Development Level

Tclin 12 | 602
Tchem 2 | 1,890

IMPC Term

abnormal behavior 1 | 226
abnormal lens morphology 1 | 73
abnormal whole-body plethysmog... 1 | 4
decreased body temperature 1 | 2
decreased body weight 1 | 174
decreased circulating amylase ... 1 | 24
decreased circulating triglyce... 1 | 83
enlarged heart 1 | 111
hypoactivity 1 | 89
increased blood uric acid leve... 1 | 5
increased cellular hemoglobin ... 1 | 2
increased circulating potassiu... 1 | 31
increased mean corpuscular vol... 1 | 91
macrophthalmia 1 | 2

Disease

Atrial Fibrillation 13 | 110
Chronic heart failure 13 | 46
Myocardial Perfusion Imaging Adjunct 13 | 25
Platelet Aggregation Inhibition 13 | 22
Prevention of Cerebral Thrombosis 13 | 29
invasive ductal carcinoma 7 | 2,950
medulloblastoma, large-cell 7 | 6,234
Breast cancer 5 | 3,094
atypical teratoid / rhabdoid tumor 5 | 4,369
breast carcinoma 5 | 1,614
osteosarcoma 5 | 7,933
ovarian cancer 5 | 8,484
Impotence 4 | 45
colon cancer 4 | 1,475
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,289
lung cancer 4 | 4,466
malignant mesothelioma 4 | 3,162
oligodendroglioma 4 | 2,849
pilocytic astrocytoma 4 | 3,086
psoriasis 4 | 6,685
Blindness 3 | 84
Fundus dystrophy 3 | 77
Pick disease 3 | 1,893
Retinitis pigmentosa 3 | 153
ductal carcinoma in situ 3 | 1,745
fibroadenoma 3 | 557
group 4 medulloblastoma 3 | 1,875
interstitial cystitis 3 | 2,299
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,956
lung adenocarcinoma 3 | 2,713
pituitary cancer 3 | 1,972
posterior fossa group A ependymoma 3 | 1,511
sonic hedgehog group medulloblastoma 3 | 1,482
ulcerative colitis 3 | 2,087
Achromatopsia 2 | 14
Acute heart failure 2 | 2
Benign prostatic hyperplasia 2 | 7
Carcinoma 2 | 2,147
Pulmonary hypertension 2 | 52
Retinal Degeneration 2 | 49
Rheumatoid Arthritis 2 | 1,160
astrocytic glioma 2 | 2,241
cutaneous lupus erythematosus 2 | 1,056
diabetes mellitus 2 | 1,663
glioblastoma 2 | 5,572
group 3 medulloblastoma 2 | 2,254
lung carcinoma 2 | 2,844
non-small cell lung cancer 2 | 2,798
pediatric high grade glioma 2 | 2,712
posterior fossa group B ependymoma 2 | 1,530
primitive neuroectodermal tumor 2 | 3,031
subependymal giant cell astrocytoma 2 | 2,287
tuberculosis 2 | 1,557
Acquired metabolic disease 1 | 267
Adenoma 1 | 165
Age related macular degeneration 1 | 84
Amphetamine-Related Disorders 1 | 74
Anterior ischemic optic neuropathy 1 | 7
Asthma management 1 | 20
Bipolar Disorder 1 | 266
Brachydactyly 1 | 52
Brain cancer 1 | 21
Bronchitis 1 | 44
Choreatic disease 1 | 27
Cone dystrophy 1 | 57
Congenital stationary night blindness 1 | 27
Coronary artery disease 1 | 240
Cushing's syndrome 1 | 47
Dyspepsia 1 | 34
Heart conduction disease 1 | 65
Heart disease 1 | 279
Huntington's disease 1 | 72
Hypertension 1 | 287
Hypogonadism 1 | 70
Major Depressive Disorder 1 | 106
Male infertility 1 | 170
Mammary Neoplasms 1 | 410
Multiple Sclerosis 1 | 498
Myocardial Infarction 1 | 126
Neoplasm Metastasis 1 | 138
Night Blindness 1 | 39
Peripheral vascular disease 1 | 90
Polycystic Ovary Syndrome 1 | 332
Premature ejaculation 1 | 16
Primary pigmented nodular adrenocortical disease 1 | 12
Prostatic hypertrophy 1 | 9
Pulmonary emphysema 1 | 34
Tularemia 1 | 22
X-linked cerebral adrenoleukodystrophy 1 | 115
active Crohn's disease 1 | 918
active ulcerative colitis 1 | 477
head and neck cancer 1 | 270
inflammatory breast cancer 1 | 404
non-inflammatory breast cancer 1 | 208
non-small cell lung carcinoma 1 | 413
pancreatic carcinoma 1 | 567
progressive supranuclear palsy 1 | 674
pulmonary arterial hypertension 1 | 36
tuberculosis and treatment for 3 months 1 | 327
type II diabetes mellitus and post-ischemic heart failure 1 | 89

