Development Level

Tdark 445 | 6,588
Tbio 117 | 11,445
Tchem 80 | 1,598
Tclin 16 | 613

Collection

GPCR: IDG Consortium (Targets) 106 | 126
RFA-RM-18-021 84 | 328
GPCR: IDG Consortium (Complete... 22 | 25

IMPC Phenotype

decreased vertical activity 10 | 208
enlarged heart 6 | 210
abnormal behavior 5 | 298
decreased bone mineral density 5 | 126
hyperactivity 5 | 148
preweaning lethality, complete... 5 | 979
abnormal bone structure 4 | 187
abnormal heart morphology 4 | 162
decreased body weight 4 | 161
preweaning lethality, incomple... 4 | 499
abnormal seminal vesicle morph... 3 | 114
abnormal skin coloration 3 | 25
decreased bone mineral content 3 | 151
decreased startle reflex 3 | 75
embryonic lethality prior to t... 3 | 278
impaired glucose tolerance 3 | 75
increased hemoglobin content 3 | 45
increased lean body mass 3 | 172
increased or absent threshold ... 3 | 101
abnormal epididymis morphology 2 | 42
abnormal eye morphology 2 | 68
abnormal gait 2 | 69
abnormal kidney morphology 2 | 65
abnormal liver morphology 2 | 17
abnormal skin morphology 2 | 50
decreased heart weight 2 | 27
decreased hemoglobin content 2 | 68
decreased lean body mass 2 | 135
decreased leukocyte cell numbe... 2 | 73
decreased mean corpuscular hem... 2 | 50
decreased prepulse inhibition 2 | 82
decreased total body fat amoun... 2 | 207
embryonic lethality prior to o... 2 | 239
enlarged epididymis 2 | 31
female infertility 2 | 60
increased bone mineral content 2 | 108
increased circulating choleste... 2 | 66
increased circulating creatini... 2 | 38
increased circulating sodium l... 2 | 71
increased circulating triglyce... 2 | 42
increased erythrocyte cell num... 2 | 39
increased heart weight 2 | 62
increased mean corpuscular vol... 2 | 92
increased startle reflex 2 | 112
increased total body fat amoun... 2 | 134
mammalian phenotype 2 | 17
microphthalmia 2 | 26
polycystic kidney 2 | 15
short tibia 2 | 97
small superior vagus ganglion 2 | 74
abnormal behavioral response t... 1 | 66
abnormal coat-hair pigmentatio... 1 | 64
abnormal embryo turning 1 | 31
abnormal head morphology 1 | 10
abnormal pancreas morphology 1 | 13
abnormal pericardium morpholog... 1 | 26
abnormal retinal blood vessel ... 1 | 26
abnormal sleep behavior 1 | 70
abnormal snout morphology 1 | 23
abnormal startle reflex 1 | 15
abnormal tail movements 1 | 12
absent pinna reflex 1 | 23
absent startle reflex 1 | 24
absent vibrissae 1 | 12
cataract 1 | 92
decreased IgE level 1 | 6
decreased T cell number 1 | 15
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating choleste... 1 | 93
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased grip strength 1 | 116
decreased hematocrit 1 | 46
decreased mean corpuscular hem... 1 | 31
enlarged uterus 1 | 11
hydrometra 1 | 53
hypoactivity 1 | 132
impaired pupillary reflex 1 | 26
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating bilirubi... 1 | 16
increased circulating calcium ... 1 | 34
increased circulating chloride... 1 | 41
increased circulating glucose ... 1 | 24
increased circulating lipase l... 1 | 3
increased fasted circulating g... 1 | 76
increased heart rate variabili... 1 | 7
increased hematocrit 1 | 46
increased monocyte cell number 1 | 63
increased vertical activity 1 | 24
male infertility 1 | 123
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
scaly skin 1 | 4
small testis 1 | 58
thick skin 1 | 4
urinary bladder obstruction 1 | 4

