Development Level

Tbio 48 | 10,625
Tclin 9 | 602
Tchem 4 | 1,890

Collection

Kinase: IDG Consortium (Complete/Control) 1 | 37

IMPC Phenotype

preweaning lethality, complete... 6 | 633
decreased total body fat amoun... 3 | 186
preweaning lethality, incomple... 3 | 260
abnormal embryo size 1 | 112
abnormal heart left ventricle ... 1 | 20
abnormal retina morphology 1 | 100
abnormal retinal pigmentation 1 | 61
cardiovascular system phenotyp... 1 | 35
decreased NK T cell number 1 | 28
decreased body length 1 | 108
decreased body weight 1 | 174
decreased bone mineral content 1 | 157
decreased bone mineral density 1 | 126
decreased circulating alanine ... 1 | 53
decreased circulating alkaline... 1 | 41
decreased circulating serum al... 1 | 79
decreased lean body mass 1 | 195
decreased mature B cell number 1 | 25
embryonic lethality prior to o... 1 | 148
embryonic lethality prior to t... 1 | 187
enlarged spleen 1 | 26
female infertility 1 | 34
increased circulating alkaline... 1 | 119
increased circulating aspartat... 1 | 17
increased circulating chloride... 1 | 43
increased circulating sodium l... 1 | 71
increased exploration in new e... 1 | 56
increased leukocyte cell numbe... 1 | 37
increased mean corpuscular hem... 1 | 25
increased mean corpuscular vol... 1 | 91
increased or absent threshold ... 1 | 128

Disease

ovarian cancer 31 | 8,491
psoriasis 31 | 6,685
osteosarcoma 27 | 7,933
glioblastoma 25 | 5,572
medulloblastoma, large-cell 25 | 6,234
intraductal papillary-mucinous neoplasm (IPMN) 21 | 3,289
intraductal papillary-mucinous carcinoma (IPMC) 20 | 2,988
primitive neuroectodermal tumor 20 | 3,031
intraductal papillary-mucinous adenoma (IPMA) 18 | 2,956
lung cancer 18 | 4,473
atypical teratoid / rhabdoid tumor 15 | 4,369
pediatric high grade glioma 15 | 2,712
pilocytic astrocytoma 15 | 3,086
invasive ductal carcinoma 14 | 2,950
oligodendroglioma 14 | 2,849
Breast cancer 13 | 3,098
subependymal giant cell astrocytoma 13 | 2,287
Cancer 12 | 2,346
astrocytic glioma 12 | 2,241
ependymoma 12 | 2,514
malignant mesothelioma 12 | 3,163
non-small cell lung cancer 11 | 2,798
Multiple myeloma 10 | 1,327
Pick disease 10 | 1,893
colon cancer 10 | 1,475
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,795
