Development Level

Tbio 19 | 11,445
Tchem 1 | 1,598

IMPC Phenotype

preweaning lethality, complete... 3 | 979
embryonic lethality prior to t... 2 | 278
abnormal embryo size 1 | 220
abnormal pericardium morpholog... 1 | 26
abnormal seminal vesicle morph... 1 | 114
abnormal vocalization 1 | 21
decreased body weight 1 | 161
decreased fluid intake 1 | 3
decreased lymphocyte cell numb... 1 | 83
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
hypoactivity 1 | 132
increased body length 1 | 32
increased grip strength 1 | 41
increased neutrophil cell numb... 1 | 46
male infertility 1 | 123
preweaning lethality, incomple... 1 | 499
small testis 1 | 58

Disease

Carcinoma 19 | 11,493
ovarian cancer 14 | 8,520
medulloblastoma, large-cell 12 | 6,241
psoriasis 12 | 6,694
lung cancer 11 | 4,740
malignant mesothelioma 10 | 3,232
Cancer 9 | 2,499
glioblastoma 9 | 5,792
osteosarcoma 9 | 7,950
Kidney cancer 8 | 2,613
atypical teratoid / rhabdoid tumor 8 | 5,112
group 3 medulloblastoma 8 | 4,104
primitive neuroectodermal tumor 8 | 3,035
Autosomal recessive predisposition 7 | 1,442
colon cancer 7 | 1,478
non-small cell lung cancer 7 | 2,890
Breast cancer 6 | 3,578
adult high grade glioma 6 | 3,801
ependymoma 6 | 4,679
lung adenocarcinoma 6 | 2,716
nasopharyngeal carcinoma 6 | 1,058
Bloom syndrome 5 | 29
Werner syndrome 5 | 29
adrenocortical carcinoma 5 | 1,428
diabetes mellitus 5 | 1,728
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
Endometriosis 4 | 540
Fanconi anemia 4 | 56
Multiple myeloma 4 | 1,332
Rothmund-Thomson syndrome 4 | 19
Short stature 4 | 531
Small head 4 | 374
Waldenstrons macroglobulinemia 4 | 765
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
invasive ductal carcinoma 4 | 2,951
Astrocytoma, Pilocytic 3 | 3,081
Baller-Gerold syndrome 3 | 12
Fetal Growth Retardation 3 | 189
Infant, Small for Gestational Age 3 | 176
Intellectual disability 3 | 1,016
Intrauterine retardation 3 | 176
Liver cancer 3 | 604
Postnatal growth retardation 3 | 57
Rapadilino syndrome 3 | 7
Slow progression 3 | 89
astrocytoma 3 | 1,146
ductal carcinoma in situ 3 | 1,745
juvenile dermatomyositis 3 | 1,187
oligodendroglioma 3 | 2,850
primary Sjogren syndrome 3 | 735
Abnormality of metabolism/homeostasis 2 | 134
Autistic Disorder 2 | 364
Blepharoptosis 2 | 231
Cockayne syndrome 2 | 60
Cognitive delay 2 | 608
Congenital clubfoot 2 | 109
Constipation 2 | 181
Creatine phosphokinase serum increased 2 | 110
Degeneration of anterior horn cells 2 | 7
Delayed bone age 2 | 136
Diabetes Mellitus, Non-Insulin-Dependent 2 | 145
Diarrhea 2 | 253
Distal limb muscle weakness due to peripheral neuropathy 2 | 62
Distal muscle weakness 2 | 62
Dull intelligence 2 | 645
Dyschezia 2 | 135
Elevated creatine kinase 2 | 110
Global developmental delay 2 | 608
Hyperreflexia 2 | 209
Hypogonadism 2 | 173
Hypoplastic mandible condyle 2 | 275
Hypotrophic malar bone 2 | 129
Kyphoscoliosis deformity of spine 2 | 60
Long narrow head 2 | 75
Low intelligence 2 | 645
Malar flattening 2 | 129
Mandibular hypoplasia 2 | 275
Mental Retardation 2 | 645
Mental and motor retardation 2 | 608
Mental deficiency 2 | 645
Micrognathism 2 | 275
Narrow cranium shape 2 | 75
Narrow face 2 | 54
Narrow head shape 2 | 75
Narrow skull shape 2 | 75
Neurodegenerative disease 2 | 414
Neuropathy 2 | 261
Nijmegen breakage syndrome 2 | 24
Poor school performance 2 | 645
Recurrent respiratory infections 2 | 141
Rheumatoid arthritis 2 | 1,191
Short nose 2 | 132
Small nose 2 | 132
Thin face 2 | 54
Turridolichocephaly 2 | 75
Xeroderma pigmentosum 2 | 43
acute myeloid leukemia 2 | 783
astrocytic glioma 2 | 2,597
pituitary cancer 2 | 1,972
ulcerative colitis 2 | 1,819

Tissue

Blood and immune system 20 | 16,909
Cardiovascular System 20 | 15,192
Digestive Tract 20 | 17,369
Endocrine System 20 | 18,159
Female tissues 20 | 17,400
Liver and Pancreas 20 | 16,750
Male tissues 20 | 17,142
Nervous System 20 | 16,725
Respiratory system 20 | 16,393
Skin and soft tissues 20 | 17,230
Urinary Tract 20 | 16,678

Target Family

Non-IDG 11 | 12,091
Enzyme 8 | 4,145
Epigenetic 1 | 242

GO Function

DNA helicase activity 20 | 20
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA repair and recombination protein RAD54B RAD54B Tbio Non-IDG -1.41173 28.9 153
ATP-dependent DNA helicase Q5 RECQL5 Tbio Enzyme -1.67373 56.2 148
F-box DNA helicase 1 FBXO18 Tbio Enzyme -1.16507 17.7 87
ATP-dependent DNA helicase Q1 RECQL Tbio Enzyme -1.87053 80.0 73
Transcriptional regulator ATRX ATRX Tbio Non-IDG -2.85277 705.9 248
DNA replication licensing factor MCM2 MCM2 Tbio Non-IDG -2.41622 246.0 777
DNA replication licensing factor MCM6 MCM6 Tbio Non-IDG -1.99059 90.3 260
Chromodomain-helicase-DNA-binding protein 8 CHD8 Tbio Epigenetic -1.64766 47.4 81
DNA helicase INO80 INO80 Tbio Enzyme -2.54124 327.2 47
DNA-binding protein SMUBP-2 IGHMBP2 Tbio Non-IDG -1.90459 79.9 52