Development Level

Tbio 812 | 10,625
Tdark 509 | 7,003
Tchem 88 | 1,890
Tclin 23 | 602

Collection

Eligible Kinase Proteins 1 | 134

IMPC Term

preweaning lethality, complete... 53 | 633
embryonic lethality prior to t... 21 | 187
embryonic lethality prior to o... 17 | 148
preweaning lethality, incomple... 16 | 260
abnormal embryo size 14 | 112
decreased lean body mass 14 | 195
decreased body weight 12 | 174
abnormal behavior 11 | 226
decreased total body fat amoun... 11 | 186
abnormal bone structure 10 | 131
decreased body length 10 | 108
decreased bone mineral density 9 | 126
decreased circulating triglyce... 9 | 83
decreased grip strength 9 | 123
hypoactivity 9 | 89
decreased bone mineral content 8 | 157
increased bone mineral content 8 | 92
increased lean body mass 8 | 107
abnormal retina morphology 7 | 100
decreased circulating HDL chol... 7 | 77
decreased circulating choleste... 7 | 85
decreased circulating glucose ... 7 | 121
decreased erythrocyte cell num... 7 | 43
increased or absent threshold ... 7 | 128
increased sacral vertebrae num... 7 | 62
abnormal neural tube closure 6 | 37
abnormal retinal pigmentation 6 | 61
decreased circulating serum al... 6 | 79
decreased hemoglobin content 6 | 53
increased grip strength 6 | 83
increased mean corpuscular hem... 6 | 93
prenatal lethality prior to he... 6 | 64
abnormal cornea morphology 5 | 24
abnormal hindbrain development 5 | 24
abnormal spleen morphology 5 | 36
decreased caudal vertebrae num... 5 | 49
decreased circulating insulin ... 5 | 75
decreased lumbar vertebrae num... 5 | 62
decreased rib number 5 | 59
short tibia 5 | 82
vertebral fusion 5 | 23
abnormal behavioral response t... 4 | 52
abnormal bone mineralization 4 | 55
abnormal forebrain development 4 | 18
abnormal gait 4 | 51
abnormal heart morphology 4 | 51
abnormal tail morphology 4 | 17
corneal opacity 4 | 25
decreased T cell number 4 | 31
decreased circulating total pr... 4 | 41
decreased hematocrit 4 | 25
increased blood urea nitrogen ... 4 | 44
increased circulating HDL chol... 4 | 63
increased circulating alkaline... 4 | 119
increased fasted circulating g... 4 | 68
increased mean corpuscular vol... 4 | 91
increased total body fat amoun... 4 | 57
pale yolk sac 4 | 12
straub tail 4 | 26
thrombocytopenia 4 | 46
abnormal coat/hair pigmentatio... 3 | 54
abnormal cranium morphology 3 | 32
abnormal embryo turning 3 | 15
abnormal eye morphology 3 | 38
abnormal lens morphology 3 | 73
abnormal midbrain development 3 | 22
abnormal sleep behavior 3 | 63
abnormal vocalization 3 | 21
anophthalmia 3 | 20
decreased circulating LDL chol... 3 | 37
decreased circulating chloride... 3 | 32
decreased heart weight 3 | 44
decreased startle reflex 3 | 48
embryonic growth retardation 3 | 28
female infertility 3 | 34
increased body length 3 | 20
increased bone mineral density 3 | 52
increased circulating chloride... 3 | 43
increased circulating sodium l... 3 | 71
increased exploration in new e... 3 | 56
increased hemoglobin content 3 | 45
increased mean corpuscular hem... 3 | 25
increased startle reflex 3 | 38
male infertility 3 | 62
prenatal lethality 3 | 16
small testis 3 | 37
abnormal head morphology 2 | 10
abnormal heart left ventricle ... 2 | 20
abnormal optic disc morphology 2 | 10
abnormal tooth morphology 2 | 24
decreased circulating calcium ... 2 | 33
decreased circulating glycerol... 2 | 19
decreased mean corpuscular hem... 2 | 34
increased circulating choleste... 2 | 53
increased circulating fructosa... 2 | 11
increased heart weight 2 | 37
increased respiratory quotient 2 | 12
long tibia 2 | 13
persistence of hyaloid vascula... 2 | 22
tremors 2 | 34