Disease

Carcinoma 484 | 11,493
psoriasis 107 | 6,694
osteosarcoma 99 | 7,950
diabetes mellitus 98 | 1,728
medulloblastoma, large-cell 88 | 6,241
ovarian cancer 84 | 8,520
atypical teratoid / rhabdoid tumor 70 | 5,112
lung cancer 69 | 4,740
ependymoma 65 | 4,679
glioblastoma 64 | 5,792
adult high grade glioma 60 | 3,801
interstitial cystitis 59 | 2,312
lung carcinoma 54 | 2,843
Kidney cancer 45 | 2,613
Breast cancer 43 | 3,578
lung adenocarcinoma 41 | 2,716
Astrocytoma, Pilocytic 40 | 3,081
group 3 medulloblastoma 37 | 4,104
primitive neuroectodermal tumor 35 | 3,035
intraductal papillary-mucinous neoplasm (IPMN) 34 | 3,291
malignant mesothelioma 34 | 3,232
intraductal papillary-mucinous adenoma (IPMA) 33 | 2,955
non-small cell lung cancer 33 | 2,890
invasive ductal carcinoma 32 | 2,951
pituitary cancer 32 | 1,972
Schizophrenia 31 | 1,160
ulcerative colitis 31 | 1,819
intraductal papillary-mucinous carcinoma (IPMC) 30 | 2,989
Cancer 29 | 2,499
oligodendroglioma 29 | 2,850
ductal carcinoma in situ 28 | 1,745
astrocytic glioma 26 | 2,597
breast carcinoma 26 | 1,638
tuberculosis 26 | 2,010
pancreatic cancer 25 | 2,398
subependymal giant cell astrocytoma 23 | 2,287
Obesity 20 | 678
cystic fibrosis 20 | 1,696
Pick disease 19 | 1,894
cutaneous lupus erythematosus 19 | 1,057
Multiple Sclerosis 18 | 540
primary Sjogren syndrome 18 | 735
Bipolar Disorder 17 | 666
group 4 medulloblastoma 16 | 1,855
medulloblastoma 16 | 720
colon cancer 15 | 1,478
mucosa-associated lymphoid tissue lymphoma 15 | 484
Liver cancer 14 | 604
Melanoma 14 | 711
pancreatic ductal adenocarcinoma liver metastasis 14 | 1,962
Alcoholic Intoxication, Chronic 13 | 289
Rheumatoid arthritis 13 | 1,191
gastric carcinoma 13 | 807
Atopic dermatitis 12 | 952
Depressive disorder 12 | 409
Epilepsy 12 | 792
Hemolytic anemia 12 | 77
Skin cancer 12 | 469
adrenocortical carcinoma 12 | 1,428
pediatric high grade glioma 12 | 1,064
primary pancreatic ductal adenocarcinoma 12 | 1,109
esophageal adenocarcinoma 11 | 737
non primary Sjogren syndrome sicca 11 | 891
Mood Disorders 10 | 184
active Crohn's disease 10 | 922
astrocytoma 10 | 1,146
fibroadenoma 10 | 559
Acquired metabolic disease 9 | 336
Mental Depression 9 | 333
juvenile dermatomyositis 9 | 1,187
non-small cell lung carcinoma 9 | 317
Autosomal recessive predisposition 8 | 1,442
Cardiovascular system disease 8 | 246
Down syndrome 8 | 499
Duchenne muscular dystrophy 8 | 601
Liver Cirrhosis, Experimental 8 | 769
Pain agnosia 8 | 104
acute myeloid leukemia 8 | 783
spina bifida 8 | 1,074
Alzheimer's disease 7 | 658
Intellectual disability 7 | 1,016
Major Depressive Disorder 7 | 301
hepatocellular carcinoma 7 | 547
sonic hedgehog group medulloblastoma 7 | 467
Alcohol dependence 6 | 107
Anorexia nervosa 6 | 80
Asthma 6 | 385
Breast Neoplasms 6 | 445
Common cold 6 | 67
Endometrial cancer 6 | 311
Endometriosis 6 | 540
Epilepsy, Temporal Lobe 6 | 23
Mammary Neoplasms 6 | 425
Osteoarthritis 6 | 184
Vascular disease 6 | 319
active ulcerative colitis 6 | 764
aldosterone-producing adenoma 6 | 665
autosomal dominant Emery-Dreifuss muscular dystrophy 6 | 510
nasopharyngeal carcinoma 6 | 1,058
non diabetic and post-ischemic heart failure 5 | 200

Tissue

Endocrine System 319 | 18,159
Female tissues 247 | 17,400
Blood and immune system 231 | 16,909
Male tissues 228 | 17,142
Digestive Tract 223 | 17,369
Nervous System 220 | 16,725
Skin and soft tissues 217 | 17,230
Urinary Tract 201 | 16,678
Liver and Pancreas 197 | 16,750
Respiratory system 188 | 16,393
Cardiovascular System 159 | 15,192

Target Family

oGPCR 404 | 421
GPCR 237 | 408
Non-IDG 16 | 12,091
Enzyme 1 | 4,145

GO Function

G-protein coupled receptor act... 658 | 658
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Metabotropic glutamate receptor 5 GRM5 Tchem GPCR -3.12353 1370.3 396
Olfactory receptor 51B2 OR51B2 Tdark oGPCR 0.12 0.65 26
Olfactory receptor 51B4 OR51B4 Tdark oGPCR 0.05 1.19 4
Metabotropic glutamate receptor 3 GRM3 Tchem GPCR -2.30964 186.9 274
Metabotropic glutamate receptor 4 GRM4 Tchem GPCR -2.34335 217.2 150
Olfactory receptor 5B2 OR5B2 Tdark oGPCR 0.00000 1
Relaxin receptor 2 RXFP2 Tbio GPCR -1.97913 85.3 207
Olfactory receptor 2A7 OR2A7 Tdark oGPCR 0.00000 23
Olfactory receptor 2A14 OR2A14 Tdark oGPCR 0.85 0.13 6
Olfactory receptor 52A1 OR52A1 Tdark oGPCR 0.18 1.00 92