Development Level

Tbio 785 | 11,178
Tchem 471 | 1,885
Tdark 147 | 6,569
Tclin 74 | 612

Collection

Kinase: IDG Consortium (Target... 123 | 125
Kinase: IDG Consortium (Comple... 37 | 37
Ion Channel: IDG Consortium (T... 2 | 99

IMPC Phenotype

preweaning lethality, complete... 145 | 979
preweaning lethality, incomple... 50 | 499
embryonic lethality prior to o... 46 | 239
embryonic lethality prior to t... 44 | 278
abnormal embryo size 37 | 220
abnormal behavior 34 | 298
decreased body weight 24 | 161
abnormal bone structure 21 | 187
decreased bone mineral content 19 | 151
decreased lean body mass 19 | 135
embryonic growth retardation 18 | 106
increased total body fat amoun... 18 | 134
enlarged heart 16 | 210
abnormal behavioral response t... 14 | 66
decreased circulating glucose ... 14 | 126
hyperactivity 14 | 148
decreased bone mineral density 13 | 126
decreased total body fat amoun... 13 | 207
decreased body length 12 | 101
decreased vertical activity 12 | 208
increased bone mineral content 12 | 108
increased or absent threshold ... 12 | 101
male infertility 12 | 123
increased lean body mass 11 | 172
abnormal heart morphology 10 | 162
abnormal lens morphology 10 | 81
abnormal seminal vesicle morph... 10 | 114
decreased circulating choleste... 10 | 93
decreased grip strength 10 | 116
decreased prepulse inhibition 10 | 82
increased circulating alkaline... 10 | 122
increased mean corpuscular hem... 10 | 96
increased startle reflex 10 | 112
prenatal lethality prior to he... 10 | 87
cataract 9 | 92
decreased fasted circulating g... 9 | 65
decreased lymphocyte cell numb... 9 | 83
decreased mean corpuscular vol... 9 | 79
impaired glucose tolerance 9 | 75
increased bone mineral density 9 | 72
increased circulating HDL chol... 9 | 80
increased circulating choleste... 9 | 66
increased heart weight 9 | 62
increased mean corpuscular vol... 9 | 92
abnormal coat-hair pigmentatio... 8 | 64
decreased circulating triglyce... 8 | 79
decreased hemoglobin content 8 | 68
decreased leukocyte cell numbe... 8 | 73
decreased startle reflex 8 | 75
increased circulating sodium l... 8 | 71
increased fasted circulating g... 8 | 76
increased grip strength 8 | 41
increased monocyte cell number 8 | 63
abnormal gait 7 | 69
decreased circulating serum al... 7 | 82
decreased circulating total pr... 7 | 49
decreased mean corpuscular hem... 7 | 50
decreased neutrophil cell numb... 7 | 42
increased hematocrit 7 | 46
short tibia 7 | 97
small testis 7 | 58
abnormal bone mineralization 6 | 38
abnormal epididymis morphology 6 | 42
abnormal kidney morphology 6 | 65
abnormal neural tube closure 6 | 46
abnormal retina morphology 6 | 71
abnormal spleen morphology 6 | 55
decreased circulating HDL chol... 6 | 68
decreased circulating alkaline... 6 | 46
edema 6 | 59
hypoactivity 6 | 132
increased blood urea nitrogen ... 6 | 48
increased body length 6 | 32
increased erythrocyte cell num... 6 | 39
abnormal cranium morphology 5 | 36
abnormal embryo turning 5 | 31
abnormal skin morphology 5 | 50
abnormal sleep behavior 5 | 70
cardiovascular system phenotyp... 5 | 36
decreased blood urea nitrogen ... 5 | 51
decreased circulating alanine ... 5 | 47
decreased heart left ventricle... 5 | 28
decreased hematocrit 5 | 46
decreased mean platelet volume 5 | 25
decreased red blood cell distr... 5 | 41
enlarged epididymis 5 | 31
enlarged lymph nodes 5 | 37
female infertility 5 | 60
improved glucose tolerance 5 | 79
increased circulating chloride... 5 | 41
increased leukocyte cell numbe... 5 | 47
increased mean platelet volume 5 | 45
prenatal lethality 5 | 28
thin ventricular wall 5 | 24
abnormal eye morphology 4 | 68
decreased circulating aspartat... 4 | 34
decreased circulating calcium ... 4 | 36
decreased circulating creatini... 4 | 39
increased hemoglobin content 4 | 45
pallor 4 | 34