Disease

osteosarcoma 675 | 7,933
ovarian cancer 627 | 8,484
medulloblastoma, large-cell 462 | 6,234
psoriasis 461 | 6,685
glioblastoma 379 | 5,572
lung cancer 379 | 4,466
atypical teratoid / rhabdoid tumor 308 | 4,369
malignant mesothelioma 285 | 3,162
Cancer 254 | 2,346
primitive neuroectodermal tumor 248 | 3,031
Breast cancer 238 | 3,094
intraductal papillary-mucinous neoplasm (IPMN) 233 | 3,289
group 3 medulloblastoma 214 | 2,254
Carcinoma 208 | 2,147
intraductal papillary-mucinous carcinoma (IPMC) 207 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 193 | 2,956
group 4 medulloblastoma 186 | 1,875
invasive ductal carcinoma 186 | 2,950
pediatric high grade glioma 186 | 2,712
oligodendroglioma 180 | 2,849
ependymoma 172 | 2,514
non-small cell lung cancer 163 | 2,798
lung adenocarcinoma 160 | 2,713
pilocytic astrocytoma 138 | 3,086
lung carcinoma 135 | 2,844
pancreatic cancer 133 | 2,300
Pick disease 130 | 1,893
pituitary cancer 126 | 1,972
adrenocortical carcinoma 124 | 1,427
astrocytic glioma 124 | 2,241
astrocytoma 119 | 1,493
sonic hedgehog group medulloblastoma 119 | 1,482
subependymal giant cell astrocytoma 117 | 2,287
adult high grade glioma 114 | 2,148
ductal carcinoma in situ 107 | 1,745
interstitial cystitis 107 | 2,299
ulcerative colitis 107 | 2,087
Rheumatoid Arthritis 106 | 1,160
colon cancer 104 | 1,475
medulloblastoma 102 | 1,524
breast carcinoma 97 | 1,614
diabetes mellitus 97 | 1,663
Multiple myeloma 96 | 1,327
cystic fibrosis 96 | 1,665
tuberculosis 94 | 1,557
juvenile dermatomyositis 91 | 1,189
posterior fossa group A ependymoma 90 | 1,511
acute quadriplegic myopathy 89 | 1,157
pancreatic ductal adenocarcinoma liver metastasis 89 | 1,795
spina bifida 89 | 1,064
atypical teratoid/rhabdoid tumor 85 | 1,095
acute myeloid leukemia 84 | 780
Waldenstrons macroglobulinemia 76 | 765
posterior fossa group B ependymoma 76 | 1,530
primary pancreatic ductal adenocarcinoma 74 | 1,271
dermatomyositis 73 | 933
cutaneous lupus erythematosus 67 | 1,056
non primary Sjogren syndrome sicca 67 | 840
Intellectual disability 66 | 573
nasopharyngeal carcinoma 66 | 1,056
tuberculosis and treatment for 6 months 59 | 686
hepatocellular carcinoma 55 | 532
primary Sjogren syndrome 54 | 789
Mammary Neoplasms 51 | 410
gastric cancer 51 | 430
progressive supranuclear palsy 51 | 674
Prostatic Neoplasms 44 | 471
Atopic dermatitis 43 | 944
aldosterone-producing adenoma 43 | 664
active Crohn's disease 42 | 918
gastric carcinoma 42 | 832
Alzheimer's disease 41 | 644
Amyotrophic Lateral Sclerosis 40 | 431
pancreatic carcinoma 38 | 567
Stomach Neoplasms 37 | 282
inflammatory breast cancer 37 | 404
Obesity 36 | 616
Down syndrome 35 | 548
Endometriosis 35 | 535
Multiple Sclerosis 32 | 498
chronic rhinosinusitis 32 | 512
esophageal adenocarcinoma 32 | 737
Peripheral Neuropathy 31 | 303
Schizophrenia 31 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 31 | 499
non-small cell lung carcinoma 30 | 413
Acquired metabolic disease 29 | 267
Liver carcinoma 29 | 217
IGA Glomerulonephritis 27 | 454
fibroadenoma 26 | 557
active ulcerative colitis 25 | 477
Duchenne muscular dystrophy 24 | 602
Melanoma 24 | 261
glioblastoma multiforme 24 | 347
Craniofacial Abnormalities 23 | 147
chronic lymphosyte leukemia 23 | 232
Colorectal Neoplasms 22 | 217
Infertility 22 | 163
Osteoporosis 22 | 257
tuberculosis and treatment for 3 months 22 | 327

Tissue

Female tissues 1,378 | 18,647
Nervous System 1,372 | 18,561
Digestive Tract 1,369 | 18,473
Endocrine System 1,366 | 18,512
Male tissues 1,364 | 17,969
Urinary Tract 1,364 | 18,444
Blood and immune system 1,363 | 17,995
Liver and Pancreas 1,359 | 18,136
Cardiovascular System 1,348 | 17,958
Skin and soft tissues 1,331 | 18,115
Respiratory system 1,317 | 17,484

Target Family

Transcription Factor 724 | 1,400
Non-IDG 437 | 11,971
Enzyme 162 | 4,146
Epigenetic 48 | 242
Nuclear Receptor 28 | 48
TF/Epigenetic 23 | 38
Kinase 8 | 634
Ion Channel 1 | 341
Transporter 1 | 473

