Development Level

Tbio 100 | 11,445
Tchem 15 | 1,598
Tdark 11 | 6,588
Tclin 2 | 613

IMPC Phenotype

preweaning lethality, complete... 20 | 979
embryonic lethality prior to t... 5 | 278
abnormal embryo size 4 | 220
abnormal behavior 3 | 298
decreased body weight 3 | 161
decreased circulating choleste... 3 | 93
decreased total body fat amoun... 3 | 207
embryonic lethality prior to o... 3 | 239
increased fasted circulating g... 3 | 76
male infertility 3 | 123
abnormal behavioral response t... 2 | 66
abnormal cranium morphology 2 | 36
abnormal skin coloration 2 | 25
abnormal snout morphology 2 | 23
cardiovascular system phenotyp... 2 | 36
cataract 2 | 92
decreased circulating alanine ... 2 | 47
decreased circulating aspartat... 2 | 34
decreased circulating glucose ... 2 | 126
decreased circulating insulin ... 2 | 76
decreased circulating total pr... 2 | 49
decreased lean body mass 2 | 135
embryonic growth retardation 2 | 106
hemorrhage 2 | 23
hyperactivity 2 | 148
increased circulating potassiu... 2 | 29
increased heart rate variabili... 2 | 7
increased mean corpuscular vol... 2 | 92
prenatal lethality prior to he... 2 | 87
preweaning lethality, incomple... 2 | 499
prolonged QT interval 2 | 38
prolonged ST segment 2 | 36
abnormal body wall morphology 1 | 9
abnormal facial morphology 1 | 17
abnormal hair texture 1 | 4
abnormal head shape 1 | 10
abnormal heart morphology 1 | 162
abnormal incisor morphology 1 | 4
abnormal joint morphology 1 | 23
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal limb morphology 1 | 13
abnormal maxilla morphology 1 | 17
abnormal motor capabilities-co... 1 | 5
abnormal outer ear morphology 1 | 3
abnormal pericardium morpholog... 1 | 26
abnormal placenta size 1 | 20
abnormal response to tactile s... 1 | 17
abnormal retina morphology 1 | 71
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
abnormal skin morphology 1 | 50
abnormal sleep behavior 1 | 70
abnormal tooth morphology 1 | 24
abnormal vocalization 1 | 21
cyanosis 1 | 7
decreased CD8-positive, alpha-... 1 | 8
decreased T cell number 1 | 15
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased circulating HDL chol... 1 | 68
decreased circulating serum al... 1 | 82
decreased circulating triglyce... 1 | 79
decreased fluid intake 1 | 3
decreased heart left ventricle... 1 | 28
decreased lactate dehydrogenas... 1 | 16
decreased lymphocyte cell numb... 1 | 83
decreased startle reflex 1 | 75
edema 1 | 59
enlarged heart 1 | 210
enlarged spleen 1 | 41
female infertility 1 | 60
hypoactivity 1 | 132
improved glucose tolerance 1 | 79
increased body length 1 | 32
increased circulating HDL chol... 1 | 80
increased circulating amylase ... 1 | 25
increased circulating chloride... 1 | 41
increased circulating choleste... 1 | 66
increased circulating glucose ... 1 | 24
increased circulating sodium l... 1 | 71
increased grip strength 1 | 41
increased heart weight 1 | 62
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased or absent threshold ... 1 | 101
increased total body fat amoun... 1 | 134
long tibia 1 | 25
protruding tongue 1 | 3
small testis 1 | 58
vertebral fusion 1 | 23

