Development Level

Tbio 835 | 11,651
Tdark 553 | 6,593
Tchem 70 | 1,388
Tclin 23 | 612

Collection

Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 81 | 979
preweaning lethality, incomple... 36 | 499
embryonic lethality prior to t... 29 | 278
embryonic lethality prior to o... 24 | 239
abnormal embryo size 21 | 220
abnormal behavior 13 | 298
abnormal bone structure 13 | 187
abnormal heart morphology 13 | 162
decreased bone mineral density 13 | 126
increased lean body mass 13 | 172
decreased body weight 11 | 161
decreased bone mineral content 11 | 151
decreased circulating glucose ... 11 | 126
enlarged heart 11 | 210
increased startle reflex 11 | 112
decreased body length 10 | 101
decreased lean body mass 10 | 135
hypoactivity 10 | 132
decreased circulating triglyce... 9 | 79
decreased vertical activity 9 | 208
decreased erythrocyte cell num... 8 | 62
decreased hemoglobin content 8 | 68
decreased total body fat amoun... 8 | 207
increased bone mineral content 8 | 108
increased bone mineral density 8 | 72
increased total body fat amoun... 8 | 134
abnormal retina morphology 7 | 71
decreased circulating HDL chol... 7 | 68
decreased circulating choleste... 7 | 93
embryonic growth retardation 7 | 106
increased mean corpuscular hem... 7 | 96
increased mean corpuscular vol... 7 | 92
prenatal lethality prior to he... 7 | 87
abnormal spleen morphology 6 | 55
decreased circulating serum al... 6 | 82
decreased grip strength 6 | 116
decreased prepulse inhibition 6 | 82
short tibia 6 | 97
abnormal behavioral response t... 5 | 66
abnormal cornea morphology 5 | 31
abnormal gait 5 | 69
abnormal neural tube closure 5 | 46
decreased circulating insulin ... 5 | 76
decreased circulating total pr... 5 | 49
decreased lymphocyte cell numb... 5 | 83
decreased startle reflex 5 | 75
increased circulating alkaline... 5 | 122
increased monocyte cell number 5 | 63
increased neutrophil cell numb... 5 | 46
male infertility 5 | 123
prenatal lethality 5 | 28
thrombocytopenia 5 | 56
vertebral fusion 5 | 23
abnormal cranium morphology 4 | 36
abnormal eye morphology 4 | 68
abnormal skin morphology 4 | 50
abnormal tail morphology 4 | 25
anophthalmia 4 | 33
corneal opacity 4 | 32
decreased T cell number 4 | 15
decreased caudal vertebrae num... 4 | 53
improved glucose tolerance 4 | 79
increased body temperature 4 | 9
increased circulating HDL chol... 4 | 80
increased hemoglobin content 4 | 45
increased or absent threshold ... 4 | 101
pale yolk sac 4 | 25
small superior vagus ganglion 4 | 74
small testis 4 | 58
abnormal embryo turning 3 | 31
abnormal forebrain development 3 | 20
abnormal head morphology 3 | 10
abnormal hindbrain development 3 | 16
abnormal kidney morphology 3 | 65
abnormal seminal vesicle morph... 3 | 114
abnormal tooth morphology 3 | 24
cataract 3 | 92
decreased circulating glycerol... 3 | 16
decreased hematocrit 3 | 46
decreased leukocyte cell numbe... 3 | 73
decreased neutrophil cell numb... 3 | 42
female infertility 3 | 60
increased blood urea nitrogen ... 3 | 48
increased circulating choleste... 3 | 66
increased circulating potassiu... 3 | 29
increased circulating triglyce... 3 | 42
increased grip strength 3 | 41
increased heart weight 3 | 62
microphthalmia 3 | 26
shortened RR interval 3 | 17
tremors 3 | 39
unresponsive to tactile stimul... 3 | 8
abnormal retinal vasculature m... 2 | 27
decreased circulating calcium ... 2 | 36
increased body weight 2 | 25
increased circulating chloride... 2 | 41
increased circulating fructosa... 2 | 13
increased circulating total pr... 2 | 28
increased fasted circulating g... 2 | 76
increased mean platelet volume 2 | 45

