Development Level

Tbio 28 | 11,445
Tclin 10 | 613
Tdark 2 | 6,588

IMPC Phenotype

preweaning lethality, complete... 9 | 979
abnormal behavior 3 | 298
cataract 2 | 92
embryonic lethality prior to o... 2 | 239
abnormal allantois morphology 1 | 8
abnormal chorioallantoic fusio... 1 | 8
abnormal embryo development 1 | 7
abnormal embryo size 1 | 220
abnormal embryo turning 1 | 31
abnormal epididymis morphology 1 | 42
abnormal heart morphology 1 | 162
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal neural tube morpholog... 1 | 12
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal stomach morphology 1 | 10
abnormal visceral yolk sac mor... 1 | 6
abnormal vitelline vasculature... 1 | 6
decreased IgM level 1 | 1
decreased blood urea nitrogen ... 1 | 51
decreased body weight 1 | 161
decreased circulating phosphat... 1 | 27
decreased circulating triglyce... 1 | 79
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
enlarged lymph nodes 1 | 37
hemorrhage 1 | 23
hypoactivity 1 | 132
impaired pupillary reflex 1 | 26
increased circulating alkaline... 1 | 122
increased circulating amylase ... 1 | 25
increased circulating choleste... 1 | 66
increased circulating sodium l... 1 | 71
increased or absent threshold ... 1 | 101
increased prepulse inhibition 1 | 32
increased vertical activity 1 | 24
pale yolk sac 1 | 25
pallor 1 | 34
prenatal lethality prior to he... 1 | 87
preweaning lethality, incomple... 1 | 499
small adrenal glands 1 | 16
small superior vagus ganglion 1 | 74
small thymus 1 | 16

Disease

Carcinoma 27 | 11,493
ovarian cancer 20 | 8,520
Autosomal recessive predisposition 18 | 1,442
osteosarcoma 16 | 7,950
psoriasis 14 | 6,694
medulloblastoma, large-cell 13 | 6,241
Cognitive delay 12 | 608
Global developmental delay 12 | 608
Mental and motor retardation 12 | 608
group 3 medulloblastoma 12 | 4,104
malignant mesothelioma 12 | 3,232
Muscle hypotonia 11 | 571
glioblastoma 11 | 5,792
lung cancer 11 | 4,740
primitive neuroectodermal tumor 11 | 3,035
Epilepsy 10 | 792
Seizures 10 | 596
Cancer 9 | 2,499
Dull intelligence 9 | 645
Failure to gain weight 9 | 365
Intellectual disability 9 | 1,016
Low intelligence 9 | 645
Mental Retardation 9 | 645
Mental deficiency 9 | 645
Pediatric failure to thrive 9 | 365
Poor school performance 9 | 645
non-small cell lung cancer 9 | 2,890
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,962
adult high grade glioma 8 | 3,801
atypical teratoid / rhabdoid tumor 8 | 5,112
invasive ductal carcinoma 8 | 2,951
Acidosis, Lactic 7 | 97
Cerebellar Ataxia 7 | 304
Lactic acidemia 7 | 95
Nystagmus 7 | 317
Small head 7 | 374
Strabismus 7 | 270
lung adenocarcinoma 7 | 2,716
Blepharoptosis 6 | 231
Breast cancer 6 | 3,578
Feeding difficulties in infancy 6 | 175
Growth delay 6 | 114
Growth failure 6 | 114
Growth retardation 6 | 115
Leigh disease 6 | 100
Mitochondrial complex I deficiency 6 | 46
Muscle Spasticity 6 | 195
Muscle Weakness 6 | 170
NADH:Q(1) Oxidoreductase deficiency 6 | 24
Poor growth 6 | 114
Respiratory Failure 6 | 104
Sensorineural Hearing Loss (disorder) 6 | 284
Stomach Neoplasms 6 | 300
Very poor growth 6 | 114
colon cancer 6 | 1,478
Cerebral atrophy 5 | 178
Deafness 5 | 198
Decreased tendon reflex 5 | 122
Diabetes mellitus type 2 5 | 69
Highly variable clinical phenotype 5 | 150
Highly variable phenotype and severity 5 | 150
Highly variable phenotype, even within families 5 | 150
Impaired exercise tolerance 5 | 42
Lethargy 5 | 77
Leukodystrophy 5 | 55
Mitochondrial Complex 1 Deficiency 5 | 28
Multiple myeloma 5 | 1,332
Phenotypic variability 5 | 150
Treatment Refractory Type 2 Diabetes Mellitus 5 | 53
aldosterone-producing adenoma 5 | 665
breast carcinoma 5 | 1,638
ependymoma 5 | 4,679
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
non primary Sjogren syndrome sicca 5 | 891
Anemia 4 | 365
Atrophy of cerebellum 4 | 103
Cerebellar degeneration 4 | 103
Developmental regression 4 | 95
Hyperreflexia 4 | 209
Hypoglycemia 4 | 152
Increased head circumference 4 | 147
Increased size of cranium 4 | 147
Increased size of skull 4 | 147
Infratentorial atrophy 4 | 103
Kidney cancer 4 | 2,613
Loss of developmental milestones 4 | 95
Mental deterioration in childhood 4 | 95
Neurodevelopmental regression 4 | 95
Psychomotor regression 4 | 95
Psychomotor regression beginning in infancy 4 | 95
Psychomotor regression in infants 4 | 95
Psychomotor regression, progressive 4 | 95
Schizophrenia 4 | 1,160
Short stature 4 | 531
Vomiting 4 | 116
adrenocortical carcinoma 4 | 1,428
astrocytic glioma 4 | 2,597
ductal carcinoma in situ 4 | 1,745
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
nasopharyngeal carcinoma 4 | 1,058

Tissue

Blood and immune system 39 | 16,909
Cardiovascular System 39 | 15,192
Digestive Tract 39 | 17,369
Endocrine System 39 | 18,159
Female tissues 39 | 17,400
Liver and Pancreas 39 | 16,750
Male tissues 39 | 17,142
Nervous System 39 | 16,725
Respiratory system 39 | 16,393
Skin and soft tissues 39 | 17,230
Urinary Tract 39 | 16,678

Target Family

Enzyme 27 | 4,145
Non-IDG 13 | 12,091

GO Function

4 iron, 4 sulfur cluster bindi... 40 | 40
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cytosolic Fe-S cluster assembly factor NUBP2 NUBP2 Tbio Non-IDG -1.46950 32.1 59
Aconitate hydratase, mitochondrial ACO2 Tbio Enzyme -2.21106 157.2 307
Endonuclease III-like protein 1 NTHL1 Tbio Enzyme -1.85066 66.8 155
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1 Tbio Enzyme -1.13540 12.8 55
Adenine DNA glycosylase MUTYH Tbio Enzyme -2.86910 750.8 255
Cytosolic Fe-S cluster assembly factor NUBP1 NUBP1 Tbio Non-IDG -1.31867 20.0 105
Dihydropyrimidine dehydrogenase [NADP(+)] DPYD Tclin Enzyme -2.62432 395.0 159
Iron-responsive element-binding protein 2 IREB2 Tbio Non-IDG -2.33609 211.7 253
Regulator of telomere elongation helicase 1 RTEL1 Tbio Enzyme -2.66156 233.0 85
Fanconi anemia group J protein BRIP1 Tbio Non-IDG -1.81875 78.3 223