Development Level

Tbio 19 | 11,445
Tdark 2 | 6,588
Tchem 1 | 1,598

IMPC Phenotype

preweaning lethality, complete... 6 | 979
embryonic lethality prior to o... 4 | 239
embryonic lethality prior to t... 2 | 278
abnormal clavicle morphology 1 | 6
abnormal heart morphology 1 | 162
abnormal rib morphology 1 | 10
decreased circulating insulin ... 1 | 76
decreased fasted circulating g... 1 | 65
decreased total body fat amoun... 1 | 207
enlarged heart 1 | 210
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased fasted circulating g... 1 | 76
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased startle reflex 1 | 112
prenatal lethality prior to he... 1 | 87

Disease

osteosarcoma 17 | 7,950
ovarian cancer 12 | 8,520
group 3 medulloblastoma 10 | 4,104
Carcinoma 9 | 11,493
psoriasis 7 | 6,694
medulloblastoma, large-cell 6 | 6,241
Multiple myeloma 5 | 1,332
glioblastoma 5 | 5,792
lung cancer 5 | 4,740
Breast cancer 4 | 3,578
Kidney cancer 4 | 2,613
ependymoma 4 | 4,679
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
invasive ductal carcinoma 4 | 2,951
malignant mesothelioma 4 | 3,232
Perlman syndrome 3 | 9
Pick disease 3 | 1,894
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
non primary Sjogren syndrome sicca 3 | 891
non-small cell lung cancer 3 | 2,890
oligodendroglioma 3 | 2,850
pituitary cancer 3 | 1,972
primitive neuroectodermal tumor 3 | 3,035
Amyotrophic lateral sclerosis type 4 2 | 5
Astrocytoma, Pilocytic 2 | 3,081
Dyskeratosis congenita 2 | 24
Microphthalmia with limb anomalies 2 | 40
Myositis 2 | 30
Neurodegenerative disease 2 | 414
Polyhydramnios 2 | 108
Pontocerebellar hypoplasia 2 | 36
Rheumatoid arthritis 2 | 1,191
Systemic scleroderma 2 | 60
astrocytic glioma 2 | 2,597
atypical teratoid / rhabdoid tumor 2 | 5,112
dermatomyositis 2 | 966
diabetes mellitus 2 | 1,728
ductal carcinoma in situ 2 | 1,745
group 4 medulloblastoma 2 | 1,855
juvenile dermatomyositis 2 | 1,187
pancreatic cancer 2 | 2,398
pediatric high grade glioma 2 | 1,064
progressive supranuclear palsy 2 | 676
subependymal giant cell astrocytoma 2 | 2,287
ulcerative colitis 2 | 1,819
Absent speech 1 | 43
Acquired metabolic disease 1 | 336
Atrophy of cerebellum 1 | 103
Axial hypotonia 1 | 46
Brachydactyly 1 | 156
Candidiasis 1 | 55
Carcinoma, Hepatocellular 1 | 228
Cerebellar degeneration 1 | 103
Cerebral atrophy 1 | 178
Chemical and Drug Induced Liver Injury 1 | 195
Contracture 1 | 96
Contracture of joint 1 | 93
Degenerative brain disorder 1 | 100
Dental caries 1 | 164
Dental fluorosis 1 | 20
Disease Progression 1 | 136
Flexion contracture 1 | 93
Flexion contractures of joints 1 | 93
Foot Deformities 1 | 30
Globe disease 1 | 67
Growth delay 1 | 114
Growth failure 1 | 114
Growth retardation 1 | 115
Hepatitis C 1 | 94
Highly variable severity 1 | 157
Hyperreflexia 1 | 209
Infratentorial atrophy 1 | 103
Liver Cirrhosis, Experimental 1 | 769
Liver carcinoma 1 | 240
Liver neoplasms 1 | 130
Muscle Spasticity 1 | 195
Nephroblastoma 1 | 51
Neurogenic Muscular Atrophy 1 | 139
Neurogenic muscle atrophy, especially in the lower limbs 1 | 139
Neutropenia 1 | 72
Nonsyndromic deafness 1 | 142
Poikiloderma with neutropenia 1 | 5
Pontocerebellar Hypoplasia Type 1 1 | 5
Poor growth 1 | 114
Prenatal onset 1 | 139
Respiratory Insufficiency 1 | 132
Respiratory function loss 1 | 121
Skeletal muscle atrophy 1 | 139
Stomach Neoplasms 1 | 300
Supratentorial atrophy 1 | 94
Systemic lupus erythematosus 1 | 194
Telangiectasis 1 | 36
Variable expressivity 1 | 157
Very poor growth 1 | 114
atypical teratoid/rhabdoid tumor 1 | 357
interstitial lung disease 1 | 298
muscle degeneration 1 | 139
nonverbal 1 | 43
tuberculosis and treatment for 6 months 1 | 409

Tissue

Blood and immune system 22 | 16,909
Cardiovascular System 22 | 15,192
Digestive Tract 22 | 17,369
Endocrine System 22 | 18,159
Female tissues 22 | 17,400
Liver and Pancreas 22 | 16,750
Male tissues 22 | 17,142
Nervous System 22 | 16,725
Respiratory system 22 | 16,393
Skin and soft tissues 22 | 17,230
Urinary Tract 22 | 16,678

Target Family

Enzyme 15 | 4,145
Non-IDG 7 | 12,091

GO Function

3'-5'-exoribonuclease activity 22 | 22
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Exosome component 10 EXOSC10 Tbio Non-IDG -2.45249 279.1 123
Oligoribonuclease, mitochondrial REXO2 Tbio Enzyme -2.15502 143.8 115
Exosome complex exonuclease RRP44 DIS3 Tbio Enzyme -1.80730 64.2 141
Exosome complex component RRP4 EXOSC2 Tbio Non-IDG -0.28065 2.13 121
3'-5' exoribonuclease 1 ERI1 Tbio Enzyme -1.96395 87.8 172
5'-3' exoribonuclease 2 XRN2 Tbio Enzyme -1.52792 31.8 121
Exosome complex component RRP41 EXOSC4 Tbio Enzyme -1.96200 85.3 113
DIS3-like exonuclease 1 DIS3L Tdark Enzyme -0.68418 3.89 94
Exosome complex component RRP45 EXOSC9 Tbio Enzyme -1.17714 13.5 92
DIS3-like exonuclease 2 DIS3L2 Tbio Enzyme -1.32394 21.5 118