Disease

Carcinoma 108 | 11,493
ovarian cancer 75 | 8,520
osteosarcoma 58 | 7,950
psoriasis 54 | 6,694
lung cancer 53 | 4,740
glioblastoma 50 | 5,792
medulloblastoma, large-cell 48 | 6,241
Kidney cancer 41 | 2,613
atypical teratoid / rhabdoid tumor 39 | 5,112
ependymoma 36 | 4,679
Breast cancer 35 | 3,578
malignant mesothelioma 35 | 3,232
group 3 medulloblastoma 33 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 31 | 3,291
adult high grade glioma 30 | 3,801
intraductal papillary-mucinous carcinoma (IPMC) 29 | 2,989
Cancer 25 | 2,499
invasive ductal carcinoma 23 | 2,951
non-small cell lung cancer 23 | 2,890
lung adenocarcinoma 22 | 2,716
primitive neuroectodermal tumor 22 | 3,035
intraductal papillary-mucinous adenoma (IPMA) 21 | 2,955
Astrocytoma, Pilocytic 20 | 3,081
Autosomal recessive predisposition 20 | 1,442
oligodendroglioma 20 | 2,850
Multiple myeloma 17 | 1,332
Pick disease 17 | 1,894
lung carcinoma 17 | 2,843
Liver cancer 16 | 604
pancreatic cancer 16 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 16 | 1,962
acute quadriplegic myopathy 14 | 1,158
astrocytic glioma 14 | 2,597
colon cancer 14 | 1,478
interstitial cystitis 14 | 2,312
subependymal giant cell astrocytoma 13 | 2,287
Atopic dermatitis 12 | 952
adrenocortical carcinoma 12 | 1,428
diabetes mellitus 12 | 1,728
nasopharyngeal carcinoma 12 | 1,058
progressive supranuclear palsy 12 | 676
Epilepsy 11 | 792
Intellectual disability 11 | 1,016
Muscle hypotonia 11 | 571
astrocytoma 11 | 1,146
juvenile dermatomyositis 11 | 1,187
Neurodegenerative disease 10 | 414
Seizures 10 | 596
Small head 10 | 374
breast carcinoma 10 | 1,638
ductal carcinoma in situ 10 | 1,745
group 4 medulloblastoma 10 | 1,855
Melanoma 9 | 711
Short stature 9 | 531
Waldenstrons macroglobulinemia 9 | 765
pituitary cancer 9 | 1,972
tuberculosis 9 | 2,010
ulcerative colitis 9 | 1,819
Colorectal Neoplasms 8 | 243
Endometrial cancer 8 | 311
Endometriosis 8 | 540
Skin cancer 8 | 469
cutaneous lupus erythematosus 8 | 1,057
dermatomyositis 8 | 966
medulloblastoma 8 | 720
pediatric high grade glioma 8 | 1,064
Alzheimer's disease 7 | 658
Amyotrophic lateral sclerosis 7 | 451
Attention deficit hyperactivity disorder 7 | 278
Dull intelligence 7 | 645
Fatigue 7 | 182
Low intelligence 7 | 645
Lynch syndrome 7 | 35
Mental Retardation 7 | 645
Mental deficiency 7 | 645
Myocardial Infarction 7 | 151
Poor school performance 7 | 645
Schizophrenia 7 | 1,160
Vascular disease 7 | 319
Adenoma 6 | 167
Cataract 6 | 297
Cognitive delay 6 | 608
Congestive heart failure 6 | 113
Depressive disorder 6 | 409
Familial adenomatous polyposis 6 | 32
Global developmental delay 6 | 608
Heart failure 6 | 162
Hyperreflexia 6 | 209
Malabsorption 6 | 82
Mental and motor retardation 6 | 608
Muscle Spasticity 6 | 195
Neuropathy 6 | 261
active Crohn's disease 6 | 922
acute myeloid leukemia 6 | 783
Multiple Sclerosis 5 | 540
autosomal dominant Emery-Dreifuss muscular dystrophy 5 | 510
cystic fibrosis 5 | 1,696
gastric cancer 5 | 459
pancreatic carcinoma 5 | 562
primary Sjogren syndrome 5 | 735

Tissue

Endocrine System 121 | 18,159
Skin and soft tissues 120 | 17,230
Digestive Tract 119 | 17,369
Female tissues 119 | 17,400
Male tissues 119 | 17,142
Nervous System 118 | 16,725
Blood and immune system 117 | 16,909
Liver and Pancreas 117 | 16,750
Urinary Tract 116 | 16,678
Cardiovascular System 115 | 15,192
Respiratory system 115 | 16,393

Target Family

Non-IDG 71 | 12,091
Enzyme 39 | 4,145
Transporter 13 | 473
Epigenetic 3 | 242
Ion Channel 1 | 344
Transcription Factor 1 | 1,400

GO Function

ATPase activity 128 | 128
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Putative postmeiotic segregation increased 2-like protein 1 PMS2P1 Tdark Enzyme -2.19299 339.5 0
ATPase family AAA domain-containing protein 2B ATAD2B Tchem Epigenetic 0.27 1.01 18
Kinesin-like protein KIF18B KIF18B Tbio Non-IDG -0.83463 5.23 17
Apoptotic chromatin condensation inducer in the nucleus ACIN1 Tbio Non-IDG -1.51987 31.1 429
von Willebrand factor A domain-containing protein 8 VWA8 Tbio Non-IDG -0.36798 2.42 8
Myosin-4 MYH4 Tbio Non-IDG -1.81214 51.8 52
Kinesin-like protein KIF20B KIF20B Tbio Non-IDG -1.04680 12.5 48
Carnosine synthase 1 CARNS1 Tbio Enzyme -0.64427 4.21 70
ATP-binding cassette sub-family D member 3 ABCD3 Tbio Transporter -1.82051 64.2 166
ATP-binding cassette sub-family F member 3 ABCF3 Tdark Transporter -0.30626 2.60 137