acute quadriplegic myopathy 9 | 1,157
ductal carcinoma in situ 9 | 1,745
interstitial cystitis 9 | 2,299
lung carcinoma 9 | 2,844
medulloblastoma 9 | 1,524
pituitary cancer 9 | 1,972
astrocytoma 8 | 1,493
juvenile dermatomyositis 8 | 1,189
lung adenocarcinoma 8 | 2,714
Atopic dermatitis 7 | 944
Carcinoma 7 | 2,147
Prostatic Neoplasms 7 | 471
atypical teratoid/rhabdoid tumor 7 | 1,095
breast carcinoma 7 | 1,614
diabetes mellitus 7 | 1,663
group 4 medulloblastoma 7 | 1,875
pancreatic cancer 7 | 2,300
posterior fossa group B ependymoma 7 | 1,530
tuberculosis 7 | 1,563
adult high grade glioma 6 | 2,148
dermatomyositis 6 | 966
fibroadenoma 6 | 557
group 3 medulloblastoma 6 | 2,254
ulcerative colitis 6 | 2,087
Down syndrome 5 | 548
Heart disease 5 | 279
Mammary Neoplasms 5 | 410
Parkinson's disease 5 | 364
Waldenstrons macroglobulinemia 5 | 764
adrenocortical carcinoma 5 | 1,427
non primary Sjogren syndrome sicca 5 | 840
posterior fossa group A ependymoma 5 | 1,511
sonic hedgehog group medulloblastoma 5 | 1,482
Animal Mammary Neoplasms 4 | 135
Atrial Fibrillation 4 | 110
Duchenne muscular dystrophy 4 | 602
IGA Glomerulonephritis 4 | 454
Kennedy's disease 4 | 13
Mammary Neoplasms, Experimental 4 | 149
Osteopetrosis 4 | 40
Prostate cancer 4 | 172
cutaneous lupus erythematosus 4 | 1,056
cystic fibrosis 4 | 1,670
primary pancreatic ductal adenocarcinoma 4 | 1,271
progressive supranuclear palsy 4 | 674
spina bifida 4 | 1,064
Alzheimer's disease 3 | 644
Amyotrophic Lateral Sclerosis 3 | 432
Atherosclerosis 3 | 275
Chronic heart failure 3 | 46
Congestive heart failure 3 | 36
Dystonia 3 | 77
Endometriosis 3 | 535
Huntington's disease 3 | 72
Infertility 3 | 163
Liver carcinoma 3 | 217
Menopausal flushing 3 | 17
Neurodegenerative disease 3 | 383
Poisoning by digitalis glycoside 3 | 8
Stomach Neoplasms 3 | 282
Type 2 diabetes mellitus 3 | 192
Vascular disease 3 | 281
active Crohn's disease 3 | 918
active ulcerative colitis 3 | 477
aldosterone-producing adenoma 3 | 664
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 499
chronic rhinosinusitis 3 | 512
hereditary spastic paraplegia 3 | 313
pancreatic carcinoma 3 | 567
primary Sjogren syndrome 3 | 788
sarcoidosis 3 | 368
Leukemia 2 | 88
Peripheral Neuropathy 2 | 303
Polycystic Ovary Syndrome 2 | 334

