Development Level

Tbio 20 | 11,651
Tchem 4 | 1,388
Tclin 1 | 612

IMPC Phenotype

decreased circulating iron lev... 1 | 32
embryonic lethality prior to t... 1 | 278
increased circulating alkaline... 1 | 122
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
preweaning lethality, complete... 1 | 979

Disease

Carcinoma 22 | 11,493
Breast cancer 12 | 3,578
ovarian cancer 12 | 8,520
osteosarcoma 11 | 7,950
Cancer 10 | 2,499
Kidney cancer 10 | 2,613
medulloblastoma, large-cell 10 | 6,241
Autosomal recessive predisposition 9 | 1,442
group 3 medulloblastoma 9 | 4,104
lung cancer 9 | 4,740
psoriasis 9 | 6,694
Fetal Growth Retardation 8 | 189
Infant, Small for Gestational Age 8 | 176
Intellectual disability 8 | 1,016
Intrauterine retardation 8 | 176
Small head 8 | 374
malignant mesothelioma 8 | 3,232
Cockayne syndrome 7 | 60
atypical teratoid / rhabdoid tumor 7 | 5,112
glioblastoma 7 | 5,792
Cryptorchidism 6 | 296
Dull intelligence 6 | 645
Epilepsy 6 | 792
Low intelligence 6 | 645
Mental Retardation 6 | 645
Mental deficiency 6 | 645
Muscle hypotonia 6 | 571
Poor school performance 6 | 645
Seizures 6 | 596
Short stature 6 | 531
ependymoma 6 | 4,679
lung adenocarcinoma 6 | 2,716
primitive neuroectodermal tumor 6 | 3,035
Breast Neoplasms 5 | 445
Cognitive delay 5 | 608
Fanconi anemia 5 | 56
Global developmental delay 5 | 608
Mammary Neoplasms 5 | 425
Mental and motor retardation 5 | 608
adult high grade glioma 5 | 3,801
invasive ductal carcinoma 5 | 2,951
nasopharyngeal carcinoma 5 | 1,058
Basal cell carcinoma 4 | 54
Chromosome Breakage 4 | 36
Death in early childhood 4 | 82
Death in infancy 4 | 82
Failure to gain weight 4 | 365
Hyperpigmented macules 4 | 42
Leukemia 4 | 104
Liver cancer 4 | 604
Multiple myeloma 4 | 1,332
Muscle Hypertonia 4 | 88
Neuroblastoma 4 | 80
Ovarian Neoplasms 4 | 102
Pediatric failure to thrive 4 | 365
Photosensitive trichothiodystrophy 4 | 30
Stomach Neoplasms 4 | 300
Xeroderma pigmentosum 4 | 43
colon cancer 4 | 1,478
hearing impairment 4 | 199
non-small cell lung cancer 4 | 2,890
ovarian neoplasm 4 | 99
pituitary cancer 4 | 1,972
Acquired scoliosis 3 | 281
Adenocarcinoma of lung 3 | 142
Broad flat nasal bridge 3 | 236
Cerebellar hypoplasia and atrophy 3 | 41
Congenital deafness 3 | 185
Constipation 3 | 181
Curvature of spine 3 | 282
Deafness 3 | 198
Decreased platelet count 3 | 111
Decreased tendon reflex 3 | 122
Dental caries 3 | 164
Dyschezia 3 | 135
Fatigue 3 | 182
Feeding difficulties in infancy 3 | 175
Flexion contracture of proximal interphalangeal joint 3 | 75
Hearing Loss, Partial 3 | 185
Low Birth Weights 3 | 69
Lymphoma 3 | 81
Lynch syndrome 3 | 35
Nasal bridge wide 3 | 236
Prostatic Neoplasms 3 | 495
Short neck 3 | 140
Small for gestational age (disorder) 3 | 69
Strabismus 3 | 270
Thrombocytopenia 3 | 197
Waldenstrons macroglobulinemia 3 | 765
Xeroderma pigmentosum group D 3 | 33
astrocytoma 3 | 1,146
dermatomyositis 3 | 966
diabetes mellitus 3 | 1,728
ductal carcinoma in situ 3 | 1,745
hypopigmented skin patch 3 | 59
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
juvenile dermatomyositis 3 | 1,187
oligodendroglioma 3 | 2,850
pancreatic cancer 3 | 2,398
tuberculosis 3 | 2,010

Tissue

Blood and immune system 25 | 16,909
Digestive Tract 25 | 17,369
Endocrine System 25 | 18,159
Female tissues 25 | 17,400
Liver and Pancreas 25 | 16,750
Male tissues 25 | 17,142
Nervous System 25 | 16,725
Respiratory system 25 | 16,393
Skin and soft tissues 25 | 17,230
Urinary Tract 25 | 16,678
Cardiovascular System 24 | 15,192

Target Family

Non-IDG 15 | 12,091
Epigenetic 5 | 242
Enzyme 4 | 4,145
Kinase 1 | 634

GO Function

DNA-dependent ATPase activity 25 | 25
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
MutS protein homolog 5 MSH5 Tbio Non-IDG -1.75314 0.00000 142
Chromodomain-helicase-DNA-binding protein 8 CHD8 Tbio Epigenetic -1.64766 47.4 81
DNA repair protein RAD51 homolog 3 RAD51C Tbio Non-IDG -1.92798 88.3 269
DNA repair protein XRCC2 XRCC2 Tbio Non-IDG -2.76304 492.9 270
Probable global transcription activator SNF2L2 SMARCA2 Tchem Epigenetic -2.57435 345.3 153
Transcription activator BRG1 SMARCA4 Tchem Epigenetic -2.86389 713.1 332
DNA-binding protein SMUBP-2 IGHMBP2 Tbio Non-IDG -1.90459 79.9 52
DNA repair protein RAD51 homolog 2 RAD51B Tbio Non-IDG -1.94564 84.8 171
Cyclin-dependent kinase 7 CDK7 Tchem Kinase -2.35186 219.0 582
DNA repair protein RAD51 homolog 4 RAD51D Tbio Non-IDG -1.53387 26.9 226