Development Level

Tdark 446 | 6,593
Tbio 142 | 11,651
Tchem 54 | 1,388
Tclin 16 | 612

Collection

GPCR: IDG Consortium (Targets) 106 | 126
RFA-RM-18-021 84 | 328
GPCR: IDG Consortium (Complete... 22 | 25

IMPC Phenotype

decreased vertical activity 10 | 208
enlarged heart 6 | 210
abnormal behavior 5 | 298
decreased bone mineral density 5 | 126
hyperactivity 5 | 148
preweaning lethality, complete... 5 | 979
abnormal bone structure 4 | 187
abnormal heart morphology 4 | 162
decreased body weight 4 | 161
preweaning lethality, incomple... 4 | 499
abnormal seminal vesicle morph... 3 | 114
abnormal skin coloration 3 | 25
decreased bone mineral content 3 | 151
decreased startle reflex 3 | 75
embryonic lethality prior to t... 3 | 278
impaired glucose tolerance 3 | 75
increased hemoglobin content 3 | 45
increased lean body mass 3 | 172
increased or absent threshold ... 3 | 101
abnormal epididymis morphology 2 | 42
abnormal eye morphology 2 | 68
abnormal gait 2 | 69
abnormal kidney morphology 2 | 65
abnormal liver morphology 2 | 17
abnormal skin morphology 2 | 50
decreased heart weight 2 | 27
decreased hemoglobin content 2 | 68
decreased lean body mass 2 | 135
decreased leukocyte cell numbe... 2 | 73
decreased mean corpuscular hem... 2 | 50
decreased prepulse inhibition 2 | 82
decreased total body fat amoun... 2 | 207
embryonic lethality prior to o... 2 | 239
enlarged epididymis 2 | 31
female infertility 2 | 60
increased bone mineral content 2 | 108
increased circulating choleste... 2 | 66
increased circulating creatini... 2 | 38
increased circulating sodium l... 2 | 71
increased circulating triglyce... 2 | 42
increased erythrocyte cell num... 2 | 39
increased heart weight 2 | 62
increased mean corpuscular vol... 2 | 92
increased startle reflex 2 | 112
increased total body fat amoun... 2 | 134
mammalian phenotype 2 | 17
microphthalmia 2 | 26
polycystic kidney 2 | 15
short tibia 2 | 97
small superior vagus ganglion 2 | 74
abnormal behavioral response t... 1 | 66
abnormal coat-hair pigmentatio... 1 | 64
abnormal embryo turning 1 | 31
abnormal head morphology 1 | 10
abnormal pancreas morphology 1 | 13
abnormal pericardium morpholog... 1 | 26
abnormal retinal blood vessel ... 1 | 26
abnormal sleep behavior 1 | 70
abnormal snout morphology 1 | 23
abnormal startle reflex 1 | 15
abnormal tail movements 1 | 12
absent pinna reflex 1 | 23
absent startle reflex 1 | 24
absent vibrissae 1 | 12
cataract 1 | 92
decreased IgE level 1 | 6
decreased T cell number 1 | 15
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating choleste... 1 | 93
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased grip strength 1 | 116
decreased hematocrit 1 | 46
decreased mean corpuscular hem... 1 | 31
enlarged uterus 1 | 11
hydrometra 1 | 53
hypoactivity 1 | 132
impaired pupillary reflex 1 | 26
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating bilirubi... 1 | 16
increased circulating calcium ... 1 | 34
increased circulating chloride... 1 | 41
increased circulating glucose ... 1 | 24
increased circulating lipase l... 1 | 3
increased fasted circulating g... 1 | 76
increased heart rate variabili... 1 | 7
increased hematocrit 1 | 46
increased monocyte cell number 1 | 63
increased vertical activity 1 | 24
male infertility 1 | 123
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
scaly skin 1 | 4
small testis 1 | 58
thick skin 1 | 4
urinary bladder obstruction 1 | 4

