Development Level

Tbio 765 | 10,625
Tchem 472 | 1,890
Tdark 161 | 7,003
Tclin 69 | 602

Collection

Eligible Kinase Proteins 128 | 134
Eligible Ion Channel Proteins 1 | 117

IMPC Term

preweaning lethality, complete... 99 | 633
embryonic lethality prior to o... 32 | 148
embryonic lethality prior to t... 31 | 187
abnormal behavior 29 | 226
decreased body weight 25 | 174
decreased lean body mass 25 | 195
preweaning lethality, incomple... 25 | 260
abnormal embryo size 19 | 112
decreased body length 15 | 108
decreased bone mineral content 15 | 157
decreased total body fat amoun... 15 | 186
decreased grip strength 13 | 123
increased circulating alkaline... 13 | 119
increased grip strength 13 | 83
increased or absent threshold ... 13 | 128
abnormal bone structure 12 | 131
decreased circulating glucose ... 12 | 121
abnormal behavioral response t... 11 | 52
decreased circulating choleste... 11 | 85
abnormal retina morphology 10 | 100
decreased circulating triglyce... 10 | 83
increased mean corpuscular hem... 10 | 93
abnormal lens morphology 9 | 73
decreased circulating serum al... 9 | 79
hyperactivity 9 | 108
increased bone mineral content 9 | 92
increased circulating HDL chol... 9 | 63
increased circulating choleste... 9 | 53
abnormal bone mineralization 8 | 55
decreased bone mineral density 8 | 126
enlarged heart 8 | 111
increased blood urea nitrogen ... 8 | 44
increased circulating sodium l... 8 | 71
male infertility 8 | 62
abnormal retinal pigmentation 7 | 61
abnormal seminal vesicle morph... 7 | 47
decreased circulating HDL chol... 7 | 77
increased circulating chloride... 7 | 43
increased lean body mass 7 | 107
prenatal lethality prior to he... 7 | 64
short tibia 7 | 82
small testis 7 | 37
abnormal coat/hair pigmentatio... 6 | 54
abnormal gait 6 | 51
abnormal kidney morphology 6 | 30
abnormal sleep behavior 6 | 63
decreased blood urea nitrogen ... 6 | 31
increased fasted circulating g... 6 | 68
increased mean corpuscular vol... 6 | 91
increased total body fat amoun... 6 | 57
abnormal hindbrain development 5 | 24
abnormal neural tube closure 5 | 37
cardiovascular system phenotyp... 5 | 35
decreased fasted circulating g... 5 | 49
decreased hemoglobin content 5 | 53
decreased leukocyte cell numbe... 5 | 54
decreased lumbar vertebrae num... 5 | 62
decreased neutrophil cell numb... 5 | 37
decreased prepulse inhibition 5 | 52
hypoactivity 5 | 89
impaired glucose tolerance 5 | 52
increased circulating potassiu... 5 | 31
increased erythrocyte cell num... 5 | 26
increased exploration in new e... 5 | 56
increased heart weight 5 | 37
increased hemoglobin content 5 | 45
abnormal cranium morphology 4 | 32
abnormal forebrain development 4 | 18
abnormal maxilla morphology 4 | 16
abnormal midbrain development 4 | 22
abnormal response to tactile s... 4 | 16
abnormal snout morphology 4 | 18
abnormal spleen morphology 4 | 36
abnormal tooth morphology 4 | 24
anophthalmia 4 | 20
cataract 4 | 26
decreased circulating alanine ... 4 | 53
decreased circulating aspartat... 4 | 27
decreased circulating creatini... 4 | 31
decreased circulating glycerol... 4 | 19
decreased circulating total pr... 4 | 41
decreased heart weight 4 | 44
decreased mean corpuscular hem... 4 | 34
decreased startle reflex 4 | 48
female infertility 4 | 34
improved glucose tolerance 4 | 56
increased NK cell number 4 | 19
increased bone mineral density 4 | 52
increased circulating bilirubi... 4 | 16
increased hematocrit 4 | 36
increased leukocyte cell numbe... 4 | 37
increased startle reflex 4 | 38
microphthalmia 4 | 15
abnormal epididymis morphology 3 | 31
decreased Ly6C high monocyte n... 3 | 18
decreased caudal vertebrae num... 3 | 49
increased NK T cell number 3 | 11
increased body weight 3 | 42
increased circulating aspartat... 3 | 17
increased circulating iron lev... 3 | 25

