Development Level

Tbio 17 | 11,651
Tchem 4 | 1,388

IMPC Phenotype

abnormal embryo size 2 | 220
preweaning lethality, complete... 2 | 979
abnormal coat-hair pigmentatio... 1 | 64
abnormal craniofacial morpholo... 1 | 33
abnormal embryo turning 1 | 31
abnormal epididymis morphology 1 | 42
abnormal eye morphology 1 | 68
abnormal lung morphology 1 | 26
abnormal neural tube closure 1 | 46
abnormal tail bud morphology 1 | 8
abnormal vitreous body morphol... 1 | 10
abnormal vocalization 1 | 21
anophthalmia 1 | 33
decreased fasted circulating g... 1 | 65
edema 1 | 59
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
enlarged lymph nodes 1 | 37
hyperactivity 1 | 148
hypoactivity 1 | 132
increased blood urea nitrogen ... 1 | 48
increased bone mineral density 1 | 72
increased circulating sodium l... 1 | 71
increased fasted circulating g... 1 | 76
increased mean corpuscular hem... 1 | 96
pallor 1 | 34
persistence of hyaloid vascula... 1 | 33
preweaning lethality, incomple... 1 | 499
short tibia 1 | 97
small kidney 1 | 16

Disease

Carcinoma 16 | 11,493
osteosarcoma 12 | 7,950
ovarian cancer 11 | 8,520
medulloblastoma, large-cell 10 | 6,241
glioblastoma 9 | 5,792
Autosomal recessive predisposition 7 | 1,442
lung cancer 7 | 4,740
malignant mesothelioma 7 | 3,232
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
psoriasis 7 | 6,694
Liver Cirrhosis, Experimental 6 | 769
Schizophrenia 6 | 1,160
atypical teratoid / rhabdoid tumor 6 | 5,112
subependymal giant cell astrocytoma 6 | 2,287
Astrocytoma, Pilocytic 5 | 3,081
Breast cancer 5 | 3,578
Cognitive delay 5 | 608
Global developmental delay 5 | 608
Mental and motor retardation 5 | 608
adult high grade glioma 5 | 3,801
ependymoma 5 | 4,679
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
invasive ductal carcinoma 5 | 2,951
primitive neuroectodermal tumor 5 | 3,035
Dull intelligence 4 | 645
Failure to gain weight 4 | 365
Infantile onset 4 | 238
Intellectual disability 4 | 1,016
Low intelligence 4 | 645
Mental Retardation 4 | 645
Mental deficiency 4 | 645
Muscle hypotonia 4 | 571
Pediatric failure to thrive 4 | 365
Poor school performance 4 | 645
ductal carcinoma in situ 4 | 1,745
group 3 medulloblastoma 4 | 4,104
oligodendroglioma 4 | 2,850
spina bifida 4 | 1,074
tuberculosis 4 | 2,010
Bipolar Disorder 3 | 666
Epilepsy 3 | 792
Nystagmus 3 | 317
Proteinuria 3 | 144
Respiratory Insufficiency 3 | 132
Respiratory function loss 3 | 121
Rheumatoid arthritis 3 | 1,191
Seizures 3 | 596
Velocardiofacial syndrome 3 | 46
astrocytic glioma 3 | 2,597
breast carcinoma 3 | 1,638
cutaneous lupus erythematosus 3 | 1,057
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
lung carcinoma 3 | 2,843
nephrosclerosis 3 | 333
non-small cell lung cancer 3 | 2,890
Cancer 2 | 2,499
Cerebral atrophy 2 | 178
Depressive disorder 2 | 409
Developmental regression 2 | 95
Down syndrome 2 | 499
Electroencephalogram abnormal 2 | 101
Generalized muscle weakness 2 | 57
Homocystinuria 2 | 21
Hyperhomocysteinemia 2 | 37
Hyperhomocystinemia 2 | 6
Kidney Diseases 2 | 114
Loss of developmental milestones 2 | 95
Mental deterioration in childhood 2 | 95
Methylmalonic acidemia 2 | 37
Muscle Hypertonia 2 | 88
Nervous System Diseases 2 | 53
Neurodevelopmental regression 2 | 95
Neurogenic Muscular Atrophy 2 | 139
Neurogenic muscle atrophy, especially in the lower limbs 2 | 139
Pick disease 2 | 1,894
Pilocytic astrocytoma 2 | 56
Primary hyperoxaluria 2 | 15
Psychomotor regression 2 | 95
Psychomotor regression beginning in infancy 2 | 95
Psychomotor regression in infants 2 | 95
Psychomotor regression, progressive 2 | 95
Schizoaffective Disorder 2 | 55
Sensorineural Hearing Loss (disorder) 2 | 284
Skeletal muscle atrophy 2 | 139
Strabismus 2 | 270
Zellweger syndrome 2 | 37
active ulcerative colitis 2 | 764
adrenocortical carcinoma 2 | 1,428
aldosterone-producing adenoma 2 | 665
gastric carcinoma 2 | 807
interstitial cystitis 2 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
juvenile dermatomyositis 2 | 1,187
lung adenocarcinoma 2 | 2,716
muscle degeneration 2 | 139
nervous system disorder 2 | 53
pancreatic cancer 2 | 2,398
pancreatic carcinoma 2 | 562
pediatric high grade glioma 2 | 1,064
sonic hedgehog group medulloblastoma 2 | 467

Tissue

Blood and immune system 21 | 16,909
Digestive Tract 21 | 17,369
Endocrine System 21 | 18,159
Liver and Pancreas 21 | 16,750
Nervous System 21 | 16,725
Urinary Tract 21 | 16,678
Female tissues 20 | 17,400
Respiratory system 20 | 16,393
Skin and soft tissues 20 | 17,230
Cardiovascular System 19 | 15,192
Male tissues 19 | 17,142

Target Family

Enzyme 17 | 4,145
Non-IDG 3 | 12,091
Epigenetic 1 | 242

GO Function

FAD binding 21 | 21
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Hydroxyproline dehydrogenase PRODH2 Tbio Enzyme -0.72861 5.94 76
Proline dehydrogenase 1, mitochondrial PRODH Tbio Enzyme -2.88785 779.3 222
Apoptosis-inducing factor 1, mitochondrial AIFM1 Tbio Non-IDG -1.74072 50.5 637
NADH-cytochrome b5 reductase 3 CYB5R3 Tbio Enzyme -1.96694 94.6 261
Cryptochrome-2 CRY2 Tbio Non-IDG -2.39567 232.3 149
Peroxisomal acyl-coenzyme A oxidase 3 ACOX3 Tbio Enzyme -1.26872 15.0 70
Kynurenine 3-monooxygenase KMO Tchem Enzyme -2.15501 134.1 127
D-amino-acid oxidase DAO Tchem Enzyme -2.43018 262.5 215
D-2-hydroxyglutarate dehydrogenase, mitochondrial D2HGDH Tbio Enzyme -1.02855 10.8 65
Alkyldihydroxyacetonephosphate synthase, peroxisomal AGPS Tbio Enzyme -2.84508 679.5 84