2 | 7
Dyspepsia 2 | 33
Eating disorder 2 | 26
Epilepsy 2 | 792
Fever 2 | 138
Gastroparesis 2 | 22
Heart disease 2 | 306
Hyperactive behavior 2 | 91
Hyperkinesis 2 | 32
Hypertension 2 | 396
Hypotension 2 | 82
Infantile autism 2 | 4
Lack or loss of sexual desire 2 | 3
Learning Disorders 2 | 29
Migraine Disorders 2 | 76
Motion sickness 2 | 21
Pain 2 | 103
Pain agnosia 2 | 104
Postabortal Hemorrhage 2 | 3
Postpartum hemorrhage 2 | 6
Psychoses, Substance-Induced 2 | 17
Schizoaffective Disorder 2 | 55
Seasonal affective disorder 2 | 28
Seizures 2 | 596
Sexual dysfunction 2 | 9
Single major depressive episode 2 | 8
Sudden infant death syndrome 2 | 32
adult high grade glioma 2 | 3,801
group 3 medulloblastoma 2 | 4,104
non diabetic and post-ischemic heart failure 2 | 200
ovarian cancer 2 | 8,520
post-traumatic stress disorder 2 | 40
pulmonary arterial hypertension 2 | 76
substance-related disorder 2 | 162
Anorexia 1 | 43
Anxiety Disorders 1 | 38
Chronic schizophrenia 1 | 16
Ileus 1 | 19
Nasal congestion 1 | 23
Nonorganic psychosis 1 | 84

Tissue

Endocrine System 13 | 18,159
Nervous System 12 | 16,725
Female tissues 11 | 17,400
Digestive Tract 10 | 17,369
Liver and Pancreas 10 | 16,750
Male tissues 10 | 17,142
Blood and immune system 9 | 16,909
Respiratory system 9 | 16,393
Skin and soft tissues 9 | 17,230
Urinary Tract 9 | 16,678
Cardiovascular System 8 | 15,192

Target Family

GPCR 12 | 408
oGPCR 12 | 421

GO Function

G-protein coupled serotonin re... 24 | 24
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
5-hydroxytryptamine receptor 7 HTR7 Tclin GPCR -4.15964 13643.7 259
5-hydroxytryptamine receptor 1A HTR1A Tclin GPCR -3.67718 4891.4 254
5-hydroxytryptamine receptor 2A HTR2A Tclin GPCR -3.33563 2152.8 231
5-hydroxytryptamine receptor 2C HTR2C Tclin GPCR -3.08158 1199.3 336
5-hydroxytryptamine receptor 1B HTR1B Tclin GPCR -3.03042 1068.4 211
5-hydroxytryptamine receptor 4 HTR4 Tclin GPCR -2.87235 796.4 248
5-hydroxytryptamine receptor 2B HTR2B Tclin GPCR -2.66641 486.3 265
5-hydroxytryptamine receptor 1D HTR1D Tclin GPCR -2.54328 350.8 140
5-hydroxytryptamine receptor 1F HTR1F Tchem GPCR -2.39159 244.1 131
5-hydroxytryptamine receptor 6 HTR6 Tchem GPCR -2.31880 213.2 64