Development Level

Tbio 5 | 11,445

IMPC Phenotype

abnormal retina morphology 1 | 71
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
increased circulating potassiu... 1 | 29
preweaning lethality, complete... 1 | 979

Disease

Carcinoma 5 | 11,493
lung cancer 4 | 4,740
Cockayne syndrome 3 | 60
medulloblastoma, large-cell 3 | 6,241
osteosarcoma 3 | 7,950
ovarian cancer 3 | 8,520
psoriasis 3 | 6,694
Autosomal recessive predisposition 2 | 1,442
Breast cancer 2 | 3,578
Cataract 2 | 297
Decreased fertility 2 | 33
Fanconi anemia 2 | 56
Hyperkeratosis 2 | 50
Hypogonadism 2 | 173
Kidney cancer 2 | 2,613
Lens Opacities 2 | 231
Photosensitive trichothiodystrophy 2 | 30
Rothmund-Thomson syndrome 2 | 19
Short stature 2 | 531
Telangiectasia of the skin 2 | 39
Wizened face 2 | 9
Xeroderma pigmentosum 2 | 43
adrenocortical carcinoma 2 | 1,428
ductal carcinoma in situ 2 | 1,745
glioblastoma 2 | 5,792
group 3 medulloblastoma 2 | 4,104
invasive ductal carcinoma 2 | 2,951
lung adenocarcinoma 2 | 2,716
malignant mesothelioma 2 | 3,232
non-small cell lung cancer 2 | 2,890
primitive neuroectodermal tumor 2 | 3,035
Abnormal CNS myelination 1 | 4
Aplasia/Hypoplasia of the skin 1 | 16
Arsenic Poisoning 1 | 62
Arteriosclerosis 1 | 11
Arthralgia 1 | 90
Atrophic condition of skin 1 | 25
Baller-Gerold syndrome 1 | 12
Basal cell carcinoma 1 | 54
Basal cell nevi 1 | 23
Basal ganglia calcification 1 | 27
Bloom syndrome 1 | 29
Brittle hair 1 | 25
Cachexia 1 | 50
Calcium pyrophosphate deposition disease 1 | 13
Congenital Nonbullous Ichthyosiform Erythroderma 1 | 16
Congestive heart failure 1 | 113
Conjunctival telangiectasis 1 | 14
Convex nasal ridge 1 | 37
Decreased nerve conduction velocity 1 | 35
Dental abnormalities 1 | 60
DiGeorge syndrome 1 | 47
Dry skin 1 | 75
EAR, PATELLA, SHORT STATURE SYNDROME 1 | 7
Erythema 1 | 58
Fatigue 1 | 182
Flushing 1 | 60
Fractured hair 1 | 25
Fragile hair 1 | 25
Freckles 1 | 33
Hair shaft abnormalities 1 | 30
Heart failure 1 | 162
Hyperpigmented macules 1 | 42
Insulin Resistance 1 | 72
Lack of skin elasticity 1 | 10
Lipoatrophy 1 | 19
Meier-Gorlin syndrome 1 | 10
Meningioma 1 | 41
Myocardial Infarction 1 | 151
Narrow face 1 | 54
Nijmegen breakage syndrome 1 | 24
Osteosclerosis 1 | 31
Papilloma 1 | 44
Peripheral Nervous System Diseases 1 | 52
Peripheral Neuropathy 1 | 134
Peripheral demyelinating neuropathy 1 | 7
Photosensitivity of skin 1 | 51
Poikiloderma 1 | 14
Precociously senile appearance 1 | 18
Premature canities 1 | 24
Progeria 1 | 25
Progressive mental retardation 1 | 37
Pulmonary artery stenosis 1 | 22
Rapadilino syndrome 1 | 7
Reduced tensile strength of hair 1 | 25
Retinitis pigmentosa 4 1 | 38
Skin Ulcer 1 | 48
Slender build 1 | 14
Small hand 1 | 36
Sparse scalp hair 1 | 42
Squamous cell carcinoma of skin 1 | 11
Stretched skin 1 | 10
Thin face 1 | 54
Tooth Abnormalities 1 | 69
UV-sensitive syndrome 1 | 10
Velocardiofacial syndrome 1 | 46
Werner syndrome 1 | 29
Xerosis 1 | 75
hair abnormalities (non-specific) 1 | 30
hypopigmented skin patch 1 | 59

Tissue

Blood and immune system 5 | 16,909
Cardiovascular System 5 | 15,192
Digestive Tract 5 | 17,369
Endocrine System 5 | 18,159
Female tissues 5 | 17,400
Liver and Pancreas 5 | 16,750
Male tissues 5 | 17,142
Nervous System 5 | 16,725
Respiratory system 5 | 16,393
Skin and soft tissues 5 | 17,230
Urinary Tract 5 | 16,678

Target Family

Enzyme 3 | 4,145
Non-IDG 2 | 12,091

GO Function

3'-5' DNA helicase activity 5 | 5
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Werner syndrome ATP-dependent helicase WRN Tbio Enzyme -2.73759 569.7 210
TFIIH basal transcription factor complex helicase XPB subunit ERCC3 Tbio Enzyme -1.96419 91.4 163
Cell division control protein 45 homolog CDC45 Tbio Non-IDG -2.10913 117.6 265
F-box DNA helicase 1 FBXO18 Tbio Enzyme -1.16507 17.7 87
DNA replication complex GINS protein PSF1 GINS1 Tbio Non-IDG -0.62279 2.63 130