Development Level

Tbio 20 | 11,445
Tchem 2 | 1,598
Tdark 2 | 6,588

IMPC Phenotype

embryonic lethality prior to o... 3 | 239
preweaning lethality, complete... 3 | 979
embryonic lethality prior to t... 2 | 278
increased body temperature 2 | 9
abnormal bone structure 1 | 187
abnormal embryo size 1 | 220
abnormal eye morphology 1 | 68
abnormal maxilla morphology 1 | 17
abnormal retina morphology 1 | 71
abnormal tooth morphology 1 | 24
anophthalmia 1 | 33
decreased body length 1 | 101
decreased body weight 1 | 161
decreased erythrocyte cell num... 1 | 62
decreased hemoglobin content 1 | 68
embryonic growth retardation 1 | 106
hypoactivity 1 | 132
increased circulating potassiu... 1 | 29
prenatal lethality 1 | 28
preweaning lethality, incomple... 1 | 499
short tibia 1 | 97
unresponsive to tactile stimul... 1 | 8

Disease

Carcinoma 23 | 11,493
medulloblastoma, large-cell 14 | 6,241
osteosarcoma 14 | 7,950
ovarian cancer 14 | 8,520
glioblastoma 12 | 5,792
lung cancer 12 | 4,740
Cancer 10 | 2,499
Cockayne syndrome 9 | 60
Kidney cancer 9 | 2,613
atypical teratoid / rhabdoid tumor 9 | 5,112
psoriasis 9 | 6,694
Photosensitive trichothiodystrophy 8 | 30
primitive neuroectodermal tumor 8 | 3,035
Fanconi anemia 7 | 56
Intellectual disability 7 | 1,016
Rothmund-Thomson syndrome 7 | 19
group 3 medulloblastoma 7 | 4,104
malignant mesothelioma 7 | 3,232
Autosomal recessive predisposition 6 | 1,442
Baller-Gerold syndrome 6 | 12
Dull intelligence 6 | 645
Low intelligence 6 | 645
Mental Retardation 6 | 645
Mental deficiency 6 | 645
Poor school performance 6 | 645
Warsaw breakage syndrome 6 | 11
Xeroderma pigmentosum group D 6 | 33
adult high grade glioma 6 | 3,801
Breast cancer 5 | 3,578
Multiple myeloma 5 | 1,332
Short stature 5 | 531
Small head 5 | 374
Werner syndrome 5 | 29
Xeroderma pigmentosum 5 | 43
ependymoma 5 | 4,679
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
lung adenocarcinoma 5 | 2,716
Bloom syndrome 4 | 29
Cognitive delay 4 | 608
Fetal Growth Retardation 4 | 189
Global developmental delay 4 | 608
Infant, Small for Gestational Age 4 | 176
Intrauterine retardation 4 | 176
Mental and motor retardation 4 | 608
Telangiectasia of the skin 4 | 39
Waldenstrons macroglobulinemia 4 | 765
colon cancer 4 | 1,478
diabetes mellitus 4 | 1,728
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
Atrophic condition of skin 3 | 25
Cataract 3 | 297
Cerebellar Ataxia 3 | 304
Congenital deafness 3 | 185
Cryptorchidism 3 | 296
Deafness 3 | 198
Developmental regression 3 | 95
Electroencephalogram abnormal 3 | 101
Erythema 3 | 58
Failure to gain weight 3 | 365
Flushing 3 | 60
Hearing Loss, Partial 3 | 185
Hyperkeratosis 3 | 50
Hyperpigmented macules 3 | 42
Hypogonadism 3 | 173
Keratitis 3 | 62
Lens Opacities 3 | 231
Loss of developmental milestones 3 | 95
Mental deterioration in childhood 3 | 95
Microcephaly 3 | 166
Muscle hypotonia 3 | 571
Neurodevelopmental regression 3 | 95
Pediatric failure to thrive 3 | 365
Photosensitivity of skin 3 | 51
Psychomotor regression 3 | 95
Psychomotor regression beginning in infancy 3 | 95
Psychomotor regression in infants 3 | 95
Psychomotor regression, progressive 3 | 95
Rheumatoid arthritis 3 | 1,191
Roberts syndrome 3 | 15
astrocytoma 3 | 1,146
hearing impairment 3 | 199
hypopigmented skin patch 3 | 59
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
invasive ductal carcinoma 3 | 2,951
non-small cell lung cancer 3 | 2,890
pediatric high grade glioma 3 | 1,064
ulcerative colitis 3 | 1,819
Adenocarcinoma of lung 2 | 142
Anemia 2 | 365
Cerebral atrophy 2 | 178
Disease Models, Animal 2 | 155
Impaired cognition 2 | 96
Melanoma 2 | 711
Mental impairment 2 | 95
Muscle Hypertonia 2 | 88
Muscle Spasticity 2 | 195
Retinal Diseases 2 | 55
Thin skin 2 | 47
Vertical Talus 2 | 25
medulloblastoma 2 | 720

Tissue

Blood and immune system 22 | 16,909
Cardiovascular System 22 | 15,192
Digestive Tract 22 | 17,369
Endocrine System 22 | 18,159
Female tissues 22 | 17,400
Liver and Pancreas 22 | 16,750
Male tissues 22 | 17,142
Nervous System 22 | 16,725
Respiratory system 22 | 16,393
Skin and soft tissues 22 | 17,230
Urinary Tract 22 | 16,678

Target Family

Enzyme 13 | 4,145
Non-IDG 7 | 12,091
Epigenetic 4 | 242

GO Function

ATP-dependent DNA helicase act... 24 | 24
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
X-ray repair cross-complementing protein 5 XRCC5 Tbio Non-IDG -2.68622 470.8 874
X-ray repair cross-complementing protein 6 XRCC6 Tbio Non-IDG -2.86424 688.3 865
ATP-dependent RNA helicase DDX3X DDX3X Tchem Enzyme -2.32036 221.7 479
Ras GTPase-activating protein-binding protein 1 G3BP1 Tbio Enzyme -2.01627 111.4 426
Bloom syndrome protein BLM Tchem Non-IDG -2.03028 104.1 314
RuvB-like 1 RUVBL1 Tbio Non-IDG -1.88763 79.0 257
RuvB-like 2 RUVBL2 Tbio Non-IDG -1.95930 93.1 233
Fanconi anemia group J protein BRIP1 Tbio Non-IDG -1.81875 78.3 223
Werner syndrome ATP-dependent helicase WRN Tbio Enzyme -2.73759 569.7 210
ATP-dependent RNA helicase A DHX9 Tbio Enzyme -2.85807 734.3 204