Development Level

Tbio 10 | 10,625
Tchem 1 | 1,890

IMPC Term

preweaning lethality, complete... 2 | 633
abnormal behavior 1 | 226
abnormal spleen morphology 1 | 36
decreased bone mineral content 1 | 157
decreased fasted circulating g... 1 | 49
decreased respiratory quotient 1 | 12
decreased startle reflex 1 | 48
hyperactivity 1 | 108
impaired righting response 1 | 19
increased blood urea nitrogen ... 1 | 44
increased circulating creatini... 1 | 29

Disease

glioblastoma 6 | 5,572
medulloblastoma, large-cell 6 | 6,234
osteosarcoma 6 | 7,933
atypical teratoid / rhabdoid tumor 4 | 4,369
oligodendroglioma 4 | 2,849
ovarian cancer 4 | 8,492
psoriasis 4 | 6,685
subependymal giant cell astrocytoma 4 | 2,287
ulcerative colitis 4 | 2,087
astrocytoma 3 | 1,493
breast carcinoma 3 | 1,614
colon cancer 3 | 1,475
group 3 medulloblastoma 3 | 2,254
invasive ductal carcinoma 3 | 2,950
lung carcinoma 3 | 2,844
pediatric high grade glioma 3 | 2,712
pilocytic astrocytoma 3 | 3,086
posterior fossa group A ependymoma 3 | 1,511
Amnesia 2 | 17
Breast cancer 2 | 3,099
Pick disease 2 | 1,893
Substance Withdrawal Syndrome 2 | 55
acute quadriplegic myopathy 2 | 1,157
adult high grade glioma 2 | 2,148
astrocytic glioma 2 | 2,241
interstitial cystitis 2 | 2,299
juvenile dermatomyositis 2 | 1,189
lung cancer 2 | 4,473
primary Sjogren syndrome 2 | 789
primitive neuroectodermal tumor 2 | 3,031
ACTH-secreting pituitary adenoma 1 | 8
Achromatopsia 1 | 14
Acquired metabolic disease 1 | 267
Alzheimer's disease 1 | 644
Animal Mammary Neoplasms 1 | 136
Ataxia with oculomotor apraxia type 2 1 | 4
Ataxia-oculomotor apraxia 3 1 | 1
Atrioventricular block 1 | 21
Autosomal recessive nonsyndromic deafness 1 | 4
Blindness 1 | 84
Bradycardia 1 | 24
Burkitt Lymphoma 1 | 19
Cholera 1 | 33
Color vision defect 1 | 3
Cone dystrophy 1 | 59
Congenital nystagmus 1 | 26
Congenital stationary night blindness 1 | 28
Crohn's disease 1 | 304
Diffuse large B-cell lymphoma 1 | 42
Duchenne muscular dystrophy 1 | 602
Early infantile epileptic encephalopathy with suppression bursts 1 | 18
Epilepsy 1 | 346
Epileptic encephalopathy, early infantile, 17 1 | 1
Familial ventricular tachycardia 1 | 1
Fundus Albipunctatus 1 | 8
Fundus dystrophy 1 | 77
Gaucher disease type 3 1 | 76
Granulosa cell tumor of the ovary 1 | 1
Major Depressive Disorder 1 | 106
Male infertility 1 | 170
Mammary Neoplasms 1 | 410
Mammary Neoplasms, Experimental 1 | 150
Mental depression 1 | 58
Multiple myeloma 1 | 1,328
Myocardial Ischemia 1 | 169
Myopia 1 | 99
Neoplasm Recurrence, Local 1 | 23
Neurodegenerative disease 1 | 383
Night Blindness 1 | 39
Night blindness, congenital stationary 1 | 14
Ocular albinism 1 | 29
Organ system cancer 1 | 15
Pituitary-dependent Cushing's disease 1 | 8
Polycystic Ovary Syndrome 1 | 335
Progressive cone dystrophy (without rod involvement) 1 | 4
Pseudosarcomatous fibromatosis 1 | 10
Retinal Degeneration 1 | 49
Retinitis pigmentosa 1 | 156
Ventricular Tachycardia, Familial 1 | 1
Waldenstrons macroglobulinemia 1 | 765
acute myeloid leukemia 1 | 785
ataxia with oculomotor apraxia type 3 1 | 1
atypical teratoid/rhabdoid tumor 1 | 1,095
chronic lymphosyte leukemia 1 | 232
cutaneous lupus erythematosus 1 | 1,056
dermatomyositis 1 | 967
diabetes mellitus 1 | 1,663
ductal carcinoma in situ 1 | 1,745
ependymoma 1 | 2,514
facioscapulohumeral dystrophy 1 | 286
fibroadenoma 1 | 557
lung adenocarcinoma 1 | 2,714
mucosa-associated lymphoid tissue lymphoma 1 | 480
non-small cell lung cancer 1 | 2,798
pancreatic cancer 1 | 2,300
primary pancreatic ductal adenocarcinoma 1 | 1,271
sarcoidosis 1 | 368
sonic hedgehog group medulloblastoma 1 | 1,482
spina bifida 1 | 1,064
tuberculosis 1 | 1,563

