Development Level

Tbio 19 | 11,178
Tchem 3 | 1,885
Tclin 3 | 612
Tdark 3 | 6,569

IMPC Phenotype

preweaning lethality, complete... 7 | 979
embryonic lethality prior to o... 3 | 239
abnormal retina morphology 1 | 71
decreased body length 1 | 101
decreased erythrocyte cell num... 1 | 62
decreased mean corpuscular hem... 1 | 31
embryonic lethality prior to t... 1 | 278
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased mean corpuscular vol... 1 | 92
male infertility 1 | 123
prenatal lethality prior to he... 1 | 87
preweaning lethality, incomple... 1 | 499
tremors 1 | 39

Disease

Carcinoma 18 | 11,192
osteosarcoma 15 | 7,766
group 3 medulloblastoma 13 | 4,002
ovarian cancer 12 | 8,297
medulloblastoma, large-cell 11 | 6,086
Cancer 10 | 2,388
glioblastoma 10 | 5,635
primitive neuroectodermal tumor 10 | 2,957
psoriasis 10 | 6,514
malignant mesothelioma 8 | 3,135
atypical teratoid / rhabdoid tumor 7 | 4,971
non-small cell lung cancer 7 | 2,799
adult high grade glioma 6 | 3,701
ependymoma 6 | 4,559
lung cancer 5 | 4,607
Astrocytoma, Pilocytic 4 | 3,006
Xeroderma pigmentosum 4 | 42
diabetes mellitus 4 | 1,683
invasive ductal carcinoma 4 | 2,867
Acute lymphoid leukemia 3 | 25
Acute myeloid leukemia, disease 3 | 30
Acute promyelocytic leukemia, FAB M3 3 | 11
Adenocarcinoma of pancreas 3 | 14
Autosomal recessive predisposition 3 | 1,407
Bell Palsy 3 | 57
Blepharoptosis 3 | 229
Breast cancer 3 | 3,469
Colorectal Neoplasms 3 | 235
Facial Paresis 3 | 58
Facial muscle weakness of muscles innervated by CN VII 3 | 57
Lymphomatous meningitis 3 | 3
Malignant tumor of ovary 3 | 25
Meningeal Leukemia 3 | 7
Metastatic Breast Carcinoma 3 | 21
acute myeloid leukemia 3 | 760
adrenocortical carcinoma 3 | 1,385
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,872
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,204
lung adenocarcinoma 3 | 2,627
Abnormal vision 2 | 51
Adult onset 2 | 81
Atrophic condition of skin 2 | 24
Chronic progressive external ophthalmoplegia 2 | 24
Cockayne syndrome 2 | 59
Cognitive delay 2 | 596
Creatine phosphokinase serum increased 2 | 110
Cryptorchidism 2 | 287
Deafness 2 | 193
Decreased activity of cytochrome C oxidase in muscle tissue 2 | 10
Deglutition Disorders 2 | 128
Elevated creatine kinase 2 | 110
Elevated hepatic transaminases 2 | 79
Epilepsy 2 | 775
Familial adenomatous polyposis 2 | 32
Global developmental delay 2 | 596
Hepatic enzyme increased 2 | 79
Hepatomegaly 2 | 280
Highly variable severity 2 | 149
Impaired exercise tolerance 2 | 42
Increased serum lactate 2 | 60
Kidney cancer 2 | 2,548
Liver Dysfunction 2 | 97
Liver enzymes abnormal 2 | 79
Liver function test increased 2 | 79
Liver function tests abnormal finding 2 | 79
Lynch syndrome 2 | 34
Mental and motor retardation 2 | 596
Multiple mitochondrial DNA (mtDNA) deletions 2 | 5
Muscle hypotonia 2 | 562
Muscle weakness of limb 2 | 21
Muscle weakness, progressive 2 | 22
Neuropathy 2 | 254
Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions, Autosomal Dominant 1 2 | 5
Progressive External Ophthalmoplegia with Mitochondrial DNA Deletions, Autosomal Dominant, 1 2 | 5
Progressive disorder 2 | 139
Rheumatoid arthritis 2 | 1,156
Seizures 2 | 584
Sensorineural Hearing Loss (disorder) 2 | 281
Spider Veins 2 | 17
Subclinical abnormal liver function tests 2 | 79
Telangiectasis 2 | 35
Transaminases increased 2 | 79
Variable expressivity 2 | 149
colon cancer 2 | 1,428
gastric cancer 2 | 445
group 4 medulloblastoma 2 | 1,806
hepatocellular carcinoma 2 | 536
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,902
juvenile dermatomyositis 2 | 1,147
non primary Sjogren syndrome sicca 2 | 861
oligodendroglioma 2 | 2,768
pediatric high grade glioma 2 | 1,035
posterior fossa group B ependymoma 2 | 406
progressive supranuclear palsy 2 | 656
tuberculosis 2 | 1,963
Dysphonia 1 | 7
Ectropion 1 | 36
Mitochondrial encephalomyopathy 1 | 15
Mobius syndrome 1 | 5
Werner syndrome 1 | 29

Tissue

Blood and immune system 27 | 16,909
Digestive Tract 27 | 17,369
Endocrine System 27 | 18,159
Cardiovascular System 26 | 15,192
Female tissues 26 | 17,400
Liver and Pancreas 26 | 16,750
Male tissues 26 | 17,142
Nervous System 26 | 16,725
Respiratory system 26 | 16,393
Skin and soft tissues 26 | 17,230
Urinary Tract 26 | 16,678

Target Family

Enzyme 25 | 4,145
Non-IDG 3 | 12,091

GO Function

DNA-directed DNA polymerase ac... 28 | 28
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA polymerase kappa POLK Tbio Enzyme -2.42142 256.3 224
DNA polymerase subunit gamma-1 POLG Tchem Enzyme -2.63005 414.1 128
Myb-binding protein 1A MYBBP1A Tbio Non-IDG -1.24204 21.4 192
DNA polymerase zeta catalytic subunit REV3L Tbio Enzyme -2.20108 158.5 41
DNA nucleotidylexotransferase DNTT Tchem Enzyme -3.41739 1725.2 436
DNA polymerase delta subunit 4 POLD4 Tbio Enzyme -0.84887 7.32 24
Endogenous retrovirus group K member 9 Pol protein ERVK-9 Tdark Non-IDG 0.00000 0
Non-canonical poly(A) RNA polymerase PAPD5 PAPD5 Tbio Enzyme -0.76848 4.57 124
DNA polymerase iota POLI Tbio Enzyme -3.24008 1701.9 333
DNA primase large subunit PRIM2 Tbio Enzyme 0.00000 89