Development Level

Tbio 61 | 11,445
Tclin 9 | 613
Tchem 6 | 1,598
Tdark 3 | 6,588

Collection

Ion Channel: IDG Consortium (T... 1 | 99
Kinase: IDG Consortium (Comple... 1 | 37
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 7 | 979
preweaning lethality, incomple... 4 | 499
increased mean corpuscular hem... 2 | 36
abnormal QT variability 1 | 10
abnormal embryo size 1 | 220
abnormal seminal vesicle morph... 1 | 114
cardiovascular system phenotyp... 1 | 36
decreased body length 1 | 101
decreased body weight 1 | 161
decreased bone mineral density 1 | 126
decreased circulating serum al... 1 | 82
decreased grip strength 1 | 116
decreased mean corpuscular vol... 1 | 79
decreased total body fat amoun... 1 | 207
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged spleen 1 | 41
female infertility 1 | 60
hyperactivity 1 | 148
increased bone mineral content 1 | 108
increased circulating alkaline... 1 | 122
increased circulating aspartat... 1 | 15
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
increased startle reflex 1 | 112
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36

Disease

Carcinoma 48 | 11,493
ovarian cancer 39 | 8,520
psoriasis 36 | 6,694
osteosarcoma 33 | 7,950
glioblastoma 31 | 5,792
medulloblastoma, large-cell 29 | 6,241
atypical teratoid / rhabdoid tumor 28 | 5,112
ependymoma 26 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 23 | 3,291
lung cancer 23 | 4,740
adult high grade glioma 22 | 3,801
group 3 medulloblastoma 22 | 4,104
primitive neuroectodermal tumor 22 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 20 | 2,989
Astrocytoma, Pilocytic 19 | 3,081
intraductal papillary-mucinous adenoma (IPMA) 19 | 2,955
Breast cancer 17 | 3,578
invasive ductal carcinoma 16 | 2,951
malignant mesothelioma 16 | 3,232
oligodendroglioma 16 | 2,850
astrocytic glioma 15 | 2,597
subependymal giant cell astrocytoma 15 | 2,287
Cancer 14 | 2,499
non-small cell lung cancer 14 | 2,890
Autosomal recessive predisposition 13 | 1,442
Kidney cancer 13 | 2,613
Multiple myeloma 13 | 1,332
pancreatic ductal adenocarcinoma liver metastasis 13 | 1,962
Pick disease 12 | 1,894
colon cancer 12 | 1,478
lung adenocarcinoma 11 | 2,716
diabetes mellitus 10 | 1,728
group 4 medulloblastoma 10 | 1,855
interstitial cystitis 10 | 2,312
lung carcinoma 10 | 2,843
acute quadriplegic myopathy 9 | 1,158
breast carcinoma 9 | 1,638
ductal carcinoma in situ 9 | 1,745
non primary Sjogren syndrome sicca 9 | 891
pancreatic cancer 9 | 2,398
pituitary cancer 9 | 1,972
Failure to gain weight 8 | 365
Hepatomegaly 8 | 285
Pediatric failure to thrive 8 | 365
Prostatic Neoplasms 8 | 495
Schizophrenia 8 | 1,160
juvenile dermatomyositis 8 | 1,187
Atopic dermatitis 7 | 952
Nystagmus 7 | 317
Short stature 7 | 531
Waldenstrons macroglobulinemia 7 | 765
astrocytoma 7 | 1,146
dermatomyositis 7 | 966
fibroadenoma 7 | 559
tuberculosis 7 | 2,010
Atrial Fibrillation 6 | 124
Cryptorchidism 6 | 296
Depressive disorder 6 | 409
Dull intelligence 6 | 645
Epilepsy 6 | 792
Intellectual disability 6 | 1,016
Low intelligence 6 | 645
Mental Depression 6 | 333
Mental Retardation 6 | 645
Mental deficiency 6 | 645
Poor school performance 6 | 645
Seizures 6 | 596
adrenocortical carcinoma 6 | 1,428
ulcerative colitis 6 | 1,819
Anemia 5 | 365
Blepharoptosis 5 | 231
Breast Neoplasms 5 | 445
Broad flat nasal bridge 5 | 236
Cognitive delay 5 | 608
Down syndrome 5 | 499
Global developmental delay 5 | 608
Growth delay 5 | 114
Growth failure 5 | 114
Growth retardation 5 | 115
Heart disease 5 | 306
Hypertension 5 | 396
Icterus 5 | 82
Low Vision 5 | 174
Mammary Neoplasms 5 | 425
Mental and motor retardation 5 | 608
Muscle hypotonia 5 | 571
Nasal bridge wide 5 | 236
Optic Atrophy 5 | 242
Parkinson's disease 5 | 392
Poor growth 5 | 114
Very poor growth 5 | 114
Visual Impairment 5 | 174
cutaneous lupus erythematosus 5 | 1,057
cystic fibrosis 5 | 1,696
pediatric high grade glioma 5 | 1,064
primary pancreatic ductal adenocarcinoma 5 | 1,109
Duchenne muscular dystrophy 4 | 601
Endometriosis 4 | 540
aldosterone-producing adenoma 4 | 665
spina bifida 4 | 1,074

Tissue

Urinary Tract 79 | 16,678
Male tissues 78 | 17,142
Digestive Tract 77 | 17,369
Endocrine System 77 | 18,159
Female tissues 77 | 17,400
Liver and Pancreas 77 | 16,750
Nervous System 77 | 16,725
Skin and soft tissues 77 | 17,230
Blood and immune system 76 | 16,909
Respiratory system 76 | 16,393
Cardiovascular System 75 | 15,192

Target Family

Non-IDG 40 | 12,091
Enzyme 23 | 4,145
Ion Channel 5 | 344
Transporter 5 | 473
Nuclear Receptor 4 | 48
Kinase 2 | 634

GO Function

ATPase binding 79 | 79
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Box C/D snoRNA protein 1 ZNHIT6 Tbio Non-IDG 0.48 0.74 87
Sorting nexin-10 SNX10 Tbio Non-IDG -1.13183 16.8 72
Tyrosine-protein phosphatase non-receptor type 3 PTPN3 Tbio Enzyme -1.40961 29.1 162
Adenylate cyclase type 10 ADCY10 Tchem Enzyme -3.13751 1324.4 108
Derlin-1 DERL1 Tbio Non-IDG -1.88253 69.7 178
V-type proton ATPase 116 kDa subunit a isoform 4 ATP6V0A4 Tbio Enzyme -2.84949 692.2 90
Polycystin-2 PKD2 Tchem Ion Channel -2.63806 461.3 231
Nucleolar protein 58 NOP58 Tbio Non-IDG -1.46442 30.0 85
Bcl-2-binding component 3 BBC3 Tbio Non-IDG -2.02081 88.0 559
Ankyrin-2 ANK2 Tbio Non-IDG -2.08421 120.5 236