Development Level

Tbio 54 | 11,445
Tdark 10 | 6,588
Tchem 2 | 1,598

IMPC Phenotype

preweaning lethality, complete... 15 | 979
embryonic lethality prior to o... 7 | 239
embryonic lethality prior to t... 6 | 278
abnormal embryo size 3 | 220
abnormal embryo turning 2 | 31
decreased lean body mass 2 | 135
enlarged heart 2 | 210
increased total body fat amoun... 2 | 134
preweaning lethality, incomple... 2 | 499
abnormal behavior 1 | 298
abnormal behavioral response t... 1 | 66
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal coat appearance 1 | 31
abnormal coat-hair pigmentatio... 1 | 64
abnormal neural tube closure 1 | 46
abnormal retinal vasculature m... 1 | 27
decreased NK cell number 1 | 2
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating potassiu... 1 | 20
decreased eosinophil cell numb... 1 | 24
decreased fasted circulating g... 1 | 65
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
increased body temperature 1 | 9
increased bone mineral content 1 | 108
increased fasted circulating g... 1 | 76
increased hematocrit 1 | 46
increased lean body mass 1 | 172
increased urine magnesium leve... 1 | 2
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
unresponsive to tactile stimul... 1 | 8

Disease

Carcinoma 56 | 11,493
ovarian cancer 35 | 8,520
osteosarcoma 26 | 7,950
medulloblastoma, large-cell 22 | 6,241
group 3 medulloblastoma 21 | 4,104
psoriasis 21 | 6,694
Kidney cancer 17 | 2,613
glioblastoma 16 | 5,792
lung cancer 15 | 4,740
atypical teratoid / rhabdoid tumor 14 | 5,112
oligodendroglioma 14 | 2,850
ependymoma 12 | 4,679
primitive neuroectodermal tumor 11 | 3,035
Cancer 10 | 2,499
Multiple myeloma 10 | 1,332
astrocytic glioma 10 | 2,597
diabetes mellitus 9 | 1,728
acute quadriplegic myopathy 8 | 1,158
malignant mesothelioma 8 | 3,232
Breast cancer 7 | 3,578
Waldenstrons macroglobulinemia 6 | 765
adult high grade glioma 6 | 3,801
dermatomyositis 6 | 966
group 4 medulloblastoma 6 | 1,855
juvenile dermatomyositis 6 | 1,187
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
pancreatic cancer 5 | 2,398
subependymal giant cell astrocytoma 5 | 2,287
Male infertility 4 | 206
Pick disease 4 | 1,894
Rheumatoid arthritis 4 | 1,191
colon cancer 4 | 1,478
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
non primary Sjogren syndrome sicca 4 | 891
pediatric high grade glioma 4 | 1,064
progressive supranuclear palsy 4 | 676
Astrocytoma, Pilocytic 3 | 3,081
adrenocortical carcinoma 3 | 1,428
aldosterone-producing adenoma 3 | 665
astrocytoma 3 | 1,146
cystic fibrosis 3 | 1,696
gastric cancer 3 | 459
invasive ductal carcinoma 3 | 2,951
lung adenocarcinoma 3 | 2,716
medulloblastoma 3 | 720
non-small cell lung cancer 3 | 2,890
pancreatic carcinoma 3 | 562
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
Amyotrophic lateral sclerosis 2 | 451
Autosomal dominant Robinow syndrome 1 2 | 15
Autosomal recessive predisposition 2 | 1,442
Azoospermia 2 | 110
Bipolar Disorder 2 | 666
Dull intelligence 2 | 645
Fragile X-associated tremor/ataxia syndrome 2 | 6
Gaucher disease type 1 2 | 180
Infertility 2 | 188
Influenza 2 | 142
Intellectual disability 2 | 1,016
Keratoconus 2 | 113
Kidney disease 2 | 430
Low intelligence 2 | 645
Mental Retardation 2 | 645
Mental deficiency 2 | 645
Mesothelioma, Malignant 2 | 105
Microcephaly 2 | 166
Neuronal ceroid lipofuscinosis 1 2 | 15
Ophthalmoplegia 2 | 106
Polycystic ovary syndrome 2 | 360
Poor school performance 2 | 645
Premature ovarian failure 2 | 65
Retinitis Pigmentosa 2 | 226
Retinitis pigmentosa 29 2 | 6
acute myeloid leukemia 2 | 783
breast carcinoma 2 | 1,638
interstitial lung disease 2 | 298
non diabetic and post-ischemic heart failure 2 | 200
pituitary cancer 2 | 1,972
primary Sjogren syndrome 2 | 735
spina bifida 2 | 1,074
tuberculosis 2 | 2,010
tuberculosis and treatment for 3 months 2 | 179
tuberculosis and treatment for 6 months 2 | 409
ulcerative colitis 2 | 1,819
Acrofacial dysostosis 1 | 8
Bowen-Conradi syndrome 1 | 16
Breast abscess 1 | 5
Choanal Atresia 1 | 42
Coloboma 1 | 51
DOID:3858 1 | 6
Lyme disease 1 | 26
Oligospermia 1 | 36
Orofaciodigital syndrome 1 | 21
Pilomatrixoma 1 | 12
Skin Abnormalities 1 | 37
Spermatogenic Failure, Nonobstructive, Y-Linked 1 | 15
Spinocerebellar ataxia type 2 1 | 23
Tetanus 1 | 68
Waterhouse-Friderichsen syndrome 1 | 11

Tissue

Endocrine System 66 | 18,159
Blood and immune system 65 | 16,909
Digestive Tract 65 | 17,369
Female tissues 65 | 17,400
Liver and Pancreas 64 | 16,750
Male tissues 64 | 17,142
Nervous System 64 | 16,725
Skin and soft tissues 64 | 17,230
Urinary Tract 64 | 16,678
Respiratory system 63 | 16,393
Cardiovascular System 62 | 15,192

Target Family

Enzyme 60 | 4,145
Non-IDG 5 | 12,091
Epigenetic 1 | 242

GO Function

ATP-dependent RNA helicase act... 66 | 66
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Probable ATP-dependent RNA helicase DDX5 DDX5 Tbio Enzyme -2.08566 121.1 344
ATP-dependent RNA helicase DDX42 DDX42 Tbio Enzyme -1.10894 13.3 60
ATP-dependent RNA helicase DDX25 DDX25 Tbio Enzyme -1.23468 21.8 47
Probable ATP-dependent RNA helicase DDX52 DDX52 Tbio Enzyme -1.26645 18.0 73
ATP-dependent RNA helicase DDX18 DDX18 Tbio Enzyme -0.74619 5.48 53
Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 DHX15 Tbio Enzyme -1.74929 55.5 106
RNA helicase Mov10l1 MOV10L1 Tbio Enzyme -0.73306 5.20 57
Probable ATP-dependent RNA helicase DDX49 DDX49 Tdark Enzyme 0.39 0.08 93
Probable ATP-dependent RNA helicase DDX56 DDX56 Tbio Enzyme -0.74504 5.47 246
Spliceosome RNA helicase DDX39B DDX39B Tbio Enzyme -1.74494 60.6 182