Development Level

Tchem 3 | 1,598
Tbio 2 | 11,445

IMPC Phenotype

enlarged spleen 2 | 41
increased mean platelet volume 2 | 45
abnormal heart morphology 1 | 162
abnormal lens morphology 1 | 81
abnormal response to new envir... 1 | 10
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal spleen morphology 1 | 55
abnormal thymus morphology 1 | 7
anophthalmia 1 | 33
cataract 1 | 92
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating amylase ... 1 | 28
decreased circulating choleste... 1 | 93
decreased circulating iron lev... 1 | 32
decreased circulating magnesiu... 1 | 13
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased mean platelet volume 1 | 25
enlarged heart 1 | 210
enlarged thymus 1 | 5
impaired glucose tolerance 1 | 75
increased circulating alkaline... 1 | 122
increased circulating bilirubi... 1 | 16
increased glycosylated hemoglo... 1 | 1
increased monocyte cell number 1 | 63
increased red blood cell distr... 1 | 34
increased spleen weight 1 | 10
preweaning lethality, incomple... 1 | 499

Disease

Carcinoma 4 | 11,493
medulloblastoma, large-cell 4 | 6,241
glioblastoma 3 | 5,792
group 4 medulloblastoma 3 | 1,855
osteosarcoma 3 | 7,950
ovarian cancer 3 | 8,520
Breast cancer 2 | 3,578
Cardiomegaly 2 | 116
Cardiomyopathies 2 | 110
Cerebrovascular accident 2 | 63
Glucose Intolerance 2 | 19
Glycogen storage disease 2 | 39
Impaired glucose tolerance 2 | 28
Insulin Resistance 2 | 72
Stomach Neoplasms 2 | 300
Wolff-Parkinson-White syndrome 2 | 19
adult high grade glioma 2 | 3,801
astrocytic glioma 2 | 2,597
atypical teratoid / rhabdoid tumor 2 | 5,112
ependymoma 2 | 4,679
oligodendroglioma 2 | 2,850
Ascites 1 | 22
Asthma 1 | 385
Asymmetric Septal Hypertrophy 1 | 7
Atrial Fibrillation 1 | 124
Atrioventricular block 1 | 35
Atrioventricular nodal disease 1 | 10
Autosomal recessive predisposition 1 | 1,442
Bipolar Disorder 1 | 666
Biventricular hypertrophy 1 | 1
CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 6 (disorder) 1 | 1
Carbohydrate Metabolism, Inborn Errors 1 | 1
Cardiomyopathy 1 | 116
Cardiomyopathy, Familial Hypertrophic, 6 1 | 1
Congestive heart failure 1 | 113
Cyanosis 1 | 17
Danon disease 1 | 8
Disease Progression 1 | 136
Endometriosis 1 | 540
Episodic rapid heart beat 1 | 1
Fabry disease 1 | 11
Familial atrial fibrillation 1 | 23
Fatal congenital hypertrophic cardiomyopathy due to glycogen storage disease 1 | 1
Gastrointestinal stromal tumor 1 | 62
Gaucher disease type 1 1 | 180
Glycogen Storage Disease of Heart, Lethal Congenital 1 | 1
Gout 1 | 106
Heart disease 1 | 306
Heart failure 1 | 162
Hypertrophic Cardiomyopathy 1 | 117
Hypotension 1 | 82
Kidney cancer 1 | 2,613
Kidney disease 1 | 430
Left Bundle-Branch Block 1 | 2
Lipid Metabolism, Inborn Errors 1 | 6
Neonatal hypoglycemia 1 | 17
Palpitations 1 | 18
Pancreatic Neuroendocrine Tumor 1 | 45
Paroxysmal atrial fibrillation 1 | 14
Paroxysmal supraventricular tachycardia 1 | 12
Peripheral vascular disease 1 | 87
Pulmonary edema 1 | 17
Renal Cell Carcinoma 1 | 214
Shortened PR interval 1 | 3
Sinus bradycardia 1 | 7
Stomach cancer 1 | 30
Stroke 1 | 33
Sudden Cardiac Death 1 | 29
Ventricular preexcitation 1 | 1
Ventricular preexcitation with multiple accessory pathways 1 | 1
Wide QRS complex 1 | 1
interstitial cystitis 1 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 1 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 1 | 3,291
juvenile dermatomyositis 1 | 1,187
lung cancer 1 | 4,740
lung carcinoma 1 | 2,843
malignant mesothelioma 1 | 3,232
pancreatic ductal adenocarcinoma liver metastasis 1 | 1,962
primitive neuroectodermal tumor 1 | 3,035
psoriasis 1 | 6,694
subependymal giant cell astrocytoma 1 | 2,287

Tissue

Cardiovascular System 5 | 15,192
Digestive Tract 5 | 17,369
Endocrine System 5 | 18,159
Female tissues 5 | 17,400
Male tissues 5 | 17,142
Skin and soft tissues 5 | 17,230
Blood and immune system 4 | 16,909
Liver and Pancreas 4 | 16,750
Nervous System 4 | 16,725
Respiratory system 4 | 16,393
Urinary Tract 4 | 16,678

Target Family

Kinase 3 | 634
Enzyme 2 | 4,145

GO Function

AMP-activated protein kinase a... 5 | 5
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

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