Disease

Carcinoma 484 | 11,493
psoriasis 107 | 6,694
osteosarcoma 99 | 7,950
diabetes mellitus 98 | 1,728
medulloblastoma, large-cell 88 | 6,241
ovarian cancer 84 | 8,520
atypical teratoid / rhabdoid tumor 70 | 5,112
lung cancer 69 | 4,740
ependymoma 65 | 4,679
glioblastoma 64 | 5,792
adult high grade glioma 60 | 3,801
interstitial cystitis 59 | 2,312
lung carcinoma 54 | 2,843
Kidney cancer 45 | 2,613
Breast cancer 43 | 3,578
lung adenocarcinoma 41 | 2,716
Astrocytoma, Pilocytic 40 | 3,081
group 3 medulloblastoma 37 | 4,104
primitive neuroectodermal tumor 35 | 3,035
intraductal papillary-mucinous neoplasm (IPMN) 34 | 3,291
malignant mesothelioma 34 | 3,232
intraductal papillary-mucinous adenoma (IPMA) 33 | 2,955
non-small cell lung cancer 33 | 2,890
invasive ductal carcinoma 32 | 2,951
pituitary cancer 32 | 1,972
Schizophrenia 31 | 1,160
ulcerative colitis 31 | 1,819
intraductal papillary-mucinous carcinoma (IPMC) 30 | 2,989
Cancer 29 | 2,499
oligodendroglioma 29 | 2,850
ductal carcinoma in situ 28 | 1,745
astrocytic glioma 26 | 2,597
breast carcinoma 26 | 1,638
tuberculosis 26 | 2,010
pancreatic cancer 25 | 2,398
subependymal giant cell astrocytoma 23 | 2,287
Obesity 20 | 678
cystic fibrosis 20 | 1,696
Pick disease 19 | 1,894
cutaneous lupus erythematosus 19 | 1,057
Multiple Sclerosis 18 | 540
primary Sjogren syndrome 18 | 735
Bipolar Disorder 17 | 666
group 4 medulloblastoma 16 | 1,855
medulloblastoma 16 | 720
colon cancer 15 | 1,478
mucosa-associated lymphoid tissue lymphoma 15 | 484
Liver cancer 14 | 604
Melanoma 14 | 711
pancreatic ductal adenocarcinoma liver metastasis 14 | 1,962
Alcoholic Intoxication, Chronic 13 | 289
Rheumatoid arthritis 13 | 1,191
gastric carcinoma 13 | 807
Atopic dermatitis 12 | 952
Depressive disorder 12 | 409
Epilepsy 12 | 792
Hemolytic anemia 12 | 77
Skin cancer 12 | 469
adrenocortical carcinoma 12 | 1,428
pediatric high grade glioma 12 | 1,064
primary pancreatic ductal adenocarcinoma 12 | 1,109
esophageal adenocarcinoma 11 | 737
non primary Sjogren syndrome sicca 11 | 891
Mood Disorders 10 | 184
active Crohn's disease 10 | 922
astrocytoma 10 | 1,146
fibroadenoma 10 | 559
Acquired metabolic disease 9 | 336
Mental Depression 9 | 333
juvenile dermatomyositis 9 | 1,187
non-small cell lung carcinoma 9 | 317
Autosomal recessive predisposition 8 | 1,442
Cardiovascular system disease 8 | 246
Down syndrome 8 | 499
Duchenne muscular dystrophy 8 | 601
Liver Cirrhosis, Experimental 8 | 769
Pain agnosia 8 | 104
acute myeloid leukemia 8 | 783
spina bifida 8 | 1,074
Alzheimer's disease 7 | 658
Intellectual disability 7 | 1,016
Major Depressive Disorder 7 | 301
hepatocellular carcinoma 7 | 547
sonic hedgehog group medulloblastoma 7 | 467
Alcohol dependence 6 | 107
Anorexia nervosa 6 | 80
Asthma 6 | 385
Breast Neoplasms 6 | 445
Common cold 6 | 69
Endometrial cancer 6 | 311
Endometriosis 6 | 540
Epilepsy, Temporal Lobe 6 | 23
Mammary Neoplasms 6 | 425
Osteoarthritis 6 | 184
Vascular disease 6 | 319
active ulcerative colitis 6 | 764
aldosterone-producing adenoma 6 | 665
autosomal dominant Emery-Dreifuss muscular dystrophy 6 | 510
nasopharyngeal carcinoma 6 | 1,058
non diabetic and post-ischemic heart failure 5 | 200

Tissue

Endocrine System 319 | 18,159
Female tissues 247 | 17,400
Blood and immune system 231 | 16,909
Male tissues 228 | 17,142
Digestive Tract 223 | 17,369
Nervous System 220 | 16,725
Skin and soft tissues 217 | 17,230
Urinary Tract 201 | 16,678
Liver and Pancreas 197 | 16,750
Respiratory system 188 | 16,393
Cardiovascular System 159 | 15,192

Target Family

oGPCR 404 | 421
GPCR 237 | 408
Non-IDG 16 | 12,091
Enzyme 1 | 4,145

GO Function

G-protein coupled receptor act... 658 | 658
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Olfactory receptor 5H15 OR5H15 Tdark oGPCR 0.00000 35
Olfactory receptor 7D2 OR7D2 Tdark oGPCR 0.00000 2
Olfactory receptor 5B21 OR5B21 Tdark oGPCR 0.00000 4
Mas-related G-protein coupled receptor member X1 MRGPRX1 Tchem GPCR -1.21830 18.4 75
G-protein coupled receptor 176 GPR176 Tbio GPCR -2.38327 235.4 133
Metabotropic glutamate receptor 2 GRM2 Tchem GPCR -2.77035 612.3 315
Sphingosine 1-phosphate receptor 4 S1PR4 Tclin GPCR -1.78966 58.4 256
Olfactory receptor 1A2 OR1A2 Tdark oGPCR -0.35218 1.89 21
Neuropeptide FF receptor 2 NPFFR2 Tchem GPCR -1.63803 38.0 161
5-hydroxytryptamine receptor 1E HTR1E Tchem GPCR -1.56886 35.9 110