GO Function

DNA binding 1,432 | 1,432
metal ion binding 1,917 | 1,917
ATP binding 1,467 | 1,467
zinc ion binding 1,155 | 1,155
poly(A) RNA binding 1,107 | 1,107
transcription factor activity,... 853 | 853
calcium ion binding 695 | 695
G-protein coupled receptor act... 661 | 661
protein homodimerization activ... 569 | 569
RNA binding 445 | 445
olfactory receptor activity 424 | 424
sequence-specific DNA binding 398 | 398
GTP binding 374 | 374
chromatin binding 372 | 372
protein serine/threonine kinas... 336 | 336
RNA polymerase II core promote... 332 | 332
identical protein binding 311 | 311
nucleotide binding 311 | 311
receptor binding 303 | 303
protein kinase binding 289 | 289
enzyme binding 286 | 286
cadherin binding involved in c... 277 | 277
GTPase activator activity 273 | 273
ubiquitin protein ligase bindi... 258 | 258
ubiquitin-protein transferase ... 253 | 253
serine-type endopeptidase acti... 246 | 246
transcription coactivator acti... 241 | 241
transcription factor binding 240 | 240
structural molecule activity 232 | 232
GTPase activity 231 | 231
transcriptional activator acti... 230 | 230
ligase activity 227 | 227
protein heterodimerization act... 227 | 227
structural constituent of ribo... 212 | 212
transcription regulatory regio... 202 | 202
transmembrane signaling recept... 201 | 201
RNA polymerase II regulatory r... 200 | 200
receptor activity 200 | 200
transcription corepressor acti... 198 | 198
magnesium ion binding 197 | 197
signal transducer activity 196 | 196
nucleic acid binding 184 | 184
protein kinase activity 183 | 183
carbohydrate binding 180 | 180
ubiquitin protein ligase activ... 173 | 173
RNA polymerase II transcriptio... 162 | 162
heparin binding 160 | 160
iron ion binding 141 | 141
lipid binding 136 | 136
transporter activity 136 | 136
actin binding 133 | 133
ATPase activity 132 | 132
protein C-terminus binding 129 | 129
heme binding 127 | 127
microtubule binding 123 | 123
protein tyrosine kinase activi... 119 | 119
cytokine activity 118 | 118
Ras guanyl-nucleotide exchange... 113 | 113
mRNA binding 112 | 112
metalloendopeptidase activity 112 | 112
transcriptional repressor acti... 110 | 110
structural constituent of cyto... 108 | 108
Rab GTPase binding 105 | 105
antigen binding 104 | 104
protein domain specific bindin... 102 | 102
peptide antigen binding 101 | 101
guanyl-nucleotide exchange fac... 98 | 98
protein complex binding 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 92 | 92
oxidoreductase activity 91 | 91
transcriptional activator acti... 91 | 91
actin filament binding 89 | 89
hydrolase activity 89 | 89
ion channel binding 89 | 89
protein tyrosine phosphatase a... 88 | 88
electron carrier activity 87 | 87
protease binding 87 | 87
histone binding 86 | 86
integrin binding 83 | 83
growth factor activity 82 | 82
phospholipid binding 82 | 82
single-stranded DNA binding 81 | 81
unfolded protein binding 77 | 77
kinase activity 75 | 75
thiol-dependent ubiquitin-spec... 75 | 75
phosphatidylinositol binding 74 | 74
calmodulin binding 73 | 73
histone deacetylase binding 73 | 73
Rho guanyl-nucleotide exchange... 72 | 72
drug binding 71 | 71
double-stranded DNA binding 70 | 70
peptidase activity 70 | 70
protein N-terminus binding 70 | 70
virus receptor activity 68 | 68
beta-catenin binding 67 | 67
microtubule motor activity 67 | 67
protein transporter activity 67 | 67
calcium channel activity 66 | 66
ubiquitin binding 66 | 66

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
Zinc finger protein 136 ZNF136 Tdark Transcription Factor 0.12 0.68 102
Zinc finger protein 485 ZNF485 Tdark Transcription Factor 0.00000 48
Achaete-scute homolog 1 ASCL1 Tbio Transcription Factor -2.39907 258.0 359
Forkhead box protein M1 FOXM1 Tbio Transcription Factor -3.09305 1275.4 345
Basic helix-loop-helix transcription factor scleraxis SCX Tbio Transcription Factor -2.80657 344.1 42
V(D)J recombination-activating protein 1 RAG1 Tbio Non-IDG -3.00063 1061.1 65
Transcription factor 24 TCF24 Tdark Non-IDG 0.30 0.09 0
Sex comb on midleg-like protein 2 SCML2 Tbio Epigenetic -1.13986 13.7 93
mRNA decay activator protein ZFP36 ZFP36 Tbio Non-IDG -2.38153 220.3 0