Development Level

Tbio 26 | 11,445
Tchem 6 | 1,598
Tclin 1 | 613

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 6 | 979
decreased body weight 4 | 161
abnormal behavior 2 | 298
abnormal bone structure 2 | 187
abnormal placenta size 2 | 20
decreased circulating triglyce... 2 | 79
increased lean body mass 2 | 172
increased total body fat amoun... 2 | 134
abnormal behavioral response t... 1 | 66
abnormal bone mineralization 1 | 38
abnormal coat-hair pigmentatio... 1 | 64
abnormal embryo size 1 | 220
abnormal eye morphology 1 | 68
abnormal limb bud morphology 1 | 17
abnormal locomotor activation 1 | 16
abnormal pericardium morpholog... 1 | 26
abnormal rib morphology 1 | 10
abnormal skin coloration 1 | 25
abnormal whole-body plethysmog... 1 | 4
absent pinna reflex 1 | 23
cardiovascular system phenotyp... 1 | 36
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased circulating amylase ... 1 | 28
decreased circulating glucose ... 1 | 126
decreased prepulse inhibition 1 | 82
edema 1 | 59
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
hemorrhage 1 | 23
hyperactivity 1 | 148
impaired righting response 1 | 26
improved glucose tolerance 1 | 79
increased blood urea nitrogen ... 1 | 48
increased circulating sodium l... 1 | 71
increased heart rate variabili... 1 | 7
increased or absent threshold ... 1 | 101
increased startle reflex 1 | 112
increased thermal nociceptive ... 1 | 9
increased urine magnesium leve... 1 | 2
increased vertical activity 1 | 24
pale liver 1 | 6
pale yolk sac 1 | 25
pallor 1 | 34
persistence of hyaloid vascula... 1 | 33
prenatal lethality prior to he... 1 | 87
stereotypic behavior 1 | 3
tremors 1 | 39
trunk curl 1 | 16
vertebral fusion 1 | 23

Disease

Carcinoma 30 | 11,493
osteosarcoma 23 | 7,950
ovarian cancer 21 | 8,520
medulloblastoma, large-cell 15 | 6,241
glioblastoma 14 | 5,792
psoriasis 14 | 6,694
atypical teratoid / rhabdoid tumor 13 | 5,112
lung cancer 13 | 4,740
adult high grade glioma 10 | 3,801
ependymoma 10 | 4,679
Autosomal recessive predisposition 9 | 1,442
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,989
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,962
primitive neuroectodermal tumor 9 | 3,035
group 4 medulloblastoma 8 | 1,855
Breast cancer 7 | 3,578
Cancer 7 | 2,499
group 3 medulloblastoma 7 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,955
invasive ductal carcinoma 7 | 2,951
lung adenocarcinoma 7 | 2,716
malignant mesothelioma 7 | 3,232
Kidney cancer 6 | 2,613
Schizophrenia 6 | 1,160
adrenocortical carcinoma 6 | 1,428
diabetes mellitus 6 | 1,728
oligodendroglioma 6 | 2,850
subependymal giant cell astrocytoma 6 | 2,287
Astrocytoma, Pilocytic 5 | 3,081
Cognitive delay 5 | 608
Down syndrome 5 | 499
Global developmental delay 5 | 608
Intellectual disability 5 | 1,016
Mental and motor retardation 5 | 608
Nonsyndromic deafness 5 | 142
astrocytic glioma 5 | 2,597
colon cancer 5 | 1,478
ductal carcinoma in situ 5 | 1,745
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
juvenile dermatomyositis 5 | 1,187
lung carcinoma 5 | 2,843
pancreatic cancer 5 | 2,398
pituitary cancer 5 | 1,972
ulcerative colitis 5 | 1,819
Dull intelligence 4 | 645
Low intelligence 4 | 645
Mental Retardation 4 | 645
Mental deficiency 4 | 645
Multiple myeloma 4 | 1,332
Neurodegenerative disease 4 | 414
Poor school performance 4 | 645
Rheumatoid arthritis 4 | 1,191
Sensorineural hearing loss 4 | 106
astrocytoma 4 | 1,146
breast carcinoma 4 | 1,638
cystic fibrosis 4 | 1,696
interstitial cystitis 4 | 2,312
non-small cell lung cancer 4 | 2,890
tuberculosis 4 | 2,010
Amyotrophic lateral sclerosis 3 | 451
Cataract 3 | 297
Cerebellar Ataxia 3 | 304
Congenital pes cavus 3 | 88
Distal limb muscle weakness due to peripheral neuropathy 3 | 62
Distal muscle weakness 3 | 62
Duchenne muscular dystrophy 3 | 601
Gout 3 | 106
Hearing loss, progressive sensorineural 3 | 23
Hypertensive disease 3 | 292
Lens Opacities 3 | 231
Motor delay 3 | 147
Muscle hypotonia 3 | 571
Myocardial Ischemia 3 | 169
Myopathy 3 | 185
No development of motor milestones 3 | 147
Pick disease 3 | 1,894
Sensorineural Hearing Loss (disorder) 3 | 284
Weight Gain 3 | 100
active Crohn's disease 3 | 922
active ulcerative colitis 3 | 764
acute quadriplegic myopathy 3 | 1,158
adrenocortical adenoma 3 | 131
dermatomyositis 3 | 966
fibroadenoma 3 | 559
spina bifida 3 | 1,074
Acquired scoliosis 2 | 281
Alzheimer's disease 2 | 658
Atrial Fibrillation 2 | 124
Curvature of spine 2 | 282
Endometriosis 2 | 540
Epilepsy 2 | 792
Hypertension 2 | 396
Kidney disease 2 | 430
Multiple Sclerosis 2 | 540
Purine nucleoside phosphorylase deficiency 2 | 11
Waldenstrons macroglobulinemia 2 | 765
esophageal adenocarcinoma 2 | 737
hepatocellular carcinoma 2 | 547
nasopharyngeal carcinoma 2 | 1,058
progressive supranuclear palsy 2 | 676

Tissue

Blood and immune system 32 | 16,909
Digestive Tract 32 | 17,369
Endocrine System 32 | 18,159
Female tissues 32 | 17,400
Liver and Pancreas 32 | 16,750
Male tissues 32 | 17,142
Nervous System 32 | 16,725
Respiratory system 32 | 16,393
Skin and soft tissues 32 | 17,230
Urinary Tract 32 | 16,678
Cardiovascular System 31 | 15,192

Target Family

Non-IDG 14 | 12,091
Enzyme 9 | 4,145
Kinase 7 | 634
Transporter 2 | 473
GPCR 1 | 408

GO Function

ADP binding 33 | 33
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Unconventional myosin-VIIa MYO7A Tbio Non-IDG -2.14713 133.5 129
Unconventional myosin-IXb MYO9B Tbio Non-IDG -1.68591 55.7 79
NADP-dependent malic enzyme ME1 Tchem Non-IDG -1.98857 92.8 234
Pyruvate kinase PKM PKM Tchem Kinase -3.15332 1424.2 749
Sodium/potassium-transporting ATPase subunit alpha-1 ATP1A1 Tclin Transporter -1.68777 43.2 399
ATP-binding cassette sub-family G member 1 ABCG1 Tbio Transporter -2.52701 319.9 260
Unconventional myosin-XVIIIa MYO18A Tbio Non-IDG -1.15048 14.2 35
Myosin-IIIa MYO3A Tbio Kinase -1.25280 20.1 130
Glutamate dehydrogenase 1, mitochondrial GLUD1 Tbio Enzyme -2.39787 257.7 148
Myosin-10 MYH10 Tbio Non-IDG -1.77478 55.4 94