Development Level

Tbio 9 | 10,625
Tchem 3 | 1,890
Tclin 2 | 602
Tdark 2 | 7,003

IMPC Term

preweaning lethality, complete... 3 | 633
abnormal behavioral response t... 1 | 52
abnormal bone structure 1 | 131
decreased fasted circulating g... 1 | 49
increased circulating HDL chol... 1 | 63
increased circulating choleste... 1 | 53
increased exploration in new e... 1 | 56

Disease

osteosarcoma 12 | 7,933
Cancer 6 | 2,346
glioblastoma 6 | 5,572
medulloblastoma, large-cell 6 | 6,234
ovarian cancer 6 | 8,492
group 3 medulloblastoma 5 | 2,254
lung cancer 5 | 4,473
atypical teratoid / rhabdoid tumor 4 | 4,369
malignant mesothelioma 4 | 3,163
psoriasis 4 | 6,685
Carcinoma 3 | 2,147
Neurodegenerative disease 3 | 383
Peripheral Neuropathy 3 | 303
primitive neuroectodermal tumor 3 | 3,031
Acute lymphoid leukemia 2 | 25
Acute myeloid leukemia, disease 2 | 16
Acute promyelocytic leukemia, FAB M3 2 | 10
Adenocarcinoma of pancreas 2 | 12
Breast cancer 2 | 3,099
Lymphomatous meningitis 2 | 3
Malignant tumor of ovary 2 | 25
Meningeal Leukemia 2 | 7
Metastatic Breast Carcinoma 2 | 21
Multiple myeloma 2 | 1,328
Nijmegen breakage syndrome 2 | 23
Seizures 2 | 95
Werner syndrome 2 | 29
colon cancer 2 | 1,475
dermatomyositis 2 | 967
invasive ductal carcinoma 2 | 2,950
lung adenocarcinoma 2 | 2,714
non primary Sjogren syndrome sicca 2 | 840
non-small cell lung cancer 2 | 2,798
pediatric high grade glioma 2 | 2,712
pilocytic astrocytoma 2 | 3,086
pituitary cancer 2 | 1,972
posterior fossa group B ependymoma 2 | 1,530
sonic hedgehog group medulloblastoma 2 | 1,482
subependymal giant cell astrocytoma 2 | 2,287
AICARDI-GOUTIERES SYNDROME 1 1 | 5
Age related macular degeneration 1 | 84
Aicardi-Goutieres syndrome 1 | 18
Ataxia telangiectasia 1 | 32
Atrial heart septal defect 1 | 15
Baller-Gerold syndrome 1 | 14
Bipolar Disorder 1 | 266
Bloom syndrome 1 | 30
Brachydactyly 1 | 52
Brain Diseases 1 | 22
Brain disease 1 | 84
Cerebellar Ataxia 1 | 72
Charcot-Marie-Tooth disease 1 | 74
Chilblain lupus 1 1 | 2
Chronic lymphoid leukemia, disease 1 | 10
Colorectal Cancer 1 | 62
Colorectal Neoplasms 1 | 217
Connective tissue disease 1 | 59
Cortical blindness 1 | 15
Drug-Induced Liver Injury 1 | 118
Familial adenomatous polyposis 1 | 33
Fanconi's anemia 1 | 50
Friedreich ataxia 1 | 23
Globe disease 1 | 57
Heart Diseases 1 | 42
Hereditary Breast and Ovarian Cancer Syndrome 1 | 14
Inflammation 1 | 109
Influenza 1 | 142
Inhalation anthrax 1 | 5
Junctional epidermolysis bullosa 1 | 9
Lactic acidosis 1 | 43
Leigh disease 1 | 81
Leigh syndrome 1 | 34
Lupus Erythematosus, Systemic 1 | 73
Lupus erythematosus 1 | 80
Lynch syndrome 1 | 35
Mantle cell lymphoma 1 | 20
Melanoma 1 | 261
Menopause present (finding) 1 | 20
Micronuclei, Chromosome-Defective 1 | 20
Mitochondrial encephalomyopathy 1 | 18
Mobius syndrome 1 | 7
Myocardial Infarction 1 | 126
Neoplasms, Second Primary 1 | 6
Neoplastic Syndromes, Hereditary 1 | 48
Obstructive sleep apnea 1 | 28
Oromandibular-limb hypogenesis spectrum 1 | 3
Osteoporosis 1 | 259
Parkinsonian Disorders 1 | 23
Photosensitive trichothiodystrophy 1 | 24
Polyneuropathy 1 | 30
Progeria 1 | 22
Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions, Autosomal Dominant 1 1 | 5
RAPADILINO syndrome 1 | 7
Rothmund-Thomson syndrome 1 | 22
Seckel syndrome 1 | 35
Syphilis 1 | 18
Thoracic outlet syndrome 1 | 8
Tumor Predisposition Syndrome 1 | 6
systemic lupus erythematosus 1 | 172
ventricular septal defect 1 | 20

Tissue

Blood and immune system 16 | 17,995
Cardiovascular System 16 | 17,958
Digestive Tract 16 | 18,473
Endocrine System 16 | 18,512
Female tissues 16 | 18,647
Liver and Pancreas 16 | 18,136
Male tissues 16 | 17,969
Nervous System 16 | 18,561
Respiratory system 16 | 17,484
Skin and soft tissues 16 | 18,115
Urinary Tract 16 | 18,444

