Development Level

Tbio 3 | 11,445

IMPC Phenotype

decreased prepulse inhibition 1 | 82
preweaning lethality, complete... 1 | 979

Disease

Carcinoma 3 | 11,493
ovarian cancer 3 | 8,520
psoriasis 3 | 6,694
glioblastoma 2 | 5,792
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
invasive ductal carcinoma 2 | 2,951
osteosarcoma 2 | 7,950
ATRIOVENTRICULAR CANAL DEFECT 1 | 17
Abnormality of epiphysis morphology 1 | 39
Acquired scoliosis 1 | 281
Alzheimer's disease 1 | 658
Anteverted nostril 1 | 191
Atrial Septal Defects 1 | 85
Autosomal recessive predisposition 1 | 1,442
Blepharoptosis 1 | 231
Brachydactyly 1 | 156
Breast cancer 1 | 3,578
Broad skull 1 | 2
CODAS syndrome 1 | 1
Cancer 1 | 2,499
Carpal delayed ossification 1 | 4
Cataract 1 | 297
Central cleft of nose 1 | 3
Charcot-Marie-Tooth disease X-linked recessive 4 1 | 2
Cognitive delay 1 | 608
Concave bridge of nose 1 | 195
Congenital Bilateral Cataracts 1 | 50
Congenital Epicanthus 1 | 177
Congenital cataract 1 | 50
Coronal cleft vertebrae 1 | 8
Curvature of spine 1 | 282
Defective enamel matrix 1 | 35
Defective tooth enamel 1 | 31
Delayed bone age 1 | 136
Delayed maturation of wrist bone 1 | 4
Dental Enamel Hypoplasia 1 | 43
Dental abnormalities 1 | 60
Depressed nasal bridge 1 | 195
Depressed nasal root/bridge 1 | 195
Dysplasia of tooth enamel 1 | 35
Dystrophic tooth enamel 1 | 31
Enamel abnormalities 1 | 31
Endocardial Cushion Defects 1 | 17
Flat face 1 | 52
Global developmental delay 1 | 608
Hip Dislocation, Congenital 1 | 48
Hoarse voice due to vocal cord paresis 1 | 3
Hypoplasia of corpus callosum 1 | 90
Joint hyperflexibility 1 | 78
Knee joint valgus deformity 1 | 56
Late tooth eruption 1 | 61
Leishmaniasis 1 | 47
Lens Opacities 1 | 231
Mental and motor retardation 1 | 608
Midline defect of the nose 1 | 3
Multiple myeloma 1 | 1,332
Muscle hypotonia 1 | 571
ODONTOID HYPOPLASIA 1 | 16
OPTIC ATROPHY 11 1 | 1
Optic Atrophy 1 | 242
Overfolded helix 1 | 24
Paraplegia 1 | 74
Partial Paralysis (Paresis) Vocal Cords 1 | 3
Pick disease 1 | 1,894
Polyhydramnios 1 | 108
Pyle metaphyseal dysplasia 1 | 8
Rheumatoid arthritis 1 | 1,191
Sensorineural Hearing Loss (disorder) 1 | 284
Short metacarpal 1 | 43
Short nose 1 | 132
Short phalanx of finger 1 | 32
Short stature 1 | 531
Short upper arms 1 | 16
Small nose 1 | 132
Square iliac bones 1 | 4
Thin dental enamel 1 | 35
Tooth Abnormalities 1 | 69
Ventricular Septal Defects 1 | 119
Vocal cord paresis in severe cases 1 | 3
Waldenstrons macroglobulinemia 1 | 765
Weakness of vocal cord 1 | 3
astrocytic glioma 1 | 2,597
atypical teratoid / rhabdoid tumor 1 | 5,112
atypical teratoid/rhabdoid tumor 1 | 357
colon cancer 1 | 1,478
cutaneous lupus erythematosus 1 | 1,057
diabetes mellitus 1 | 1,728
ependymoma 1 | 4,679
group 3 medulloblastoma 1 | 4,104
group 4 medulloblastoma 1 | 1,855
intraductal papillary-mucinous carcinoma (IPMC) 1 | 2,989
lung cancer 1 | 4,740
malignant mesothelioma 1 | 3,232
medulloblastoma, large-cell 1 | 6,241
non-small cell lung cancer 1 | 2,890
oligodendroglioma 1 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 1 | 1,962
pituitary cancer 1 | 1,972
primitive neuroectodermal tumor 1 | 3,035
spina bifida 1 | 1,074

Tissue

Blood and immune system 3 | 16,909
Cardiovascular System 3 | 15,192
Digestive Tract 3 | 17,369
Endocrine System 3 | 18,159
Female tissues 3 | 17,400
Liver and Pancreas 3 | 16,750
Male tissues 3 | 17,142
Nervous System 3 | 16,725
Respiratory system 3 | 16,393
Skin and soft tissues 3 | 17,230
Urinary Tract 3 | 16,678

Target Family

Enzyme 3 | 4,145

GO Function

ATP-dependent peptidase activi... 3 | 3
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Lon protease homolog 2, peroxisomal LONP2 Tbio Enzyme -1.00177 8.20 100
ATP-dependent zinc metalloprotease YME1L1 YME1L1 Tbio Enzyme -2.42377 268.0 75
Lon protease homolog, mitochondrial LONP1 Tbio Enzyme -2.24805 169.6 174