Development Level

Tclin 5 | 613

Collection

GPCR: IDG Consortium (Complete... 1 | 25

IMPC Phenotype

abnormal behavior 1 | 298
hyperactivity 1 | 148

Disease

Biliary dyskinesia 5 | 7
Chronic gastritis 5 | 5
Chronic obstructive lung disease 5 | 6
Excessive salivation 5 | 5
Gastric ulcer 5 | 33
General anesthesia 5 | 53
Peptic Ulcer 5 | 27
Urinary Incontinence 5 | 50
Vagal Reflex Bradycardia 5 | 5
Carcinoma 4 | 11,493
Schizophrenia 4 | 1,160
psoriasis 4 | 6,694
Bladder muscle dysfunction - overactive 3 | 4
Cholinesterase Inhibitors Toxicity 3 | 4
Dysuria 3 | 26
Epilepsy 3 | 792
Gastrointestinal Radiography Adjunct 3 | 11
Increased Urinary Frequency 3 | 11
Muscarine Toxicity 3 | 3
Perioperative Mydriasis 3 | 3
Sinus bradycardia 3 | 7
Urge incontinence of urine 3 | 3
Urgent desire to urinate 3 | 11
Urinary Tract Irritation 3 | 24
medulloblastoma, large-cell 3 | 6,241
Acute cystitis 2 | 35
Allergic rhinitis 2 | 94
Bipolar Disorder 2 | 666
Cycloplegia 2 | 12
Dilated pupil 2 | 6
Enterocolitis 2 | 8
Irritable bowel syndrome 2 | 60
Major Depressive Disorder 2 | 301
Mood Disorders 2 | 184
Nasal discharge 2 | 24
Neurogenic bladder 2 | 16
Parkinson's disease 2 | 392
Retention of urine 2 | 3
Xerostomia Secondary to Sjogren's Syndrome 2 | 2
astrocytic glioma 2 | 2,597
atypical teratoid / rhabdoid tumor 2 | 5,112
diabetes mellitus 2 | 1,728
ependymoma 2 | 4,679
glioblastoma 2 | 5,792
group 4 medulloblastoma 2 | 1,855
oligodendroglioma 2 | 2,850
osteosarcoma 2 | 7,950
ovarian cancer 2 | 8,520
Abnormality of the ribs 1 | 32
Alcohol dependence 1 | 107
Arteriosclerotic Parkinsonism 1 | 8
Ascites 1 | 22
Bradycardia 1 | 36
Brain Injuries 1 | 65
Bronchitis 1 | 43
Chemical and Drug Induced Liver Injury 1 | 195
Chronic schizophrenia 1 | 16
Common cold 1 | 67
Congenital Heart Defects 1 | 58
Congenital heart disease 1 | 93
Congenital pectus carinatum 1 | 52
Cough 1 | 23
Decreased fertility 1 | 33
Dermatologic disorders 1 | 93
Diabetes Mellitus, Experimental 1 | 108
Diabetes Mellitus, Insulin-Dependent 1 | 48
Diabetes Mellitus, Type 1 1 | 43
Diabetic Neuropathies 1 | 14
Dilatation of ureter 1 | 15
Extrapyramidal disease 1 | 8
Hydronephrosis 1 | 89
Iridocyclitis 1 | 19
Marijuana Abuse 1 | 31
Memory Disorders 1 | 40
Motion sickness 1 | 21
Nasal congestion 1 | 21
Neurogenic Urinary Bladder 1 | 6
Ocular hypertension 1 | 42
Open-angle glaucoma 1 | 27
Pelizaeus-Merzbacher disease 1 | 19
Postencephalitic parkinsonism 1 | 12
Prevention of Motion Sickness 1 | 3
Prevention of Posterior Synechiae 1 | 4
Pulmonary emphysema 1 | 48
Pyelonephritis 1 | 13
Recurrent respiratory infections 1 | 141
Recurrent urinary tract infection 1 | 24
Schistosomiasis 1 | 35
Skin Abnormalities 1 | 37
Small testicle 1 | 75
Substance Withdrawal Syndrome 1 | 55
Tremor 1 | 113
Urinary tract obstruction 1 | 11
Urofacial syndrome 1 | 7
Uroureter 1 | 15
Uveitis 1 | 103
Vasomotor rhinitis 1 | 12
Vertigo 1 | 29
Vesico-Ureteral Reflux 1 | 33
Xerostomia 1 | 42

Tissue

Digestive Tract 5 | 17,369
Endocrine System 5 | 18,159
Female tissues 5 | 17,400
Liver and Pancreas 5 | 16,750
Nervous System 5 | 16,725
Respiratory system 5 | 16,393
Skin and soft tissues 5 | 17,230
Blood and immune system 4 | 16,909
Male tissues 4 | 17,142
Urinary Tract 4 | 16,678
Cardiovascular System 2 | 15,192

Target Family

GPCR 5 | 408

GO Function

G-protein coupled acetylcholin... 5 | 5
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Muscarinic acetylcholine receptor M1 CHRM1 Tclin GPCR -2.16159 140.8 222
Muscarinic acetylcholine receptor M5 CHRM5 Tclin GPCR -1.35374 22.9 141
Muscarinic acetylcholine receptor M2 CHRM2 Tclin GPCR -2.70017 498.2 391
Muscarinic acetylcholine receptor M4 CHRM4 Tclin GPCR -1.90995 79.8 130
Muscarinic acetylcholine receptor M3 CHRM3 Tclin GPCR -2.65353 447.9 234