Tissue

Blood and immune system 11 | 17,995
Cardiovascular System 11 | 17,958
Digestive Tract 11 | 18,473
Endocrine System 11 | 18,512
Female tissues 11 | 18,647
Liver and Pancreas 11 | 18,136
Male tissues 11 | 17,969
Nervous System 11 | 18,561
Respiratory system 11 | 17,484
Skin and soft tissues 11 | 18,115
Urinary Tract 11 | 18,444

Target Family

Non-IDG 10 | 11,969
Enzyme 1 | 4,146

GO Function

G-protein beta/gamma-subunit c... 11 | 11
metal ion binding 1,917 | 1,917
ATP binding 1,467 | 1,467
DNA binding 1,432 | 1,432
zinc ion binding 1,155 | 1,155
poly(A) RNA binding 1,107 | 1,107
transcription factor activity,... 853 | 853
calcium ion binding 695 | 695
G-protein coupled receptor act... 661 | 661
protein homodimerization activ... 569 | 569
RNA binding 445 | 445
olfactory receptor activity 424 | 424
sequence-specific DNA binding 398 | 398
GTP binding 374 | 374
chromatin binding 372 | 372
protein serine/threonine kinas... 336 | 336
RNA polymerase II core promote... 332 | 332
identical protein binding 311 | 311
nucleotide binding 311 | 311
receptor binding 303 | 303
protein kinase binding 289 | 289
enzyme binding 286 | 286
cadherin binding involved in c... 277 | 277
GTPase activator activity 273 | 273
ubiquitin protein ligase bindi... 258 | 258
ubiquitin-protein transferase ... 253 | 253
serine-type endopeptidase acti... 246 | 246
transcription coactivator acti... 241 | 241
transcription factor binding 240 | 240
structural molecule activity 232 | 232
GTPase activity 231 | 231
transcriptional activator acti... 230 | 230
ligase activity 227 | 227
protein heterodimerization act... 227 | 227
structural constituent of ribo... 212 | 212
transcription regulatory regio... 202 | 202
transmembrane signaling recept... 201 | 201
RNA polymerase II regulatory r... 200 | 200
receptor activity 200 | 200
transcription corepressor acti... 198 | 198
magnesium ion binding 197 | 197
signal transducer activity 196 | 196
nucleic acid binding 184 | 184
protein kinase activity 183 | 183
carbohydrate binding 180 | 180
ubiquitin protein ligase activ... 173 | 173
RNA polymerase II transcriptio... 162 | 162
heparin binding 160 | 160
iron ion binding 141 | 141
lipid binding 136 | 136
transporter activity 136 | 136
actin binding 133 | 133
ATPase activity 132 | 132
protein C-terminus binding 129 | 129
heme binding 127 | 127
microtubule binding 123 | 123
protein tyrosine kinase activi... 119 | 119
cytokine activity 118 | 118
Ras guanyl-nucleotide exchange... 113 | 113
mRNA binding 112 | 112
metalloendopeptidase activity 112 | 112
transcriptional repressor acti... 110 | 110
structural constituent of cyto... 108 | 108
Rab GTPase binding 105 | 105
antigen binding 104 | 104
protein domain specific bindin... 102 | 102
peptide antigen binding 101 | 101
guanyl-nucleotide exchange fac... 98 | 98
protein complex binding 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 92 | 92
oxidoreductase activity 91 | 91
transcriptional activator acti... 91 | 91
actin filament binding 89 | 89
hydrolase activity 89 | 89
ion channel binding 89 | 89
protein tyrosine phosphatase a... 88 | 88
electron carrier activity 87 | 87
protease binding 87 | 87
histone binding 86 | 86
integrin binding 83 | 83
growth factor activity 82 | 82
phospholipid binding 82 | 82
single-stranded DNA binding 81 | 81
unfolded protein binding 77 | 77
kinase activity 75 | 75
thiol-dependent ubiquitin-spec... 75 | 75
phosphatidylinositol binding 74 | 74
calmodulin binding 73 | 73
histone deacetylase binding 73 | 73
Rho guanyl-nucleotide exchange... 72 | 72
drug binding 71 | 71
double-stranded DNA binding 70 | 70
peptidase activity 70 | 70
protein N-terminus binding 70 | 70
virus receptor activity 68 | 68
beta-catenin binding 67 | 67
microtubule motor activity 67 | 67
protein transporter activity 67 | 67
calcium channel activity 66 | 66
ubiquitin binding 66 | 66

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