Development Level

Tbio 32 | 11,651
Tchem 3 | 1,388

IMPC Phenotype

decreased total body fat amoun... 2 | 207
increased bone mineral density 2 | 72
increased lean body mass 2 | 172
abnormal retina morphology 1 | 71
decreased blood urea nitrogen ... 1 | 51
decreased caudal vertebrae num... 1 | 53
decreased circulating alanine ... 1 | 47
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating triglyce... 1 | 79
decreased fasted circulating g... 1 | 65
decreased vertical activity 1 | 208
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
increased bone mineral content 1 | 108
increased fasted circulating g... 1 | 76
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
prenatal lethality prior to he... 1 | 87
preweaning lethality, incomple... 1 | 499
small superior vagus ganglion 1 | 74
thrombocytopenia 1 | 56

Disease

Carcinoma 21 | 11,493
psoriasis 20 | 6,694
osteosarcoma 19 | 7,950
medulloblastoma, large-cell 18 | 6,241
ovarian cancer 18 | 8,520
Cancer 16 | 2,499
lung cancer 15 | 4,740
glioblastoma 14 | 5,792
invasive ductal carcinoma 13 | 2,951
non-small cell lung cancer 12 | 2,890
pancreatic cancer 12 | 2,398
Breast cancer 11 | 3,578
atypical teratoid / rhabdoid tumor 11 | 5,112
ductal carcinoma in situ 11 | 1,745
ependymoma 11 | 4,679
oligodendroglioma 11 | 2,850
primitive neuroectodermal tumor 11 | 3,035
Astrocytoma, Pilocytic 10 | 3,081
astrocytic glioma 10 | 2,597
group 3 medulloblastoma 10 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,291
lung adenocarcinoma 10 | 2,716
diabetes mellitus 9 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,989
malignant mesothelioma 9 | 3,232
Bipolar Disorder 8 | 666
acute quadriplegic myopathy 8 | 1,158
breast carcinoma 8 | 1,638
subependymal giant cell astrocytoma 8 | 2,287
gastric carcinoma 7 | 807
interstitial cystitis 7 | 2,312
lung carcinoma 7 | 2,843
pediatric high grade glioma 7 | 1,064
pituitary cancer 7 | 1,972
ulcerative colitis 7 | 1,819
Schizophrenia 6 | 1,160
cystic fibrosis 6 | 1,696
juvenile dermatomyositis 6 | 1,187
tuberculosis 6 | 2,010
Kidney cancer 5 | 2,613
Rheumatoid arthritis 5 | 1,191
Strabismus 5 | 270
adrenocortical carcinoma 5 | 1,428
group 4 medulloblastoma 5 | 1,855
primary pancreatic ductal adenocarcinoma 5 | 1,109
Chronic Lymphocytic Leukemia 4 | 262
Cleft Palate 4 | 271
Congenital Heart Defects 4 | 58
Neoplasm Invasiveness 4 | 161
Obesity 4 | 678
Parkinson's disease 4 | 392
Stomach Neoplasms 4 | 300
acute myeloid leukemia 4 | 783
adult high grade glioma 4 | 3,801
aldosterone-producing adenoma 4 | 665
astrocytoma 4 | 1,146
autosomal dominant Emery-Dreifuss muscular dystrophy 4 | 510
colon cancer 4 | 1,478
fibroadenoma 4 | 559
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
primary Sjogren syndrome 4 | 735
Breast Neoplasms 3 | 445
Cell Transformation, Neoplastic 3 | 97
Chemical and Drug Induced Liver Injury 3 | 195
Deafness 3 | 198
Disease Progression 3 | 136
Epilepsy 3 | 792
Heart Defects, Congenital 3 | 37
Liver Cirrhosis, Experimental 3 | 769
Liver neoplasms 3 | 130
Major Depressive Disorder 3 | 301
Mammary Neoplasms 3 | 425
Mental Depression 3 | 333
Mood Disorders 3 | 184
Myocardial Ischemia 3 | 169
Neoplasm Metastasis 3 | 168
Neoplastic Cell Transformation 3 | 89
Pancreatic Neoplasm 3 | 85
Pancreatic Neoplasms 3 | 85
Pitt-Hopkins syndrome 3 | 20
Prostatic Neoplasms 3 | 495
Seasonal affective disorder 3 | 28
Skin cancer 3 | 469
Vascular disease 3 | 319
active ulcerative colitis 3 | 764
dermatomyositis 3 | 966
head and neck cancer 3 | 271
medulloblastoma 3 | 720
nasopharyngeal carcinoma 3 | 1,058
nephrosclerosis 3 | 333
Acrocephalosyndactylia 2 | 17
Carcinoma, Hepatocellular 2 | 228
Colonic Neoplasms 2 | 142
Intracranial hypertension 2 | 32
Liver carcinoma 2 | 240
Lung Neoplasms 2 | 232
Myopathy 2 | 185
Unipolar Depression 2 | 250
atypical teratoid/rhabdoid tumor 2 | 357

Tissue

Digestive Tract 33 | 17,369
Endocrine System 33 | 18,159
Female tissues 33 | 17,400
Skin and soft tissues 32 | 17,230
Male tissues 31 | 17,142
Blood and immune system 30 | 16,909
Liver and Pancreas 30 | 16,750
Nervous System 30 | 16,725
Cardiovascular System 29 | 15,192
Urinary Tract 29 | 16,678
Respiratory system 28 | 16,393

Target Family

Transcription Factor 31 | 1,400
Non-IDG 3 | 12,091
TF/Epigenetic 1 | 38

GO Function

E-box binding 35 | 35
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Transcription factor AP-4 TFAP4 Tbio Transcription Factor -1.33384 19.4 276
Aryl hydrocarbon receptor nuclear translocator-like protein 2 ARNTL2 Tbio Transcription Factor -2.09050 123.6 94
Protein max MAX Tbio Transcription Factor -2.14268 110.6 398
Heart- and neural crest derivatives-expressed protein 2 HAND2 Tbio Transcription Factor -2.99854 926.7 220
Neurogenic differentiation factor 1 NEUROD1 Tbio Transcription Factor -2.56661 344.4 371
Myogenin MYOG Tbio Transcription Factor -2.97963 827.3 659
Myoblast determination protein 1 MYOD1 Tbio Transcription Factor -3.16910 1355.7 632
Myc proto-oncogene protein MYC Tbio Transcription Factor -4.11278 12358.0 2705
Circadian locomoter output cycles protein kaput CLOCK Tbio TF/Epigenetic -2.63013 392.7 323
Microphthalmia-associated transcription factor MITF Tbio Transcription Factor -3.09082 1244.1 549