Development Level

Tclin 12 | 612
Tchem 2 | 1,885

IMPC Phenotype

abnormal heart morphology 2 | 162
enlarged heart 2 | 210
abnormal behavior 1 | 298
abnormal whole-body plethysmog... 1 | 4
decreased body weight 1 | 161
decreased circulating amylase ... 1 | 28
decreased circulating triglyce... 1 | 79
decreased lymphocyte cell numb... 1 | 83
hyperactivity 1 | 148
hypoactivity 1 | 132
increased blood uric acid leve... 1 | 5
increased cellular hemoglobin ... 1 | 1
increased circulating potassiu... 1 | 29
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
macrophthalmia 1 | 2
prolonged PR interval 1 | 15

Disease

Atrial Fibrillation 13 | 120
Chronic heart failure 13 | 44
Myocardial Perfusion Imaging Adjunct 13 | 25
Platelet Aggregation Inhibition 13 | 22
Prevention of Cerebral Thrombosis 13 | 29
Carcinoma 12 | 11,192
invasive ductal carcinoma 7 | 2,867
medulloblastoma, large-cell 7 | 6,086
Autosomal recessive predisposition 5 | 1,407
Breast cancer 5 | 3,469
Electroretinogram abnormal 5 | 94
Hypogonadism 5 | 169
Photodysphoria 5 | 117
Photophobia 5 | 117
Retinitis Pigmentosa 5 | 223
atypical teratoid / rhabdoid tumor 5 | 4,971
breast carcinoma 5 | 1,589
osteosarcoma 5 | 7,766
ovarian cancer 5 | 8,297
Abnormality of retinal pigmentation 4 | 109
Astrocytoma, Pilocytic 4 | 3,006
Difficulties with night vision 4 | 85
Impotence 4 | 44
Kidney cancer 4 | 2,548
Night Blindness 4 | 99
Nystagmus 4 | 309
Obesity 4 | 655
Retinal pigment epithelial abnormality 4 | 109
colon cancer 4 | 1,428
ependymoma 4 | 4,559
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,204
lung cancer 4 | 4,607
malignant mesothelioma 4 | 3,135
oligodendroglioma 4 | 2,768
psoriasis 4 | 6,514
Abnormality of the retinal vasculature 3 | 58
Anteverted nostril 3 | 186
Atypical scarring of skin 3 | 61
Blind Vision 3 | 110
Blindness 3 | 86
Blindness, Legal 3 | 109
Broad flat nasal bridge 3 | 232
Cataract 3 | 290
Conductive hearing loss 3 | 122
Congenital anomaly of testis 3 | 51
Congenital hypoplasia of penis 3 | 168
Dull intelligence 3 | 634
Fundus dystrophy 3 | 80
Glaucoma 3 | 232
Hyperinsulinism 3 | 128
Intellectual disability 3 | 998
Keratoconus 3 | 111
Lens Opacities 3 | 227
Low Vision 3 | 167
Low intelligence 3 | 634
Mental Retardation 3 | 634
Mental deficiency 3 | 634
Nasal bridge wide 3 | 232
Night blindness, progressive 3 | 50
Ophthalmoplegia 3 | 105
Optic Atrophy 3 | 239
Pick disease 3 | 1,856
Poor school performance 3 | 634
Reduced visual acuity 3 | 60
Sensorineural Hearing Loss (disorder) 3 | 281
Visual Impairment 3 | 167
adult high grade glioma 3 | 3,701
astrocytic glioma 3 | 2,530
diabetes mellitus 3 | 1,683
ductal carcinoma in situ 3 | 1,686
fibroadenoma 3 | 538
group 4 medulloblastoma 3 | 1,806
interstitial cystitis 3 | 2,237
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,872
lung adenocarcinoma 3 | 2,627
medulloblastoma 3 | 702
non-small cell lung cancer 3 | 2,799
pituitary cancer 3 | 1,915
tuberculosis 3 | 1,963
ulcerative colitis 3 | 1,765
Asthma 2 | 370
Bipolar Disorder 2 | 646
Cone dystrophy 2 | 68
Depressive disorder 2 | 401
Exotropia 2 | 35
Hyperopia 2 | 68
Increase in blood pressure 2 | 118
Major Depressive Disorder 2 | 293
Pallor of optic disc 2 | 39
Psychotic Disorders 2 | 150
Pulmonary hypertension 2 | 85
Retinal Degeneration 2 | 103
Rheumatoid arthritis 2 | 1,156
Short stature 2 | 514
cutaneous lupus erythematosus 2 | 1,016
glioblastoma 2 | 5,635
group 3 medulloblastoma 2 | 4,002
lung carcinoma 2 | 2,755
primitive neuroectodermal tumor 2 | 2,957
subependymal giant cell astrocytoma 2 | 2,230

Tissue

Blood and immune system 14 | 16,909
Digestive Tract 14 | 17,369
Endocrine System 14 | 18,159
Nervous System 14 | 16,725
Urinary Tract 14 | 16,678
Female tissues 13 | 17,400
Liver and Pancreas 13 | 16,750
Respiratory system 13 | 16,393
Skin and soft tissues 13 | 17,230
Cardiovascular System 12 | 15,192
Male tissues 12 | 17,142

Target Family

Enzyme 14 | 4,145

GO Function

3',5'-cyclic-GMP phosphodieste... 14 | 14
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

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