Disease

Carcinoma 1,024 | 11,493
osteosarcoma 688 | 7,950
ovarian cancer 628 | 8,520
medulloblastoma, large-cell 466 | 6,241
psoriasis 462 | 6,694
lung cancer 411 | 4,740
glioblastoma 403 | 5,792
group 3 medulloblastoma 388 | 4,104
atypical teratoid / rhabdoid tumor 363 | 5,112
malignant mesothelioma 292 | 3,232
Breast cancer 289 | 3,578
ependymoma 283 | 4,679
Cancer 276 | 2,499
primitive neuroectodermal tumor 263 | 3,035
Kidney cancer 260 | 2,613
intraductal papillary-mucinous neoplasm (IPMN) 243 | 3,291
intraductal papillary-mucinous carcinoma (IPMC) 211 | 2,989
adult high grade glioma 201 | 3,801
intraductal papillary-mucinous adenoma (IPMA) 195 | 2,955
invasive ductal carcinoma 184 | 2,951
oligodendroglioma 177 | 2,850
non-small cell lung cancer 168 | 2,890
group 4 medulloblastoma 162 | 1,855
lung adenocarcinoma 154 | 2,716
astrocytic glioma 146 | 2,597
Astrocytoma, Pilocytic 139 | 3,081
pancreatic cancer 139 | 2,398
Pick disease 135 | 1,894
lung carcinoma 131 | 2,843
tuberculosis 129 | 2,010
pituitary cancer 127 | 1,972
adrenocortical carcinoma 126 | 1,428
subependymal giant cell astrocytoma 113 | 2,287
Intellectual disability 109 | 1,016
Rheumatoid arthritis 105 | 1,191
colon cancer 105 | 1,478
ductal carcinoma in situ 104 | 1,745
interstitial cystitis 103 | 2,312
breast carcinoma 99 | 1,638
diabetes mellitus 99 | 1,728
ulcerative colitis 97 | 1,819
cystic fibrosis 96 | 1,696
pediatric high grade glioma 95 | 1,064
astrocytoma 94 | 1,146
pancreatic ductal adenocarcinoma liver metastasis 92 | 1,962
spina bifida 92 | 1,074
Multiple myeloma 91 | 1,332
juvenile dermatomyositis 90 | 1,187
acute myeloid leukemia 87 | 783
acute quadriplegic myopathy 86 | 1,158
dermatomyositis 76 | 966
Waldenstrons macroglobulinemia 74 | 765
Dull intelligence 73 | 645
Low intelligence 73 | 645
Mental Retardation 73 | 645
Mental deficiency 73 | 645
Poor school performance 73 | 645
non primary Sjogren syndrome sicca 73 | 891
Schizophrenia 72 | 1,160
Autosomal recessive predisposition 70 | 1,442
cutaneous lupus erythematosus 70 | 1,057
Short stature 69 | 531
primary pancreatic ductal adenocarcinoma 66 | 1,109
nasopharyngeal carcinoma 65 | 1,058
hepatocellular carcinoma 63 | 547
Cognitive delay 58 | 608
Global developmental delay 58 | 608
Mental and motor retardation 58 | 608
medulloblastoma 56 | 720
progressive supranuclear palsy 56 | 676
Breast Neoplasms 55 | 445
Muscle hypotonia 55 | 571
gastric cancer 54 | 459
Alzheimer's disease 51 | 658
Epilepsy 51 | 792
Mammary Neoplasms 51 | 425
Small head 51 | 374
Liver cancer 49 | 604
Prostatic Neoplasms 49 | 495
Obesity 48 | 678
Bipolar Disorder 46 | 666
active Crohn's disease 46 | 922
Cryptorchidism 45 | 296
primary Sjogren syndrome 45 | 735
Atopic dermatitis 44 | 952
Melanoma 44 | 711
Seizures 44 | 596
tuberculosis and treatment for 6 months 43 | 409
Amyotrophic lateral sclerosis 42 | 451
aldosterone-producing adenoma 39 | 665
Hypoplastic mandible condyle 38 | 275
Mandibular hypoplasia 38 | 275
Micrognathism 38 | 275
Strabismus 38 | 270
sonic hedgehog group medulloblastoma 38 | 467
Multiple Sclerosis 37 | 540
Stomach Neoplasms 37 | 300
active ulcerative colitis 37 | 764
gastric carcinoma 37 | 807
Endometriosis 36 | 540

Tissue

Endocrine System 1,415 | 18,159
Female tissues 1,369 | 17,400
Digestive Tract 1,367 | 17,369
Skin and soft tissues 1,364 | 17,230
Male tissues 1,361 | 17,142
Nervous System 1,349 | 16,725
Blood and immune system 1,348 | 16,909
Urinary Tract 1,332 | 16,678
Liver and Pancreas 1,330 | 16,750
Respiratory system 1,325 | 16,393
Cardiovascular System 1,279 | 15,192

Target Family

Transcription Factor 786 | 1,400
Non-IDG 437 | 12,091
Enzyme 153 | 4,145
Epigenetic 46 | 242
Nuclear Receptor 28 | 48
TF/Epigenetic 22 | 38
Kinase 8 | 634
Ion Channel 1 | 344

GO Function

DNA binding 1,481 | 1,481
metal ion binding 2,256 | 2,256
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
DNA-binding death effector domain-containing protein 2 DEDD2 Tbio Non-IDG -0.55115 3.37 164
DBIRD complex subunit ZNF326 ZNF326 Tbio Non-IDG -0.42207 3.94 120
Zinc finger protein 236 ZNF236 Tbio Transcription Factor -0.40816 2.56 30
Homeobox protein SIX6 SIX6 Tbio Transcription Factor -2.23077 163.2 112
Transcriptional repressor scratch 2 SCRT2 Tdark Transcription Factor 0.22 1.09 25
Transcription factor HES-1 HES1 Tbio Transcription Factor -1.77409 55.5 444
Zinc finger protein 561 ZNF561 Tdark Transcription Factor 0.00000 36
Zinc finger protein 808 ZNF808 Tdark Transcription Factor 0.00000 1.00 0
Lamina-associated polypeptide 2, isoform alpha TMPO Tbio Non-IDG -2.11834 246.0 283