Disease

ovarian cancer 789 | 8,484
osteosarcoma 734 | 7,933
medulloblastoma, large-cell 604 | 6,234
psoriasis 592 | 6,685
glioblastoma 516 | 5,572
lung cancer 479 | 4,466
atypical teratoid / rhabdoid tumor 408 | 4,369
Carcinoma 366 | 2,147
malignant mesothelioma 329 | 3,162
primitive neuroectodermal tumor 306 | 3,031
Breast cancer 299 | 3,094
Cancer 296 | 2,346
intraductal papillary-mucinous neoplasm (IPMN) 294 | 3,289
non-small cell lung cancer 293 | 2,798
pediatric high grade glioma 280 | 2,712
intraductal papillary-mucinous carcinoma (IPMC) 277 | 2,988
invasive ductal carcinoma 266 | 2,950
pilocytic astrocytoma 261 | 3,086
oligodendroglioma 251 | 2,849
intraductal papillary-mucinous adenoma (IPMA) 246 | 2,956
lung adenocarcinoma 242 | 2,713
ependymoma 238 | 2,514
lung carcinoma 235 | 2,844
group 3 medulloblastoma 219 | 2,254
astrocytic glioma 197 | 2,241
Pick disease 194 | 1,893
pancreatic cancer 193 | 2,300
ulcerative colitis 187 | 2,087
subependymal giant cell astrocytoma 182 | 2,287
interstitial cystitis 174 | 2,299
adult high grade glioma 161 | 2,148
adrenocortical carcinoma 157 | 1,427
ductal carcinoma in situ 151 | 1,745
pituitary cancer 151 | 1,972
astrocytoma 149 | 1,493
colon cancer 148 | 1,475
group 4 medulloblastoma 147 | 1,875
medulloblastoma 142 | 1,524
pancreatic ductal adenocarcinoma liver metastasis 142 | 1,795
posterior fossa group B ependymoma 140 | 1,530
Multiple myeloma 139 | 1,327
sonic hedgehog group medulloblastoma 138 | 1,482
cystic fibrosis 134 | 1,665
diabetes mellitus 134 | 1,663
breast carcinoma 129 | 1,614
juvenile dermatomyositis 123 | 1,189
tuberculosis 123 | 1,557
posterior fossa group A ependymoma 122 | 1,511
Rheumatoid Arthritis 119 | 1,160
acute quadriplegic myopathy 119 | 1,157
nasopharyngeal carcinoma 110 | 1,056
atypical teratoid/rhabdoid tumor 108 | 1,095
dermatomyositis 107 | 933
primary pancreatic ductal adenocarcinoma 103 | 1,271
Waldenstrons macroglobulinemia 94 | 765
spina bifida 82 | 1,064
primary Sjogren syndrome 81 | 789
cutaneous lupus erythematosus 80 | 1,056
progressive supranuclear palsy 77 | 674
Atopic dermatitis 76 | 944
Renal Cell Carcinoma 74 | 199
Intellectual disability 69 | 573
tuberculosis and treatment for 6 months 69 | 686
IGA Glomerulonephritis 67 | 454
Endometriosis 65 | 535
active Crohn's disease 65 | 918
Neurodegenerative disease 63 | 383
acute myeloid leukemia 62 | 780
esophageal adenocarcinoma 61 | 737
Alzheimer's disease 60 | 644
Colorectal Neoplasms 60 | 217
Down syndrome 59 | 548
aldosterone-producing adenoma 58 | 664
non primary Sjogren syndrome sicca 57 | 840
Chronic Myelocytic Leukemia Accelerated Phase 55 | 59
Peripheral Neuropathy 55 | 303
Blastic phase chronic myeloid leukemia 54 | 58
Obesity 53 | 616
gastric carcinoma 53 | 832
chronic rhinosinusitis 50 | 512
Amyotrophic Lateral Sclerosis 48 | 431
Mammary Neoplasms 48 | 410
Schizophrenia 48 | 501
Gastrointestinal stromal tumor 47 | 61
Prostatic Neoplasms 45 | 471
fibroadenoma 44 | 557
non-small cell lung carcinoma 44 | 413
pancreatic carcinoma 44 | 567
Parkinson's disease 43 | 364
Philadelphia chromosome-positive acute lymphoblastic leukemia 43 | 47
Vascular disease 43 | 281
Pancreatic Neuroendocrine Tumor 42 | 45
Chronic phase chronic myeloid leukemia 41 | 45
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia 41 | 45
Epilepsy 40 | 346
hepatocellular carcinoma 37 | 532
Hamman-Rich syndrome 35 | 35
Kidney disease 35 | 396
inflammatory breast cancer 33 | 404
gastric cancer 32 | 430

Tissue

Nervous System 1,440 | 18,561
Female tissues 1,438 | 18,647
Blood and immune system 1,437 | 17,995
Digestive Tract 1,437 | 18,473
Endocrine System 1,437 | 18,512
Male tissues 1,437 | 17,969
Urinary Tract 1,437 | 18,444
Liver and Pancreas 1,435 | 18,136
Cardiovascular System 1,433 | 17,958
Skin and soft tissues 1,424 | 18,115
Respiratory system 1,421 | 17,484

Target Family

Kinase 613 | 634
Non-IDG 369 | 11,971
Enzyme 351 | 4,146
Transporter 85 | 473
Ion Channel 24 | 341
Epigenetic 18 | 242
Transcription Factor 5 | 1,400
GPCR 2 | 406