Target Family

Enzyme 11 | 4,146
Non-IDG 5 | 11,969

GO Function

3'-5' exonuclease activity 16 | 16
metal ion binding 1,917 | 1,917
ATP binding 1,467 | 1,467
DNA binding 1,432 | 1,432
zinc ion binding 1,155 | 1,155
poly(A) RNA binding 1,107 | 1,107
transcription factor activity,... 853 | 853
calcium ion binding 695 | 695
G-protein coupled receptor act... 661 | 661
protein homodimerization activ... 569 | 569
RNA binding 445 | 445
olfactory receptor activity 424 | 424
sequence-specific DNA binding 398 | 398
GTP binding 374 | 374
chromatin binding 372 | 372
protein serine/threonine kinas... 336 | 336
RNA polymerase II core promote... 332 | 332
identical protein binding 311 | 311
nucleotide binding 311 | 311
receptor binding 303 | 303
protein kinase binding 289 | 289
enzyme binding 286 | 286
cadherin binding involved in c... 277 | 277
GTPase activator activity 273 | 273
ubiquitin protein ligase bindi... 258 | 258
ubiquitin-protein transferase ... 253 | 253
serine-type endopeptidase acti... 246 | 246
transcription coactivator acti... 241 | 241
transcription factor binding 240 | 240
structural molecule activity 232 | 232
GTPase activity 231 | 231
transcriptional activator acti... 230 | 230
ligase activity 227 | 227
protein heterodimerization act... 227 | 227
structural constituent of ribo... 212 | 212
transcription regulatory regio... 202 | 202
transmembrane signaling recept... 201 | 201
RNA polymerase II regulatory r... 200 | 200
receptor activity 200 | 200
transcription corepressor acti... 198 | 198
magnesium ion binding 197 | 197
signal transducer activity 196 | 196
nucleic acid binding 184 | 184
protein kinase activity 183 | 183
carbohydrate binding 180 | 180
ubiquitin protein ligase activ... 173 | 173
RNA polymerase II transcriptio... 162 | 162
heparin binding 160 | 160
iron ion binding 141 | 141
lipid binding 136 | 136
transporter activity 136 | 136
actin binding 133 | 133
ATPase activity 132 | 132
protein C-terminus binding 129 | 129
heme binding 127 | 127
microtubule binding 123 | 123
protein tyrosine kinase activi... 119 | 119
cytokine activity 118 | 118
Ras guanyl-nucleotide exchange... 113 | 113
mRNA binding 112 | 112
metalloendopeptidase activity 112 | 112
transcriptional repressor acti... 110 | 110
structural constituent of cyto... 108 | 108
Rab GTPase binding 105 | 105
antigen binding 104 | 104
protein domain specific bindin... 102 | 102
peptide antigen binding 101 | 101
guanyl-nucleotide exchange fac... 98 | 98
protein complex binding 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 92 | 92
oxidoreductase activity 91 | 91
transcriptional activator acti... 91 | 91
actin filament binding 89 | 89
hydrolase activity 89 | 89
ion channel binding 89 | 89
protein tyrosine phosphatase a... 88 | 88
electron carrier activity 87 | 87
protease binding 87 | 87
histone binding 86 | 86
integrin binding 83 | 83
growth factor activity 82 | 82
phospholipid binding 82 | 82
single-stranded DNA binding 81 | 81
unfolded protein binding 77 | 77
kinase activity 75 | 75
thiol-dependent ubiquitin-spec... 75 | 75
phosphatidylinositol binding 74 | 74
calmodulin binding 73 | 73
histone deacetylase binding 73 | 73
Rho guanyl-nucleotide exchange... 72 | 72
drug binding 71 | 71
double-stranded DNA binding 70 | 70
peptidase activity 70 | 70
protein N-terminus binding 70 | 70
virus receptor activity 68 | 68
beta-catenin binding 67 | 67
microtubule motor activity 67 | 67
protein transporter activity 67 | 67
calcium channel activity 66 | 66
ubiquitin binding 66 | 66

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cell cycle checkpoint control protein RAD9A RAD9A Tbio Non-IDG -2.13819 136.3 864
DNA-(apurinic or apyrimidinic site) lyase APEX1 Tchem Enzyme -3.44060 2815.1 550
Oligoribonuclease, mitochondrial REXO2 Tbio Enzyme -2.13508 139.2 93
Exonuclease mut-7 homolog EXD3 Tdark Enzyme -0.45611 3.91 57
Cell cycle checkpoint control protein RAD9B RAD9B Tdark Non-IDG -0.05436 1.38 29
Exonuclease 3'-5' domain-containing protein 2 EXD2 Tbio Enzyme -0.74135 5.74 39
3'-5' exoribonuclease 1 ERI1 Tbio Enzyme -1.94694 85.1 155
Aprataxin and PNK-like factor APLF Tbio Non-IDG -1.67289 45.0 169
Double-strand break repair protein MRE11A MRE11 Tbio Non-IDG -1.98669 90.0 412
DNA polymerase alpha catalytic subunit POLA1 Tclin Enzyme -2.39718 244.4 128