Development Level

Tbio 11 | 11,445
Tchem 5 | 1,598

IMPC Phenotype

preweaning lethality, complete... 3 | 979
abnormal craniofacial morpholo... 1 | 33
abnormal embryo size 1 | 220
abnormal limb morphology 1 | 13
abnormal snout morphology 1 | 23
decreased eosinophil cell numb... 1 | 24
decreased prepulse inhibition 1 | 82
edema 1 | 59
increased grip strength 1 | 41
male infertility 1 | 123
preweaning lethality, incomple... 1 | 499

Disease

ovarian cancer 11 | 8,520
Carcinoma 9 | 11,493
medulloblastoma, large-cell 9 | 6,241
Cancer 8 | 2,499
lung cancer 8 | 4,740
psoriasis 8 | 6,694
Breast cancer 7 | 3,578
Cognitive delay 6 | 608
Global developmental delay 6 | 608
Mental and motor retardation 6 | 608
Short stature 6 | 531
atypical teratoid / rhabdoid tumor 6 | 5,112
invasive ductal carcinoma 6 | 2,951
lung adenocarcinoma 6 | 2,716
osteosarcoma 6 | 7,950
Acquired scoliosis 5 | 281
Curvature of spine 5 | 282
Waldenstrons macroglobulinemia 5 | 765
adult high grade glioma 5 | 3,801
glioblastoma 5 | 5,792
group 3 medulloblastoma 5 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
non-small cell lung cancer 5 | 2,890
primitive neuroectodermal tumor 5 | 3,035
Autosomal recessive predisposition 4 | 1,442
Dull intelligence 4 | 645
Intellectual disability 4 | 1,016
Kidney cancer 4 | 2,613
Low intelligence 4 | 645
Mental Retardation 4 | 645
Mental deficiency 4 | 645
Multiple myeloma 4 | 1,332
Poor school performance 4 | 645
Small head 4 | 374
acute quadriplegic myopathy 4 | 1,158
ductal carcinoma in situ 4 | 1,745
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
pancreatic cancer 4 | 2,398
Almond-shaped eyes 3 | 23
Anemia 3 | 365
Bloom syndrome 3 | 29
Chromosome Breakage 3 | 36
Decreased platelet count 3 | 111
Endometriosis 3 | 540
Fanconi anemia 3 | 56
Increased chromosomal breakage 3 | 27
Irregular hyperpigmentation 3 | 33
Leukopenia 3 | 72
Pyridoxine-responsive sideroblastic anemia 3 | 17
Radial aplasia/hypoplasia 3 | 29
Short palpebral fissure 3 | 38
Thrombocytopenia 3 | 197
breast carcinoma 3 | 1,638
colon cancer 3 | 1,478
diabetes mellitus 3 | 1,728
hypopigmented skin patch 3 | 59
juvenile dermatomyositis 3 | 1,187
Atopic dermatitis 2 | 952
Breast Neoplasms 2 | 445
Cardiovascular system disease 2 | 246
Cockayne syndrome 2 | 60
Concave bridge of nose 2 | 195
Congenital deafness 2 | 185
Cryptorchidism 2 | 296
Deafness 2 | 198
Dental abnormalities 2 | 60
Depressed nasal bridge 2 | 195
Depressed nasal root/bridge 2 | 195
Esophageal atresia 2 | 43
Esophageal atresia with or without tracheoesophageal fistula 2 | 21
HIV Infections 2 | 102
Hearing Loss, Partial 2 | 185
Joint hyperflexibility 2 | 78
Mammary Neoplasms 2 | 425
Muscle hypotonia 2 | 571
Myocardial Infarction 2 | 151
Neurodegenerative disease 2 | 414
Strabismus 2 | 270
Tooth Abnormalities 2 | 69
Tracheoesophageal Fistula 2 | 36
Vascular disease 2 | 319
adrenocortical carcinoma 2 | 1,428
astrocytoma 2 | 1,146
dermatomyositis 2 | 966
ependymoma 2 | 4,679
esophageal atresia/tracheoesophageal fistula 2 | 22
hearing impairment 2 | 199
malignant mesothelioma 2 | 3,232
nasopharyngeal carcinoma 2 | 1,058
oligodendroglioma 2 | 2,850
pancreatic carcinoma 2 | 562
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
pituitary cancer 2 | 1,972
primary Sjogren syndrome 2 | 735
subependymal giant cell astrocytoma 2 | 2,287
Defective tooth enamel 1 | 31
Dystrophic tooth enamel 1 | 31
ODONTOID HYPOPLASIA 1 | 16
Overfolded helix 1 | 24
Short distal phalanges 1 | 50

Tissue

Blood and immune system 16 | 16,909
Cardiovascular System 16 | 15,192
Digestive Tract 16 | 17,369
Endocrine System 16 | 18,159
Female tissues 16 | 17,400
Liver and Pancreas 16 | 16,750
Male tissues 16 | 17,142
Nervous System 16 | 16,725
Respiratory system 16 | 16,393
Skin and soft tissues 16 | 17,230
Urinary Tract 16 | 16,678

Target Family

Non-IDG 9 | 12,091
Enzyme 5 | 4,145
Epigenetic 1 | 242
Transcription Factor 1 | 1,400

GO Function

DNA polymerase binding 16 | 16
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Telomerase-binding protein EST1A SMG6 Tbio Enzyme -1.48788 32.6 37
RNA cytidine acetyltransferase NAT10 Tbio Enzyme -1.79762 61.5 125
Protein SMG5 SMG5 Tbio Non-IDG -1.02024 9.67 88
Fanconi anemia group D2 protein FANCD2 Tbio Non-IDG -2.59123 391.6 404
Lon protease homolog, mitochondrial LONP1 Tbio Enzyme -2.24805 169.6 174
Fanconi anemia group I protein FANCI Tbio Non-IDG -1.72955 47.4 82
Transcription activator BRG1 SMARCA4 Tchem Epigenetic -2.86389 713.1 332
DNA repair protein RAD51 homolog 1 RAD51 Tchem Non-IDG -3.82649 6590.0 594
Cyclin-dependent kinase 2-associated protein 1 CDK2AP1 Tbio Enzyme -2.04718 111.1 118
Adrenocortical dysplasia protein homolog ACD Tbio Non-IDG -2.42999 246.5 205