Tissue

Blood and immune system 61 | 17,994
Cardiovascular System 61 | 17,957
Digestive Tract 61 | 18,472
Male tissues 61 | 17,968
Nervous System 61 | 18,560
Endocrine System 60 | 18,511
Female tissues 60 | 18,646
Liver and Pancreas 60 | 18,135
Skin and soft tissues 60 | 18,114
Urinary Tract 60 | 18,443
Respiratory system 59 | 17,483

Target Family

Non-IDG 32 | 11,969
Enzyme 17 | 4,146
Transporter 5 | 473
Nuclear Receptor 4 | 48
Kinase 2 | 634
Ion Channel 1 | 341

GO Function

ATPase binding 61 | 61
metal ion binding 1,917 | 1,917
ATP binding 1,467 | 1,467
DNA binding 1,432 | 1,432
zinc ion binding 1,155 | 1,155
poly(A) RNA binding 1,107 | 1,107
transcription factor activity,... 853 | 853
calcium ion binding 695 | 695
G-protein coupled receptor act... 661 | 661
protein homodimerization activ... 569 | 569
RNA binding 445 | 445
olfactory receptor activity 424 | 424
sequence-specific DNA binding 398 | 398
GTP binding 374 | 374
chromatin binding 372 | 372
protein serine-threonine kinas... 336 | 336
RNA polymerase II core promote... 332 | 332
identical protein binding 311 | 311
nucleotide binding 311 | 311
receptor binding 303 | 303
protein kinase binding 289 | 289
enzyme binding 286 | 286
cadherin binding involved in c... 277 | 277
GTPase activator activity 273 | 273
ubiquitin protein ligase bindi... 258 | 258
ubiquitin-protein transferase ... 253 | 253
serine-type endopeptidase acti... 246 | 246
transcription coactivator acti... 241 | 241
transcription factor binding 240 | 240
structural molecule activity 232 | 232
GTPase activity 231 | 231
transcriptional activator acti... 230 | 230
ligase activity 227 | 227
protein heterodimerization act... 227 | 227
structural constituent of ribo... 212 | 212
transcription regulatory regio... 202 | 202
transmembrane signaling recept... 201 | 201
RNA polymerase II regulatory r... 200 | 200
receptor activity 200 | 200
transcription corepressor acti... 198 | 198
magnesium ion binding 197 | 197
signal transducer activity 196 | 196
nucleic acid binding 184 | 184
protein kinase activity 183 | 183
carbohydrate binding 180 | 180
ubiquitin protein ligase activ... 173 | 173
RNA polymerase II transcriptio... 162 | 162
heparin binding 160 | 160
iron ion binding 141 | 141
lipid binding 136 | 136
transporter activity 136 | 136
actin binding 133 | 133
ATPase activity 132 | 132
protein C-terminus binding 129 | 129
heme binding 127 | 127
microtubule binding 123 | 123
protein tyrosine kinase activi... 119 | 119
cytokine activity 118 | 118
Ras guanyl-nucleotide exchange... 113 | 113
mRNA binding 112 | 112
metalloendopeptidase activity 112 | 112
transcriptional repressor acti... 110 | 110
structural constituent of cyto... 108 | 108
Rab GTPase binding 105 | 105
antigen binding 104 | 104
protein domain specific bindin... 102 | 102
peptide antigen binding 101 | 101
guanyl-nucleotide exchange fac... 98 | 98
protein complex binding 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 92 | 92
oxidoreductase activity 91 | 91
transcriptional activator acti... 91 | 91
actin filament binding 89 | 89
hydrolase activity 89 | 89
ion channel binding 89 | 89
protein tyrosine phosphatase a... 88 | 88
electron carrier activity 87 | 87
protease binding 87 | 87
histone binding 86 | 86
integrin binding 83 | 83
growth factor activity 82 | 82
phospholipid binding 82 | 82
single-stranded DNA binding 81 | 81
unfolded protein binding 77 | 77
kinase activity 75 | 75
thiol-dependent ubiquitin-spec... 75 | 75
phosphatidylinositol binding 74 | 74
calmodulin binding 73 | 73
histone deacetylase binding 73 | 73
Rho guanyl-nucleotide exchange... 72 | 72
drug binding 71 | 71
double-stranded DNA binding 70 | 70
peptidase activity 70 | 70
protein N-terminus binding 70 | 70
virus receptor activity 68 | 68
beta-catenin binding 67 | 67
microtubule motor activity 67 | 67
protein transporter activity 67 | 67
calcium channel activity 66 | 66
ubiquitin binding 66 | 66

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Protein N-lysine methyltransferase METTL21A METTL21A Tchem Enzyme 0.02 1.05 62
Sodium/potassium-transporting ATPase subunit beta-3 ATP1B3 Tclin Transporter -1.08214 10.9 189
Sodium/potassium-transporting ATPase subunit beta-2 ATP1B2 Tclin Transporter -1.33849 19.3 155
Charged multivesicular body protein 4a CHMP4A Tbio Non-IDG -1.11491 14.8 25
ATP-binding cassette sub-family A member 1 ABCA1 Tclin Transporter -3.12014 1383.2 302
Ataxin-3 ATXN3 Tbio Non-IDG -2.85838 721.6 233
V-type proton ATPase subunit G 3 ATP6V1G3 Tbio Enzyme -0.65332 4.31 51
Gamma-aminobutyric acid receptor-associated protein-like 2 GABARAPL2 Tbio Non-IDG -2.34411 203.8 347
Androgen receptor AR Tclin Nuclear Receptor -3.79989 6683.7 1366
Peroxisome assembly protein 26 PEX26 Tbio Non-IDG -0.98794 10.00 80