Disease

Carcinoma 1,200 | 11,192
ovarian cancer 798 | 8,297
osteosarcoma 735 | 7,766
medulloblastoma, large-cell 607 | 6,086
psoriasis 590 | 6,514
glioblastoma 539 | 5,635
lung cancer 509 | 4,607
atypical teratoid / rhabdoid tumor 482 | 4,971
ependymoma 414 | 4,559
Kidney cancer 413 | 2,548
group 3 medulloblastoma 391 | 4,002
Breast cancer 367 | 3,469
malignant mesothelioma 337 | 3,135
adult high grade glioma 336 | 3,701
Cancer 311 | 2,388
primitive neuroectodermal tumor 304 | 2,957
non-small cell lung cancer 298 | 2,799
intraductal papillary-mucinous neoplasm (IPMN) 294 | 3,204
intraductal papillary-mucinous carcinoma (IPMC) 275 | 2,902
invasive ductal carcinoma 269 | 2,867
Astrocytoma, Pilocytic 260 | 3,006
oligodendroglioma 246 | 2,768
intraductal papillary-mucinous adenoma (IPMA) 244 | 2,872
lung adenocarcinoma 243 | 2,627
lung carcinoma 234 | 2,755
astrocytic glioma 225 | 2,530
pancreatic cancer 214 | 2,322
Autosomal recessive predisposition 200 | 1,407
Pick disease 192 | 1,856
subependymal giant cell astrocytoma 186 | 2,230
interstitial cystitis 173 | 2,237
tuberculosis 162 | 1,963
ulcerative colitis 162 | 1,765
pancreatic ductal adenocarcinoma liver metastasis 158 | 1,911
adrenocortical carcinoma 157 | 1,385
ductal carcinoma in situ 153 | 1,686
pituitary cancer 152 | 1,915
group 4 medulloblastoma 151 | 1,806
colon cancer 150 | 1,428
Multiple myeloma 141 | 1,296
diabetes mellitus 139 | 1,683
breast carcinoma 138 | 1,589
cystic fibrosis 137 | 1,629
Intellectual disability 134 | 998
juvenile dermatomyositis 124 | 1,147
acute quadriplegic myopathy 121 | 1,133
Rheumatoid arthritis 120 | 1,156
Schizophrenia 119 | 1,136
Epilepsy 117 | 775
astrocytoma 117 | 1,113
nasopharyngeal carcinoma 113 | 1,024
Liver cancer 110 | 589
dermatomyositis 108 | 941
pediatric high grade glioma 104 | 1,035
Dull intelligence 101 | 634
Low intelligence 101 | 634
Mental Retardation 101 | 634
Mental deficiency 101 | 634
Poor school performance 101 | 634
Waldenstrons macroglobulinemia 95 | 742
Melanoma 94 | 689
Seizures 91 | 584
Cognitive delay 88 | 596
Global developmental delay 88 | 596
Mental and motor retardation 88 | 596
primary pancreatic ductal adenocarcinoma 86 | 1,071
spina bifida 82 | 1,053
primary Sjogren syndrome 81 | 710
Muscle hypotonia 80 | 562
Renal Cell Carcinoma 80 | 211
cutaneous lupus erythematosus 80 | 1,016
progressive supranuclear palsy 78 | 656
Atopic dermatitis 77 | 915
Short stature 77 | 514
Small head 77 | 366
Skin cancer 76 | 451
medulloblastoma 76 | 702
Bipolar Disorder 75 | 646
Endometriosis 67 | 521
active Crohn's disease 67 | 882
Neurodegenerative disease 65 | 402
Failure to gain weight 64 | 359
Pediatric failure to thrive 64 | 359
Alzheimer's disease 63 | 640
Endometrial cancer 63 | 301
acute myeloid leukemia 63 | 760
esophageal adenocarcinoma 62 | 696
Colorectal Neoplasms 61 | 235
aldosterone-producing adenoma 59 | 646
non primary Sjogren syndrome sicca 57 | 861
Liver Cirrhosis, Experimental 56 | 733
Chronic Myelocytic Leukemia Accelerated Phase 55 | 59
Down syndrome 55 | 480
gastric carcinoma 55 | 781
Blastic phase chronic myeloid leukemia 54 | 58
Obesity 54 | 655
Breast Neoplasms 53 | 423
Hypoplastic mandible condyle 52 | 273
Mandibular hypoplasia 52 | 273
Micrognathism 52 | 273

Tissue

Endocrine System 1,450 | 18,159
Digestive Tract 1,416 | 17,369
Female tissues 1,415 | 17,400
Skin and soft tissues 1,415 | 17,230
Male tissues 1,411 | 17,142
Liver and Pancreas 1,391 | 16,750
Blood and immune system 1,390 | 16,909
Urinary Tract 1,387 | 16,678
Nervous System 1,385 | 16,725
Respiratory system 1,374 | 16,393
Cardiovascular System 1,322 | 15,192

Target Family

Kinase 614 | 634
Non-IDG 373 | 12,091
Enzyme 354 | 4,145
Transporter 86 | 473
Ion Channel 25 | 344
Epigenetic 18 | 242
Transcription Factor 5 | 1,400
GPCR 2 | 408

GO Function

ATP binding 1,477 | 1,477
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Probable gluconokinase IDNK Tbio Kinase -1.00330 9.91 94
Ryanodine receptor 1 RYR1 Tclin Ion Channel -3.00978 1018.9 103
Protein SLFN14 SLFN14 Tbio Non-IDG -0.61542 3.98 53
ATP-dependent DNA helicase DDX11 DDX11 Tbio Enzyme -1.05592 30.0 163
Protein monoglycylase TTLL8 TTLL8 Tdark Enzyme -0.12494 0.88 19
Chromodomain-helicase-DNA-binding protein 6 CHD6 Tbio Epigenetic -1.01113 11.4 31
Insulin receptor INSR Tclin Kinase -2.50045 306.8 1417
Serine/threonine-protein kinase D1 PRKD1 Tchem Kinase -2.88440 775.2 667
Serine/threonine-protein kinase N1 PKN1 Tchem Kinase -2.03368 117.6 153
2-5A-dependent ribonuclease RNASEL Tchem Kinase -2.71673 525.8 127