Development Level

Tbio 16 | 11,651
Tdark 4 | 6,593

IMPC Phenotype

preweaning lethality, complete... 2 | 979
abnormal bone structure 1 | 187
abnormal embryo size 1 | 220
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating amylase ... 1 | 28
decreased circulating bilirubi... 1 | 19
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased lymphocyte cell numb... 1 | 83
decreased startle reflex 1 | 75
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
increased anti-nuclear antigen... 1 | 19
increased circulating amylase ... 1 | 25
increased monocyte cell number 1 | 63
increased or absent threshold ... 1 | 101
increased total body fat amoun... 1 | 134

Disease

Carcinoma 17 | 11,493
osteosarcoma 15 | 7,950
glioblastoma 12 | 5,792
ovarian cancer 11 | 8,520
atypical teratoid / rhabdoid tumor 10 | 5,112
medulloblastoma, large-cell 10 | 6,241
Astrocytoma, Pilocytic 9 | 3,081
adult high grade glioma 9 | 3,801
ependymoma 8 | 4,679
group 3 medulloblastoma 8 | 4,104
primitive neuroectodermal tumor 7 | 3,035
subependymal giant cell astrocytoma 7 | 2,287
astrocytic glioma 6 | 2,597
Kidney cancer 5 | 2,613
interstitial cystitis 5 | 2,312
invasive ductal carcinoma 5 | 2,951
lung carcinoma 5 | 2,843
non-small cell lung cancer 5 | 2,890
oligodendroglioma 5 | 2,850
psoriasis 5 | 6,694
aldosterone-producing adenoma 4 | 665
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
lung adenocarcinoma 4 | 2,716
malignant mesothelioma 4 | 3,232
Breast cancer 3 | 3,578
Demyelinating polyneuropathy 3 | 6
Intellectual disability 3 | 1,016
Periventricular nodular heterotopia 3 | 30
breast carcinoma 3 | 1,638
cutaneous lupus erythematosus 3 | 1,057
cystic fibrosis 3 | 1,696
dermatomyositis 3 | 966
ductal carcinoma in situ 3 | 1,745
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
lung cancer 3 | 4,740
spina bifida 3 | 1,074
Atopic dermatitis 2 | 952
Autosomal recessive predisposition 2 | 1,442
Dull intelligence 2 | 645
Endometrial cancer 2 | 311
Epilepsy 2 | 792
Low intelligence 2 | 645
Mental Retardation 2 | 645
Mental deficiency 2 | 645
Pick disease 2 | 1,894
Poor school performance 2 | 645
Schizophrenia 2 | 1,160
Seizures 2 | 596
active Crohn's disease 2 | 922
acute myeloid leukemia 2 | 783
adrenocortical carcinoma 2 | 1,428
non-syndromic X-linked intellectual disability 2 | 20
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
tuberculosis 2 | 2,010
ulcerative colitis 2 | 1,819
Amphetamine-Related Disorders 1 | 74
Bruxism 1 | 18
COPD 1 | 118
Cardiovascular system disease 1 | 246
Congenital pes cavus 1 | 88
Crohn Disease 1 | 45
Delayed speech and language development 1 | 112
Diarrhea 1 | 253
Essential Hypertension 1 | 94
Fever 1 | 138
Gaucher disease type 1 1 | 180
Glioma 1 | 74
Hepatomegaly 1 | 285
Hypertrophy of breast 1 | 17
Hypoplasia of corpus callosum 1 | 90
Hypsarrhythmia 1 | 25
Infantile onset 1 | 238
Language Delay 1 | 112
Large intestine cancer 1 | 126
Liver cancer 1 | 604
Lung Neoplasms 1 | 232
Malabsorption 1 | 82
Microcephaly 1 | 166
Motor neuron disease 1 | 49
Neutrophil abnormality 1 | 20
Otitis Media 1 | 52
Pilocytic astrocytoma 1 | 56
Precocious Puberty 1 | 28
Pyloric Stenosis 1 | 47
Recurrent respiratory infections 1 | 141
Recurrent sinus disease 1 | 22
Recurrent sinusitis 1 | 22
Retinal Degeneration 1 | 106
Severe mental retardation (I.Q. 20-34) 1 | 99
Speech Delay 1 | 112
Speech impairment 1 | 112
Syndactyly of the toes 1 | 45
X- linked recessive 1 | 110
chronic kidney disease 1 | 90
head and neck cancer 1 | 271
head and neck cancer and chronic obstructive pulmonary disease 1 | 239
hereditary spastic paraplegia 1 | 318
medulloblastoma 1 | 720
tuberculosis and treatment for 6 months 1 | 409

Tissue

Blood and immune system 20 | 16,909
Cardiovascular System 20 | 15,192
Digestive Tract 20 | 17,369
Endocrine System 20 | 18,159
Female tissues 20 | 17,400
Liver and Pancreas 20 | 16,750
Male tissues 20 | 17,142
Nervous System 20 | 16,725
Respiratory system 20 | 16,393
Skin and soft tissues 20 | 17,230
Urinary Tract 20 | 16,678

Target Family

Non-IDG 18 | 12,091
Enzyme 2 | 4,145

GO Function

ARF guanyl-nucleotide exchange... 20 | 20
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
F-box only protein 8 FBXO8 Tbio Non-IDG -1.66674 51.2 143
Probable E3 ubiquitin-protein ligase HERC1 HERC1 Tbio Enzyme -1.02371 5.75 39
Cytohesin-4 CYTH4 Tbio Non-IDG -1.03866 11.3 145
Protein transport protein Sec61 subunit beta SEC61B Tbio Non-IDG -0.47875 2.73 128
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 GBF1 Tbio Non-IDG -0.60758 4.31 61
Neutrophil cytosol factor 4 NCF4 Tbio Non-IDG -2.45708 273.9 346
Brefeldin A-inhibited guanine nucleotide-exchange protein 1 ARFGEF1 Tbio Non-IDG -0.85174 8.71 57
Brefeldin A-inhibited guanine nucleotide-exchange protein 2 ARFGEF2 Tbio Non-IDG -1.15371 14.4 81
IQ motif and SEC7 domain-containing protein 1 IQSEC1 Tbio Non-IDG -1.04789 14.7 28
Brefeldin A-inhibited guanine nucleotide-exchange protein 3 ARFGEF3 Tdark Non-IDG -0.47852 3.29 6