Development Level

Tbio 15 | 11,651

IMPC Phenotype

preweaning lethality, complete... 2 | 979
decreased caudal vertebrae num... 1 | 53
decreased circulating alanine ... 1 | 47

Disease

Carcinoma 13 | 11,493
psoriasis 10 | 6,694
group 3 medulloblastoma 9 | 4,104
lung cancer 9 | 4,740
glioblastoma 7 | 5,792
medulloblastoma, large-cell 7 | 6,241
osteosarcoma 7 | 7,950
ovarian cancer 7 | 8,520
adrenocortical carcinoma 6 | 1,428
atypical teratoid / rhabdoid tumor 6 | 5,112
malignant mesothelioma 6 | 3,232
non-small cell lung cancer 6 | 2,890
primitive neuroectodermal tumor 6 | 3,035
adult high grade glioma 5 | 3,801
ependymoma 5 | 4,679
Autosomal recessive predisposition 4 | 1,442
Breast cancer 4 | 3,578
Meier-Gorlin syndrome 4 | 10
ductal carcinoma in situ 4 | 1,745
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
invasive ductal carcinoma 4 | 2,951
lung adenocarcinoma 4 | 2,716
oligodendroglioma 4 | 2,850
Cancer 3 | 2,499
EAR, PATELLA, SHORT STATURE SYNDROME 3 | 7
Fetal Growth Retardation 3 | 189
Infant, Small for Gestational Age 3 | 176
Intrauterine retardation 3 | 176
Microcephaly 3 | 166
Multiple myeloma 3 | 1,332
Rothmund-Thomson syndrome 3 | 19
Small head 3 | 374
colon cancer 3 | 1,478
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
Atopic dermatitis 2 | 952
Birth length less than 3rd percentile 2 | 6
Cognitive delay 2 | 608
Congenital hypoplasia of breast 2 | 25
Congenital small ears 2 | 48
Delayed bone age 2 | 136
DiGeorge syndrome 2 | 47
Failure to gain weight 2 | 365
Feeding difficulties 2 | 127
Global developmental delay 2 | 608
Hypertrophy of clitoris 2 | 40
Isolated growth hormone deficiency 2 | 30
Kidney cancer 2 | 2,613
Mental and motor retardation 2 | 608
Microstomia 2 | 78
Muscle hypotonia 2 | 571
Pediatric failure to thrive 2 | 365
Pulmonary emphysema 2 | 48
Seckel syndrome 2 | 34
Slender, gracile long tubular bones 2 | 21
diabetes mellitus 2 | 1,728
nasopharyngeal carcinoma 2 | 1,058
Adenocarcinoma 1 | 122
Astigmatism 1 | 54
Autosomal recessive Robinow syndrome 1 | 27
Capuchin ears 1 | 17
Carcinoma, Renal Cell 1 | 124
Cardiomyopathy, Hypertrophic 1 | 24
Corneal edema 1 | 14
Cupped ears (finding) 1 | 17
Decreased projection of maxilla 1 | 66
Deficiency of upper jaw bones 1 | 66
Dyspnea 1 | 76
Endocarditis 1 | 19
Fanconi anemia 1 | 56
Full lower lip 1 | 64
Gastritis 1 | 47
Genu varum 1 | 29
HIV Infections 1 | 102
Hypoplasia of the maxilla 1 | 66
Hypotrophic maxilla 1 | 66
Infarction, Middle Cerebral Artery 1 | 33
Infectious disease of lung 1 | 29
Keratoconus 1 | 113
Leukodystrophy 1 | 55
Maxillary retrognathia 1 | 66
Multiple pulmonary infections 1 | 29
Narrow thorax 1 | 53
Neonatal onset 1 | 21
Overactive bladder syndrome 1 | 14
Patella aplasia-hypoplasia 1 | 12
Pelvic inflammatory disease 1 | 21
Progressive spasticity 1 | 6
Prominent lower lip 1 | 64
Recurrent pneumonia 1 | 29
Recurrent pulmonary infections 1 | 29
Renal Cell Carcinoma 1 | 214
Retrusion of upper jaw bones 1 | 66
Roberts syndrome 1 | 15
Short ribs 1 | 30
Short thorax 1 | 21
Tetanus 1 | 68
Tularemia 1 | 23
Urgency frequency syndrome 1 | 14
Velocardiofacial syndrome 1 | 46
Xeroderma pigmentosum group D 1 | 33

Tissue

Blood and immune system 14 | 16,909
Cardiovascular System 14 | 15,192
Digestive Tract 14 | 17,369
Endocrine System 14 | 18,159
Female tissues 14 | 17,400
Liver and Pancreas 14 | 16,750
Male tissues 14 | 17,142
Nervous System 14 | 16,725
Respiratory system 14 | 16,393
Skin and soft tissues 14 | 17,230
Urinary Tract 14 | 16,678

Target Family

Non-IDG 11 | 12,091
Enzyme 3 | 4,145
TF/Epigenetic 1 | 38

GO Function

DNA replication origin binding 15 | 15
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Origin recognition complex subunit 6 ORC6 Tbio Non-IDG -1.38268 26.3 165
Origin recognition complex subunit 4 ORC4 Tbio Non-IDG -1.52127 33.7 155
60 kDa heat shock protein, mitochondrial HSPD1 Tbio Non-IDG -3.55978 3802.6 1303
DNA replication licensing factor MCM2 MCM2 Tbio Non-IDG -2.41622 246.0 777
Putative metaphase chromosome protein 1 HSMCR30 Tbio Enzyme 0.00000 0
Origin recognition complex subunit 2 ORC2 Tbio Non-IDG -0.68275 4.92 168
ATP-dependent RNA helicase A DHX9 Tbio Enzyme -2.85807 734.3 204
Origin recognition complex subunit 5 ORC5 Tbio Non-IDG -1.50983 31.3 71
Cell division control protein 45 homolog CDC45 Tbio Non-IDG -2.10913 117.6 265
Glutamate-rich WD repeat-containing protein 1 GRWD1 Tbio Non-IDG -0.77781 6.68 103