GO Function

ATP binding 1,467 | 1,467
metal ion binding 1,917 | 1,917
DNA binding 1,432 | 1,432
zinc ion binding 1,155 | 1,155
poly(A) RNA binding 1,107 | 1,107
transcription factor activity,... 853 | 853
calcium ion binding 695 | 695
G-protein coupled receptor act... 661 | 661
protein homodimerization activ... 569 | 569
RNA binding 445 | 445
olfactory receptor activity 424 | 424
sequence-specific DNA binding 398 | 398
GTP binding 374 | 374
chromatin binding 372 | 372
protein serine/threonine kinas... 336 | 336
RNA polymerase II core promote... 332 | 332
identical protein binding 311 | 311
nucleotide binding 311 | 311
receptor binding 303 | 303
protein kinase binding 289 | 289
enzyme binding 286 | 286
cadherin binding involved in c... 277 | 277
GTPase activator activity 273 | 273
ubiquitin protein ligase bindi... 258 | 258
ubiquitin-protein transferase ... 253 | 253
serine-type endopeptidase acti... 246 | 246
transcription coactivator acti... 241 | 241
transcription factor binding 240 | 240
structural molecule activity 232 | 232
GTPase activity 231 | 231
transcriptional activator acti... 230 | 230
ligase activity 227 | 227
protein heterodimerization act... 227 | 227
structural constituent of ribo... 212 | 212
transcription regulatory regio... 202 | 202
transmembrane signaling recept... 201 | 201
RNA polymerase II regulatory r... 200 | 200
receptor activity 200 | 200
transcription corepressor acti... 198 | 198
magnesium ion binding 197 | 197
signal transducer activity 196 | 196
nucleic acid binding 184 | 184
protein kinase activity 183 | 183
carbohydrate binding 180 | 180
ubiquitin protein ligase activ... 173 | 173
RNA polymerase II transcriptio... 162 | 162
heparin binding 160 | 160
iron ion binding 141 | 141
lipid binding 136 | 136
transporter activity 136 | 136
actin binding 133 | 133
ATPase activity 132 | 132
protein C-terminus binding 129 | 129
heme binding 127 | 127
microtubule binding 123 | 123
protein tyrosine kinase activi... 119 | 119
cytokine activity 118 | 118
Ras guanyl-nucleotide exchange... 113 | 113
mRNA binding 112 | 112
metalloendopeptidase activity 112 | 112
transcriptional repressor acti... 110 | 110
structural constituent of cyto... 108 | 108
Rab GTPase binding 105 | 105
antigen binding 104 | 104
protein domain specific bindin... 102 | 102
peptide antigen binding 101 | 101
guanyl-nucleotide exchange fac... 98 | 98
protein complex binding 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 92 | 92
oxidoreductase activity 91 | 91
transcriptional activator acti... 91 | 91
actin filament binding 89 | 89
hydrolase activity 89 | 89
ion channel binding 89 | 89
protein tyrosine phosphatase a... 88 | 88
electron carrier activity 87 | 87
protease binding 87 | 87
histone binding 86 | 86
integrin binding 83 | 83
growth factor activity 82 | 82
phospholipid binding 82 | 82
single-stranded DNA binding 81 | 81
unfolded protein binding 77 | 77
kinase activity 75 | 75
thiol-dependent ubiquitin-spec... 75 | 75
phosphatidylinositol binding 74 | 74
calmodulin binding 73 | 73
histone deacetylase binding 73 | 73
Rho guanyl-nucleotide exchange... 72 | 72
drug binding 71 | 71
double-stranded DNA binding 70 | 70
peptidase activity 70 | 70
protein N-terminus binding 70 | 70
virus receptor activity 68 | 68
beta-catenin binding 67 | 67
microtubule motor activity 67 | 67
protein transporter activity 67 | 67
calcium channel activity 66 | 66
ubiquitin binding 66 | 66

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Probable phospholipid-transporting ATPase IIB ATP9B Tdark Transporter -0.57248 3.74 5
Endoplasmin HSP90B1 Tchem Non-IDG -2.72785 604.5 748
Insulin receptor-related protein INSRR Tchem Kinase -1.96888 93.2 241
Interleukin-1 receptor-associated kinase 1 IRAK1 Tchem Kinase -2.51851 320.4 729
Uridine-cytidine kinase 2 UCK2 Tbio Kinase -1.39159 27.7 106
Kinesin-like protein KIF1C KIF1C Tbio Non-IDG -1.21884 20.0 95
Cyclin-dependent kinase 8 CDK8 Tchem Kinase -1.96301 102.7 307
N-acylglucosamine 2-epimerase RENBP Tbio Enzyme -1.52686 33.5 80
Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B Tclin Ion Channel -2.21210 162.9 67
ATP-binding cassette sub-family A member 2 ABCA2 Tbio Transporter -1.41708 32.2 125