Development Level

Tbio 9 | 11,651
Tchem 3 | 1,388
Tdark 2 | 6,593
Tclin 1 | 612

IMPC Phenotype

preweaning lethality, complete... 4 | 979
abnormal embryo turning 2 | 31
embryonic lethality prior to t... 2 | 278
abnormal blood vessel morpholo... 1 | 5
abnormal bone structure 1 | 187
abnormal chorioallantoic fusio... 1 | 8
abnormal embryo development 1 | 7
abnormal embryo size 1 | 220
abnormal forebrain development 1 | 20
abnormal heart morphology 1 | 162
abnormal hindbrain development 1 | 16
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal pharyngeal arch morph... 1 | 8
abnormal somite shape 1 | 5
abnormal visceral yolk sac mor... 1 | 6
abnormal vitelline vasculature... 1 | 6
decreased fasted circulating g... 1 | 65
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased erythrocyte cell num... 1 | 39
pale yolk sac 1 | 25
pallor 1 | 34

Disease

Carcinoma 11 | 11,493
osteosarcoma 11 | 7,950
medulloblastoma, large-cell 7 | 6,241
ovarian cancer 7 | 8,520
glioblastoma 6 | 5,792
Cancer 5 | 2,499
group 3 medulloblastoma 5 | 4,104
lung cancer 5 | 4,740
Autosomal recessive predisposition 4 | 1,442
Seizures 4 | 596
atypical teratoid / rhabdoid tumor 4 | 5,112
ependymoma 4 | 4,679
Cognitive delay 3 | 608
Dysarthria 3 | 192
Epilepsy 3 | 792
Global developmental delay 3 | 608
Mental and motor retardation 3 | 608
Neurodegenerative disease 3 | 414
Progressive disorder 3 | 142
malignant mesothelioma 3 | 3,232
primitive neuroectodermal tumor 3 | 3,035
psoriasis 3 | 6,694
Abnormal vision 2 | 52
Abnormality of the voice 2 | 46
Adult onset 2 | 82
Astrocytoma, Pilocytic 2 | 3,081
Atrophy of cerebellum 2 | 103
Bell Palsy 2 | 58
Blepharoptosis 2 | 231
Brachydactyly 2 | 156
Cataract 2 | 297
Cerebellar degeneration 2 | 103
Decreased tendon reflex 2 | 122
Deglutition Disorders 2 | 132
Dementia 2 | 175
Distal amyotrophy 2 | 51
Dystonia 2 | 164
Dystonic disease 2 | 106
Elevated hepatic transaminases 2 | 81
Facial Paresis 2 | 59
Facial muscle weakness of muscles innervated by CN VII 2 | 58
Feeding difficulties in infancy 2 | 175
Gait Ataxia 2 | 51
Heart disease 2 | 306
Hepatic enzyme increased 2 | 81
Highly variable severity 2 | 157
Infratentorial atrophy 2 | 103
Intermittent migraine headaches 2 | 68
Lens Opacities 2 | 231
Leukoencephalopathies 2 | 29
Liver Dysfunction 2 | 99
Liver enzymes abnormal 2 | 81
Liver function test increased 2 | 81
Liver function tests abnormal finding 2 | 81
Low Vision 2 | 174
Migraine Disorders 2 | 76
Multiple myeloma 2 | 1,332
Muscle Spasticity 2 | 195
Muscle hypotonia 2 | 571
Myocardial Infarction 2 | 151
Neurogenic Muscular Atrophy 2 | 139
Neurogenic muscle atrophy, especially in the lower limbs 2 | 139
Nijmegen breakage syndrome 2 | 24
Nystagmus 2 | 317
Skeletal muscle atrophy 2 | 139
Skin Ulcer 2 | 48
Spider Veins 2 | 17
Strabismus 2 | 270
Subclinical abnormal liver function tests 2 | 81
Telangiectasis 2 | 36
Transaminases increased 2 | 81
Variable expressivity 2 | 157
Visual Impairment 2 | 174
Werner syndrome 2 | 29
colon cancer 2 | 1,478
dermatomyositis 2 | 966
invasive ductal carcinoma 2 | 2,951
lung adenocarcinoma 2 | 2,716
muscle degeneration 2 | 139
non primary Sjogren syndrome sicca 2 | 891
pituitary cancer 2 | 1,972
subependymal giant cell astrocytoma 2 | 2,287
Absent pectoralis major muscle 1 | 2
Choreoathetoid movements 1 | 32
Choreoathetosis 1 | 32
Decreased activity of cytochrome C oxidase in muscle tissue 1 | 10
ESR raised 1 | 20
Favorable response to levodopa 1 | 6
Hematologic Neoplasms 1 | 22
Micronuclei, Chromosome-Defective 1 | 25
Mitochondrial Myopathies 1 | 21
N syndrome 1 | 6
Neoplasms, Second Primary 1 | 6
Oromandibular-limb hypogenesis spectrum 1 | 3
Petechiae 1 | 13
Photosensitive trichothiodystrophy 1 | 30
Seizures, Focal 1 | 14
Slender build 1 | 14
Vestibular dysfunction 1 | 7
Xeroderma pigmentosum group G 1 | 16

Tissue

Blood and immune system 15 | 16,909
Cardiovascular System 15 | 15,192
Digestive Tract 15 | 17,369
Endocrine System 15 | 18,159
Female tissues 15 | 17,400
Liver and Pancreas 15 | 16,750
Male tissues 15 | 17,142
Nervous System 15 | 16,725
Respiratory system 15 | 16,393
Skin and soft tissues 15 | 17,230
Urinary Tract 15 | 16,678

Target Family

Enzyme 10 | 4,145
Non-IDG 5 | 12,091

GO Function

3'-5' exonuclease activity 15 | 15
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cell cycle checkpoint control protein RAD9B RAD9B Tdark Non-IDG -0.07767 1.44 35
Cell cycle checkpoint control protein RAD9A RAD9A Tbio Non-IDG -2.15330 141.0 919
Exonuclease 3'-5' domain-containing protein 2 EXD2 Tbio Enzyme -0.97829 7.74 51
DNA-(apurinic or apyrimidinic site) lyase APEX1 Tchem Enzyme -3.47746 2989.0 646
Aprataxin and PNK-like factor APLF Tbio Non-IDG -1.69718 49.9 226
Double-strand break repair protein MRE11 MRE11 Tbio Non-IDG -2.02762 98.5 459
DNA polymerase alpha catalytic subunit POLA1 Tclin Enzyme -2.40809 246.5 129
Werner syndrome ATP-dependent helicase WRN Tbio Enzyme -2.73759 569.7 210
Exonuclease mut-7 homolog EXD3 Tdark Enzyme -0.45611 3.91 67
Oligoribonuclease, mitochondrial REXO2 Tbio Enzyme -2.15502 143.8 115