Tissue

Blood and immune system 14 | 17,995
Cardiovascular System 14 | 17,958
Digestive Tract 14 | 18,473
Endocrine System 14 | 18,512
Female tissues 14 | 18,647
Liver and Pancreas 14 | 18,136
Male tissues 14 | 17,969
Nervous System 14 | 18,561
Respiratory system 14 | 17,484
Skin and soft tissues 14 | 18,115
Urinary Tract 14 | 18,444

Target Family

Enzyme 14 | 4,146

GO Function

3',5'-cyclic-GMP phosphodieste... 14 | 14
metal ion binding 1,917 | 1,917
ATP binding 1,467 | 1,467
DNA binding 1,432 | 1,432
zinc ion binding 1,155 | 1,155
poly(A) RNA binding 1,107 | 1,107
transcription factor activity,... 853 | 853
calcium ion binding 695 | 695
G-protein coupled receptor act... 661 | 661
protein homodimerization activ... 569 | 569
RNA binding 445 | 445
olfactory receptor activity 424 | 424
sequence-specific DNA binding 398 | 398
GTP binding 374 | 374
chromatin binding 372 | 372
protein serine/threonine kinas... 336 | 336
RNA polymerase II core promote... 332 | 332
identical protein binding 311 | 311
nucleotide binding 311 | 311
receptor binding 303 | 303
protein kinase binding 289 | 289
enzyme binding 286 | 286
cadherin binding involved in c... 277 | 277
GTPase activator activity 273 | 273
ubiquitin protein ligase bindi... 258 | 258
ubiquitin-protein transferase ... 253 | 253
serine-type endopeptidase acti... 246 | 246
transcription coactivator acti... 241 | 241
transcription factor binding 240 | 240
structural molecule activity 232 | 232
GTPase activity 231 | 231
transcriptional activator acti... 230 | 230
ligase activity 227 | 227
protein heterodimerization act... 227 | 227
structural constituent of ribo... 212 | 212
transcription regulatory regio... 202 | 202
transmembrane signaling recept... 201 | 201
RNA polymerase II regulatory r... 200 | 200
receptor activity 200 | 200
transcription corepressor acti... 198 | 198
magnesium ion binding 197 | 197
signal transducer activity 196 | 196
nucleic acid binding 184 | 184
protein kinase activity 183 | 183
carbohydrate binding 180 | 180
ubiquitin protein ligase activ... 173 | 173
RNA polymerase II transcriptio... 162 | 162
heparin binding 160 | 160
iron ion binding 141 | 141
lipid binding 136 | 136
transporter activity 136 | 136
actin binding 133 | 133
ATPase activity 132 | 132
protein C-terminus binding 129 | 129
heme binding 127 | 127
microtubule binding 123 | 123
protein tyrosine kinase activi... 119 | 119
cytokine activity 118 | 118
Ras guanyl-nucleotide exchange... 113 | 113
mRNA binding 112 | 112
metalloendopeptidase activity 112 | 112
transcriptional repressor acti... 110 | 110
structural constituent of cyto... 108 | 108
Rab GTPase binding 105 | 105
antigen binding 104 | 104
protein domain specific bindin... 102 | 102
peptide antigen binding 101 | 101
guanyl-nucleotide exchange fac... 98 | 98
protein complex binding 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 92 | 92
oxidoreductase activity 91 | 91
transcriptional activator acti... 91 | 91
actin filament binding 89 | 89
hydrolase activity 89 | 89
ion channel binding 89 | 89
protein tyrosine phosphatase a... 88 | 88
electron carrier activity 87 | 87
protease binding 87 | 87
histone binding 86 | 86
integrin binding 83 | 83
growth factor activity 82 | 82
phospholipid binding 82 | 82
single-stranded DNA binding 81 | 81
unfolded protein binding 77 | 77
kinase activity 75 | 75
thiol-dependent ubiquitin-spec... 75 | 75
phosphatidylinositol binding 74 | 74
calmodulin binding 73 | 73
histone deacetylase binding 73 | 73
Rho guanyl-nucleotide exchange... 72 | 72
drug binding 71 | 71
double-stranded DNA binding 70 | 70
peptidase activity 70 | 70
protein N-terminus binding 70 | 70
virus receptor activity 68 | 68
beta-catenin binding 67 | 67
microtubule motor activity 67 | 67
protein transporter activity 67 | 67
calcium channel activity 66 | 66
ubiquitin binding 66 | 66

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